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3921por Deng, Feng, Ye, Gang, Liu, Qianqian, Navid, Muhammad Tariq, Zhong, Xiaoli, Li, Youwen, Wan, Chunyun, Xiao, Shaobo, He, Qigai, Fu, Zhen F., Peng, Guiqing“…Strategies targeting the receptor binding domain (RBD) may be helpful for developing vaccines or antiviral drugs for PEDV. …”
Publicado 2016
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3922por Wang, Chong, Zheng, Xuexing, Gai, Weiwei, Zhao, Yongkun, Wang, Hualei, Wang, Haijun, Feng, Na, Chi, Hang, Qiu, Boning, Li, Nan, Wang, Tiecheng, Gao, Yuwei, Yang, Songtao, Xia, Xianzhu“…Rhesus macaques inoculated with MERS-CoV VLPs and Alum adjuvant induced virus-neutralizing antibodies titers up to 1:40 and induced specific IgG antibodies against the receptor binding domain (RBD), with endpoint titers reaching 1:1,280. MERS-CoV VLPs also elicited T-helper 1 cell (Th1)-mediated immunity, as measured by ELISpot. …”
Publicado 2016
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3923“…This assay adapts a conventional ELISA format with immobilized RalGDS-RBD as a bait to selectively capture GTP-bound active Rap1. …”
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3924por Lambert, Marine, Pépin, Geneviève, Peralta-Zaragoza, Oscar, Matusiak, Raphaël, Ly, Sophia, Landry, Patricia, Provost, Patrick“…To gain further insights into the function and regulation of Dicer in human cells, we performed a yeast two-hybrid (Y2HB) screen using human Dicer double-stranded RNA-binding domain (dsRBD) as bait. This approach identified tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) as a Dicer-interacting protein candidate. …”
Publicado 2016
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3925por Lazzaretti, Daniela, Bandholz-Cajamarca, Lina, Emmerich, Christiane, Schaaf, Kristina, Basquin, Claire, Irion, Uwe, Bono, Fulvia“…Staufen proteins bind structured mRNA motifs through dsRNA-binding domains (dsRBD) and are involved in mRNA localization in Drosophila and mammals. …”
Publicado 2018
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3926por Chang, Chung-ke, Sue, Shih-Che, Yu, Tsan-hung, Hsieh, Chiu-Min, Tsai, Cheng-Kun, Chiang, Yen-Chieh, Lee, Shin-jye, Hsiao, Hsin-hao, Wu, Wen-Jin, Chang, Wei-Lun, Lin, Chun-Hung, Huang, Tai-huang“…Here we show that the N protein consists of two non-interacting structural domains, the N-terminal RNA-binding domain (RBD) (residues 45–181) and the C-terminal dimerization domain (residues 248–365) (DD), surrounded by flexible linkers. …”
Publicado 2005
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3927por Pirone, Luciano, Del Gatto, Annarita, Di Gaetano, Sonia, Saviano, Michele, Capasso, Domenica, Zaccaro, Laura, Pedone, Emilia“…One is represented by the recently identified ganglioside binding site, exactly localized in our study in the galectin-like domain, and the other one by the putative integrin binding sites contained in the RBD. We propose that a cooperating therapy using inhibitors against multiple targets altogether i.e., ACE2, integrins and sugars could be definitely more effective.…”
Publicado 2020
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3928por Gotor, Nieves Lorenzo, Armaos, Alexandros, Calloni, Giulia, Torrent Burgas, Marc, Vabulas, R Martin, De Groot, Natalia Sanchez, Tartaglia, Gian Gaetano“…In the case of stress granule protein Pub1 we show that the PrLD promotes sequestration of protein partners and the RBD confers liquid-like behaviour to the condensate. …”
Publicado 2020
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3929por Thuy-Boun, Alexander S, Thomas, Justin M, Grajo, Herra L, Palumbo, Cody M, Park, SeHee, Nguyen, Luan T, Fisher, Andrew J, Beal, Peter A“…Here we report the X-ray crystal structure of a fragment of human ADAR2 comprising its deaminase domain and double stranded RNA binding domain 2 (dsRBD2) bound to an RNA duplex as an asymmetric homodimer. …”
Publicado 2020
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3930“…This mGHG motif interacts with the double-stranded RNA-binding domain (dsRBD) of DROSHA, switching its orientation on pri-mir-146a from the basal to the apical junction. …”
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3931“…In this Opinion piece we highlight a series of sophisticated studies describing the identification of ultrapotent sdAbs directed against the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein. We discuss the possible applications of these antibodies in the global fight against COVID-19.…”
