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3661por León, Guillermo, Herrera, María, Vargas, Mariángela, Arguedas, Mauricio, Sánchez, Andrés, Segura, Álvaro, Gómez, Aarón, Solano, Gabriela, Corrales-Aguilar, Eugenia, Risner, Kenneth, Narayanan, Aarthi, Bailey, Charles, Villalta, Mauren, Hernández, Andrés, Sánchez, Adriana, Cordero, Daniel, Solano, Daniela, Durán, Gina, Segura, Eduardo, Cerdas, Maykel, Umaña, Deibid, Moscoso, Edwin, Estrada, Ricardo, Gutiérrez, Jairo, Méndez, Marcos, Castillo, Ana Cecilia, Sánchez, Laura, Sánchez, Ronald, Gutiérrez, José María, Díaz, Cecilia, Alape, Alberto“…Due to high anti-S1 and anti-RBD antibody content, final products exhibited high in vitro neutralizing capacity of SARS-CoV-2 infection, 80 times higher than a pool of human convalescent plasma. …”
Publicado 2021
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3662por He, Bing, Liu, Shuning, Wang, Yuanyuan, Xu, Mengxin, Cai, Wei, Liu, Jia, Bai, Wendi, Ye, Shupei, Ma, Yong, Hu, Hengrui, Meng, Huicui, Sun, Tao, Li, Yanling, Luo, Huanle, Shi, Mang, Du, Xiangjun, Zhao, Wenjing, Chen, Shoudeng, Yang, Jingyi, Zhu, Haipeng, Jie, Yusheng, Yang, Yuedong, Guo, Deyin, Wang, Qiao, Liu, Yuwen, Yan, Huimin, Wang, Manli, Chen, Yao-Qing“…Moreover, several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain (RBD) or nucleoprotein (NP) via ELISA assay. Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro. …”
Publicado 2021
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3663por Carnell, George W., Ciazynska, Katarzyna A., Wells, David A., Xiong, Xiaoli, Aguinam, Ernest T., McLaughlin, Stephen H., Mallery, Donna, Ebrahimi, Soraya, Ceron-Gutierrez, Lourdes, Asbach, Benedikt, Einhauser, Sebastian, Wagner, Ralf, James, Leo C., Doffinger, Rainer, Heeney, Jonathan L., Briggs, John A. G.“…S is present on virions as prefusion trimers in which the receptor binding domain (RBD) is stochastically open or closed. Neutralizing antibodies have been described against both open and closed conformations. …”
Publicado 2021
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3664por Baldelli, Luca, Schade, Sebastian, Jesús, Silvia, Schreglmann, Sebastian R., Sambati, Luisa, Gómez-Garre, Pilar, Halsband, Claire, Calandra-Buonaura, Giovanna, Adarmes-Gómez, Astrid Daniela, Sixel-Döring, Friederike, Zenesini, Corrado, Pirazzini, Chiara, Garagnani, Paolo, Bacalini, Maria Giulia, Bhatia, Kailash P., Cortelli, Pietro, Mollenhauer, Brit, Franceschi, Claudio, Mir, Pablo, Trenkwalder, Claudia, Provini, Federica“…No differences were found for olfaction and overall cognition; German-siblings performed worse than CTRs in visuospatial-executive and language tasks. 3/147 siblings had video-polysomnography-confirmed REM sleep behavior disorder (RBD), none was positive on the RBD Screening Questionnaire. 173/300 siblings had <1% probability of having prodromal PD; 100 between 1 and 10%, 26 siblings between 10 and 80%, one fulfilled the criteria for prodromal PD. …”
Publicado 2021
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3665“…During this process, the receptor binding domain (RBD) of the S protein plays an essential role, since it contains the receptor binding motif (RBM), responsible for the docking to the receptor. …”
