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3801por Duarte, Luisa F., Gálvez, Nicolás M. S., Iturriaga, Carolina, Melo-González, Felipe, Soto, Jorge A., Schultz, Bárbara M., Urzúa, Marcela, González, Liliana A., Vázquez, Yaneisi, Ríos, Mariana, Berríos-Rojas, Roslye V., Rivera-Pérez, Daniela, Moreno-Tapia, Daniela, Pacheco, Gaspar A., Vallejos, Omar P., Hoppe-Elsholz, Guillermo, Navarrete, María S., Rojas, Álvaro, Fasce, Rodrigo A., Fernández, Jorge, Mora, Judith, Ramírez, Eugenio, Zeng, Gang, Meng, Weining, González-Aramundiz, José V., González, Pablo A., Abarca, Katia, Bueno, Susan M., Kalergis, Alexis M.“…Two cases exhibited low circulating anti-S1-RBD IgG and almost non-existing neutralizing capacity after either vaccination or infection, although they developed a mild disease. …”
Publicado 2021
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3802por Seija, Mariana, Rammauro, Florencia, Santiago, José, Orihuela, Natalia, Zulberti, Catherine, Machado, Danilo, Recalde, Cecilia, Noboa, Javier, Frantchez, Victoria, Astesiano, Rossana, Yandián, Federico, Guerisoli, Ana, Morra, Álvaro, Cassinelli, Daniela, Coelho, Cecilia, de Aramburu, Belén, González-Severgnini, Paulina, Moreno, Romina, Pippolo, Aldana, López, Gabriela, Lemos, Mónica, Somariva, Lorena, López, Eliana, Fumero, Soledad, Orihuela, Carla, Rodríguez, Rosalía, Acuña, Gonzalo, Rabaza, Victoria, Perg, Nancy, Cordero, Rossana, Reisfeld, Cristina, Olivera, Paula, Montero, Paola, Nogueira, Cecilia, Nalerio, Catheryn, Orihuela, Sergio, Curi, Lilián, Burgstaller, Ema, Noboa, Oscar, Pritsch, Otto, Nin, Marcelo, Bianchi, Sergio“…Serum-specific immunoglobulin G (IgG) antibodies against the receptor-binding domain (RBD) of SARS-CoV-2 Spike protein were determined using the COVID-19 IgG QUANT ELISA Kit. …”
Publicado 2021
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3803por Brumme, Zabrina L., Mwimanzi, Francis, Lapointe, Hope R., Cheung, Peter K., Sang, Yurou, Duncan, Maggie C., Yaseen, Fatima, Agafitei, Olga, Ennis, Siobhan, Ng, Kurtis, Basra, Simran, Lim, Li Yi, Kalikawe, Rebecca, Speckmaier, Sarah, Moran-Garcia, Nadia, Young, Landon, Ali, Hesham, Ganase, Bruce, Umviligihozo, Gisele, Omondi, F. Harrison, Atkinson, Kieran, Sudderuddin, Hanwei, Toy, Junine, Sereda, Paul, Burns, Laura, Costiniuk, Cecilia T., Cooper, Curtis, Anis, Aslam H., Leung, Victor, Holmes, Daniel, DeMarco, Mari L., Simons, Janet, Hedgcock, Malcolm, Romney, Marc G., Barrios, Rolando, Guillemi, Silvia, Brumme, Chanson J., Pantophlet, Ralph, Montaner, Julio S. G., Niikura, Masahiro, Harris, Marianne, Hull, Mark, Brockman, Mark A.“…After adjustment for sociodemographic, health and vaccine-related variables, HIV infection was associated with lower anti-RBD antibody concentrations and ACE2 displacement activity after one vaccine dose. …”
Publicado 2022
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3804por Lin, Simeng, Kennedy, Nicholas A., Saifuddin, Aamir, Sandoval, Diana Muñoz, Reynolds, Catherine J., Seoane, Rocio Castro, Kottoor, Sherine H., Pieper, Franziska P., Lin, Kai-Min, Butler, David K., Chanchlani, Neil, Nice, Rachel, Chee, Desmond, Bewshea, Claire, Janjua, Malik, McDonald, Timothy J., Sebastian, Shaji, Alexander, James L., Constable, Laura, Lee, James C., Murray, Charles D., Hart, Ailsa L., Irving, Peter M., Jones, Gareth-Rhys, Kok, Klaartje B., Lamb, Christopher A., Lees, Charlie W., Altmann, Daniel M., Boyton, Rosemary J., Goodhand, James R., Powell, Nick, Ahmad, Tariq“…Breakthrough SARS-CoV-2 infections are more frequent (5.8% (201/3441) vs 3.9% (66/1682), p = 0.0039) in patients treated with infliximab than vedolizumab, and the risk of breakthrough SARS-CoV-2 infection is predicted by peak anti-S RBD antibody concentration after two vaccine doses. …”
Publicado 2022