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3932por Starr, Tyler N., Greaney, Allison J., Addetia, Amin, Hannon, William W., Choudhary, Manish C., Dingens, Adam S., Li, Jonathan Z., Bloom, Jesse D.“…Here we map how all mutations to the receptor binding domain (RBD) of SARS-CoV-2 affect binding by the antibodies in the REGN-COV2 cocktail and the antibody LY-CoV016. …”
Publicado 2021
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3933por Azad, Taha, Rezaei, Reza, Singaravelu, Ragunath, Jamieson, Taylor R., Crupi, Mathieu J. F., Surendran, Abera, Poutou, Joanna, Taklifi, Parisa, Cowan, Juthaporn, Cameron, Donald William, Ilkow, Carolina S.“…Here, we demonstrate a novel NanoBiT-based serological assay for fast and sensitive detection of SARS-CoV-2 RBD-specific antibodies in sera of COVID-19 patients. …”
Publicado 2021
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3934por Odolczyk, Norbert, Marzec, Ewa, Winiewska-Szajewska, Maria, Poznański, Jarosław, Zielenkiewicz, Piotr“…In this work, we design three very short peptides based on the ACE2 sequence/structure fragments, which may effectively bind to the receptor-binding domain (RBD) of S protein and may, in turn, disrupt the important virus-host protein–protein interactions, blocking early steps of SARS-CoV-2 infection. …”
Publicado 2021
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3935“…Currently, the receptor-binding domain (RBD) of the spike (S) protein is the main target of neutralizing antibodies when SARS-CoV-2 enters human cells through an interaction between the S protein and the angiotensin-converting enzyme 2 expressed on various human cells. …”
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3936por Sikora, R., Bun, P., Danglot, L., Alqabandi, M., Bassereau, P., Niedergang, F., Galli, T., Zahraoui, A.“…The process of membrane tubulation was monitored in vitro, and we observe that recombinant MICAL-L1-RBD domain may contribute to promote PACSINs-mediated membrane tubulation. …”
Publicado 2021
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3937por Laiton-Donato, Katherine, Usme-Ciro, Jose A., Franco-Muñoz, Carlos, Álvarez-Díaz, Diego A., Ruiz-Moreno, Hector Alejandro, Reales-González, Jhonnatan, Prada, Diego Andrés, Corchuelo, Sheryll, Herrera-Sepúlveda, Maria T., Naizaque, Julian, Santamaría, Gerardo, Wiesner, Magdalena, Walteros, Diana Marcela, Ospina Martínez, Martha Lucia, Mercado-Reyes, Marcela“…The amino acid changes L249S and E484K located at the CTD and RBD of the Spike protein could be of special interest due to their potential biological role in the virus-host relationship. …”
Publicado 2021
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3938por Wang, Lin, Wu, Yan, Yao, Sheng, Ge, Huan, Zhu, Ya, Chen, Kun, Chen, Wen-zhang, Zhang, Yi, Zhu, Wei, Wang, Hong-yang, Guo, Yu, Ma, Pei-xiang, Ren, Peng-xuan, Zhang, Xiang-lei, Li, Hui-qiong, Ali, Mohammad A., Xu, Wen-qing, Jiang, Hua-liang, Zhang, Lei-ke, Zhu, Li-li, Ye, Yang, Shang, Wei-juan, Bai, Fang“…The five molecules were natural products that binding to the RBD domain of SARS-CoV-2 was qualitatively and quantitively validated by both native Mass Spectrometry (MS) and Surface Plasmon Resonance (SPR). …”
Publicado 2021
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3939por Jara, Luis M., Ferradas, Cusi, Schiaffino, Francesca, Sánchez-Carrión, Camila, Martínez-Vela, Ana, Ulloa, Alexandra, Isasi-Rivas, Gisela, Montalván, Angela, Sarmiento, Luis Guevara, Fernández, Manolo, Zimic, Mirko“…In this report we demonstrate the presence of serum neutralizing antibodies against the receptor binding-domain (RBD) of the SARS-CoV-2 in cats whose owners had been infected with SARS-CoV-2 in Lima, Peru, using a commercial competitive ELISA SARS-CoV-2 Surrogate Virus Neutralization Test. …”
Publicado 2021
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3940por AlQahtani, Hadi, Alswieleh, Abdullah, Al-Khurayyif, Ibrahim, AlGarni, Saad, Grell, Martin“…Instead, the potentiometric response follows the Nikolsky-Eisenman law, treating the analyte ‘RBD spike protein’ as an ion carrying two elementary charges. …”
Publicado 2021
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