Mostrando 3,921 - 3,940 Resultados de 5,191 Para Buscar '"RBD"', tiempo de consulta: 0.18s Limitar resultados
  1. 3921
    “…Strategies targeting the receptor binding domain (RBD) may be helpful for developing vaccines or antiviral drugs for PEDV. …”
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    Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus Strains
  2. 3922
    “…Rhesus macaques inoculated with MERS-CoV VLPs and Alum adjuvant induced virus-neutralizing antibodies titers up to 1:40 and induced specific IgG antibodies against the receptor binding domain (RBD), with endpoint titers reaching 1:1,280. MERS-CoV VLPs also elicited T-helper 1 cell (Th1)-mediated immunity, as measured by ELISpot. …”
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    MERS-CoV virus-like particles produced in insect cells induce specific humoural and cellular imminity in rhesus macaques
  3. 3923
    “…This assay adapts a conventional ELISA format with immobilized RalGDS-RBD as a bait to selectively capture GTP-bound active Rap1. …”
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    A cell-based, quantitative and isoform-specific assay for exchange proteins directly activated by cAMP
  4. 3924
    “…To gain further insights into the function and regulation of Dicer in human cells, we performed a yeast two-hybrid (Y2HB) screen using human Dicer double-stranded RNA-binding domain (dsRBD) as bait. This approach identified tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) as a Dicer-interacting protein candidate. …”
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    TWEAK Negatively Regulates Human Dicer
  5. 3925
    “…Staufen proteins bind structured mRNA motifs through dsRNA-binding domains (dsRBD) and are involved in mRNA localization in Drosophila and mammals. …”
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    The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity
  6. 3926
    “…Here we show that the N protein consists of two non-interacting structural domains, the N-terminal RNA-binding domain (RBD) (residues 45–181) and the C-terminal dimerization domain (residues 248–365) (DD), surrounded by flexible linkers. …”
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    Modular organization of SARS coronavirus nucleocapsid protein
  7. 3927
    “…One is represented by the recently identified ganglioside binding site, exactly localized in our study in the galectin-like domain, and the other one by the putative integrin binding sites contained in the RBD. We propose that a cooperating therapy using inhibitors against multiple targets altogether i.e., ACE2, integrins and sugars could be definitely more effective.…”
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    A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment
  8. 3928
    “…In the case of stress granule protein Pub1 we show that the PrLD promotes sequestration of protein partners and the RBD confers liquid-like behaviour to the condensate. …”
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    RNA-binding and prion domains: the Yin and Yang of phase separation
  9. 3929
    “…Here we report the X-ray crystal structure of a fragment of human ADAR2 comprising its deaminase domain and double stranded RNA binding domain 2 (dsRBD2) bound to an RNA duplex as an asymmetric homodimer. …”
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    Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition
  10. 3930
    “…This mGHG motif interacts with the double-stranded RNA-binding domain (dsRBD) of DROSHA, switching its orientation on pri-mir-146a from the basal to the apical junction. …”
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    Human disease-associated single nucleotide polymorphism changes the orientation of DROSHA on pri-mir-146a
  11. 3931
    “…In this Opinion piece we highlight a series of sophisticated studies describing the identification of ultrapotent sdAbs directed against the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein. We discuss the possible applications of these antibodies in the global fight against COVID-19.…”
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    Slaying SARS-CoV-2 One (Single-domain) Antibody at a Time
  12. 3932
    “…Here we map how all mutations to the receptor binding domain (RBD) of SARS-CoV-2 affect binding by the antibodies in the REGN-COV2 cocktail and the antibody LY-CoV016. …”
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    Prospective mapping of viral mutations that escape antibodies used to treat COVID-19
  13. 3933
    “…Here, we demonstrate a novel NanoBiT-based serological assay for fast and sensitive detection of SARS-CoV-2 RBD-specific antibodies in sera of COVID-19 patients. …”
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    A High-Throughput NanoBiT-Based Serological Assay Detects SARS-CoV-2 Seroconversion
  14. 3934
    “…In this work, we design three very short peptides based on the ACE2 sequence/structure fragments, which may effectively bind to the receptor-binding domain (RBD) of S protein and may, in turn, disrupt the important virus-host protein–protein interactions, blocking early steps of SARS-CoV-2 infection. …”
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    Native Structure-Based Peptides as Potential Protein–Protein Interaction Inhibitors of SARS-CoV-2 Spike Protein and Human ACE2 Receptor
  15. 3935
    “…Currently, the receptor-binding domain (RBD) of the spike (S) protein is the main target of neutralizing antibodies when SARS-CoV-2 enters human cells through an interaction between the S protein and the angiotensin-converting enzyme 2 expressed on various human cells. …”
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    Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections
  16. 3936
    “…The process of membrane tubulation was monitored in vitro, and we observe that recombinant MICAL-L1-RBD domain may contribute to promote PACSINs-mediated membrane tubulation. …”
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    MICAL-L1 is required for cargo protein delivery to the cell surface
  17. 3937
    “…The amino acid changes L249S and E484K located at the CTD and RBD of the Spike protein could be of special interest due to their potential biological role in the virus-host relationship. …”
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    Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K
  18. 3938
    “…The five molecules were natural products that binding to the RBD domain of SARS-CoV-2 was qualitatively and quantitively validated by both native Mass Spectrometry (MS) and Surface Plasmon Resonance (SPR). …”
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    Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein
  19. 3939
    “…In this report we demonstrate the presence of serum neutralizing antibodies against the receptor binding-domain (RBD) of the SARS-CoV-2 in cats whose owners had been infected with SARS-CoV-2 in Lima, Peru, using a commercial competitive ELISA SARS-CoV-2 Surrogate Virus Neutralization Test. …”
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    Evidence of neutralizing antibodies against SARS-CoV-2 in domestic cats living with owners with a history of COVID-19 in Lima – Peru
  20. 3940
    “…Instead, the potentiometric response follows the Nikolsky-Eisenman law, treating the analyte ‘RBD spike protein’ as an ion carrying two elementary charges. …”
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    Parallel Potentiometric and Capacitive Response in a Water-Gate Thin Film Transistor Biosensor at High Ionic Strength
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