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361por Barreiro, Antonio, Prenafeta, Antoni, Bech-Sabat, Gregori, Roca, Mercè, Perozo Mur, Eva, March, Ricard, González-González, Luis, Madrenas, Laia, Corominas, Júlia, Fernández, Alex, Moros, Alexandra, Cañete, Manuel, Molas, Mercè, Pentinat-Pelegrin, Thais, Panosa, Clara, Moreno, Alberto, Puigvert Molas, Ester, Pol Vilarrassa, Eva, Palmada, Jordi, Garriga, Carme, Prat Cabañas, Teresa, Iglesias-Fernández, Javier, Vergara-Alert, Júlia, Lorca-Oró, Cristina, Roca, Núria, Fernández-Bastit, Leira, Rodon, Jordi, Pérez, Mònica, Segalés, Joaquim, Pradenas, Edwards, Marfil, Silvia, Trinité, Benjamin, Ortiz, Raquel, Clotet, Bonaventura, Blanco, Julià, Díaz Pedroza, Jorge, Ampudia Carrasco, Rosa, Rosales Salgado, Yaiza, Loubat-Casanovas, Jordina, Capdevila Larripa, Sara, Prado, Julia Garcia, Barretina, Jordi, Sisteré-Oró, Marta, Cebollada Rica, Paula, Meyerhans, Andreas, Ferrer, Laura“…Here, we present data on preclinical studies in mice of a receptor-binding domain (RBD)-based recombinant protein vaccine (PHH-1V) consisting of an RBD fusion heterodimer comprising the B.1.351 and B.1.1.7 SARS-CoV-2 variants formulated in SQBA adjuvant, an oil-in-water emulsion. …”
Publicado 2023
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362por He, Siqi, Wang, Jiali, Chen, Hanyi, Qian, Zhaohui, Hu, Keping, Shi, Bingjie, Wang, Jianxun“…Here, we report a novel nanobody (Nb) identified by an RBD-ACE2 competitive panning method that could specifically bind to the RBD of SARS-CoV-2 with a high affinity (EC(50) = 0.03 nM) and successfully block the binding between the RBD and ACE2 recombinant protein. …”
Publicado 2023
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363por Carnell, George W., Billmeier, Martina, Vishwanath, Sneha, Suau Sans, Maria, Wein, Hannah, George, Charlotte L., Neckermann, Patrick, Del Rosario, Joanne Marie M., Sampson, Alexander T., Einhauser, Sebastian, Aguinam, Ernest T., Ferrari, Matteo, Tonks, Paul, Nadesalingam, Angalee, Schütz, Anja, Huang, Chloe Qingzhou, Wells, David A., Paloniemi, Minna, Jordan, Ingo, Cantoni, Diego, Peterhoff, David, Asbach, Benedikt, Sandig, Volker, Temperton, Nigel, Kinsley, Rebecca, Wagner, Ralf, Heeney, Jonathan L.“…Here, we present a targeted approach to elicit antibodies that neutralise both the ancestral SARS-CoV-2, and the VOCs, by introducing a specific glycosylation site on a non-neutralising epitope of the RBD. The addition of a specific glycosylation site in the RBD based vaccine candidate focused the immune response towards other broadly neutralising epitopes on the RBD. …”
Publicado 2023
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364“…The receptor-binding domain (RBD) of SARS-CoV-2 S protein is proved to be the major target of neutralizing antibodies. …”
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365“…In comparison to Omicron, BA.4 and BF.7 share nine mutations in the spike protein, Leu371Phe, Thr376Ala, Asp405Asn, Arg408Ser, Ser446Gly, Leu452Arg, Phe486Val, Arg493Gln, Ser496Gly, whereas BF.7 contains an additional mutation, Arg346Thr, in the receptor binding domain (RBD) region. Due to the critical need for analysis and data on the BA.4 and BF.7 variants, we have computationally analyzed the interaction pattern between the Omicron, BA.4 and BF.7 RBD and angiotensin-converting enzyme 2 (ACE2) to determine the influence of these unique mutations on the structures, functions, and binding affinity of RBD towards ACE2. …”
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366por Byazrova, Maria, Gattinger, Pia, Astakhova, Ekaterina, Hofer, Gerhard, Khaitov, Musa, Filatov, Alexander, Valenta, Rudolf“…Besides the antibodies specific for RBD, the antibodies induced against a peptide close to the N-terminus of RBD were also associated with virus-neutralization.…”
