-
3961por Cieslewicz, Brian, Makrinos, Daniel, Burke, Heidi, Bree, Dara, Haridas, Renuka, Tonkiss, Ian, Bartsch, Yannic, Alter, Galit, Malley, Richard, Besin, Gilles“…This vaccine contains a fragment of the spike (S) protein receptor-binding domain (RBD) sequence of the original D614G strain and was used to immunize nonhuman primates (NHP) for assessment of immunological responses and protection against SARS-CoV-2 challenge. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3962por Aston, Emily J., Wallach, Michael G., Narayanan, Aarthi, Egaña-Labrin, Sofia, Gallardo, Rodrigo A.“…In this study we demonstrate that hens hyperimmunized against the SARS-CoV-2 recombinant S1 and receptor binding domain (RBD) proteins produced neutralizing antibodies against SARS-CoV-2. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3963Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concernpor Chaouat, Abigael E., Brizic, Ilija, Kucan Brlic, Paola, Atari, Nofar, Kliker, Limor, Alfi, Or, Mandelboim, Michal, Wolf, Dana, Tafish, Laith, Kol, Inbal, Jonjic, Stipan, Mandelboim, Ofer“…Here, we report on the generation of hACE2.16, an anti-ACE2 antibody that recognizes and blocks ACE2-RBD binding without affecting ACE2 enzymatic activity. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3964por Vakhrusheva, Anna V., Kudriavtsev, Aleksandr V., Kryuchkov, Nickolay A., Deev, Roman V., Frolova, Maria E., Blagodatskikh, Konstantin A., Djonovic, Milana, Nedorubov, Andrey A., Odintsova, Elena, Ivanov, Aleksandr V., Romanovskaya-Romanko, Ekaterina A., Stukova, Marina A., Isaev, Artur A., Krasilnikov, Igor V.“…This paper presents preclinical trial results of “Betuvax-CoV-2”, a vaccine developed as a subunit vaccine containing a recombinant RBD-Fc fusion protein and betulin-based spherical virus-like nanoparticles as an adjuvant (“Betuspheres”). …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3965por Deimel, Lachlan P., Liu, Xin, Gilbert-Jaramillo, Javier, Liu, Sai, James, William S., Sattentau, Quentin J.“…Further, we test a heterologous intranasal immunisation regimen, priming with S and boosting with RBD-Fc. Our data identify small volume PEI adjuvantation as a novel platform with potential for protective mucosal vaccine development.…”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3966por Miki, Takayuki, Namii, Keigo, Seko, Kenta, Kakehi, Shota, Moro, Goshi, Mihara, Hisakazu“…We also performed selection targeting the SARS-CoV-2 spike RBD in the same manner. The results showed that similar patterns were enriched among the hit peptides that inhibited the protein–protein interaction.…”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3967por Quadir, Neha, Singh, Jasdeep, Alam, Anwar, Malik, Asrar Ahmad, Rahman, Syed Asad, Hira, Subhash, Ehtesham, Nasreen Zafar, Sundar, Durai, Hasnain, Seyed Ehtesham“…The acquisition of a high number of mutations, notably, the gain of two mutations L452R and F486V in RBD, and the ability to evade vaccine/natural infection-induced immunity suggests that Omicron is continuing to use “immune-escape potential” as an evolutionary space to maintain a selection advantage within the population. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3968“…We focused on betacoronaviruses and identified nonhuman-infecting receptor binding domain (RBD) sequences that were more genetically similar to human coronaviruses than expected given their phylogenetic divergence. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3969por Sahay, Rima R., Yadav, Pragya D., Nandapurkar, Ashok, Dhawde, Rutuja, Suryawanshi, Annasaheb, Patil, Deepak Y., Shete, Anita M., Sapkal, Gajanan N., Kulkarni, Milind, Gurav, Yogesh K., Deshpande, Gururaj R., Ghodke, Jagdevi S., Jain, Rajlaxmi, Hawale, Raj, Kalele, Kaumudi, Yemul, Jyoti, Gawande, Pranita, Abraham, Priya“…The immune response in the study population were assessed at three follow-ups, namely at one month post first dose, one and six months after the second dose. The persistence of S1RBD IgG and neutralizing antibodies for six months post vaccination was observed at different time intervals. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3970“…We have also found that the receptor-binding domain (RBD) and N-terminal domain (NTD) of the D614G mutant extend more outwards than those of the WT spike. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3971por Błaszczuk, Agata, Sikora, Dominika, Kiś, Jacek, Stępień, Ewa, Drop, Bartłomiej, Polz-Dacewicz, Małgorzata“…For the study, we used the Microblot-Array COVID-19 IgG test to detect antibodies against the three main SARS-CoV-2 antigens: NCP, RBD, and S2. Our results showed that prostate cancer patients had significantly lower levels of anti-SARS-CoV-2 IgG antibodies compared to controls. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3972por Chothe, Shubhada K., Jakka, Padmaja, Boorla, Veda Sheersh, Ramasamy, Santhamani, Gontu, Abhinay, Nissly, Ruth H., Brown, Justin, Turner, Gregory, Sewall, Brent J., Reeder, DeeAnn M., Field, Kenneth A., Engiles, Julie B., Amirthalingam, Saranya, Ravichandran, Abirami, LaBella, Lindsey, Nair, Meera Surendran, Maranas, Costas D., Kuchipudi, Suresh V.“…All-atom molecular dynamics (MD) simulations revealed that LBB ACE2 formed strong electrostatic interactions with the RBD similar to human and cat ACE2 proteins. In summary, LBBs, a widely distributed North American bat species, could be at risk of SARS-CoV-2 infection and potentially serve as a natural reservoir. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3973“…From our results we found four highly potent drug candidates that can bind to the Spike-RBD of all the variants of the virus. Additionally, we also found that certain signature residues on the RBM region commonly bind to each of these inhibitors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3974por Wang, Zijun, Muecksch, Frauke, Raspe, Raphael, Johannsen, Frederik, Turroja, Martina, Canis, Marie, ElTanbouly, Mohamed A., Santos, Gabriela S. Silva, Johnson, Brianna, Baharani, Viren A., Patejak, Rachel, Yao, Kai-Hui, Chirco, Bennett J., Millard, Katrina G., Shimeliovich, Irina, Gazumyan, Anna, Oliveira, Thiago Y., Bieniasz, Paul D., Hatziioannou, Theodora, Caskey, Marina, Nussenzweig, Michel C.“…Notably, memory antibodies from the elderly preferentially targeted the ACE2-binding site on the RBD, while those from younger individuals targeted less accessible but more conserved epitopes. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3975por Hoffman, Tove, Kolstad, Linda, Akaberi, Dario, Järhult, Josef D., Rönnberg, Bengt, Lundkvist, Åke“…Binding between the hACE2 receptor and the S1 domain of the B.1.1.529 lineage of the Omicron variant was not observed in the assay but between the receptor and an S1 + S2 trimer and the receptor binding domain (RBD) in a reduced manner, suggesting less efficient receptor binding for the B.1.1.529 Omicron variant. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3976por Zhang, Xixi, Li, Zimu, Zhang, Yanjun, Liu, Yutong, Wang, Jingjing, Liu, Banghui, Chen, Qiuluan, Wang, Qian, Fu, Lutang, Wang, Peiyi, Zhong, Xiaolin, Jin, Liang, Yan, Qihong, Chen, Ling, He, Jun, Zhao, Jincun, Xiong, Xiaoli“…S-trimers adopting locked conformations are tightly packed featuring structural elements incompatible with RBD in the “up” position. For SARS-CoV-2 S, it has been shown that the locked conformations are transient under neutral pH. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3977por Minosse, Claudia, Matusali, Giulia, Meschi, Silvia, Grassi, Germana, Francalancia, Massimo, D’Offizi, Gianpiero, Spezia, Pietro Giorgio, Garbuglia, Anna Rosa, Montalbano, Marzia, Focosi, Daniele, Girardi, Enrico, Vaia, Francesco, Ettorre, Giuseppe Maria, Maggi, Fabrizio“…We found that TTV viremia before the first and third vaccine doses predicts serum anti-SARS-CoV-2 Spike receptor-binding domain (RBD) IgG levels measured 2–4 weeks after the second or third dose. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3978por D’Orso, Silvia, Pirronello, Marta, Verdiani, Alice, Rossini, Angelo, Guerrera, Gisella, Picozza, Mario, Sambucci, Manolo, Misiti, Andrea, De Marco, Lorenzo, Salvia, Antonino, Caltagirone, Carlo, Giardina, Emiliano, Battistini, Luca, Borsellino, Giovanna“…Natural infection determined an immediate and sharp rise in anti-RBD antibody titres and in the frequency of both S-specific antibody secreting cells (ASCs) and memory B lymphocytes. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3979por Zhang, Yanqiong, Chen, Dongliang, Smith, Michael A., Zhang, Baohong, Pan, Xiaoping“…In this study, we selected 13 reference gene candidates (act-1, cdc-42, pmp-3, eif-3.C, actin, act-2, csq-1, Y45F10D.4, tba-1, mdh-1, ama-1, F35G12.2, and rbd-1) to test their expression stability under different doses of nano-copper oxide (CuO 0, 1, 10, and 50 µg/mL) using RT-qPCR. …”
Publicado 2012
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
3980“…K-Ras and its interactive proteins, Ras binding domain (RBD) of Raf-1 and Grb2 were used to confirm the accuracy of the BEVL-BiFC system. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto