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3781por Chakraborty, Chiranjib, Bhattacharya, Manojit, Sharma, Ashish Ranjan, Lee, Sang-Soo, Agoramoorthy, Govindasamy“…The essential modifications located in the spike glycoprotein RBD include E484K, K417T and N501Y. Along with the P.1 lineage, P.2 lineage (B.1.1.28.2) has also appeared recently. …”
Publicado 2021
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3782por Aleshkin, A. V., Novikova, L. I., Bochkareva, S. S., Kombarova, S. Yu., Lebedin, Yu. S., Vorob’ev, A. M., Mekhtiev, E. R., Zul’karneev, E. R., Laishevtsev, A. I., Karaulov, A. V.“…Different levels of IgM antibodies to N-protein and receptor binding domain of the Spike protein (RBD) were revealed. The dynamics of IgG antibodies to the whole virion antigen and recombinant antigens showed high values on weeks 4-5 of the disease. …”
Publicado 2021
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3783“…The full-length spike (S) protein, the S1 subunit and its receptor binding domain (RBD) of the virus are the best candidates. The vaccine development to cease this COVID-19 pandemic sets a milestone for the pan-coronavirus vaccine’s designing and manufacturing. …”
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3784por Liu, Jiankai, Kan, Mujie, Zhang, Lianzhi, Yue, Yuan, Wang, Shaohua, Hong, Min, Hong, Xinyu“…It can be inferred that the S, S1 and RBD of SARS-CoV-2 variants can also be easily degraded by ASPNJ. …”
Publicado 2022
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3785“…In this work, using in silico methods, bioactive compounds from the neem tree were investigated for their ability to block viral cell entry as spike RBD-ACE2 inhibitors. Azadirachtin H, quentin and margocin were identified as potential compounds that demonstrated viral cell entry inhibition properties. …”
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3786“…‘Affinity escape’: Novel SARS-CoV-2 variants may escape immunity by raising the RBD-ACE2 affinity high enough to outcompete the avidity of neutralizing antibodies.…”
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3787“…Conclusions: PD patients with more severe motor symptoms, cognitive impairment, depression, anxiety, RBD, excessive daytime sleep, fatigue, low education level, long disease course, poor quality of life and lower DA dosage are more prone to apathy. …”
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3788“…Here, we hypothesize that mixing S1b-RBD-expressing mesenchymal stem cell-derived exosomes (which have been previously enriched with Remdesivir) with 47D11 antibody, can promisingly guarantee effective transferring of those targeted exosomes to the targeted microenvironment of coronavirus disease 2019 infection. …”
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3789“…We further demonstrate the utility of the method by identifying antibodies targeting highly similar epitopes of the same antigens from a large pool of antibody sequences, using two case studies: SARS CoV2 Receptor Binding Domain (RBD) and Epidermal Growth Factor Receptor (EGFR). …”
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3790por Song, Joon Young, Choi, Won Suk, Heo, Jung Yeon, Lee, Jin Soo, Jung, Dong Sik, Kim, Shin-Woo, Park, Kyung-Hwa, Eom, Joong Sik, Jeong, Su Jin, Lee, Jacob, Kwon, Ki Tae, Choi, Hee Jung, Sohn, Jang Wook, Kim, Young Keun, Noh, Ji Yun, Kim, Woo Joo, Roman, François, Ceregido, Maria Angeles, Solmi, Francesca, Philippot, Agathe, Walls, Alexandra C., Carter, Lauren, Veesler, David, King, Neil P., Kim, Hun, Ryu, Ji Hwa, Lee, Su Jeen, Park, Yong Wook, Park, Ho Keun, Cheong, Hee Jin“…The geometric mean concentrations of anti-SARS-CoV-2-RBD IgG antibody reached 2163·6/2599·2 BAU/mL in GBP510 adjuvanted with AS03 recipients (10 µg/25 µg) by 14 days after the second dose. …”
Publicado 2022
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3791por Hyun, Hakjun, Jang, A-Yeung, Park, Heedo, Heo, Jung Yeon, Seo, Yu Bin, Nham, Eliel, Yoon, Jin Gu, Seong, Hye, Noh, Ji Yun, Cheong, Hee Jin, Kim, Woo Joo, Yoon, Soo-Young, Seok, Jong Hyeon, Kim, Jineui, Park, Man-Seong, Song, Joon Young“…RESULTS: A total of 89 participants were recruited (26 boosted with BNT162b2, 57 with mRNA-1273, and 7 with Ad26.COV2.S). The IgG anti-RBD antibody titers of all participants were significantly higher at 6 months post-vaccination than at baseline. …”
