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3941“…Transition between receptor binding domain (RBD) up and down forms of the SARS-CoV-2 spike protein trimer is coupled to receptor binding and is one route by which variants can alter viral properties. …”
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3942“…Based on current published evidence, we have summarized the different in silico based studies and repurposing of anti-viral drugs to target ACE2, SARS-CoV-2 S-Protein: ACE2 and SARS-CoV-2 S-RBD: ACE2. This review will be useful to researchers looking to effectively recognize and deal with SARS-CoV-2, and in the development of repurposed ACE2 inhibitors against COVID-19.…”
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3943“…Specifically, vaccine-resistant mutation Y449S in the spike (S) protein receptor-bonding domain (RBD), which occurred in co-mutation [Y449S, N501Y], has reduced infectivity compared to the original SARS-CoV-2 but can disrupt existing antibodies that neutralize the virus. …”
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3944“…The utility of the method is demonstrated for the KDEL receptor, a 23-kDa membrane protein, resulting in a map at 3.2-Å overall resolution with density sufficient for de novo model building, and for the 22-kDa receptor-binding domain (RBD) of SARS-CoV-2 spike protein, resulting in a map at 3.6-Å resolution that allows analysis of the binding interface to the nanobody. …”
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3945“…Variants of concern (alpha, beta, gamma and delta) acquired four patterns of spike glycoprotein mutations that enhance transmissibility and immune evasion: 1) mutations in the N-terminal domain (NTD), 2) mutations in the Receptor Binding Domain (RBD), 3) mutations at interchain contacts of the spike trimer, and 4) furin cleavage site mutations. …”
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3946“…This variant harbors a high number of mutations, including 15 mutations in the receptor‐binding domain (RBD) of spike. The Omicron variant also shares several mutations with the previous VOC Alpha, Beta, and Gamma variants, which immediately raised global concerns about viral transmissibility, pathogenicity, and immune evasion. …”
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3947“…Most vaccine development strategies have focused on the receptor-binding domain (RBD) in the spike protein because it is the most specific target site that recognizes and interacts with human lung cells. …”
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3948por Fan, Shengtao, Xiao, Kang, Li, Dandan, Zhao, Heng, Zhang, Jingjing, Yu, Li, Chang, Penglan, Zhu, Shuangli, Xu, Xingli, Liao, Yun, Ji, Tianjiao, Jiang, Guorun, Yan, Dongmei, Zeng, Fengyuan, Duan, Suqin, Xia, Baicheng, Wang, Lichun, Yang, Fengmei, He, Zhanlong, Song, Yang, Cui, Pingfang, Li, Xiaolei, Zhang, Yaxing, Zheng, Bangyi, Zhang, Ying, Xu, Wenbo, Li, Qihan“…Such vaccines improve the immune efficacy by increasing the neutralizing antibody titers and promoting specific T cell responses against five variants of the RBD protein. A viral challenge test with the B.1.617.2 (Delta) variant confirmed that both administration schedules (i.e. “1 + 1” and “2 + 1”) ensured protection against this strain. …”
Publicado 2022
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3949por Yu, Pei-Chen, Huang, Chen-Hao, Kuo, Chih-Jung, Liang, Po-Huang, Wang, Lily Hui-Ching, Pan, Max Yu-Chen, Chang, Sui-Yuan, Chao, Tai-Ling, Ieong, Si-Man, Fang, Jun-Tung, Huang, Hsuan-Cheng, Juan, Hsueh-Fen“…Furthermore, the capability of compounds to attach to the spike-receptor-binding domain (RBD) was considered an important factor in the present assessment. …”
Publicado 2022
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3950por Chatterjee, Debashree, Tauzin, Alexandra, Laumaea, Annemarie, Gong, Shang Yu, Bo, Yuxia, Guilbault, Aurélie, Goyette, Guillaume, Bourassa, Catherine, Gendron-Lepage, Gabrielle, Medjahed, Halima, Richard, Jonathan, Moreira, Sandrine, Côté, Marceline, Finzi, Andrés“…Some of the pivotal mutations such as N501Y and E484K in the receptor-binding domain (RBD) detected in B.1.1.7 (Alpha), B.1.351 (Beta) and P.1 (Gamma) are now present within the Mu variant. …”
Publicado 2022
