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3881“…Unexpectedly, the expression of RBD2(S20D), the N-terminal 88 amino acids with no RNA-binding activity, is sufficient to induce apoptosis via alteration, in trans, of the posttranscriptional functions of endogenous STAU1. …”
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3882“…We found that the 5′ and 3′ of the spike and nucleoprotein genes have high frequencies to form the recombination junctions and that the RBD region in S gene is always exchanged as a whole. …”
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3883“…Our results show that local conformational changes in the FP, HR1, and CH domains are associated with global conformational changes in the RBD domain. The SARS-CoV-2 variants analyzed in this manuscript (alpha, beta, gamma, delta Mink, G614, N501) show differences in the local conformations of the FP, HR1, and CH domains as well. …”
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3884por Naaber, Paul, Tserel, Liina, Kangro, Kadri, Punapart, Marite, Sepp, Epp, Jürjenson, Virge, Kärner, Jaanika, Haljasmägi, Liis, Haljasorg, Uku, Kuusk, Marilin, Sankovski, Eve, Planken, Anu, Ustav, Mart, Žusinaite, Eva, Gerhold, Joachim M., Kisand, Kai, Peterson, Pärt“…The booster dose remarkably increases the serum ability to block wild-type or Omicron variant spike protein’s receptor-binding domain (RBD) interaction with the angiotensin-converting enzyme 2 (ACE2) receptor, and these protective antibodies persist 3 months later. …”
Publicado 2022
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3885por Wei, Guo-Wei“…Two key mutation sites, L452 and N501 on the viral spike protein receptor-binding domain (RBD), were predicted in summer 2020, long before they occur in prevailing variants Alpha, Beta, Gamma, Delta, Kappa, Theta, Lambda, Mu, and Omicron. …”
Publicado 2022
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3886“…We trained a neural network to predict RBD expression and ACE2 binding from sequence, which allowed us to determine that these antigens are stable and bind to ACE2. …”
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3887por Quaglia, Federica, Salladini, Edoardo, Carraro, Marco, Minervini, Giovanni, Tosatto, Silvio C.E., Le Mercier, Philippe“…Strikingly, antigenic sites are enriched in IDRs, in the receptor‐binding domain (RBD) and in the N‐terminal domain (NTD), suggesting a key role of structural flexibility in the antigenicity of the SARS‐CoV‐2 protein surface. …”
Publicado 2022
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3888por Chen, Jiahui, Wang, Rui, Hozumi, Yuta, Liu, Gengzhuo, Qiu, Yuchi, Wei, Xiaoqi, Wei, Guo-Wei“…Based on newly available experimental data, we analyzed the impacts of all possible viral spike (S) protein receptor-binding domain (RBD) mutations on the SARS-CoV-2 infectivity. Our analysis sheds light on viral evolutionary mechanisms, i.e., natural selection through infectivity strengthening and antibody resistance. …”
Publicado 2022
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3889“…Considering the SARS-CoV-2 Spike IgG, the difference was not statistically significant but for the SARS-CoV-2 RBD IgG and SARS-CoV-2 NAB the difference was statistically significant. …”
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3890por Zannella, Carla, Chianese, Annalisa, Greco, Giuseppe, Santella, Biagio, Squillaci, Giuseppe, Monti, Alessandra, Doti, Nunzianna, Sanna, Giuseppina, Manzin, Aldo, Morana, Alessandra, De Filippis, Anna, D’Angelo, Gianni, Palmieri, Francesco, Franci, Gianluigi, Galdiero, Massimiliano“…Our results showed that the synthetic peptides analyzed inhibit the infection of both coronaviruses in a dose-dependent manner by binding the RBD of the Spike protein, as suggested by molecular docking and validated by biochemical studies. …”
Publicado 2022
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3891por Panapitakkul, Chalisa, Khorattanakulchai, Narach, Rattanapisit, Kaewta, Srisangsung, Theerakarn, Shanmugaraj, Balamurugan, Buranapraditkun, Supranee, Ketloy, Chutitorn, Prompetchara, Eakachai, Phoolcharoen, Waranyoo“…Immunogenicity of the purified S1-Fc protein formulated with alum induced both RBD specific antibodies and T cell immune responses in mice. …”
Publicado 2022
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3892por Shafaati, Maryam, Bagherzadeh, Kowsar, Lotfinia, Majid, Karimi, Hesam, Teimoori, Ali, Razazian, Mehdi, Meidaninikjeh, Sepideh, Hosseini, Hamed, Jamshidi, Hamid Reza, Jalili, Hasan, Abdoli, Asghar“…Here, we studied the neutralization activity of post-WT strain-based vaccination and a structural simulation in-silico based on the interactions of the RBD-hACE2 as the key to initiating infection among the VOCs of SARS-CoV-2. …”
Publicado 2023
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3893Mutational Analysis of Circulating Omicron SARS-CoV-2 Lineages in the Al-Baha Region of Saudi Arabiapor Almalki, Shaia S R, Izhari, Mohammad Asrar, Alyahyawi, Hanan E, Alatawi, Saleha Keder, Klufah, Faisal, Ahmed, Waled A M, Alharbi, Raed“…BA.5.2/22B, BA.5.2/22B harbored a maximum of n=24 mutations in the spike region. Twelve crucial RBD mutations: D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, and Y505H were identified except the lineage BA.5.2/22B in which F486V mutation was not observed. …”