Publicado 2023
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3792“…First, the sequence of 2019-nCoV RBD, including its receptor-binding motif (RBM) that directly contacts ACE2, is similar to that of SARS-CoV, strongly suggesting that 2019-nCoV uses ACE2 as its receptor. …”
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3793por van de Beek, M., Babapour Mofrad, R., van Steenoven, I., Vanderstichele, H., Scheltens, P., Teunissen, C. E., Lemstra, A. W., van der Flier, W. M.“…Men and women did not differ on fluctuations, RBD, parkinsonism, or other cognitive tests. CONCLUSIONS: Women had lower Aβ42 and α-syn levels than men, alongside a shorter duration of complaints. …”
Publicado 2020
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3794por Zhai, Xiaofeng, Sun, Jiumeng, Yan, Ziqing, Zhang, Jie, Zhao, Jin, Zhao, Zongzheng, Gao, Qi, He, Wan-Ting, Veit, Michael, Su, Shuo“…Here, we used X-ray structures of human ACE2 bound to the receptor-binding domain (RBD) of the spike protein (S) from SARS-CoV-2 to predict its binding to ACE2 proteins from different animals, including pets, farm animals, and putative intermediate hosts of SARS-CoV-2. …”
Publicado 2020
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3795“…MPro and BRD2 are potential targets for the tested allergen fragrance molecules, while RBD and Nucleocapsid showed weak binding energies. …”
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3796por Pradenas, Edwards, Trinité, Benjamin, Urrea, Víctor, Marfil, Silvia, Ávila-Nieto, Carlos, Rodríguez de la Concepción, María Luisa, Tarrés-Freixas, Ferran, Pérez-Yanes, Silvia, Rovirosa, Carla, Ainsua-Enrich, Erola, Rodon, Jordi, Vergara-Alert, Júlia, Segalés, Joaquim, Guallar, Victor, Valencia, Alfonso, Izquierdo-Useros, Nuria, Paredes, Roger, Mateu, Lourdes, Chamorro, Anna, Massanella, Marta, Carrillo, Jorge, Clotet, Bonaventura, Blanco, Julià“…IgG antibody titer was evaluated by ELISA against the S2 subunit, the receptor binding domain (RBD), and the nucleoprotein (NP). Statistical analyses were carried out using mixed-effects models. …”
Publicado 2021
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3797por van de Beek, M., van Steenoven, I., van der Zande, J. J., Porcelijn, I., Barkhof, F., Stam, C. J., Raijmakers, P. G. H. M., Scheltens, P., Teunissen, C. E., van der Flier, W. M., Lemstra, A. W.“…Core (hallucinations, parkinsonism, fluctuations, RBD) and suggestive (autonomous dysfunction, neuropsychiatric symptoms) symptoms were assessed using standardized questionnaires. …”
Publicado 2021
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3798por Shah, Jyotsna, Liu, Song, Potula, Hari-Hara, Bhargava, Prerna, Cruz, Iris, Force, Denise, Bazerbashi, Ammar, Ramasamy, Ranjan“…Both IgG and IgM antibodies detected RBD less frequently than S1, S2 and N proteins. …”
Publicado 2021
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3799por Zhang, Zhaoyong, Zeng, Eric, Zhang, Lu, Wang, Weiming, Jin, Yingkang, Sun, Jiye, Huang, Shuxiang, Yin, Wenguang, Dai, Jun, Zhuang, Zhen, Chen, Zhao, Sun, Jing, Zhu, Airu, Li, Fang, Cao, Weitao, Li, Xiaobo, Shi, Yongxia, Gan, Mian, Zhang, Shengnan, Wei, Peilan, Huang, Jicheng, Zhong, Nanshan, Zhong, Guocai, Zhao, Jingxian, Wang, Yanqun, Shao, Weihui, Zhao, Jincun“…In addition, hACE2-Fc proteins protected HBE from SARS-CoV-2 infection. Unlike RBD-targeting neutralizing antibodies, hACE2-Fc treatment did not induce the development of escape mutants. …”
Publicado 2021
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3800por Fränkl, Eirin, Scarpelli, Serena, Nadorff, Michael R, Bjorvatn, Bjørn, Bolstad, Courtney J, Chan, Ngan Yin, Chung, Frances, Dauvilliers, Yves, Espie, Colin A, Inoue, Yuichi, Leger, Damien, Macêdo, Tainá, Matsui, Kentaro, Merikanto, Ilona, Morin, Charles M, Mota-Rolim, Sérgio, Partinen, Markku, Penzel, Thomas, Plazzi, Giuseppe, Sieminski, Mariusz, Wing, Yun Kwok, De Gennaro, Luigi, Holzinger, Brigitte“…DRF was associated with gender and parasomnias like nightmares and RBD symptoms, sleep maintenance problems, PTSD symptoms and negatively associated with depression and anxiety. …”
Publicado 2021
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