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  1. 3841
    “…At day 14, the geometric mean(GM) of anti-S-RBD IgG in SV3w/PZ30µg was 4713 (95 %CI 4127–5382) binding-antibody unit (BAU)/ml, while geometric mean ratio(GMR) was 1.28 (1.09–1.51) in SV6w/PZ30µg. …”
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    Heterologous Prime-boost of SARS-CoV-2 inactivated vaccine and mRNA BNT162b2 among Healthy Thai Adolescents
  2. 3842
    “…Moreover, the analysis on kinetics revealed that among all responses, IgG RBD, IgA RBD, and IgG S2 decreased less within 1 year after infection. …”
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    SARS-CoV-2 infection, vaccination, and antibody response trajectories in adults: a cohort study in Catalonia
  3. 3843
    por Toledo-Romaní, María Eugenia, García-Carmenate, Mayra, Valenzuela-Silva, Carmen, Baldoquín-Rodríguez, Waldemar, Martínez-Pérez, Marisel, Rodríguez-González, Meiby, Paredes-Moreno, Beatriz, Mendoza-Hernández, Ivis, González-Mujica Romero, Raúl, Samón-Tabio, Oscar, Velazco-Villares, Pablo, Bacallao-Castillo, Juan Pablo, Licea-Martín, Ernesto, Rodríguez-Ortega, Misladys, Herrera-Marrero, Nuris, Caballero-González, Esperanza, Egües-Torres, Liudmila, Duartes-González, Reinaldo, García-Blanco, Serguey, Pérez-Cabrera, Suzette, Huete-Ferreira, Santos, Idalmis-Cisnero, Kirenia, Fonte-Galindo, Omayda, Meliá-Pérez, Dania, Rojas-Remedios, Ivonne, Doroud, Delaram, Gouya, Mohammad Mehdi, Biglari, Alireza, Fernández-Castillo, Sonsire, Climent-Ruiz, Yanet, Valdes-Balbín, Yury, García-Rivera, Dagmar, Van der Stuyft, Patrick, Verez-Bencomo, Vicente
    Publicado 2022
    “…A third heterologous dose of SOBERANA-Plus (RBD-dimer) further increased neutralising antibodies. …”
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    Safety and efficacy of the two doses conjugated protein-based SOBERANA-02 COVID-19 vaccine and of a heterologous three-dose combination with SOBERANA-Plus: a double-blind, randomised, placebo-controlled phase 3 clinical trial
  4. 3844
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    Estimating $r_{B}^{D\pi}$ as input to the determination of CKM angle $\gamma$
  5. 3845
    “…As a model, we used COVID-eVax, a plasmid DNA-based vaccine that targets the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. Increased nicked DNA was produced by using either an accelerated stability protocol or a lyophilization protocol. …”
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    Immunogenicity of COVID-eVax Delivered by Electroporation Is Moderately Impacted by Temperature and Molecular Isoforms
  6. 3846
    “…In this study, we used human cultured mast cells that are plentiful in the lungs and showed that recombinant SARS-CoV-2 full-length S protein (1–10 ng/mL), but not its receptor-binding domain (RBD), stimulates the secretion of the proinflammatory cytokine interleukin-1β (IL-1β) as well as the proteolytic enzymes chymase and tryptase. …”
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    Recombinant SARS-CoV-2 Spike Protein Stimulates Secretion of Chymase, Tryptase, and IL-1β from Human Mast Cells, Augmented by IL-33
  7. 3847
    “…The BA.3 S protein displays increased heterogeneity, with the majority in the all “up” RBD state. The different conformations preferences of the S protein are consistent with their varied transmissibility. …”
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    Structural Basis for the Enhanced Infectivity and Immune Evasion of Omicron Subvariants
  8. 3848
    “…We employed computational methodologies, including molecular mechanics and machine learning tools, to identify drugs that could potentially disrupt the SARS-CoV-2 spike RBD-ACE2 protein interaction. This led to the identification of two FDA-approved small molecule drugs, M and T, conventionally used for treating asthma and hypertension, respectively. …”
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    Montelukast and Telmisartan as Inhibitors of SARS-CoV-2 Omicron Variant
  9. 3849
    “…Contrary to a previous report, XptA2 is pentameric. RBD-B exhibits an indentation from crystal packing that indicates loose association with the shell and a hotspot for possible receptor binding or a trigger for conformational dynamics. …”
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    Structures of the Insecticidal Toxin Complex Subunit XptA2 Highlight Roles for Flexible Domains
  10. 3850
    por Liu, Ying, Ye, Qing
    Publicado 2023
    “…Therefore, the key site mutation in the S gene is of high interest. Among them, RBD, NTD, and furin cleavage sites are the most mutable regions with the most mutation sites and the most serious consequences for SARS-CoV-2 biological characteristics, including infectivity, pathogenicity, natural immunity, vaccine efficacy, and antibody therapeutics. …”