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3666por Chang-Monteagudo, Arturo, Ochoa-Azze, Rolando, Climent-Ruiz, Yanet, Macías-Abraham, Consuelo, Rodríguez-Noda, Laura, Valenzuela-Silva, Carmen, Sánchez-Ramírez, Belinda, Perez-Nicado, Rocmira, Hernández-García, Tays, Orosa-Vázquez, Ivette, Díaz-Hernández, Marianniz, García-García, María de los Ángeles, Jerez-Barceló, Yanet, Triana-Marrero, Yenisey, Ruiz-Villegas, Laura, Rodríguez-Prieto, Luis Dairon, Puga-Gómez, Rinaldo, Guerra-Chaviano, Pedro Pablo, Zúñiga-Rosales, Yaíma, Marcheco-Teruel, Beatriz, Rodríguez-Acosta, Mireida, Noa-Romero, Enrique, Enríquez-Puertas, Juliet, Porto-González, Delia, Fernández-Medina, Olivia, Valdés-Zayas, Anet, Chen, Guang-Wu, Herrera-Martínez, Luís, Valdés-Balbín, Yury, García-Rivera, Dagmar, Verez-Bencomo, Vicente“…There was also an increase in RBD-specific T cells producing IFN-γ and TNF-α. …”
Publicado 2021
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3667“…The majority of patients with iRBD will develop manifest PD within years to decades. …”
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3668por Alleva, David G., Delpero, Andrea R., Scully, Melanie M., Murikipudi, Sylaja, Ragupathy, Ramya, Greaves, Emma K., Sathiyaseelan, Thillainaygam, Haworth, Jeffrey R., Shah, Nishit J., Rao, Vidhya, Nagre, Shashikant, Lancaster, Thomas M., Webb, Sarah S., Jasa, Allison I., Ronca, Shannon E., Green, Freedom M., Elyard, Hanne Andersen, Yee, JoAnn, Klein, Jeffrey, Karnes, Larry, Sollie, Frans, Zion, Todd C.“…AKS-452 is a biologically-engineered vaccine comprising an Fc fusion protein of the SARS-CoV-2 viral spike protein receptor binding domain antigen (Ag) and human IgG1 Fc (SP/RBD-Fc) in clinical development for the induction and augmentation of neutralizing IgG titers against SARS-CoV-2 viral infection to address the COVID-19 pandemic. …”
Publicado 2021
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3669por Zhan, Yan, Zhu, Yufang, Wang, Shanshan, Jia, Shijun, Gao, Yunling, Lu, Yingying, Zhou, Caili, Liang, Ran, Sun, Dingwen, Wang, Xiaobo, Hou, Zhibing, Hu, Qiaoqiao, Du, Peng, Yu, Hao, Liu, Chang, Cui, Miao, Tong, Gangling, Zheng, Zhihua, Xu, Yunsheng, Zhu, Linyu, Cheng, Jin, Wu, Feng, Zheng, Yulan, Liu, Peijun, Hong, Peng“…Total anti-receptor-binding domain (RBD) antibodies remained stable since discharge, while anti-RBD IgG and neutralization levels decreased over time. …”
Publicado 2021
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3670por Yang, Zhenlin, Wang, Yulu, Jin, Yujia, Zhu, Yuanfei, Wu, Yanling, Li, Cheng, Kong, Yu, Song, Wenping, Tian, Xiaolong, Zhan, Wuqiang, Huang, Ailing, Zhou, Shanshan, Xia, Shuai, Tian, Xiaoxu, Peng, Chao, Chen, Cuicui, Shi, Yibing, Hu, Gaowei, Du, Shujuan, Wang, Yuyan, Xie, Youhua, Jiang, Shibo, Lu, Lu, Sun, Lei, Song, Yuanlin, Ying, Tianlei“…The crystal structure of n3113 in complex with the receptor-binding domain (RBD) of SARS-CoV-2, combined with the cryo-EM structures of n3113 and spike ecto-domain, reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2. …”
Publicado 2021
