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4021“…In this review, we discuss (1) the emerging SARS-CoV-2 variants; (2) the structural basis for antibody-mediated neutralization of SARS-CoV-2 and nAb classification; and (3) identification of the RBD escape mutations for several antibodies that resist antibody binding and neutralization. …”
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4022por Dittadi, Ruggero“…We re-evaluated a previously studied set of cases (108 specimens of 48 patients and 60 specimens of 20 vaccinated subjects, collected after 14 days from the first dose and 14 days and 3 months after a second dose of the Comirnaty BNT162b2 vaccine), calculating the ratios between the results of two methods (SARS-CoV-2 IgG anti-RBD, SNIBE, and anti-SARS-CoV-2 QuantiVac ELISA IgG, Euroimmun). …”
Publicado 2022
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4023por Abel, Yoann, Charron, Christophe, Virciglio, Camille, Bourguignon-Igel, Valérie, Quinternet, Marc, Chagot, Marie-Eve, Robert, Marie-Cécile, Verheggen, Céline, Branlant, Christiane, Bertrand, Edouard, Manival, Xavier, Charpentier, Bruno, Rederstorff, Mathieu“…The RPAP3-TPR1 domain interacts with the TRBP-dsRBD3, and the 1.5 Å resolution crystal structure of this complex identifies key residues involved in the interaction. …”
Publicado 2022
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4024por Jiang, Sheng, Wu, Shuting, Zhao, Gan, He, Yue, Guo, Xinrong, Zhang, Zhiyu, Hou, Jiawang, Ding, Yuan, Cheng, Alex, Wang, Bin“…Although virus-neutralizing epitopes are mainly located within the RBD of the spike protein, the presence of T cell epitopes, particularly the CTL epitopes that are likely to be needed for killing infected cells, has received comparatively little attention. …”
Publicado 2022
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4025“…Our study on device validation may contribute to measuring natural sleep, including rapid eye movement (REM) sleep behavioral disorder (RBD), in an outpatient care setting.…”
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4026“…Furthermore, the spike glycoprotein receptor-binding domain (RBD) of SARS-CoV-2 was bound to alveolar epithelial stem-like cells. …”
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4027“…In particular, the N501Y substitution, situated in the RBD of the spike of the British variant, might be the reason for its extraordinary infective potential.…”
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4028por Mackin, Robert T., Edwards, J. Vincent, Atuk, E. Berk, Beltrami, Noah, Condon, Brian D., Jayawickramarajah, Janarthanan, French, Alfred D.“…Here, we consider mechanisms that influence host cell–virus binding between the SARS-CoV-2 spike glycoprotein (SPG) and the human angiotensin-converting enzyme 2 (ACE2) with a series of peptides designed to mimic key ACE2 hot spots through adopting a helical conformation analogous to the N-terminal α1 helix of ACE2, the region experimentally shown to bind to the SARS-CoV-2 receptor-binding domain (RBD). The approach examines putative structure/function relations by assessing SPG binding affinity with surface plasmon resonance (SPR). …”
Publicado 2022
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4029por Nikolaidis, Marios, Papakyriakou, Athanasios, Chlichlia, Katerina, Markoulatos, Panayotis, Oliver, Stephen G., Amoutzias, Grigorios D.“…Our analyses reject the hypothesis that the heavily mutated receptor binding domain (RBD) of the Omicron Spike was introduced via recombination from another closely related Sarbecovirus. …”
Publicado 2022
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4030“…Both the energy change and energy barrier between endpoint structures provide reasonable mechanism explanations for the associated biological processes, including the opening of receptor binding domain (RBD) of spike protein, the phospholipid transportation of P4-ATPase, and the loop translocation of ACLY. …”
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4031“…The limit of detection of our assay detecting the spike RBD was below 10 ng/mL.…”
