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3601por Stumpf, Julian, Siepmann, Torsten, Schwöbel, Jörg, Glombig, Grit, Paliege, Alexander, Steglich, Anne, Gembardt, Florian, Kessel, Friederike, Kröger, Hannah, Arndt, Patrick, Sradnick, Jan, Frank, Kerstin, Klimova, Anna, Mauer, René, Tonn, Torsten, Hugo, Christian“…Similar results were obtained for anti-RBD IgG antibodies (T2 p = 0.003 and T3 p = 0.135). …”
Publicado 2022
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3602por Gallego-Valcarce, Eduardo, Shabaka, Amir, Leon-Poo, Mariana, Gruss, Enrique, Acedo-Sanz, Juan Manuel, Cordón, Alfredo, Cases-Corona, Clara, Fernandez-Juarez, Gema“…The primary outcome was sustained effective humoral response defined as anti-S(RBD) levels > 1,000 AU/ml after 4 months from the third dose. …”
Publicado 2022
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3603por Ren, Ping, Hu, Yingxia, Peng, Lei, Yang, Luojia, Suzuki, Kazushi, Fang, Zhenhao, Bai, Meizhu, Zhou, Liqun, Feng, Yanzhi, Zou, Yongji, Xiong, Yong, Chen, Sidi“…Three-dimensional structural analysis shows distinct epitope of antibody - spike receptor binding domain (RBD) interactions and reveals that both Fab fragments of CoV2–0213 can simultaneously target one single spike RBD or two adjacent ones in the same spike trimer, further corroborating its mechanism of action. …”
Publicado 2023
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3604por Moody, Rhiane, Sonda, Sabrina, Johnston, Fay H., Smith, Kylie J., Stephens, Nicola, McPherson, Michelle, Flanagan, Katie L., Plebanski, Magdalena“…These were also shown to be cross-reactive to the Omicron variant spike protein at a similar level to lasting anti-RBD antibodies (correlation r=0.89). Individuals post COVID-19 infection recognised a common set of autoantigens, specific to this group in comparison to the healthy controls. …”
Publicado 2022
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3605por Hattori, Takanari, Saito, Takeshi, Okuya, Kosuke, Takahashi, Yuji, Miyamoto, Hiroko, Kajihara, Masahiro, Igarashi, Manabu, Takada, Ayato“…Previous mutational scanning studies have suggested that some substitutions corresponding to single nucleotide variants (SNVs) in human ACE2 affect the binding affinity to the receptor binding domain (RBD) of the SARS-CoV-2 S protein. However, the importance of these substitutions in actual virus infection is still unclear. …”
Publicado 2022
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3606por Ardicli, Ozge, Carli, K. Tayfun, Satitsuksanoa, Pattraporn, Dreher, Anita, Cusini, Alexia, Hutter, Sandra, Mirer, David, Rückert, Beate, Jonsdottir, Hulda R., Weber, Benjamin, Cervia, Carlo, Akdis, Mubeccel, Boyman, Onur, Eggel, Alexander, Brüggen, Marie‐Charlotte, Akdis, Cezmi A., van de Veen, Willem“…We observed a strong correlation between IBV‐specific IgG and SARS‐CoV‐2 S1‐, RBD‐, S2‐, and N‐specific IgG in poultry farm personnel compared with pre‐pandemic controls and COVID‐19 patients. …”
Publicado 2022
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3607por Ou, Feiyang, Lai, Danyun, Kuang, Xiaojun, He, Ping, Li, Yang, Jiang, He-wei, Liu, Wei, Wei, Hongping, Gu, Hongchen, Ji, Yuan qiao, Xu, Hong, Tao, Sheng-ce“…Herein, by combining the single molecule array platform (Simoa), RBD, and a previously identified SARS-CoV-2 S2 protein derivatized 12-aa peptide (S2-78), we developed and optimized an ultrasensitive assay (UIM-COVID-19 assay). …”
Publicado 2022
