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381por Cordero-Ortiz, Maritza, Reséndiz-Sandoval, Mónica, Dehesa-Canseco, Freddy, Solís-Hernández, Mario, Pérez-Sánchez, Jahir, Martínez-Borges, Carlos, Mata-Haro, Verónica, Hernández, Jesús“…After confirming that double-antigen sandwich ELISA with both RBD and N proteins had the best performance (AUC= 88%), the cutoff was adjusted using positive and negative samples from cats, humans (n = 32) and guinea pigs (n = 3). …”
Publicado 2023
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382“…The interaction of OsSRO1a with OsRBD1 was shown in yeast as well as in planta. Domain–domain interaction study revealed that C-terminal RST domain of OsSRO1a interacts with the N-terminal RRM1 domain of OsRBD1 protein. …”
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383por Hanson, Quinlin M., Wilson, Kelli M., Shen, Min, Itkin, Zina, Eastman, Richard T., Shinn, Paul, Hall, Matthew D.“…This established AlphaLISA RBD-ACE2 platform can facilitate evaluation of biologics or small molecules that can perturb this essential viral-host interaction to further the development of interventions to address the global health pandemic.…”
Publicado 2020
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384por Lowegard, Anna U., Frenkel, Marcel S., Holt, Graham T., Jou, Jonathan D., Ojewole, Adegoke A., Donald, Bruce R.“…We combined this new mutation with two previously reported mutations (which were highly-ranked by osprey) to create a new variant of c-Raf-RBD, c-Raf-RBD(RKY). fries/EWAK* in osprey computationally predicted that this new variant binds even more tightly than the previous best-binding variant, c-Raf-RBD(RK). …”
Publicado 2020
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386por Pham, Thang L., He, Jiucheng, Kakazu, Azucena H., Calandria, Jorgelina, Do, Khanh V., Nshimiyimana, Robert, Petasis, Nicos A., Bazan, Haydee E.P., Bazan, Nicolas G.“…We explore ways to block the receptor-binding domain (RBD) of SARS-CoV-2 spike (S) protein to angiotensin-converting enzyme 2 (ACE2). …”
Publicado 2020
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387por Rattanapisit, Kaewta, Shanmugaraj, Balamurugan, Manopwisedjaroen, Suwimon, Purwono, Priyo Budi, Siriwattananon, Konlavat, Khorattanakulchai, Narach, Hanittinan, Oranicha, Boonyayothin, Wanuttha, Thitithanyanont, Arunee, Smith, Duncan R., Phoolcharoen, Waranyoo“…The plant-produced RBD exhibited specific binding to the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2). …”
Publicado 2020
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388por Hanson, Quinlin M., Wilson, Kelli M., Shen, Min, Itkin, Zina, Eastman, Richard T., Shinn, Paul, Hall, Matthew D.“…This established AlphaLISA RBD–ACE2 platform can facilitate evaluation of biologics or small molecules that can perturb this essential viral–host interaction to further the development of interventions to address the global health pandemic.…”
Publicado 2020
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389por Akachar, Jihane, Bouricha, El Mehdi, Hakmi, Mohammed, Belyamani, Lahcen, El Jaoudi, Rachid, Ibrahimi, Azeddine“…In this paper, protein-protein docking was utilized for identifying the critical epitopes in CD147, CD209 and CD299 which are involved in the binding with SARS-CoV-2 Spike receptor binding domain (RBD). The results of binding free energies showed a high affinity of SARS-CoV-2 RBD to CD299 receptor which was used as a reference to derive hypothetical peptide sequences with specific binding activities to SARS-CoV-2 RBD. …”
Publicado 2020
