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3761por Rovito, Roberta, Bono, Valeria, Augello, Matteo, Tincati, Camilla, Mainoldi, Federica, Beaudoin-Bussières, Guillaume, Tauzin, Alexandra, Bianchi, Silvia, Hadla, Mohamad, Yellenki, Vaibhav, d’Arminio Monforte, Antonella, Casola, Stefano, Borghi, Elisa, Finzi, Andrés, Marchetti, Giulia“…The humoral responses were assessed with anti-S1/S2 IgG, anti-RBD total-Ig, IgM, IgA, IgG1 and IgG3, neutralization and antibody-dependent cellular cytotoxicity (ADCC). …”
Publicado 2022
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3762por Hsiao, Chia-Chun, Chiang, Yi-Wei, Chao, Tai-Ling, Tsai, Zen-Uong, Wang, Ting-Xuan, Jiang, Yu-Wei, Hsu, Hsiang-Fu, Lu, De-Chao, Wang, Jann-Tay, Wang, Jen-Ren, Wang, An-Bang, Chang, Sui-Yuan, Chang, Shih-Chung“…Surprisingly, the detection signals against the unstructured receptor-binding domain (RBD) purified from E. coli inclusion bodies were not observed, although the COVID-19 patient sera exhibited strong neutralizing potency in the PRNT assays, suggesting that the RBD-specific antibodies in patient sera mostly recognize the conformational epitopes. …”
Publicado 2022
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3763por Akhtar, Marjahan, Basher, Salima Raiyan, Nizam, Nuder Nower, Kamruzzaman, Mohammad, Khaton, Fatema, Banna, Hasan Al, Kaisar, M Hasanul, Karmakar, Polash Chandra, Hakim, Al, Akter, Afroza, Ahmed, Tasnuva, Tauheed, Imam, Islam, Shaumik, Ahmmed, Faisal, Mahamud, Shakil, Hasnat, Mohammad Abul, Sumon, Mostafa Aziz, Rashed, Asif, Ghosh, Shuvro, Calderwood, Stephen B., Harris, Jason B., Charles, Richelle C., LaRocque, Regina C., Ryan, Edward T., Banu, Sayera, Shirin, Tahmina, Chowdhury, Fahima, Bhuiyan, Taufiqur Rahman, Qadri, Firdausi“…Patients from all severity groups developed circulating memory B cells (MBCs) specific to SARS-CoV-2 spike RBD by 3 months following infection, and these persisted until the last timepoint measured at 6 months. …”
Publicado 2022
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3764por Tran, Trung The, Vaage, Eline Benno, Mehta, Adi, Chopra, Adity, Tietze, Lisa, Kolderup, Anette, Anthi, Aina, König, Marton, Nygaard, Gro, Lind, Andreas, Müller, Fredrik, Nissen-Meyer, Lise Sofie, Magnus, Per, Trogstad, Lill, Mjaaland, Siri, Søraas, Arne, Midtvedt, Karsten, Åsberg, Anders, Barratt-Due, Andreas, Medhus, Asle W., Høivik, Marte Lie, Lundin, Knut, Karlsen, Randi Fuglaas, Dahle, Reidun, Danielsson, Karin, Thomassen, Kristine Stien, Kro, Grete Birkeland, Cox, Rebecca J., Zhou, Fan, Langeland, Nina, Aukrust, Pål, Melum, Espen, Åvitsland, Tone Lise, Wiencke, Kristine, Holter, Jan Cato, Munthe, Ludvig A., Grødeland, Gunnveig, Andersen, Jan-Terje, Vaage, John Torgils, Lund-Johansen, Fridtjof“…The benefit of multiplexed analysis lies in the ability to measure a wide range of anti-RBD titers using a single dilution of serum for each assay. …”
Publicado 2022
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3765por Liu, Yang“…However, the simulated binding capacity of eugenol to SARS-CoV-2 wild type RBD and Omicron mutant RBD were less than nilotinib. …”
Publicado 2023
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3766por Boley, Patricia A., Lee, Carolyn M., Schrock, Jennifer, Yadav, Kush Kumar, Patil, Veerupaxagouda, Suresh, Raksha, Lu, Songqing, Feng, Maoqi Mark, Hanson, Juliette, Channappanavar, Rudra, Kenney, Scott P., Renukaradhya, Gourapura J.“…RESULTS: We developed SARS-CoV-2 subunit vaccine containing both Spike receptor binding domain (S-RBD) and Nucleocapsid (N) proteins (NP-COVID-Proteins) or their mRNA (NP-COVID-mRNA) and NP-monosodium urate adjuvant. …”
Publicado 2023
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3767por Lioznov, Dmitry, Amosova, Irina, Sheetikov, Savely A., Zornikova, Ksenia V., Serdyuk, Yana, Efimov, Grigory A., Tsyferov, Mikhail, Khmelevskii, Mikhail, Afanasiev, Andrei, Khomyakova, Nadezhda, Zubkov, Dmitry, Tikhonov, Anton, Zhu, Tao, Barreto, Luis, Dzutseva, Vitalina“…Geometric mean titres (GMTs) were also elevated for antibodies against the RBD (405 [95% CI: 366; 449]) and S protein (677 [95% CI: 608; 753]) compared to the GMT of neutralising antibodies against SARS-CoV-2 (16.7 [95% CI: 15.3; 18.3]). …”
Publicado 2023