Publicado 2023
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367por Sun, Chunyun, Kong, Desheng, Guo, Erhong, Zhao, Jun, Jia, Jilei, Wang, Rui, Ma, Juan, Chen, Meng, Lu, Jianbo, Yu, Chulin, Li, Kuokuo, Xie, Liangzhi“…We previously developed a polysaccharide-–RBD-conjugated nanoparticle vaccine which induced protective efficacy against SARS-CoV-2 in a mouse model. …”
Publicado 2023
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368por Rodrigues, Grazielle Motta, Volpato, Fabiana Caroline Zempulski, Wink, Priscila Lamb, Paiva, Rodrigo Minuto, Barth, Afonso Luís, de-Paris, Fernanda“…Variants of concern (VOCs) of SARS-CoV-2 are viral strains that have mutations associated with increased transmissibility and/or increased virulence, and their main mutations are in the receptor binding domain (RBD) region of the viral spike. This study aimed to characterize SARS-CoV-2 VOCs via Sanger sequencing of the RBD region and compare the results with data obtained via whole genome sequencing (WGS). …”
Publicado 2023
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369por Romanenko, Ya. O., Silkina, M. V., Kartseva, A. S., Marin, M. A., Shkuratova, M. A., Makarova, M. A., Ryabko, A. K., Konyshkova, D. A., Zeninskaya, N. A., Khlyntseva, A. E., Shemyakin, I. G., Firstova, V. V.“…We have developed a high-affinity human monoclonal antibody, called C6D7-RBD, which is specific to the S protein receptor-binding domain (RBD) from the SARS-CoV-2 Wuhan-Hu-1 strain and exhibits virus-neutralizing activity in a test with recombinant antigens: angiotensin-converting enzyme 2 (ACE2) and RBD.…”
Publicado 2023
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370por Kim, Woo Sung, Chae, Hee Do, Jung, Inji, Lee, Won-Kyu, Lee, Woo Jun, Lee, Jisun, Gong, Yejin, Lee, Dohyun, Kim, Byeong-Won, Kim, Jin-Koo, Hwang, Jaehyeon, Kweon, Dae-Hyuk, Jung, Sang Taek, Na, Jung-Hyun“…In this study, we identified variable new antigen receptors (VNARs) specific for the receptor binding domain (RBD) of SARS-CoV-2 by immunizing a banded houndshark (Triakis scyllium) with recombinant wild-type RBD. …”
Publicado 2023
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371por Song, Ge, Yuan, Meng, Liu, Hejun, Capozzola, Tazio, Lin, Ryan N., Torres, Jonathan L., He, Wan-ting, Musharrafieh, Rami, Dueker, Katharina, Zhou, Panpan, Callaghan, Sean, Mishra, Nitesh, Yong, Peter, Anzanello, Fabio, Avillion, Gabriel, Vo, Anh Lina, Li, Xuduo, Makhdoomi, Muzamil, Feng, Ziqi, Zhu, Xueyong, Peng, Linghang, Nemazee, David, Safonova, Yana, Briney, Bryan, Ward, Andrew B, Burton, Dennis R., Wilson, Ian A., Andrabi, Raiees“…In our previous work, we identified sarbecovirus spike RBD group 1 and 2 bnAbs. We have now shown that many of these bnAbs can still neutralize highly mutated SARS-CoV-2 variants, including the XBB.1.5. …”
Publicado 2023
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372por Hu, Chunfang, Guo, Ting, Zou, Yunting, Gao, Junyi, Gao, Yi, Niu, Miaomiao, Xia, Yang, Shen, Xiaozhou, Li, Jindong“…Herein, five novel dual S-RBD/NRP1-targeting peptides with nanomolar binding affinities were identified by structure-based virtual screening. …”
Publicado 2023
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373por Komori, Mai, Nogimori, Takuto, Morey, Amber L., Sekida, Takashi, Ishimoto, Keiko, Hassett, Matthew R., Masuta, Yuji, Ode, Hirotaka, Tamura, Tomokazu, Suzuki, Rigel, Alexander, Jeff, Kido, Yasutoshi, Matsuda, Kenta, Fukuhara, Takasuke, Iwatani, Yasumasa, Yamamoto, Takuya, Smith, Jonathan F., Akahata, Wataru“…Here, we report the immunological characteristics of a self-amplifying RNA (saRNA) vaccine expressing the SARS-CoV-2 Spike (S) receptor binding domain (RBD), which is membrane-anchored by fusing with an N-terminal signal sequence and a C-terminal transmembrane domain (RBD-TM). …”