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3805por Kimura, Muneyoshi, Ferreira, Victor H., Kothari, Sagar, Pasic, Ivan, Mattsson, Jonas I., Kulasingam, Vathany, Humar, Atul, Mah, Allison, Delisle, Jean-Sébastien, Ierullo, Matthew, Majchrzak-Kita, Beata, Kumar, Deepali, Hosseini-Moghaddam, Seyed M.“…The haploidentical donor status was an independent risk factor (adjusted odds ratio = 7.67, 95% confidence interval [CI], 1.86-31.60) for suboptimal antibody response (anti-RBD < 100 U/mL). S-specific CD4(+) and CD8(+) T-cell responses were measured in a subset of Allo-SCT recipients (n = 20) by flow cytometry. …”
Publicado 2022
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3806por Aiello, Alessandra, Grossi, Adriano, Meschi, Silvia, Meledandri, Marcello, Vanini, Valentina, Petrone, Linda, Casetti, Rita, Cuzzi, Gilda, Salmi, Andrea, Altera, Anna Maria, Pierelli, Luca, Gualano, Gina, Ascoli Bartoli, Tommaso, Castilletti, Concetta, Agrati, Chiara, Girardi, Enrico, Palmieri, Fabrizio, Nicastri, Emanuele, Di Rosa, Enrico, Goletti, Delia“…The serological response was assessed by quantifying anti-Receptor-Binding-Domain (RBD), anti-Nucleocapsid (N), whole virus indirect immunofluorescence, and neutralizing antibodies. …”
Publicado 2022
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3807por Luo, Sai, Zhang, Jun, Kreutzberger, Alex J.B., Eaton, Amanda, Edwards, Robert J., Jing, Changbin, Dai, Hai-Qiang, Sempowski, Gregory D., Cronin, Kenneth, Parks, Robert, Ye, Adam Yongxin, Mansouri, Katayoun, Barr, Maggie, Pishesha, Novalia, Williams, Aimee Chapdelaine, Vieira Francisco, Lucas, Saminathan, Anand, Peng, Hanqin, Batra, Himanshu, Bellusci, Lorenza, Khurana, Surender, Alam, S. Munir, Montefiori, David C., Saunders, Kevin O., Tian, Ming, Ploegh, Hidde, Kirchhausen, Tom, Chen, Bing, Haynes, Barton F., Alt, Frederick W.“…Cryo-EM studies revealed that SP1-77 bound RBD away from the receptor-binding-motif via a CDR3-dominated recognition mode. …”
Publicado 2022
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3808por Touré, F., Lamarche, F., Hantz, S., Danthu, C., Lavergne, D., Bocquentin, F., El Ouafi, Z., Rerolle, J.P., Touré, F., Alain, S.“…Enfin, nous avons quantifié la réponse humorale spécifique contre les domaines RBD, NTD, S1 et S2 de la protéine Spike et contre la protéine N à l’aide de la version quantitative du test CoViDiag IgG (Innobiochips, France). …”
Publicado 2022
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3809por Puga-Gómez, Rinaldo, Ricardo-Delgado, Yariset, Rojas-Iriarte, Chaumey, Céspedes-Henriquez, Leyanis, Piedra-Bello, Misleidys, Vega-Mendoza, Dania, Pérez, Noelvia Pestana, Paredes-Moreno, Beatriz, Rodríguez-González, Meiby, Valenzuela-Silva, Carmen, Sánchez-Ramírez, Belinda, Rodríguez-Noda, Laura, Pérez-Nicado, Rocmira, González-Mugica, Raul, Hernández-García, Tays, Fundora-Barrios, Talía, Echevarría, Martha Dubet, Enriquez-Puertas, Juliet María, Infante-Hernández, Yenicet, Palenzuela-Díaz, Ariel, Gato-Orozco, Evelyn, Chappi-Estévez, Yanet, Francisco-Pérez, Julio Cesar, Suarez-Martinez, Miladi, Castillo-Quintana, Ismavy C., Fernandez-Castillo, Sonsire, Climent-Ruiz, Yanet, Santana-Mederos, Darielys, García-Vega, Yanelda, Toledo-Romani, María Eugenia, Doroud, Delaram, Biglari, Alireza, Valdés-Balbín, Yury, García-Rivera, Dagmar, Vérez-Bencomo, Vicente“…Primary outcomes were safety (phase I) and safety/immunogenicity (phase II) measured by anti-RBD immunoglobulin (Ig)G enzyme-linked immunoassay (ELISA), molecular and live-virus neutralization titers, and specific T-cells response. …”
Publicado 2023
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3810por Flitter, Becca A, Tedjakusuma, Sarah N, Lester, Colin A, Neuhaus, Elena D, Johnson, Susan, Dora, Emery G, Peinovich, Nadine, Jegede, Clara B, Tucker, Sean N“…Serum and nasal swabs were collected every 14 days and humoral responses to full length spike (S) and receptor binding domain (RBD) were assessed. All AMGs were challenged with SARS-CoV-2 B.1.351 (beta variant) on day 56. …”
Publicado 2022
