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3721por Martin-Orozco, Natalia, Vale, Noah, Mihic, Alan, Amor, Talya, Reiter, Lawrence, Arita, Yuko, Samson, Reuben, Hu, Queenie, Gingras, Anne-Claude, Sorenson, Bradley Thomas, Marcusson, Eric Gates, Patel, Piyush“…Seroconversion was observed in all vaccinated participants, who showed high antibody titers against RBD, Spike, and neutralizing activity against the Wuhan strain. …”
Publicado 2023
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3722por Langgartner, Dominik, Winkler, Raphael, Brunner-Weisser, Jonas, Rohleder, Nicolas, Jarczok, Marc N., Gündel, Harald, Weimer, Katja, Reber, Stefan O.“…Ex vivo culturing of isolated PBMCs from individuals vaccinated with the coronavirus disease 2019 (COVID-19) vaccine BNT162b1 revealed a pronounced T cell response in the presence of the receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. …”
Publicado 2023
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3723por Maglione, Alessandro, Francese, Rachele, Arduino, Irene, Rosso, Rachele, Matta, Manuela, Rolla, Simona, Lembo, David, Clerico, Marinella“…Anti-Region Binding Domain (anti-RBD) of the spike (S) protein immunoglobulin G (IgG) titers were measured by ELISA. …”
Publicado 2023
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3724por Forsgård, Richard A., Rode, Julia, Lobenius-Palmér, Karin, Kamm, Annalena, Patil, Snehal, Tacken, Mirriam G. J., Lentjes, Marleen A. H., Axelsson, Jakob, Grompone, Gianfranco, Montgomery, Scott, Brummer, Robert J.“…Considering individuals who were fully vaccinated with mRNA-based COVID-19 vaccines, the active treatment arm (n = 10) exhibited significantly higher serum levels of anti-RBD IgA (135 [32.9–976] BAU/ml vs 61.3 [26.7–97.1] BAU/ml, p = 0.036) than the placebo arm (n = 7) >28 days postvaccination. …”
Publicado 2023
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3725por Matveev, Vitaliy A., Mihelic, Erik Z., Benko, Erika, Budylowski, Patrick, Grocott, Sebastian, Lee, Terry, Korosec, Chapin S., Colwill, Karen, Stephenson, Henry, Law, Ryan, Ward, Lesley A., Sheikh-Mohamed, Salma, Mailhot, Geneviève, Delgado-Brand, Melanie, Pasculescu, Adrian, Wang, Jenny H., Qi, Freda, Tursun, Tulunay, Kardava, Lela, Chau, Serena, Samaan, Philip, Imran, Annam, Copertino, Dennis C., Chao, Gary, Choi, Yoojin, Reinhard, Robert J., Kaul, Rupert, Heffernan, Jane M., Jones, R. Brad, Chun, Tae-Wook, Moir, Susan, Singer, Joel, Gommerman, Jennifer, Gingras, Anne-Claude, Kovacs, Colin, Ostrowski, Mario“…We measured total and neutralizing Ab responses to SARS-CoV-2 spike and RBD in sera, total anti-spike Abs in saliva, frequency of anti-RBD/NTD B cells, changes in frequency of anti-spike, HIV gag/nef-specific T cells, and HIV reservoirs in peripheral CD4(+) T cells. …”
Publicado 2023
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3726por McNamara, Ryan P., Maron, Jenny S., Boucau, Julie, Roy, Vicky, Webb, Nicholas E., Bertera, Harry L., Barczak, Amy K., Positives Study Staff, The, Franko, Nicholas, Logue, Jennifer K., Kemp, Megan, Li, Jonathan Z., Zhou, Ling, Hsieh, Ching-Lin, McLellan, Jason S., Siedner, Mark J., Seaman, Michael S., Lemieux, Jacob E., Chu, Helen Y., Alter, Galit“…Strong responses were observed on the fusion peptide (FP) region and the heptad repeat 1 (HR1) region adjacent to the RBD. Notably, the FP is highly conserved across SARS-related coronaviruses and even non-SARS-related betacoronavirus. …”
Publicado 2023
