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3701por Lu, Yuying, Li, Qianlin, Fan, Huahao, Liao, Conghui, Zhang, Jingsong, Hu, Huan, Yi, Huaimin, Peng, Yuanli, Lu, Jiahai, Chen, Zeliang“…METHODS: Four nanobodies specific to the SARS-CoV-2 wild-type receptor-binding domain (RBD) were screened from a naïve phage display library. …”
Publicado 2023
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3702por Mentzer, Alexander J., O’Connor, Daniel, Bibi, Sagida, Chelysheva, Irina, Clutterbuck, Elizabeth A., Demissie, Tesfaye, Dinesh, Tanya, Edwards, Nick J., Felle, Sally, Feng, Shuo, Flaxman, Amy L., Karp-Tatham, Eleanor, Li, Grace, Liu, Xinxue, Marchevsky, Natalie, Godfrey, Leila, Makinson, Rebecca, Bull, Maireid B., Fowler, Jamie, Alamad, Bana, Malinauskas, Tomas, Chong, Amanda Y., Sanders, Katherine, Shaw, Robert H., Voysey, Merryn, Snape, Matthew D., Pollard, Andrew J., Lambe, Teresa, Knight, Julian C.“…The most statistically significant association with higher levels of anti-RBD antibody was HLA-DQB1*06 (P = 3.2 × 10(−9)), which we replicated in 1,677 additional vaccinees. …”
Publicado 2022
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3703por Schaefer-Babajew, Dennis, Wang, Zijun, Muecksch, Frauke, Cho, Alice, Loewe, Maximilian, Cipolla, Melissa, Raspe, Raphael, Johnson, Brianna, Canis, Marie, DaSilva, Justin, Ramos, Victor, Turroja, Martina, Millard, Katrina G., Schmidt, Fabian, Witte, Leander, Dizon, Juan, Shimeliovich, Irina, Yao, Kai-Hui, Oliveira, Thiago Y., Gazumyan, Anna, Gaebler, Christian, Bieniasz, Paul D., Hatziioannou, Theodora, Caskey, Marina, Nussenzweig, Michel C.“…Moreover, only 1 out of 77 anti-RBD memory antibodies tested neutralized the virus. …”
Publicado 2022
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3704por Hanifa, Muhammad, Salman, Muhammad, Fatima, Muqaddas, Mukhtar, Naila, Almajhdi, Fahad N., Zaman, Nasib, Suleman, Muhammad, Ali, Syed Shujait, Waheed, Yasir, Khan, Abbas“…The binding free energy results revealed that wild type-RBD has a TBE of −60.55 kcal/mol while G446V-RBD reported a TBE of −73.49 kcal/mol. …”
Publicado 2023
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3705por Hu, Wen-Zheng, Cao, Ling-Xiao, Yin, Jin-Hui, Zhao, Xue-Song, Piao, Ying-Shan, Gu, Wei-Hong, Ma, Jing-Hong, Wan, Zhi-Rong, Huang, Yue“…Patients with MSA have a higher NMS burden than patients with PD or PSP. RBD, constipation, problems having sex, and loss of sexual interest may become early diagnostic clinical markers of MSA.…”
Publicado 2023
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3706por Ochoa-Azze, Rolando, Chang-Monteagudo, Arturo, Climent-Ruiz, Yanet, Macías-Abraham, Consuelo, Valenzuela-Silva, Carmen, de los Ángeles García-García, María, Jerez-Barceló, Yanet, Triana-Marrero, Yenisey, Ruiz-Villegas, Laura, Dairon Rodríguez-Prieto, Luis, Guerra-Chaviano, Pedro Pablo, Sánchez-Ramírez, Belinda, Hernández-García, Tays, Orosa-Vázquez, Ivette, Díaz-Hernández, Marianniz, Chiodo, Fabrizio, Calcagno, Andrea, Ghisetti, Valeria, Rodríguez-Acosta, Mireida, Noa-Romero, Enrique, Enríquez-Puertas, Juliet, Ortega-León, Darién, Valdivia-Álvarez, Irinia, Delahanty-Fernández, Aurora, Palenzuela-Díaz, Ariel, Rodríguez-Noda, Laura, González-Mugica, Raúl, Valdés-Balbín, Yury, García-Rivera, Dagmar, Verez-Bencomo, Vicente“…Secondary endpoints included vaccine immunogenicity assessed by ELISA anti-RBD and live-virus neutralisation test. All randomly assigned participants were included in the safety analysis (safety population), and immunogenicity was evaluated in participants without study interruptions (per-protocol population). …”
Publicado 2022
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3707“…The main emphasis of this monograph is to start with an assumed covariate model in combination with some standard ANOVA set-ups such as CRD, RBD, BIBD, GDD, BTIBD, BPEBD, cross-over, multi-factor, split-plot and strip-plot designs, treatment control designs, etc. and discuss the nature and availability of optimal covariate designs. …”
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3708por Guerrini, Giuditta, Mehn, Dora, Fumagalli, Francesco, Gioria, Sabrina, Pedotti, Mattia, Simonelli, Luca, Bianchini, Filippo, Robbiani, Davide F., Varani, Luca, Calzolai, Luigi“…Neutralizing antibodies (NAbs) targeting the S receptor binding domain (RBD) do not alter the conformer populations; by contrast, a NAb targeting a cryptic conformational epitope skews the Spike trimer toward an open conformation. …”
Publicado 2023
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3709Publicado 2017“…In this case, rapid eye movement sleep behavior disorder (RBD) serves as a characteristic feature of the organic mental disorder.…”
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3710“…These prodromal symptoms include olfactory loss, constipation, and sleep disorders, especially rapid eye movement sleep behavior disorder (RBD), all of which are also important for elucidating the mechanisms of the initiation and progression of the disease. …”