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3951por Scott, Tristan A., Supramaniam, Aroon, Idris, Adi, Cardoso, Angelo A., Shrivastava, Surya, Kelly, Gabrielle, Grepo, Nicole A., Soemardy, Citradewi, Ray, Roslyn M., McMillan, Nigel A.J., Morris, Kevin V.“…These anti-CoV-2-enriched EVs bind SARS-CoV-2 spike protein at the receptor-binding domain (RBD) site and can functionally neutralize SARS-CoV-2. …”
Publicado 2022
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3952por Haskologlu, Ismail Celil, Erdag, Emine, Sayiner, Serkan, Abacioglu, Nurettin, Sehirli, Ahmet Ozer“…REGN-COV2 (Regeneron or imdevimab-casirivimab combination), which has been shown in recent studies to be less affected by Omicron's RBD (receptor binding domain) mutations among other mAb cocktails, plays an important role in adjuvant therapy against COVID-19. …”
Publicado 2022
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3953por Flores-Vega, Verónica Roxana, Monroy-Molina, Jessica Viridiana, Jiménez-Hernández, Luis Enrique, Torres, Alfredo G., Santos-Preciado, José Ignacio, Rosales-Reyes, Roberto“…Several mutations have been documented in the receptor-binding domain (RBD) of the viral spike protein that increases the interaction between SARS-CoV-2 and its cellular receptor, the angiotensin-converting enzyme 2 (ACE2). …”
Publicado 2022
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3954“…An interactive version of the estimator is at https://jbloomlab.github.io/SARS2_RBD_Ab_escape_maps/escape-calc/ (last accessed 11 March 2022), and we provide a Python module for batch processing. …”
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3955por Das, Gaurav, Ghosh, Surojit, Garg, Shubham, Ghosh, Satyajit, Jana, Aniket, Samat, Ramkamal, Mukherjee, Nabanita, Roy, Rajsekhar, Ghosh, Surajit“…New drugs developed from the RBD domain of the virus spike protein and drugs targeting viral proteases are also undergoing further research and have shown potential from preliminary results. …”
Publicado 2020
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3956por Torres, Jonathan L., Ozorowski, Gabriel, Andreano, Emanuele, Liu, Hejun, Copps, Jeffrey, Piccini, Giulia, Donnici, Lorena, Conti, Matteo, Planchais, Cyril, Planas, Delphine, Manganaro, Noemi, Pantano, Elisa, Paciello, Ida, Pileri, Piero, Bruel, Timothée, Montomoli, Emanuele, Mouquet, Hugo, Schwartz, Olivier, Sala, Claudia, De Francesco, Raffaele, Wilson, Ian A., Rappuoli, Rino, Ward, Andrew B.“…We show that mAb J08 has low nanomolar affinity against most VoCs and binds high on the receptor binding domain (RBD) ridge, away from many VoC mutations. These findings further validate the phase II/III human clinical trial underway using mAb J08 as a monoclonal therapy.…”
Publicado 2022
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3957“…Multiple substitutions and deletions in the N-terminal domain (NTD) and the receptor binding domain (RBD) in the spike protein collaborate with the observed increased infectivity and evasion from therapeutic monoclonal antibodies and vaccine-induced neutralizing antibodies after primary/secondary immunization. …”
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3958por Poustforoosh, Alireza, Hashemipour, Hassan, Tüzün, Burak, Azadpour, Mahdiyeh, Faramarz, Sanaz, Pardakhty, Abbas, Mehrabani, Mehrnaz, Nematollahi, Mohammad Hadi“…D614G alteration affected the binding affinity of the RBD and its receptor on the cell surface. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00284-022-02921-6.…”
Publicado 2022
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3959“…Using computational approaches, we examined griseofulvin and its derivatives against four key anti-SARS-CoV-2 targets: main protease, RdRp, spike protein receptor-binding domain (RBD), and human host angiotensin-converting enzyme 2 (ACE2). …”
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3960por Sotnikov, Dmitriy V., Byzova, Nadezhda A., Zherdev, Anatoly V., Xu, Youchun, Dzantiev, Boris B.“…The proposed approach was applied for the serodiagnosis using a recombinant RBD protein of SARS-CoV-2. As a result, an increase in the intensity of test zone coloration by more than two orders of magnitude was demonstrated, which enabled the significant reduction of false-negative results. …”
Publicado 2022
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