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3727por Addetia, Amin, Piccoli, Luca, Case, James Brett, Park, Young-Jun, Beltramello, Martina, Guarino, Barbara, Dang, Ha, de Melo, Guilherme Dias, Pinto, Dora, Sprouse, Kaitlin, Scheaffer, Suzanne M., Bassi, Jessica, Silacci-Fregni, Chiara, Muoio, Francesco, Dini, Marco, Vincenzetti, Lucia, Acosta, Rima, Johnson, Daisy, Subramanian, Sambhavi, Saliba, Christian, Giurdanella, Martina, Lombardo, Gloria, Leoni, Giada, Culap, Katja, McAlister, Carley, Rajesh, Anushka, Dellota, Exequiel, Zhou, Jiayi, Farhat, Nisar, Bohan, Dana, Noack, Julia, Chen, Alex, Lempp, Florian A., Quispe, Joel, Kergoat, Lauriane, Larrous, Florence, Cameroni, Elisabetta, Whitener, Bradley, Giannini, Olivier, Cippà, Pietro, Ceschi, Alessandro, Ferrari, Paolo, Franzetti-Pellanda, Alessandra, Biggiogero, Maira, Garzoni, Christian, Zappi, Stephanie, Bernasconi, Luca, Kim, Min Jeong, Rosen, Laura E., Schnell, Gretja, Czudnochowski, Nadine, Benigni, Fabio, Franko, Nicholas, Logue, Jennifer K., Yoshiyama, Courtney, Stewart, Cameron, Chu, Helen, Bourhy, Hervé, Schmid, Michael A., Purcell, Lisa A., Snell, Gyorgy, Lanzavecchia, Antonio, Diamond, Michael S., Corti, Davide, Veesler, David“…Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots in the receptor-binding domain(1) (RBD) of the spike protein. The effects of these mutations on viral infection and transmission and the efficacy of vaccines and therapies remains poorly understood. …”
Publicado 2023
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3728por Rossi, Marcello, Candelise, Niccolò, Baiardi, Simone, Capellari, Sabina, Giannini, Giulia, Orrù, Christina D., Antelmi, Elena, Mammana, Angela, Hughson, Andrew G., Calandra-Buonaura, Giovanna, Ladogana, Anna, Plazzi, Giuseppe, Cortelli, Pietro, Caughey, Byron, Parchi, Piero“…The results show that our RT-QuIC assay can accurately detect α-synuclein seeding activity across the spectrum of Lewy Body (LB)-related disorders (LBD), including DLB, PD, iRBD, and PAF, with an overall sensitivity of 95.3%. …”
Publicado 2020
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3729por Lampasona, Vito, Secchi, Massimiliano, Scavini, Marina, Bazzigaluppi, Elena, Brigatti, Cristina, Marzinotto, Ilaria, Davalli, Alberto, Caretto, Amelia, Laurenzi, Andrea, Martinenghi, Sabina, Molinari, Chiara, Vitali, Giordano, Di Filippo, Luigi, Mercalli, Alessia, Melzi, Raffaella, Tresoldi, Cristina, Rovere-Querini, Patrizia, Landoni, Giovanni, Ciceri, Fabio, Bosi, Emanuele, Piemonti, Lorenzo“…Of the measured antibody responses, positivity for IgG against the SARS-CoV-2 spike receptor-binding domain (RBD) was predictive of survival rate, both in the presence or absence of diabetes. …”
Publicado 2020
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3730por Buzhdygan, Tetyana P., DeOre, Brandon J., Baldwin-Leclair, Abigail, Bullock, Trent A., McGary, Hannah M., Khan, Jana A., Razmpour, Roshanak, Hale, Jonathan F., Galie, Peter A., Potula, Raghava, Andrews, Allison M., Ramirez, Servio H.“…Analysis of cell viability revealed that neither the S1, S2 or a truncated form of the S1 containing only the RBD had minimal effects on hBMVEC viability within a 48 h exposure window. …”
Publicado 2020
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3731por Horspool, Alexander M., Kieffer, Theodore, Russ, Brynnan P., DeJong, Megan A., Wolf, M. Allison, Karakiozis, Jacqueline M., Hickey, Brice J., Fagone, Paolo, Tacker, Danyel H., Bevere, Justin R., Martinez, Ivan, Barbier, Mariette, Perrotta, Peter L., Damron, F. Heath“…We demonstrate that significant levels of anti-SARS-CoV-2 antibody to receptor binding domain (RBD), nucleocapsid, and spike S1 subunit of SARS-CoV-2 develop over the first 10 to 20 days of infection. …”
Publicado 2021