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3711por Bernardi, Austen, Huang, Yihan, Harris, Bradley, Xiong, Yongao, Nandi, Somen, McDonald, Karen A., Faller, Roland“…These models are tested in their interaction with a fragment of the receptor-binding domain (RBD) of the Spike Protein S of the SARS-CoV-2 virus, via atomistic molecular dynamics simulations. …”
Publicado 2020
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3712por Lok, Shee-Mei“…To date, most antibodies recognizing the SARS-CoV-2 spike (S) protein target the receptor binding domain (RBD). Three recent studies (Cerutti et al., 2021; McCallum et al., 2021; and Suryadevara et al., 2021) report on highly protective antibodies that are specific to the N-terminal domain (NTD) and target a conserved supersite.…”
Publicado 2021
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3713por Liu, Zheyi, Zhang, Wenxiang, Sun, Binwen, Ma, Yaolu, He, Min, Pan, Yuanjiang, Wang, Fangjun“…Significant alteration of the reactivities of lysine residues at the interaction interface of S1-RBD Lys(386)–Lys(462) was observed during the formation of complexes, which might be utilized as indicators for investigating the S1-ACE2 dynamic recognition and intervention at the molecular level in high throughput.…”
Publicado 2020
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3714por Henze, Larissa, Junghanss, Christian, Öner, Alper, Dohmen, Pascal M., Alozie, Anthony“…Congenital factor VII (FVII) deficiency is a rare bleeding disorder (RBD) with phenotypes ranging from asymptomatic state to life threatening bleeding episodes. …”
Publicado 2021
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3715“…Excessive daytime sleep, rapid eye movement sleep behavior disorder (RBD), and narcolepsy are the most frequent sleep disorders associated with autoimmune neurologic diseases. …”
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3716por Manning, Jessica, Zaidi, Irfan, Lon, Chanthap, Rosas, Luz Angela, Park, Jae-Keun, Ponce, Aiyana, Bohl, Jennifer, Chea, Sophana, Karkanitsa, Maria, Sreng, Sokunthea, Rekol, Huy, Chour, Char Meng, Esposito, Dominic, Taubenberger, Jeffery K., Memoli, Matthew J., Sadtler, Kaitlyn, Duffy, Patrick E., Oliveira, Fabiano“…A pre-pandemic (2005 to 2011) serosurvey of from 528 malaria-experienced Cambodians demonstrated higher-than-expected (up to 13.8 %) positivity of non-neutralizing IgG to SARS-CoV-2 spike and RBD antigens. These findings have implications for interpreting large-scale serosurveys.…”
Publicado 2021
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3717“…The spike protein is key to SARS-CoV-2 high infectivity because it facilitates the receptor binding domain (RBD) encounter with ACE2. As targeting subunit S1 has not yet delivered an ACE2-binding inhibitor, we have assessed the druggability of the conserved segment of the spike protein stalk within subunit S2 by means of an integrated computational approach that combines the molecular docking of an optimized library of fragments with high-throughput molecular dynamics simulations. …”
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3718por Peled, Y., Patel, J., Raanani, E., Segev, A., Matezki, S., Ram, E., Fardman, A., Beigel, R., Atari, N., Kliker, L., Elkader, B. Abd, Afek, A., Mandelboim, M.“…ENDPOINTS: 1) Tolerability and reactogenicity; 2) bivalent booster-induced anti-RBD IgG antibodies; 3) bivalent booster-induced variant-specific neutralizing antibodies; 3) SARS-CoV-2-specific-T-cell response, and 4) post-bivalent booster vaccine infection and hospitalization.…”
Publicado 2023
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3719por Kogevinas, Manolis, Karachaliou, Marianna, Espinosa, Ana, Aguilar, Ruth, Castaño-Vinyals, Gemma, Garcia-Aymerich, Judith, Carreras, Anna, Cortés, Beatriz, Pleguezuelos, Vanessa, Papantoniou, Kyriaki, Rubio, Rocío, Jiménez, Alfons, Vidal, Marta, Serra, Pau, Parras, Daniel, Santamaría, Pere, Izquierdo, Luis, Cirach, Marta, Nieuwenhuijsen, Mark, Dadvand, Payam, Straif, Kurt, Moncunill, Gemma, de Cid, Rafael, Dobaño, Carlota, Tonne, Cathryn“…We measured immunoglobulin M (IgM), IgG, and IgA antibodies against five viral-target antigens, including receptor-binding domain (RBD), spike-protein (S), and segment spike-protein (S2) triggered by vaccines available in Spain. …”
Publicado 2023
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3720por Sereejav, Enkhbold, Sandagdorj, Ankhbayar, Bazarjav, Purevbat, Ganbold, Sarangua, Enkhtuvshin, Altansukh, Tsedenbal, Naranzul, Namuuntsetseg, Bayasgalan, Chimedregzen, Khishigmunkh, Badarch, Darmaa, Otgonbayar, Dashpagma, Artbazar, Bayarzaya, Enebish, Oyunsuren, Tsevegmid, Erdembileg, Baigude, Huricha, Batzorig, Uyanga, Batmunkh, Bumdelger, Jantsansengee, Baigalmaa, Tserendorj, Chinbayar, Dorjderem, Bayarsaikhan, Tsolmon, Bilegtsaikhan, Ganbold, Tsogzolmaa“…The level of anti-SARS-CoV-2 S-RBD protein IgG was significantly increased in the ChAdOx1 n-CoV-19, Gam-COVID-Vac, and BNT162b2 vaccines groups as compared to the unvaccinated group. …”
Publicado 2023
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