Publicado 2023
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3894por Raglow, Zoe M, Surie, Diya, Chappell, James, Zhu, Yuwei, Martin, Emily T, Kwon, Jennie H, Frosch, Anne, Mohamed, Amira, Gilbert, Julie, Bendall, Emily E, Bahr, Auden, Halasa, Natasha B, Talbot, H Keipp, Grijalva, Carlos G, Baughman, Adrienne, Womack, Kelsey N, Johnson, Cassandra, Swan, Sydney A, Burroughs, Ashley, Koumans, Emilia, McMorrow, Meredith L, Harcourt, Jennifer L, Atherton, Lydia J, Thornburg, Natalie J, Self, Wesley, Lauring, Adam S“…[Figure: see text] Bisected squares indicate more than one genomic mutation produced the same amino acid mutation. RBD is highlighted in gray. DISCLOSURES: Emily T. …”
Publicado 2023
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3895por Buonfrate, Dora, Piubelli, Chiara, Gobbi, Federico, Martini, Davide, Bertoli, Giulia, Ursini, Tamara, Moro, Lucia, Ronzoni, Niccolò, Angheben, Andrea, Rodari, Paola, Cardellino, Chiara, Tamarozzi, Francesca, Tais, Stefano, Rizzi, Eleonora, Degani, Monica, Deiana, Michela, Prato, Marco, Silva, Ronaldo, Bisoffi, Zeno“…METHODS: HCW were tested at T0 (day of first dose), T1 (day of second dose) and T2 (2–3 weeks after second dose) for IgG anti-nucleocapsid protein, IgM anti-spike protein and IgG anti-receptor binding domain (IgG-RBD-S). The antibody response was compared between four main groups: group A, individuals with previous infection and positive antibodies at baseline; group B, individuals with the same history but negative antibodies; group C, individuals with no infection history but positive antibodies; group D, naive individuals. …”
Publicado 2021
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3896por Gilbert, Peter B., Montefiori, David C., McDermott, Adrian, Fong, Youyi, Benkeser, David, Deng, Weiping, Zhou, Honghong, Houchens, Christopher R., Martins, Karen, Jayashankar, Lakshmi, Castellino, Flora, Flach, Britta, Lin, Bob C., O’Connell, Sarah, McDanal, Charlene, Eaton, Amanda, Sarzotti-Kelsoe, Marcella, Lu, Yiwen, Yu, Chenchen, Borate, Bhavesh, van der Laan, Lars W. P., Hejazi, Nima, Huynh, Chuong, Miller, Jacqueline, El Sahly, Hana M., Baden, Lindsey R., Baron, Mira, De La Cruz, Luis, Gay, Cynthia, Kalams, Spyros, Kelley, Colleen F., Kutner, Mark, Andrasik, Michele P., Kublin, James G., Corey, Lawrence, Neuzil, Kathleen M., Carpp, Lindsay N., Pajon, Rolando, Follmann, Dean, Donis, Ruben O., Koup, Richard A.“…METHODS: Through case-cohort sampling, participants were selected for measurement of four serum antibody markers at Day 1 (first dose), Day 29 (second dose), and Day 57: IgG binding antibodies (bAbs) to Spike, bAbs to Spike receptor-binding domain (RBD), and 50% and 80% inhibitory dilution pseudovirus neutralizing antibody titers calibrated to the WHO International Standard (cID50 and cID80). …”
Publicado 2021
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3897por Lu, Mijia, Zhang, Yuexiu, Dravid, Piyush, Li, Anzhong, Zeng, Cong, KC, Mahesh, Trivedi, Sheetal, Sharma, Himanshu, Chaiwatpongsakorn, Supranee, Zani, Ashley, Kenney, Adam, Cai, Chuanxi, Ye, Chengjin, Liang, Xueya, Qiu, Jianming, Martinez-Sobrido, Luis, Yount, Jacob S., Boyaka, Prosper N., Liu, Shan-Lu, Peeples, Mark E., Kapoor, Amit, Li, Jianrong“…We generated mtdVSVs expressing SARS-CoV-2 full-length spike (S) protein, S1, or its receptor-binding domain (RBD). All of these recombinant viruses grew to high titers in mammalian cells despite high attenuation in cell culture. …”
Publicado 2021
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3898por Melo-González, Felipe, Soto, Jorge A., González, Liliana A., Fernández, Jorge, Duarte, Luisa F., Schultz, Bárbara M., Gálvez, Nicolás M. S., Pacheco, Gaspar A., Ríos, Mariana, Vázquez, Yaneisi, Rivera-Pérez, Daniela, Moreno-Tapia, Daniela, Iturriaga, Carolina, Vallejos, Omar P., Berríos-Rojas, Roslye V., Hoppe-Elsholz, Guillermo, Urzúa, Marcela, Bruneau, Nicole, Fasce, Rodrigo A., Mora, Judith, Grifoni, Alba, Sette, Alessandro, Weiskopf, Daniela, Zeng, Gang, Meng, Weining, González-Aramundiz, José V., González, Pablo A., Abarca, Katia, Ramírez, Eugenio, Kalergis, Alexis M., Bueno, Susan M.“…Sera samples were used to evaluate the capacity of antibodies induced by the vaccine to block the binding between Receptor Binding Domain (RBD) from variants of concern and the human ACE2 receptor by an in-house ELISA. …”
Publicado 2021
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3899“…BNT162b2 induced the highest seropositivity and anti-spike RBD IgG antibody titres, followed by ChAdOx1, and then by CoronaVac. …”
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3900por Cherif, I., Kharroubi, G., Chaabane, S., Yazidi, R., Dellagi, M., Snoussi, M.A., Salem, S., Marzouki, S., Kammoun Rebai, W., Rourou, S., Dellagi, K., Barbouche, M.R., Benabdessalem, C., Ahmed, M. Ben, Bettaieb, J.“…La prévalence pondérée et ajustée sur les performances du test des anticorps IgG anti-S-RBD était égale à 25,1 % (Intervalle de Confiance à 95 % : [22,2-28,4]). …”
Publicado 2022
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