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  1. 3701
    “…METHODS: Four nanobodies specific to the SARS-CoV-2 wild-type receptor-binding domain (RBD) were screened from a naïve phage display library. …”
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    A Multivalent and Thermostable Nanobody Neutralizing SARS-CoV-2 Omicron (B.1.1.529)
  2. 3702
    “…The most statistically significant association with higher levels of anti-RBD antibody was HLA-DQB1*06 (P = 3.2 × 10(−9)), which we replicated in 1,677 additional vaccinees. …”
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    Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection
  3. 3703
    “…Moreover, only 1 out of 77 anti-RBD memory antibodies tested neutralized the virus. …”
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    Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination
  4. 3704
    “…The binding free energy results revealed that wild type-RBD has a TBE of −60.55 kcal/mol while G446V-RBD reported a TBE of −73.49 kcal/mol. …”
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    Mutational analysis of the spike protein of SARS-COV-2 isolates revealed atomistic features responsible for higher binding and infectivity
  5. 3705
    “…Patients with MSA have a higher NMS burden than patients with PD or PSP. RBD, constipation, problems having sex, and loss of sexual interest may become early diagnostic clinical markers of MSA.…”
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    Non-motor symptoms in multiple system atrophy: A comparative study with Parkinson's disease and progressive supranuclear palsy
  6. 3706
    “…Secondary endpoints included vaccine immunogenicity assessed by ELISA anti-RBD and live-virus neutralisation test. All randomly assigned participants were included in the safety analysis (safety population), and immunogenicity was evaluated in participants without study interruptions (per-protocol population). …”
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    Safety and immunogenicity of the FINLAY-FR-1A vaccine in COVID-19 convalescent participants: an open-label phase 2a and double-blind, randomised, placebo-controlled, phase 2b, seamless, clinical trial
  7. 3707
    “…The main emphasis of this monograph is to start with an assumed covariate model in combination with some standard ANOVA set-ups such as CRD, RBD, BIBD, GDD, BTIBD, BPEBD, cross-over, multi-factor, split-plot and strip-plot designs, treatment control designs, etc. and discuss the nature and availability of optimal covariate designs. …”
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    Optimal covariate designs: theory and applications
  8. 3708
    “…Neutralizing antibodies (NAbs) targeting the S receptor binding domain (RBD) do not alter the conformer populations; by contrast, a NAb targeting a cryptic conformational epitope skews the Spike trimer toward an open conformation. …”
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    Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer
  9. 3709
    Publicado 2017
    “…In this case, rapid eye movement sleep behavior disorder (RBD) serves as a characteristic feature of the organic mental disorder.…”
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    Senile Depression with Somatization Symptoms and Insomnia is Diagnosed as Multiple System Atrophy: A Case Report
  10. 3710
    “…These prodromal symptoms include olfactory loss, constipation, and sleep disorders, especially rapid eye movement sleep behavior disorder (RBD), all of which are also important for elucidating the mechanisms of the initiation and progression of the disease. …”
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    Animal Model for Prodromal Parkinson’s Disease
  11. 3711
    “…These models are tested in their interaction with a fragment of the receptor-binding domain (RBD) of the Spike Protein S of the SARS-CoV-2 virus, via atomistic molecular dynamics simulations. …”
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    Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain
  12. 3712
    por Lok, Shee-Mei
    Publicado 2021
    “…To date, most antibodies recognizing the SARS-CoV-2 spike (S) protein target the receptor binding domain (RBD). Three recent studies (Cerutti et al., 2021; McCallum et al., 2021; and Suryadevara et al., 2021) report on highly protective antibodies that are specific to the N-terminal domain (NTD) and target a conserved supersite.…”
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    An NTD supersite of attack
  13. 3713
    “…Significant alteration of the reactivities of lysine residues at the interaction interface of S1-RBD Lys(386)–Lys(462) was observed during the formation of complexes, which might be utilized as indicators for investigating the S1-ACE2 dynamic recognition and intervention at the molecular level in high throughput.…”
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    Probing conformational hotspots for the recognition and intervention of protein complexes by lysine reactivity profiling
  14. 3714
    “…Congenital factor VII (FVII) deficiency is a rare bleeding disorder (RBD) with phenotypes ranging from asymptomatic state to life threatening bleeding episodes. …”
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    Aortic Valve and Coronary Artery Bypass Surgery in a Patient with Factor VII Deficiency
  15. 3715
    por Yin, Dou, Chen, Sheng, Liu, Jun
    Publicado 2021
    “…Excessive daytime sleep, rapid eye movement sleep behavior disorder (RBD), and narcolepsy are the most frequent sleep disorders associated with autoimmune neurologic diseases. …”
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    Sleep Disturbances in Autoimmune Neurologic Diseases: Manifestation and Pathophysiology
  16. 3716
    “…A pre-pandemic (2005 to 2011) serosurvey of from 528 malaria-experienced Cambodians demonstrated higher-than-expected (up to 13.8 %) positivity of non-neutralizing IgG to SARS-CoV-2 spike and RBD antigens. These findings have implications for interpreting large-scale serosurveys.…”
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    Pre-pandemic SARS-CoV-2 serological reactivity in rural malaria-experienced Cambodians
  17. 3717
    “…The spike protein is key to SARS-CoV-2 high infectivity because it facilitates the receptor binding domain (RBD) encounter with ACE2. As targeting subunit S1 has not yet delivered an ACE2-binding inhibitor, we have assessed the druggability of the conserved segment of the spike protein stalk within subunit S2 by means of an integrated computational approach that combines the molecular docking of an optimized library of fragments with high-throughput molecular dynamics simulations. …”
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    Is the Stalk of the SARS-CoV-2 Spike Protein Druggable?
  18. 3718
    “…ENDPOINTS: 1) Tolerability and reactogenicity; 2) bivalent booster-induced anti-RBD IgG antibodies; 3) bivalent booster-induced variant-specific neutralizing antibodies; 3) SARS-CoV-2-specific-T-cell response, and 4) post-bivalent booster vaccine infection and hospitalization.…”
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    (8) 5th Dose Bivalent Omicron-Containing Booster Vaccine Against Covid-19 in Heart Transplant Recipients
  19. 3719
    “…We measured immunoglobulin M (IgM), IgG, and IgA antibodies against five viral-target antigens, including receptor-binding domain (RBD), spike-protein (S), and segment spike-protein (S2) triggered by vaccines available in Spain. …”
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    Long-Term Exposure to Air Pollution and COVID-19 Vaccine Antibody Response in a General Population Cohort (COVICAT Study, Catalonia)
  20. 3720
    “…The level of anti-SARS-CoV-2 S-RBD protein IgG was significantly increased in the ChAdOx1 n-CoV-19, Gam-COVID-Vac, and BNT162b2 vaccines groups as compared to the unvaccinated group. …”
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    Antibody responses to mRNA versus non-mRNA COVID vaccines among the Mongolian population
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