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3671por Firinu, Davide, Perra, Andrea, Campagna, Marcello, Littera, Roberto, Fenu, Giuseppe, Meloni, Federico, Cipri, Selene, Sedda, Francesca, Conti, Maria, Miglianti, Michela, Costanzo, Giulia, Secci, Marta, Usai, Gianmario, Carta, Mauro Giovanni, Cappai, Riccardo, Orrù, Germano, Del Giacco, Stefano, Coghe, Ferdinando, Chessa, Luchino“…At T2 all naïve HCW developed anti-S-RBD-IgG, while 94% of IMID responded (p < 0.001). …”
Publicado 2021
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3672“…In an effort to understand the evolution of receptor binding domain (RBD) of the spike protein of SARS-CoV-2, and specifically, how the ability of RBD to bind to angiotensin-converting enzyme 2 receptor (ACE2) of humans evolved in coronaviruses, we have applied an alignment-free technique to infer functional relatedness among betacoronaviruses. …”
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3673por Xu, Qiu-Yan, Xue, Jian-Hang, Xiao, Yao, Jia, Zhi-Juan, Wu, Meng-Juan, Liu, Yan-Yun, Li, Wei-Li, Liang, Xian-Ming, Yang, Tian-Ci“…METHODS: We determined the response and duration for 5 subsets of anti-SARS-CoV-2 antibodies (neutralizing antibody, anti-RBD total antibody, anti-Spike IgG, anti-Spike IgM, and anti-Spike IgA) in 61 volunteers within 160 days after the CoronaVac vaccine. …”
Publicado 2021
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3674por Khan, Abbas, Waris, Hira, Rafique, Memoona, Suleman, Muhammad, Mohammad, Anwar, Ali, Syed Shujait, Khan, Taimoor, Waheed, Yasir, Liao, Chenguang, Wei, Dong-Qing“…Given the urgency of the required analysis and data on the B.1.1.529 variant, we have performed a detailed investigation to provide an understanding of the impact of these novel mutations on the structure, function, and binding of RBD to hACE2 and mAb to the NTD of the spike protein. …”
Publicado 2022
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3675por Long, Yiru, Sun, Jianhua, Song, Tian-Zhang, Liu, Tingting, Tang, Feng, Zhang, Xinxin, Ding, Longfei, Miao, Yunqiu, Zhu, Weiliang, Pan, Xiaoyan, An, Qi, Qin, Mian, Tong, Xiankun, Peng, Xionghua, Yu, Pan, Zhu, Peng, Xu, Jianqing, Zhang, Xiaoyan, Zhang, Yachun, Liu, Datao, Chen, Ben, Chen, Huilin, Zhang, Leike, Xiao, Gengfu, Zuo, Jianping, Tang, Wei, Zhou, Ji, Li, Heng, Xu, Zhijian, Zheng, Hong-Yi, Long, Xin-Yan, Qin, Qiuping, Gan, Yong, Ren, Jin, Huang, Wei, Zheng, Yong-Tang, Jin, Guangyi, Gong, Likun“…The vaccine contains immunodominant peptides screened from the receptor-binding domain (RBD) and is fully chemically synthesized. It has been formulated in an optimized nanoemulsion formulation and is stable at 40 °C for 1 month. …”
Publicado 2022
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3676por Wang, Zijun, Muecksch, Frauke, Cho, Alice, Gaebler, Christian, Hoffmann, Hans-Heinrich, Ramos, Victor, Zong, Shuai, Cipolla, Melissa, Johnson, Briana, Schmidt, Fabian, DaSilva, Justin, Bednarski, Eva, Tanfous, Tarek Ben, Raspe, Raphael, Yao, Kaihui, Lee, Yu E., Chen, Teresia, Turroja, Martina, Milard, Katrina G., Dizon, Juan, Kaczynska, Anna, Gazumyan, Anna, Oliveira, Thiago Y., Rice, Charles M., Caskey, Marina, Bieniasz, Paul D., Hatziioannou, Theodora, Barnes, Christopher O., Nussenzweig, Michel C.“…Neutralizing antibodies targeting the RBD bind to several different sites on this domain. …”
