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  1. 3661
    “…Due to high anti-S1 and anti-RBD antibody content, final products exhibited high in vitro neutralizing capacity of SARS-CoV-2 infection, 80 times higher than a pool of human convalescent plasma. …”
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    Development and characterization of two equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19
  2. 3662
    “…Moreover, several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain (RBD) or nucleoprotein (NP) via ELISA assay. Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro. …”
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    Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq
  3. 3663
    “…S is present on virions as prefusion trimers in which the receptor binding domain (RBD) is stochastically open or closed. Neutralizing antibodies have been described against both open and closed conformations. …”
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    SARS-CoV-2 Spike Protein Stabilized in the Closed State Induces Potent Neutralizing Responses
  4. 3664
    “…No differences were found for olfaction and overall cognition; German-siblings performed worse than CTRs in visuospatial-executive and language tasks. 3/147 siblings had video-polysomnography-confirmed REM sleep behavior disorder (RBD), none was positive on the RBD Screening Questionnaire. 173/300 siblings had <1% probability of having prodromal PD; 100 between 1 and 10%, 26 siblings between 10 and 80%, one fulfilled the criteria for prodromal PD. …”
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    Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients
  5. 3665
    “…During this process, the receptor binding domain (RBD) of the S protein plays an essential role, since it contains the receptor binding motif (RBM), responsible for the docking to the receptor. …”
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    The SARS-CoV-2 spike protein is vulnerable to moderate electric fields
  6. 3666
    por Chang-Monteagudo, Arturo, Ochoa-Azze, Rolando, Climent-Ruiz, Yanet, Macías-Abraham, Consuelo, Rodríguez-Noda, Laura, Valenzuela-Silva, Carmen, Sánchez-Ramírez, Belinda, Perez-Nicado, Rocmira, Hernández-García, Tays, Orosa-Vázquez, Ivette, Díaz-Hernández, Marianniz, García-García, María de los Ángeles, Jerez-Barceló, Yanet, Triana-Marrero, Yenisey, Ruiz-Villegas, Laura, Rodríguez-Prieto, Luis Dairon, Puga-Gómez, Rinaldo, Guerra-Chaviano, Pedro Pablo, Zúñiga-Rosales, Yaíma, Marcheco-Teruel, Beatriz, Rodríguez-Acosta, Mireida, Noa-Romero, Enrique, Enríquez-Puertas, Juliet, Porto-González, Delia, Fernández-Medina, Olivia, Valdés-Zayas, Anet, Chen, Guang-Wu, Herrera-Martínez, Luís, Valdés-Balbín, Yury, García-Rivera, Dagmar, Verez-Bencomo, Vicente
    Publicado 2021
    “…There was also an increase in RBD-specific T cells producing IFN-γ and TNF-α. …”
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    A single dose of SARS-CoV-2 FINLAY-FR-1A vaccine enhances neutralization response in COVID-19 convalescents, with a very good safety profile: An open-label phase 1 clinical trial
  7. 3667
    “…The majority of patients with iRBD will develop manifest PD within years to decades. …”
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    Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease
  8. 3668
    “…AKS-452 is a biologically-engineered vaccine comprising an Fc fusion protein of the SARS-CoV-2 viral spike protein receptor binding domain antigen (Ag) and human IgG1 Fc (SP/RBD-Fc) in clinical development for the induction and augmentation of neutralizing IgG titers against SARS-CoV-2 viral infection to address the COVID-19 pandemic. …”
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    Development of an IgG-Fc fusion COVID-19 subunit vaccine, AKS-452
  9. 3669
    “…Total anti-receptor-binding domain (RBD) antibodies remained stable since discharge, while anti-RBD IgG and neutralization levels decreased over time. …”
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    SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection
  10. 3670
    “…The crystal structure of n3113 in complex with the receptor-binding domain (RBD) of SARS-CoV-2, combined with the cryo-EM structures of n3113 and spike ecto-domain, reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2. …”
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    A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants
  11. 3671
    “…At T2 all naïve HCW developed anti-S-RBD-IgG, while 94% of IMID responded (p < 0.001). …”
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    Evaluation of antibody response to BNT162b2 mRNA COVID-19 vaccine in patients affected by immune-mediated inflammatory diseases up to 5 months after vaccination
  12. 3672
    por Dixson, Jamie D, Azad, Rajeev K
    Publicado 2021
    “…In an effort to understand the evolution of receptor binding domain (RBD) of the spike protein of SARS-CoV-2, and specifically, how the ability of RBD to bind to angiotensin-converting enzyme 2 receptor (ACE2) of humans evolved in coronaviruses, we have applied an alignment-free technique to infer functional relatedness among betacoronaviruses. …”
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    A novel predictor of ACE2-binding ability among betacoronaviruses
  13. 3673
    “…METHODS: We determined the response and duration for 5 subsets of anti-SARS-CoV-2 antibodies (neutralizing antibody, anti-RBD total antibody, anti-Spike IgG, anti-Spike IgM, and anti-Spike IgA) in 61 volunteers within 160 days after the CoronaVac vaccine. …”
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    Response and Duration of Serum Anti-SARS-CoV-2 Antibodies After Inactivated Vaccination Within 160 Days
  14. 3674
    “…Given the urgency of the required analysis and data on the B.1.1.529 variant, we have performed a detailed investigation to provide an understanding of the impact of these novel mutations on the structure, function, and binding of RBD to hACE2 and mAb to the NTD of the spike protein. …”
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    The Omicron (B.1.1.529) variant of SARS-CoV-2 binds to the hACE2 receptor more strongly and escapes the antibody response: Insights from structural and simulation data
  15. 3675
    “…The vaccine contains immunodominant peptides screened from the receptor-binding domain (RBD) and is fully chemically synthesized. It has been formulated in an optimized nanoemulsion formulation and is stable at 40 °C for 1 month. …”
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    CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity
  16. 3676
    “…Neutralizing antibodies targeting the RBD bind to several different sites on this domain. …”
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    Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins
  17. 3677
    “…Antibody quality also continued to improve for at least 9 months after primary 2-dose vaccination. Spike− and RBD-specific memory B cells were stable through 9 months post-vaccination with no evidence of decline over time, and ~40–50% of RBD-specific memory B cells were capable of simultaneously recognizing the Alpha, Beta, Delta, and Omicron variants. …”
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    Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
  18. 3678
    “…While mRNA vaccination induced a higher ratio of RBD- and S1-targeting antibodies, vector-based vaccines resulted in an increased proportion of S2-targeting antibodies. …”
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    Comparative Magnitude and Persistence of Humoral SARS-CoV-2 Vaccination Responses in the Adult Population in Germany
  19. 3679
    “…We have developed a prototype two-dose vaccine (BReC-CoV-2) by combining the Receptor Binding Domain (RBD) antigen, via conjugation to Diphtheria toxoid (EcoCRM(®)). …”
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    Intranasal administration of BReC-CoV-2 COVID-19 vaccine protects K18-hACE2 mice against lethal SARS-CoV-2 challenge
  20. 3680
    “…All 3 patients with dnDSA had robust response to the vaccine with antibodies to spike protein RBD of > 200 U/ml (Elecsys®). Eight vaccinated patients without dnDSA had anti-RBD testing, half had titres > 200 U/ml. …”
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    Development of De Novo Donor Specific Antibodies Following COVID-19 Vaccination in Cardiac Transplant
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