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3811por Mancuso, Katia, Zamagni, Elena, Solli, Vincenza, Gabrielli, Liliana, Pantani, Lucia, Rocchi, Serena, Rizzello, Ilaria, Tacchetti, Paola, Fusco, Alessio, De Cicco, Gabriella, Ursi, Margherita, Talarico, Marco, Favero, Emanuele, Nepoti, Giuliana, Ruffini, Barbara, Terragna, Carolina, Lazzarotto, Tiziana, Zinzani, Pier Luigi, Cavo, Michele“…A concentration level of IgG anti S-RBD ≥0.80 U/ml was considered a seropositive result. …”
Publicado 2021
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3812por Hulme, John“…As emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants (Omicron) continue to outpace and negate combinatorial vaccines and monoclonal antibody therapies targeting the spike protein (S) receptor binding domain (RBD), the appetite for developing similar COVID-19 treatments has significantly diminished, with the attention of the scientific community switching to long COVID treatments. …”
Publicado 2023
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3813por Liu, Kaifeng, Guo, Fangfang, Ma, Yingying, Yu, Xiangyu, Fu, Xueqi, Li, Wannan, Han, Weiwei“…During the study, it was discovered that fullerene derivatives can operate at the interface of the receptor-binding domain (RBD) and the N-terminal domain (NTD), keeping structural domains in a downward conformation. …”
Publicado 2023
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3814por Lam, Joy-Yan, Wong, Wan-Man, Yuen, Chun-Kit, Ng, Yau-Yee, San, Chun-Hin, Yuen, Kwok-Yung, Kok, Kin-Hang“…The vaccine consisted of spike RBD (as an antigen), nucleoprotein (as an adaptor), and ssRNA (as an adjuvant and RNA scaffold). …”
Publicado 2023
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3815“…In this issue of the JCI, Kawai et al. present an adjuvant-free subunit (RBD-HA) fusion vaccine, which produces robust IgG and IgA antibody responses against SARS-CoV-2, enriched within the nasal cavity, by using the host’s preexisting immunity to influenza infection. …”
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3816“…It contains two main binding domains, the receptor-binding domain (RBD) and the heparin-binding domain (HBD). This study attempted to identify the specific sequences of the VEa5 DNA aptamer that exhibit high binding affinity towards the VEGF(165) protein by truncating the original VEa5 aptamer into different segments. …”
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3817“…In general, RBDs in many proteins have been tagged with membrane-targeting functions as in the case of the well-characterized c-Raf-RBD/Ras interaction. However, it is becoming apparent that the definition and functions of RBDs need to be revamped in order to reflect the new discoveries associated with this domain. …”
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3818“…In this review, the current advancements and potential strategies in the development of MERS vaccines, particularly subunit vaccines based on MERS-CoV spike (S) protein and its receptor-binding domain (RBD), are discussed. How to improve the efficacy of subunit vaccines through novel adjuvant formulations and routes of administration as well as currently available animal models for evaluating the in vivo efficacy of MERS-CoV vaccines are also addressed. …”
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3819“…We analyzed resting-state functional MRI data collected from patients with REM sleep behavior disorder (RBD) and/or hyposmia, two of the strongest markers of prodromal PD, in comparison to age-matched controls. …”
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3820por Yin, Shengxia, Tong, Xin, Huang, Aijun, Shen, Han, Li, Yang, Liu, Yong, Wu, Chao, Huang, Rui, Chen, Yuxin“…We followed–up a mild COVID-19 patient for 91 days and serially monitored his serum antibodies to four SARS-CoV-2 related antigens (NP, RBD, S1 and ECD) and neutralization activities. …”
Publicado 2020
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