Publicado 2022
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3677por Goel, Rishi R., Painter, Mark M., Lundgreen, Kendall A., Apostolidis, Sokratis A., Baxter, Amy E., Giles, Josephine R., Mathew, Divij, Pattekar, Ajinkya, Reynaldi, Arnold, Khoury, David S., Gouma, Sigrid, Hicks, Philip, Dysinger, Sarah, Hicks, Amanda, Sharma, Harsh, Herring, Sarah, Korte, Scott, KC, Wumesh, Oldridge, Derek A., Erickson, Rachel I., Weirick, Madison E., McAllister, Christopher M., Awofolaju, Moses, Tanenbaum, Nicole, Dougherty, Jeanette, Long, Sherea, D’Andrea, Kurt, Hamilton, Jacob T., McLaughlin, Maura, Williams, Justine C., Adamski, Sharon, Kuthuru, Oliva, Drapeau, Elizabeth M., Davenport, Miles P., Hensley, Scott E., Bates, Paul, Greenplate, Allison R., Wherry, E. John“…Antibody quality also continued to improve for at least 9 months after primary 2-dose vaccination. Spike− and RBD-specific memory B cells were stable through 9 months post-vaccination with no evidence of decline over time, and ~40–50% of RBD-specific memory B cells were capable of simultaneously recognizing the Alpha, Beta, Delta, and Omicron variants. …”
Publicado 2022
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3678por Dulovic, Alex, Kessel, Barbora, Harries, Manuela, Becker, Matthias, Ortmann, Julia, Griesbaum, Johanna, Jüngling, Jennifer, Junker, Daniel, Hernandez, Pilar, Gornyk, Daniela, Glöckner, Stephan, Melhorn, Vanessa, Castell, Stefanie, Heise, Jana-Kristin, Kemmling, Yvonne, Tonn, Torsten, Frank, Kerstin, Illig, Thomas, Klopp, Norman, Warikoo, Neha, Rath, Angelika, Suckel, Christina, Marzian, Anne Ulrike, Grupe, Nicole, Kaiser, Philipp D., Traenkle, Bjoern, Rothbauer, Ulrich, Kerrinnes, Tobias, Krause, Gérard, Lange, Berit, Schneiderhan-Marra, Nicole, Strengert, Monika“…While mRNA vaccination induced a higher ratio of RBD- and S1-targeting antibodies, vector-based vaccines resulted in an increased proportion of S2-targeting antibodies. …”
Publicado 2022
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3679por Wong, Ting Y., Lee, Katherine S., Russ, Brynnan P., Horspool, Alexander M., Kang, Jason, Winters, Michael T., Allison Wolf, M., Rader, Nathaniel A., Miller, Olivia A., Shiflett, Morgane, Izac, Jerilyn, Varisco, David, Sen-Kilic, Emel, Cunningham, Casey, Cooper, Melissa, Cyphert, Holly A., Barbier, Mariette, Martinez, Ivan, Bevere, Justin R., Ernst, Robert K., Damron, F. Heath“…We have developed a prototype two-dose vaccine (BReC-CoV-2) by combining the Receptor Binding Domain (RBD) antigen, via conjugation to Diphtheria toxoid (EcoCRM(®)). …”
Publicado 2022
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3680por Maybaum, S., Rahman, A., Malhame, K., Rossi, D., Wallach, F., Kon, Z., Stevens, G.“…All 3 patients with dnDSA had robust response to the vaccine with antibodies to spike protein RBD of > 200 U/ml (Elecsys®). Eight vaccinated patients without dnDSA had anti-RBD testing, half had titres > 200 U/ml. …”
Publicado 2022
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