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    The Key Site Variation and Immune Challenges in SARS-CoV-2 Evolution
  11. 3851
    “…Due to differences in the bound substrates and global domain orientations, the localized loop conformations and occupancy of dsRNA-binding domain 2 (dsRBD2) differ between the mammalian DHX9 and MLE structures. …”
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    Crystal structures of the DExH-box RNA helicase DHX9
  12. 3852
    “…In this study, we describe a novel recombinant chimeric protein, dsRBEC, which can bind polyIC and deliver it selectively into EGFR over-expressing tumor cells. dsRBEC, comprises the dsRNA binding domain (dsRBD) of human PKR (hPKR), which serves as the polyIC binding moiety, fused to human EGF (hEGF), the targeting moiety. dsRBEC shows high affinity towards EGFR and triggers ligand-induced endocytosis of the receptor, thus leading to the selective internalization of polyIC into EGFR over-expressing tumor cells. …”
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    Targeting polyIC to EGFR over-expressing cells using a dsRNA binding protein domain tethered to EGF
  13. 3853
    “…Co-expression of N-terminal and RNA binding domain (RBD) deletion mutants of Nucleolin or inhibiting 45S rRNA synthesis reduces the sequestration of H2B-ECFP in the nucleolus. …”
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    Nucleolin modulates compartmentalization and dynamics of histone 2B-ECFP in the nucleolus
  14. 3854
    “…To obtain an aptamer with a high affinity for vascular endothelial growth factor (VEGF), we focused on the receptor-binding domain (RBD) of VEGF as a target epitope. Three rounds of screening gave Vap7, which bound to the VEGF isoforms VEGF(121) and VEGF(165) with K(D) values of 1.0 nM and 20 nM, respectively. …”
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    Screening and Improvement of an Anti-VEGF DNA Aptamer
  15. 3855
    “…In the first experiment, 10 local Turkish bottle gourd genotypes and two commercial watermelon cultivars were screened under 2 N doses (0.3 mM and 3.0 mM N) in RBD design with three replications for six weeks. …”
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    Root-growth Characteristics Contributing to Genotypic Variation in Nitrogen Efficiency of Bottle Gourd and Rootstock Potential for Watermelon
  16. 3856
    “…Additionally we tested several published SARS-CoV RBD-specific monoclonal antibodies and found that they do not have appreciable binding to nCoV-2019 S, suggesting antibody cross-reactivity may be limited between the two virus RBDs. …”
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    Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation
  17. 3857
    “…Based on this analysis, we developed two soluble ectodomain constructs in which the highly immunogenic and mobile receptor binding domain (RBD) is locked in either the all-RBDs ‘down’ position or is induced to display a previously unobserved in SARS-CoV-2 2-RBDs ‘up’ configuration. …”
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    Controlling the SARS-CoV-2 Spike Glycoprotein Conformation
  18. 3858
    “…We analyzed 294 SARS-CoV-2 antibodies and found that IGHV3–53 is the most frequently used IGHV gene for targeting the receptor binding domain (RBD) of the spike (S) protein. We determined crystal structures of two IGHV3–53 neutralizing antibodies +/− Fab CR3022 ranging from 2.33 to 3.11 Å resolution. …”
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    Structural basis of a public antibody response to SARS-CoV-2
  19. 3859
    por Lu, Jinghua, Sun, Peter D.
    Publicado 2020
    “…In addition, the enhancement was mediated by ACE2 binding of RBD domain of SARS-CoV-2 spike. These results highlighted the altered activity of ACE2 during SARS-CoV-2 infection and would shed new lights on the pathogenesis of COVID-19 and its complications for better treatments.…”
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    High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity
  20. 3860
    “…Our results showed that all studied animals are potentially susceptible to SARS-CoV-2 infection with a slight difference in the binding affinity and stability of their ACE2–RBD complexes. Furthermore, we identified a specific substitution of tyrosine to histidine at position 41 in ACE2 that likely reduces the affinity to SARS-CoV-2 in horses and greater horseshoe bats. …”
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    In silico analysis of ACE2 orthologues to predict animal host range with high susceptibility to SARS-CoV-2
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