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  1. 3941
    por Lobo, Vanessa R., Warwicker, Jim
    Publicado 2021
    “…Transition between receptor binding domain (RBD) up and down forms of the SARS-CoV-2 spike protein trimer is coupled to receptor binding and is one route by which variants can alter viral properties. …”
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    Predicted pH-dependent stability of SARS-CoV-2 spike protein trimer from interfacial acidic groups
  2. 3942
    “…Based on current published evidence, we have summarized the different in silico based studies and repurposing of anti-viral drugs to target ACE2, SARS-CoV-2 S-Protein: ACE2 and SARS-CoV-2 S-RBD: ACE2. This review will be useful to researchers looking to effectively recognize and deal with SARS-CoV-2, and in the development of repurposed ACE2 inhibitors against COVID-19.…”
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    The Repurposed ACE2 Inhibitors: SARS-CoV-2 Entry Blockers of Covid-19
  3. 3943
    por Wang, Rui, Chen, Jiahui, Wei, Guo-Wei
    Publicado 2021
    “…Specifically, vaccine-resistant mutation Y449S in the spike (S) protein receptor-bonding domain (RBD), which occurred in co-mutation [Y449S, N501Y], has reduced infectivity compared to the original SARS-CoV-2 but can disrupt existing antibodies that neutralize the virus. …”
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    The evolution of the mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and America
  4. 3944
    por Wu, Xudong, Rapoport, Tom A.
    Publicado 2021
    “…The utility of the method is demonstrated for the KDEL receptor, a 23-kDa membrane protein, resulting in a map at 3.2-Å overall resolution with density sufficient for de novo model building, and for the 22-kDa receptor-binding domain (RBD) of SARS-CoV-2 spike protein, resulting in a map at 3.6-Å resolution that allows analysis of the binding interface to the nanobody. …”
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    Cryo-EM structure determination of small proteins by nanobody-binding scaffolds (Legobodies)
  5. 3945
    por Ostrov, David A., Knox, Glenn W.
    Publicado 2022
    “…Variants of concern (alpha, beta, gamma and delta) acquired four patterns of spike glycoprotein mutations that enhance transmissibility and immune evasion: 1) mutations in the N-terminal domain (NTD), 2) mutations in the Receptor Binding Domain (RBD), 3) mutations at interchain contacts of the spike trimer, and 4) furin cleavage site mutations. …”
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    Emerging mutation patterns in SARS-CoV-2 variants
  6. 3946
    “…This variant harbors a high number of mutations, including 15 mutations in the receptor‐binding domain (RBD) of spike. The Omicron variant also shares several mutations with the previous VOC Alpha, Beta, and Gamma variants, which immediately raised global concerns about viral transmissibility, pathogenicity, and immune evasion. …”
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    SARS‐CoV‐2 Omicron variant: Characteristics and prevention
  7. 3947
    “…Most vaccine development strategies have focused on the receptor-binding domain (RBD) in the spike protein because it is the most specific target site that recognizes and interacts with human lung cells. …”
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    Neutralizing antibody: a savior in the Covid-19 disease
  8. 3948
    “…Such vaccines improve the immune efficacy by increasing the neutralizing antibody titers and promoting specific T cell responses against five variants of the RBD protein. A viral challenge test with the B.1.617.2 (Delta) variant confirmed that both administration schedules (i.e. “1 + 1” and “2 + 1”) ensured protection against this strain. …”
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    Preclinical immunological evaluation of an intradermal heterologous vaccine against SARS-CoV-2 variants
  9. 3949
    “…Furthermore, the capability of compounds to attach to the spike-receptor-binding domain (RBD) was considered an important factor in the present assessment. …”
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    Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets
  10. 3950
    “…Some of the pivotal mutations such as N501Y and E484K in the receptor-binding domain (RBD) detected in B.1.1.7 (Alpha), B.1.351 (Beta) and P.1 (Gamma) are now present within the Mu variant. …”
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    Antigenicity of the Mu (B.1.621) and A.2.5 SARS-CoV-2 Spikes
  11. 3951
    “…These anti-CoV-2-enriched EVs bind SARS-CoV-2 spike protein at the receptor-binding domain (RBD) site and can functionally neutralize SARS-CoV-2. …”
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    Engineered extracellular vesicles directed to the spike protein inhibit SARS-CoV-2
  12. 3952
    “…REGN-COV2 (Regeneron or imdevimab-casirivimab combination), which has been shown in recent studies to be less affected by Omicron's RBD (receptor binding domain) mutations among other mAb cocktails, plays an important role in adjuvant therapy against COVID-19. …”
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    Melatonin and REGN-CoV2 combination as a vaccine adjuvant for Omicron variant of SARS-CoV-2
  13. 3953
    “…Several mutations have been documented in the receptor-binding domain (RBD) of the viral spike protein that increases the interaction between SARS-CoV-2 and its cellular receptor, the angiotensin-converting enzyme 2 (ACE2). …”
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    SARS-CoV-2: Evolution and Emergence of New Viral Variants
  14. 3954
    “…An interactive version of the estimator is at https://jbloomlab.github.io/SARS2_RBD_Ab_escape_maps/escape-calc/ (last accessed 11 March 2022), and we provide a Python module for batch processing. …”
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    An antibody-escape estimator for mutations to the SARS-CoV-2 receptor-binding domain
  15. 3955
    “…New drugs developed from the RBD domain of the virus spike protein and drugs targeting viral proteases are also undergoing further research and have shown potential from preliminary results. …”
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    An overview of key potential therapeutic strategies for combat in the COVID-19 battle
  16. 3956
    “…We show that mAb J08 has low nanomolar affinity against most VoCs and binds high on the receptor binding domain (RBD) ridge, away from many VoC mutations. These findings further validate the phase II/III human clinical trial underway using mAb J08 as a monoclonal therapy.…”
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    Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody
  17. 3957
    por Kircheis, Ralf, Planz, Oliver
    Publicado 2022
    “…Multiple substitutions and deletions in the N-terminal domain (NTD) and the receptor binding domain (RBD) in the spike protein collaborate with the observed increased infectivity and evasion from therapeutic monoclonal antibodies and vaccine-induced neutralizing antibodies after primary/secondary immunization. …”
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    Could a Lower Toll-like Receptor (TLR) and NF-κB Activation Due to a Changed Charge Distribution in the Spike Protein Be the Reason for the Lower Pathogenicity of Omicron?
  18. 3958
    “…D614G alteration affected the binding affinity of the RBD and its receptor on the cell surface. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00284-022-02921-6.…”
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    The Impact of D614G Mutation of SARS-COV-2 on the Efficacy of Anti-viral Drugs: A Comparative Molecular Docking and Molecular Dynamics Study
  19. 3959
    “…Using computational approaches, we examined griseofulvin and its derivatives against four key anti-SARS-CoV-2 targets: main protease, RdRp, spike protein receptor-binding domain (RBD), and human host angiotensin-converting enzyme 2 (ACE2). …”
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    In Silico Molecular Dynamics of Griseofulvin and Its Derivatives Revealed Potential Therapeutic Applications for COVID-19
  20. 3960
    “…The proposed approach was applied for the serodiagnosis using a recombinant RBD protein of SARS-CoV-2. As a result, an increase in the intensity of test zone coloration by more than two orders of magnitude was demonstrated, which enabled the significant reduction of false-negative results. …”
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    Silent Antibodies Start Talking: Enhanced Lateral Flow Serodiagnosis with Two-Stage Incorporation of Labels into Immune Complexes
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