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3768por Gao, Lidong, Li, Yan, He, Peng, Chen, Zhen, Yang, Huaiyu, Li, Fangjun, Zhang, Siyuan, Wang, Danni, Wang, Guangyan, Yang, Shilong, Gong, Lihui, Ding, Fan, Ling, Mengyu, Wang, Xilu, Ci, Leilei, Dai, Lianpan, Gao, George Fu, Huang, Tao, Hu, Zhongyu, Ying, Zhifang, Sun, Jiufeng, Zuo, Xiaohu“…In the phase 2 trial, on day 14 after the third dose, seroconversion of neutralising antibodies against SARS-CoV-2 was seen in 392 (99%; 95% CI 98–100) participants, with a GMT of 245·4 (95% CI 220·0–273·7), and seroconversion of RBD-binding antibodies was observed in all 394 (100%; 99–100) participants, with a GMT of 8021 (7366–8734). …”
Publicado 2023
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3769“…Ceph is an attractive option due to its native block device layer RBD which is built upon its scalable, reliable, and performant object storage system, RADOS. …”
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3770por Vakhitova, Mariia, Myshkin, Mikhail, Staroverov, Dmitriy, Shagina, Irina, Izraelson, Mark, Tverdova, Nadezhda, Britanova, Olga, Merzlyak, Ekaterina“…We confirmed their reactivity toward the spike RBD domain. Such an approach can be effective for the monitoring and identification of B cells participating in an individual immune response.…”
Publicado 2023
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3771por Swick, Todd J.“…Sleep disturbances, which include sleep fragmentation, daytime somnolence, sleep-disordered breathing, restless legs syndrome (RLS), nightmares, and rapid eye movement (REM) sleep behavior disorder (RBD), are estimated to occur in 60% to 98% of patients with PD. …”
Publicado 2012
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3772“…Our previous studies have shown that the receptor-binding domain (RBD) in the spike protein of severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) is a key target for the development of SARS vaccines. …”
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3773por Suarez, Irina P., Burdisso, Paula, Benoit, Matthieu P. M. H., Boisbouvier, Jèrôme, Rasia, Rodolfo M.“…We found that it acquires a folded conformation when bound to its substrate, being the first report of a complete dsRBD folding upon binding. The free unfolded form shows tendency to adopt folded conformations, and goes through an unfolded bound state prior to the folding event. …”
Publicado 2015
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3774“…Effect of spice oleoresins (clove, black pepper, and ginger) (200 ppm) and TBHQ (200 ppm) were incorporated in stabilizing refined, bleached, and deodorized (RBD) sunflower oil heating at frying temperature (170°C) and during accelerated oxidation storage (70°C) was studied in comparison to Tert‐Butylhydroquinone (TBHQ). …”
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3775“…Some sleep disorders represent a prodromal phase of PD, with REM sleep behaviour disorder (RBD) being of particular interest in this regard, whereas others become more common as the disease advances. …”
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3776“…Here we suggest renaming 2019-nCoV as “transmissible acute respiratory syndrome coronavirus (TARS-CoV)” and briefly review the advancement of research and development of neutralizing antibodies and vaccines targeting the receptor-binding domain (RBD) and viral fusion inhibitors targeting the heptad repeat 1 (HR1) domain in spike protein of 2019-nCoV.…”
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3777por Cannalire, Rolando, Stefanelli, Irina, Cerchia, Carmen, Beccari, Andrea R., Pelliccia, Sveva, Summa, Vincenzo“…Primarily, direct-acting antivirals rely on inhibition of the interaction between ACE2 and the receptor binding domain (RBD) of the Spike (S) protein or targeting the more conserved heptad repeats (HRs), involved in the membrane fusion process. …”
Publicado 2020
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3778“…Hence, the proposed inhibitor ΔABP-D25Y could be a potential blocker of S protein and receptor binding domain (RBD) attachment.…”
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3779“…RESULTS: Top scoring peptidomimetics were found to bind at the ACE2 binding site of the receptor-binding domain (RBD) of SARS-CoV-2 spike protein. CONCLUSIONS: The current studies could pave the way for further investigations of these novel and potent compounds against the SARS-CoV-2.…”
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3780por Shahraki, Hojat, Dorgalaleh, Akbar, Fathi, Majid, Tabibian, Shadi, Teimourian, Shahram, Mollanoori, Hasan, khiabani, Alireza, Zaker, Farhad“…Congenital factor XIII (FXIII) deficiency is an extremely rare bleeding disorder (RBD) with estimated prevalence of one per 2 million in the general population. …”
Publicado 2020
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