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3608por Primpray, Vitsarut, Kamsong, Wichayaporn, Pakapongpan, Saithip, Phochakum, Kanchanok, Kaewchaem, Arissanan, Sappat, Assawapong, Wisitsoraat, Anurat, Lomas, Tanom, Tuantranont, Adisorn, Karuwan, Chanpen“…The method was based on a competitive enzyme immunoassay process utilizing horseradish peroxidase (HRP)-conjugated SARS-CoV-2 as a reporter binding molecule to compete binding with antibody against the SARS-CoV-2 receptor binding domain (SARS-CoV-2 RBD) protein. This strategy enhanced the current signal via the enzymatic reaction of HRP-conjugated SARS-CoV-2 RBD antibody on the electrode surface. …”
Publicado 2022
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3609por Leung, Daniel, Mu, Xiaofeng, Duque, Jaime S. Rosa, Cheng, Samuel M. S., Wang, Manni, Zhang, Wenyue, Zhang, Yanmei, Tam, Issan Y. S., Lee, Toby S. S., Lam, Jennifer H. Y., Chan, Sau Man, Cheang, Cheuk Hei, Chung, Yuet, Wong, Howard H. W., Lee, Amos M. T., Li, Wing Yan, Chaothai, Sara, Tsang, Leo C. H., Chua, Gilbert T., Cheong, Kai-Ning, Au, Elaine Y. L., Kwok, Janette S. Y., Chan, Koon Wing, Chong, Patrick C. Y., Lee, Pamela P. W., Ho, Marco H. K., Lee, Tsz Leung, Tu, Wenwei, Peiris, Malik, Lau, Yu Lung“…No safety concerns were identified. Inadequate S-RBD IgG and surrogate virus neutralization responses were found after 2 doses in patients with humoral immunodeficiencies and especially so against BA.1. …”
Publicado 2022
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3610por Lee, Chi-Ho, Gray, Victor, Teo, Jia Ming Nickolas, Tam, Anthony Raymond, Fong, Carol Ho-Yi, Lui, David Tak-Wai, Pang, Polly, Chan, Kwok Hung, Hung, Ivan Fan-Ngai, Tan, Kathryn Choon-Beng, Ling, Guang Sheng“…However, this initial defect was rectified by the second dose of BNT162b2, resulting in comparable levels of memory CD4(+) and CD8(+)T cells, anti-RBD IgG, and neutralizing antibodies with healthy individuals at 3-6 months after vaccination. …”
Publicado 2022
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3611por Saade, Carla, Brengel-Pesce, Karen, Gaymard, Alexandre, Trabaud, Mary-Anne, Destras, Gregory, Oriol, Guy, Cheynet, Valérie, Debombourg, Marion, Mokdad, Bouchra, Billaud, Geneviève, Oblette, Antoine, Créhalet, Hervé, Giannoli, Jean-Marc, Garrigou, Christine, Generenaz, Laurence, Compagnon, Christelle, Boibieux, André, Lina, Bruno, Morfin, Florence, Pozzetto, Bruno, Josset, Laurence, Touillet-Assant, Sophie, Bal, Antonin“…We then explored the impact of Omicron infection on pre-existing immunity assessing anti-RBD IgG levels, neutralizing antibody titres against 19A, Delta and Omicron isolates, as well as IFN-γ release following cell stimulation with SARS-CoV-2 peptides. …”
Publicado 2022
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3612por Mu, Song, Song, Shuyi, Hao, Yanan, Luo, Feiyang, Wu, Ruixin, Wang, Yi, Han, Xiaojian, Li, Tingting, Hu, Chao, Li, Shenglong, Shen, Meiying, Huang, Jingjing, Wang, Wang, Wang, Yingming, Jin, Aishun“…Early studies showed that the ability of SARS-CoV-2 RBD or NTD antibodies to elicit infection enhancement in vivo is still controversial. …”
Publicado 2022
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3613por Fernandes-Siqueira, Lorena O., Sousa, Bruna G., Cleto, Carlos E., Wermelinger, Luciana S., Caetano, Beatriz L.L., Pacheco, Agatha R., Costa, Simone M., Almeida, Fabio C.L., Ferreira, Gustavo C., Salmon, Didier, Alves, Ada M.B., Da Poian, Andrea T.“…CONCLUSIONS: Altogether our data suggest that quantification of serum anti-S or anti-RBD IgA, rather than IgG, may be a valuable tool to screen NAbs and may be considered for surveillance of vaccine coverage.…”