Publicado 2023
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374por Tai, Wanbo, Zheng, Jian, Zhang, Xiujuan, Shi, Juan, Wang, Gang, Guan, Xiaoqing, Zhu, Jiang, Perlman, Stanley, Du, Lanying“…Here, we designed a mRNA vaccine encoding the RBD of MERS-CoV S protein (RBD-mRNA) and evaluated its immunogenicity and protective efficacy in a mouse model. …”
Publicado 2023
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375por Pasquevich, Karina A., Coria, Lorena M., Ceballos, Ana, Mazzitelli, Bianca, Rodriguez, Juan Manuel, Demaría, Agostina, Pueblas Castro, Celeste, Bruno, Laura, Saposnik, Lucas, Salvatori, Melina, Varese, Augusto, González, Soledad, González Martínez, Veronica V., Geffner, Jorge, Álvarez, Diego, Feleder, Ethel, Halabe, Karina, Perez Lera, Pablo E., de Oca, Federico Montes, Vega, Julio C., Lombardo, Mónica, Yerino, Gustavo A., Fló, Juan, Cassataro, Juliana“…A Gamma Variant RBD-based aluminum hydroxide adjuvanted vaccine called ARVAC CG was selected for a first in human clinical trial. …”
Publicado 2023
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376por Guo, Shuxin, Zheng, Yuxuan, Gao, Zhengrong, Duan, Minrun, Liu, Sheng, Du, Pan, Xu, XiaoYu, Xu, Kun, Zhao, Xin, Chai, Yan, Wang, Peiyi, Zhao, Qi, Gao, George F., Dai, Lianpan“…Previously, we developed a protein subunit COVID-19 vaccine called ZF2001, based on the dimeric receptor-binding domain (RBD). This vaccine has been administered using different dosing intervals in real-world setting. …”
Publicado 2023
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377por Mamedov, Tarlan, Yuksel, Damla, Gurbuzaslan, Irem, Ilgin, Merve, Gulec, Burcu, Mammadova, Gulshan, Ozdarendeli, Aykut, Pavel, Shaikh Terkis Islam, Yetiskin, Hazel, Kaplan, Busra, Uygut, Muhammet Ali, Hasanova, Gulnara“…These data demonstrate that plant-produced RBD and cocktail-based proteins are the most promising vaccine candidates and may protect against Delta and Omicron-mediated COVID-19. …”
Publicado 2023
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378por Hentschel, Viktoria, Horsch, Cornelia, Mayer, Benjamin, Thies, Annsophie, Qian, Will, Kroschel, Joris, Seufferlein, Thomas, Perkhofer, Lukas, Müller, Martin“…Anti-SARS-CoV-2 receptor-binding domain (RBD) and nucleocapsid antigen antibody concentrations were assessed using commercially available immunoassays. …”
Publicado 2023
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379por Wu, Mengdan, Li, Wei, Lin, Sheng, Fan, Jiaqi, Cui, Lele, Xiang, Yijuan, Li, Kaiyu, Tang, Linwei, Duan, Yanping, Chen, Zimin, Yang, Fanli, Shui, Weiwei, Lu, Guangwen, Lai, Ying“…The receptor‐binding domain (RBD) of spike recognizing the receptor angiotensin‐converting enzyme 2 (ACE2) initiates membrane fusion between severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and cell membrane. …”
Publicado 2023
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380por Yong, Xiaolan, Liu, Jun, Zeng, Ying, Nie, Jing, Cui, Xuelian, Wang, Tao, Wang, Yilin, Chen, Yiyong, Kang, Wei, Yang, Zhonghua, Liu, Yan“…LYB001 is an innovative recombinant SARS-CoV-2 vaccine that displays a repetitive array of the spike glycoprotein’s receptor-binding domain (RBD) on a virus-like particle (VLP) vector to boost the immune system, produced using Covalink plug-and-display protein binding technology. …”
Publicado 2023
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