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4032por Vogt, Anne-Cathrine S., Augusto, Gilles, Martina, Byron, Chang, Xinyue, Nasrallah, Gheyath, Speiser, Daniel E., Vogel, Monique, Bachmann, Martin F., Mohsen, Mona O.“…Our data demonstrate that both Delta, as well as Omicron variants, exhibit a higher affinity for the receptor ACE2, facilitating infection and causing antibody escape by receptor affinity (affinity escape), due to the reduced ability of antibodies to compete with RBD-receptor interaction and virus neutralization. …”
Publicado 2022
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4033“…The correlation between the motion of the antibody and that of the spike receptor binding domain (RBD) can also be changed, modulating binding affinity. …”
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4034“…At the same time, a specific anti-RBD IgG using a classic ELISA before vaccination, and on days 0, 35, and 200 was performed. …”
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4035por Ginex, Tiziana, Marco-Marín, Clara, Wieczór, Miłosz, Mata, Carlos P., Krieger, James, Ruiz-Rodriguez, Paula, López-Redondo, Maria Luisa, Francés-Gómez, Clara, Melero, Roberto, Sánchez-Sorzano, Carlos Óscar, Martínez, Marta, Gougeard, Nadine, Forcada-Nadal, Alicia, Zamora-Caballero, Sara, Gozalbo-Rovira, Roberto, Sanz-Frasquet, Carla, Arranz, Rocío, Bravo, Jeronimo, Rubio, Vicente, Marina, Alberto, Geller, Ron, Comas, Iñaki, Gil, Carmen, Coscolla, Mireia, Orozco, Modesto, Llácer, José Luis, Carazo, Jose-Maria“…Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. …”
Publicado 2022
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4036por Almanza, Gonzalo, Clark, Alex E., Kouznetsova, Valentina, Olmedillas, Eduardo, Castro, Andrea, Tsigelny, Igor F., Wu, Yan, Gao, George F., Leibel, Sandra L., Bray, William, Ollmann Saphire, Erica, Carlin, Aaron F., Zanetti, Maurizio“…Immune sera antibodies bound strongly to the purified receptor-binding domain (RBD) and Spike proteins. pDNA primed for a consistent response with antibodies efficient at neutralizing authentic WA1 virus and three variants of concern (VOC), B.1.351, B.1.617.2, and BA.1. …”
Publicado 2022
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4037“…Recombination analysis and multiple alignments of spike and RBD amino acid sequences suggested that this strain underwent recombination events and could possibly use hDPP4 molecules as its receptor. …”
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4038por Mikolajek, Halina, Weckener, Miriam, Brotzakis, Z. Faidon, Huo, Jiandong, Dalietou, Evmorfia V., Le Bas, Audrey, Sormanni, Pietro, Harrison, Peter J., Ward, Philip N., Truong, Steven, Moynie, Lucile, Clare, Daniel K., Dumoux, Maud, Dormon, Joshua, Norman, Chelsea, Hussain, Naveed, Vogirala, Vinod, Owens, Raymond J., Vendruscolo, Michele, Naismith, James H.“…Using the receptor binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and a naïve library, we generated closely related nanobodies with micromolar to nanomolar binding affinities. …”
Publicado 2022
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4039por Besselink, Geert, Schütz-Trilling, Anke, Veerbeek, Janneke, Verbruggen, Michelle, van der Meer, Adriaan, Schonenberg, Rens, Dam, Henk, Evers, Kevin, Lindhout, Ernst, Garritsen, Anja, van Amerongen, Aart, Knoben, Wout, Scheres, Luc“…The current work describes the application of an aMZI-based biosensor platform for sensitive and multiplex detection of anti-SARS-CoV-2 antibodies in human plasma samples using the spike protein (SP), the receptor-binding domain (RBD), and the nucleocapsid protein (NP) as target antigens. …”
Publicado 2022
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4040por Meira, Cássio, Silva, Dahara, Santos, Ivanilson, Barreto, Breno, Rocha, Vinícius, Santos, Emanuelle, dos Reis, Bruna, Evangelista, Afrânio, Ribeiro dos Santos, Ricardo, Machado, Bruna, Ribeiro, Guilherme, Badaró, Roberto, Soares, Milena“…We found specificities of 0.98, 0.98, and 0.99 and sensitivities of 0.99, 0.91, and 0.87 for the nucleocapsid (N) protein, spike protein, and receptor binding domain (RBD) fraction, respectively. The accuracy assessment indicated the N protein (accuracy = 0.98) as the antigen most likely to give a correct diagnosis. …”
Publicado 2022
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