Publicado 2022
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3614por Zhong, Jiaying, Liu, Shuo, Cui, Tingting, Li, Jingxin, Zhu, Fengcai, Zhong, Nanshan, Huang, Weijin, Zhao, Zhuxiang, Wang, Zhongfang“…In addition, I-I-Ad5 induced higher, but later, anti-RBD IgG and IgA in plasma than I-I-I. Our study verified that mucosal immunization with aerosol inhalation of adenoviral vector COVID-19 vaccine may be an effective strategy to control the probable wave of BA.5 pandemic in addition to two inactivated vaccines.…”
Publicado 2022
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3615por Krause, Robert, Snyman, Jumari, Shi-Hsia, Hwa, Muema, Daniel, Karim, Farina, Ganga, Yashica, Ngoepe, Abigail, Zungu, Yenzekile, Gazy, Inbal, Bernstein, Mallory, Khan, Khadija, Mazibuko, Matilda, Mthabela, Ntombifuthi, Ramjit, Dirhona, Limbo, Oliver, Jardine, Joseph, Sok, Devin, Wilson, Ian A, Hanekom, Willem, Sigal, Alex, Kløverpris, Henrik, Ndung'u, Thumbi, Leslie, Alasdair“…This was mirrored by increased extrafollicular (EF) activity, with dynamic changes in activated double negative (DN2) and activated naïve B cells, which correlated with anti-RBD-titres in these individuals. An elevated SARS-CoV-2-specific EF response in PLWH was confirmed using viral spike and RBD bait proteins. …”
Publicado 2022
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3616por Ducharme, Jeremy B., McKenna, Zachary J., Fennel, Zachary J., Nava, Roberto C., Mermier, Christine M., Deyhle, Michael R.“…Body fat percentage was inversely associated with the magnitude of S1 (p = 0.006, β = − 366.56), RBD (p = 0.003, β = − 249.30), and S2 (p = 0.106, β = − 190.08) antibodies present in the serum following SARS-CoV-2 mRNA vaccination. …”
Publicado 2022
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3617por Lunderberg, Justin Mark, Dutta, Sanjucta, Collier, Ai-Ris Y., Lee, Jeng-Shin, Hsu, Yen-Ming, Wang, Qiao, Zheng, Weina, Hao, Shushun, Zhang, Haohai, Feng, Lili, Robson, Simon C., Gao, Wenda, Riedel, Stefan“…Surprisingly, potent neutAb activity was mainly noted in patients generating both IgM and IgG against the Spike receptor-binding domain (RBD), in contrast to samples possessing anti-RBD IgG alone. …”
Publicado 2022
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3618por Kumar, T.H. Vignesh, Srinivasan, Sowmiya, Krishnan, Vinoth, Vaidyanathan, Rama, Babu, Kannadasan Anand, Natarajan, Sudhakar, Veerapandian, Murugan“…In silico molecular docking of customized 25 mer peptides with RBD of SARS-CoV-2 SP were validated by AutoDock CrankPep. …”
Publicado 2023
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3619“…In addition, we found that PD patients with probable rapid eye movement sleep behavior disorder (pRBD) showed decreased CSF α-syn (β = −0.1343; P = 0.0033) levels. …”
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3620por Yamaguchi, Yuta, Nameki, Shinichiro, Kato, Yasuhiro, Saita, Ryotaro, Sato, Tomoharu, Nagao, Sayaka, Murakami, Teruaki, Yoshimine, Yuko, Amiya, Saori, Morita, Takayoshi, Okita, Yasutaka, Kawasaki, Takahiro, Fujimoto, Jun, Ueda, Yasutaka, Maeda, Yuichi, Watanabe, Akane, Takamatsu, Hyota, Nishida, Sumiyuki, Shima, Yoshihito, Narazaki, Masashi, Kumanogoh, Atsushi“…METHODS: Serum-neutralizing antibody (NAb) and anti-receptor-binding domain (RBD)/spike antibody levels were measured. Short- and medium-term effects of immunosuppressants were analyzed pre-vaccination (Term 1) and 14–42 days (Term 2) and 100–200 days (Term 3) after the second vaccination. …”
Publicado 2022
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