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390por Wang, Xiaoning, Yang, Chuanxi, Sun, Yangyang, Sui, Xin, Zhu, Tong, Wang, Qian, Wang, Shuai, Yang, Jun, Yang, Weijie, Liu, Fengying, Zhang, Minmin, Wang, Yongan, Luo, Yuan“…Using computational simulation, blockade mechanism of SARS-CoV-2 spike receptor binding domain (S RBD) and human angiotensin converting enzyme 2 (hACE2) was clarified based on interactions between RBD and hesperidin. …”
Publicado 2021
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393“…All in-house EIAs showed high specificity (98–99%) and sensitivity (97.8–98.9%) for the detection of IgG/IgM against RBD and N proteins of SARS-CoV-2. From these results, the developed Anti-RBD and anti-N IgG and IgM antibodies EIAs can be used as a specific and sensitive tool to detect SARS-CoV-2 infection, calculate the burden of disease and case fatality rates.…”
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394por Basu, Sankar, Chakravarty, Devlina, Bhattacharyya, Dhananjay, Saha, Pampa, Patra, Hirak K“…The RBD(Spike) is an independently foldable protein domain, resilient to conformational changes upon mutations and therefore an attractive target for strategic re-design. …”
Publicado 2021
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395por Dakal, Tikam Chand“…Most of the bacterial antigens that displayed molecular similarity with antigenic sites in SARS-CoV-2 RBD (receptor binding domain) were toxins and virulent factors. …”
Publicado 2021
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396por Tomassetti, Flaminia, Nuccetelli, Marzia, Sarubbi, Serena, Gisone, Francesca, Ciotti, Marco, Spinazzola, Francesco, Ricotta, Cristina, Cagnoli, Monica, Borgatti, Monica, Iannetta, Marco, Andreoni, Massimo, Calugi, Graziella, Pieri, Massimo, Bernardini, Sergio“…Hospitalized patients showed elevated serum levels of S-RBD (97.22%) and NT (77.78%) antibodies, differently, not-hospitalized, who were paucisymptomatic or asymptomatic patients, showed lower serum levels of S-RBD (65.71%) and NT (38.14%) antibodies. …”
Publicado 2021
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397por Xu, Kun, An, Yaling, Li, Qunlong, Huang, Weijin, Han, Yuxuan, Zheng, Tianyi, Fang, Fang, Liu, Hui, Liu, Chuanyu, Gao, Ping, Xu, Senyu, Liu, Xueyuan, Zhang, Rong, Zhao, Xin, Liu, William J., Bi, Yuhai, Wang, Youchun, Zhou, Dongming, Wang, Qinghan, Hou, Wenli, Xia, Qianfeng, Gao, George F., Dai, Lianpan“…AdC7-RBD-tr2 showed higher antibody responses compared to either AdC7-S or AdC7-RBD. …”
Publicado 2021
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398“…MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene. …”
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399por Núñez-Muñoz, Leandro, Marcelino-Pérez, Gabriel, Calderón-Pérez, Berenice, Pérez-Saldívar, Miriam, Acosta-Virgen, Karla, González-Conchillos, Hugo, Vargas-Hernández, Brenda, Olivares-Martínez, Ana, Ruiz-Medrano, Roberto, Roa-Velázquez, Daniela, Morales-Ríos, Edgar, Ramos-Flores, Jorge, Torres-Franco, Gustavo, Peláez-González, Diana, Fernández-Hernández, Jorge, Espinosa-Cantellano, Martha, Tapia-Sidas, Diana, Ramírez-Pool, José Abrahan, Padilla-Viveros, América, Xoconostle-Cázares, Beatriz“…The Receptor-Binding Domain (RBD) of the Spike (S) protein from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has glycosylation sites which can limit the production of reliable antigens expressed in prokaryotic platforms, due to glycan-mediated evasion of the host immune response. …”
Publicado 2021
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400por Li, Letian, Wang, Maopeng, Hao, Jiayi, Han, Jicheng, Fu, Tingting, Bai, Jieying, Tian, Mingyao, Jin, Ningyi, Zhu, Guangze, Li, Chang“…In this study, we constructed a recombinant L. plantarum LP18:RBD expressing the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein via the surface anchoring route. …”
Publicado 2021
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