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3732por Jangra, Sonia, Ye, Chengjin, Rathnasinghe, Raveen, Stadlbauer, Daniel, Krammer, Florian, Simon, Viviana, Martinez-Sobrido, Luis, García-Sastre, Adolfo, Schotsaert, Michael“…The glutamate (E) to Lysine (K) substitution at position 484 (E484K) in the receptor binding domain (RBD) of the spike protein is present in the rapidly spreading variants of concern belonging to the B.1.351 and P.1 lineages. …”
Publicado 2021
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3733por Ramos, Irene, Goforth, Carl, Soares-Schanoski, Alessandra, Weir, Dawn L., Samuels, Emily C., Phogat, Shreshta, Meyer, Michelle, Huang, Kai, Pietzsch, Colette A., Ge, Yongchao, Pike, Brian L., Regeimbal, James, Simons, Mark P., Termini, Michael S., Vangeti, Sindhu, Marjanovic, Nada, Lizewski, Stephen, Lizewski, Rhonda, George, Mary-Catherine, Nair, Venugopalan D., Smith, Gregory R., Mao, Weiguang, Chikina, Maria, Broder, Christopher C., Laing, Eric D., Bukreyev, Alexander, Sealfon, Stuart C., Letizia, Andrew G.“…IgG and IgA antibodies against SARS-CoV-2 RBD, S1, S2, and the nucleocapsid (N) protein, as well neutralization activity, were generally comparable between those participants that had asymptomatic infection or mild disease. …”
Publicado 2021
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3734por Villanueva-Saz, Sergio, Giner, Jacobo, Fernández, Antonio, Lacasta, Delia, Ortín, Aurora, Ramos, Juan José, Ferrer, Luis Miguel, Ruiz de Arcaute, Marta, Tobajas, Ana Pilar, Pérez, María Dolores, Verde, Maite, Marteles, Diana, Hurtado-Guerrero, Ramón, Pardo, Julián, Santiago, Llipsy, González-Ramírez, Andrés Manuel, Macías-León, Javier, García-García, Ana, Taleb, Víctor, Lira-Navarrete, Erandi, Paño-Pardo, José Ramón, Ruíz, Héctor“…None of the serum samples analyzed were seroreactive based on an enzyme-linked immunosorbent assay (ELISA) using the receptor-binding domain (RBD) of the spike antigen. In this sense, no statistical difference was observed compared to the pre-pandemic sheep. …”
Publicado 2021
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3735por Sholukh, Anton M., Fiore-Gartland, Andrew, Ford, Emily S., Miner, Maurine D., Hou, Yixuan J., Tse, Longping V., Kaiser, Hannah, Zhu, Haiying, Lu, Joyce, Madarampalli, Bhanupriya, Park, Arnold, Lempp, Florian A., St. Germain, Russell, Bossard, Emily L., Kee, Jia Jin, Diem, Kurt, Stuart, Andrew B., Rupert, Peter B., Brock, Chance, Buerger, Matthew, Doll, Margaret K., Randhawa, April Kaur, Stamatatos, Leonidas, Strong, Roland K., McLaughlin, Colleen, Huang, Meei-Li, Jerome, Keith R., Baric, Ralph S., Montefiori, David, Corey, Lawrence“…ND(50) titers positively correlated with plasma IgG targeting SARS-CoV-2 spike protein and RBD (r = 0.63 to 0.89), but moderately correlated with nucleoprotein IgG (r = 0.46 to 0.73). …”
Publicado 2021
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3736por Brumme, Zabrina L., Mwimanzi, Francis, Lapointe, Hope R., Cheung, Peter, Sang, Yurou, Duncan, Maggie C., Yaseen, Fatima, Agafitei, Olga, Ennis, Siobhan, Ng, Kurtis, Basra, Simran, Lim, Li Yi, Kalikawe, Rebecca, Speckmaier, Sarah, Moran-Garcia, Nadia, Young, Landon, Ali, Hesham, Ganase, Bruce, Umviligihozo, Gisele, Omondi, F. Harrison, Atkinson, Kieran, Sudderuddin, Hanwei, Toy, Junine, Sereda, Paul, Burns, Laura, Costiniuk, Cecilia T., Cooper, Curtis, Anis, Aslam H., Leung, Victor, Holmes, Daniel, DeMarco, Mari L., Simons, Janet, Hedgcock, Malcolm, Romney, Marc G., Barrios, Rolando, Guillemi, Silvia, Brumme, Chanson J., Pantophlet, Ralph, Montaner, Julio S.G., Niikura, Masahiro, Harris, Marianne, Hull, Mark, Brockman, Mark A.“…We measured circulating antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein, ACE2 displacement and live viral neutralization activities one month following the first and second COVID-19 vaccine doses in 100 adult PLWH and 152 controls. …”
Publicado 2021
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3737por Marklund, Emelie, Leach, Susannah, Nyström, Kristina, Lundgren, Anna, Liljeqvist, Jan-Åke, Nilsson, Staffan, Yilmaz, Aylin, Andersson, Lars-Magnus, Bemark, Mats, Gisslén, Magnus“…At 200-300 days post PCR-verified infection, there was a wide variation in sensitivity between the commercial IgG-assays, ranging from <30% in the N-assay to >90% in the RBD-assay. There was only moderate agreement between NAbs and CD4(+) T-cell reactivity to S1 or SMN. …”
Publicado 2021
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3738por Apostolidis, Sokratis A., Kakara, Mihir, Painter, Mark M., Goel, Rishi R., Mathew, Divij, Lenzi, Kerry, Rezk, Ayman, Patterson, Kristina R., Espinoza, Diego A., Kadri, Jessy C., Markowitz, Daniel M., E. Markowitz, Clyde, Mexhitaj, Ina, Jacobs, Dina, Babb, Allison, Betts, Michael R., Prak, Eline T. Luning, Weiskopf, Daniela, Grifoni, Alba, Lundgreen, Kendall A., Gouma, Sigrid, Sette, Alessandro, Bates, Paul, Hensley, Scott E., Greenplate, Allison R., Wherry, E. John, Li, Rui, Bar-Or, Amit“…Patients with MS treated with aCD20 lacking anti-RBD IgG had the most severe defect in circulating T(FH) responses and more robust CD8 T cell responses. …”
Publicado 2021
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3739por Dinc, Harika Oyku, Saltoglu, Nese, Can, Gunay, Balkan, Ilker Inanc, Budak, Beyhan, Ozbey, Dogukan, Caglar, Bilge, Karaali, Rıdvan, Mete, Bilgul, Tuyji Tok, Yesim, Ersoy, Yagmur, Ahmet Kuskucu, Mert, Midilli, Kenan, Ergin, Sevgi, Kocazeybek, Bekir Sami“…MATERIALS AND METHODS: The study included 330 HCWs working at Istanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty Hospital and vaccinated with inactive CoronaVac (Sinovac Life Sciences, China) SARS-CoV-2 vaccine in two doses (28 days apart). Anti-Spike /RBD IgG levels were measured 14 days after the first dose and 28 days after the second dose. …”
Publicado 2022
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3740por Joyce, M. Gordon, Chen, Wei-Hung, Sankhala, Rajeshwer S., Hajduczki, Agnes, Thomas, Paul V., Choe, Misook, Martinez, Elizabeth J., Chang, William C., Peterson, Caroline E., Morrison, Elaine B., Smith, Clayton, Chen, Rita E., Ahmed, Aslaa, Wieczorek, Lindsay, Anderson, Alexander, Case, James Brett, Li, Yifan, Oertel, Therese, Rosado, Lorean, Ganesh, Akshaya, Whalen, Connor, Carmen, Joshua M., Mendez-Rivera, Letzibeth, Karch, Christopher P., Gohain, Neelakshi, Villar, Zuzana, McCurdy, David, Beck, Zoltan, Kim, Jiae, Shrivastava, Shikha, Jobe, Ousman, Dussupt, Vincent, Molnar, Sebastian, Tran, Ursula, Kannadka, Chandrika B., Soman, Sandrine, Kuklis, Caitlin, Zemil, Michelle, Khanh, Htet, Wu, Weimin, Cole, Matthew A., Duso, Debra K., Kummer, Larry W., Lang, Tricia J., Muncil, Shania E., Currier, Jeffrey R., Krebs, Shelly J., Polonis, Victoria R., Rajan, Saravanan, McTamney, Patrick M., Esser, Mark T., Reiley, William W., Rolland, Morgane, de Val, Natalia, Diamond, Michael S., Gromowski, Gregory D., Matyas, Gary R., Rao, Mangala, Michael, Nelson L., Modjarrad, Kayvon“…A spike-ferritin nanoparticle (SpFN) vaccine elicits neutralizing titers (ID(50) > 10,000) following a single immunization, whereas RBD-ferritin nanoparticle (RFN) immunogens elicit similar responses after two immunizations and also show durable and potent neutralization against circulating VoCs. …”
Publicado 2021
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