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4041por Mullins, Edward, McCabe, Ruth, Bird, Sheila M., Randell, Paul, Pond, Marcus J., Regan, Lesley, Parker, Eleanor, McClure, Myra, Donnelly, Christl A.“…We tested over 11,000 anonymised, stored historic antenatal serum samples, given at two north-west London NHS trusts in 2019 and 2020, for total antibody to SARS-CoV-2 receptor binding domain (anti-RBD). Estimated prevalence of seroreactivity increased from 1% prior to mid-February 2020 to 17% in September 2020. …”
Publicado 2022
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4042por Mara, Elisabeth, Mader, Tobias, Gratzer, Johannes, Hochegger, Stefanie, Pekar, Thomas“…The first SARS-CoV-2 vaccine was made available in Europe at the end of 2020. 202 volunteers from the vicinity of the University of Applied Sciences Wiener Neustadt took part in this study; their IgG levels recognizing the RBD of SARS-CoV-2 were determined. The aim was to evaluate the SARS-CoV-2 titer levels of vaccinated, recovered and vaccinated plus recovered persons. …”
Publicado 2022
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4043por Kaku, Chengzi I., Starr, Tyler N., Zhou, Panpan, Dugan, Haley L., Khalifé, Paul, Song, Ge, Champney, Elizabeth R., Mielcarz, Daniel W., Geoghegan, James C., Burton, Dennis R., Raiees, Andrabi, Bloom, Jesse D., Walker, Laura M.“…Here, we tracked SARS-CoV-2 receptor binding domain (RBD)-specific antibody responses up to six months following Omicron BA.1 breakthrough infection in mRNA-vaccinated individuals. …”
Publicado 2022
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4044“…The ChAdOx1 nCoV-19 (p = 0.0013) and BNT162b2 (p = 0.0005) vaccines induced significant higher blocking activity with longer durability against the Spike (S) protein receptor binding domain (RBD) of wild type SARS-CoV-2 than the CoronaVac vaccine in uninfected vaccinees. …”
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4045por Song, Jaewon, Chow, Ryan D., Peña-Hernández, Mario A., Zhang, Li, Loeb, Skylar A., So, Eui-Young, Liang, Olin D., Ren, Ping, Chen, Sidi, Wilen, Craig B., Lee, Sanghyun“…LRRC15 directly binds to the receptor-binding domain (RBD) of spike protein with a moderate affinity and inhibits spike-mediated entry. …”
Publicado 2022
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4046por Hussein, Bidour K., Ibrahium, Omnia M., Alamin, Marwa F., Ahmed, Lamees A. M., Abuswar, Safa A. E., Abdelraheem, Mohammed H., Ibrahim, Muntaser E.“…For SARS-coV2, the focus is generally for understanding such coevolution on the virus spike protein, since it demonstrates high mutation rates compared to other genome regions, particularly in the receptor-binding domain (RBD). Viral sequences of the SARS-coV2 19B (S) clade and variants of concern from different continents were investigated, with a focus on the A.29 lineage, which presented with different mutational patterns within the 19B (S) lineages in order to learn more about how SARS-coV2 may have evolved and adapted to widely diverse populations globally. …”
Publicado 2022
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4047por Grassi, Tiziana, Lobreglio, Giambattista, Panico, Alessandra, Rosato, Chiara, Zizza, Antonella, Lazzari, Roberta, Chicone, Michele, Indino, Floriano, Bagordo, Francesco“…This study aimed to assess the level of antibodies anti-S-RBD of SARS-CoV-2 in a cohort of healthcare workers before and, on average, one and four months after the third dose of the BNT162b2 vaccine. …”
Publicado 2022
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4048por Chao, Chiao-Hsuan, Cheng, Dayna, Huang, Sheng-Wen, Chuang, Yung-Chun, Yeh, Trai-Ming, Wang, Jen-Ren“…Compared to AZD1222, the two mRNA vaccines could elicit a higher level of anti-S1-RBD binding antibodies with higher broadly neutralizing ability evaluated using pseudoviruses of various SARS-CoV-2 lineages. …”
Publicado 2022
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4049por Cucunawangsih, Cucunawangsih, Wijaya, Ratna Sari, Lugito, Nata Pratama Hardjo, Suriapranata, Ivet“…Antibody against the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein (anti-S) was measured on days 7, 14, and 21 after vaccination. …”
Publicado 2022
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4050por Yang, Hongzhong, Pan, Wei, Chen, Guoyu, Huang, Enqi, Lu, Qijiong, Chen, Yunxiang, Chen, Ying, Yang, Zhengbiao, Wen, Lei, Zhang, Siming, Xu, Cong, Lv, Wanqiang, Dai, Lianpan, Wu, Changwei, Zhang, Lijiang“…ZF2001 is a recombinant protein vaccine based on SARS-CoV-2 receptor-binding domain (RBD) subunit which contains aluminum adjuvant. In order to advance our research on ZF2001 into clinical trial, we investigated the general toxicity and immunogenicity of ZF2001 in cynomolgus monkeys and assessed the possible target organs for vaccine-induced toxicity. …”
Publicado 2022
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4051por Serna-Muñoz, Ricardo, Hernández-Terán, Alejandra, Soto-Nava, Maribel, Tapia-Trejo, Daniela, Ávila-Ríos, Santiago, Mejía-Nepomuceno, Fidencio, García, Emma, Castillejos-López, Manuel, Higuera-Iglesias, Anjarath Lorena, Aquino-Gálvez, Arnoldo, Thirion-Romero, Ireri, Pérez-Padilla, Rogelio, Aguilar-Faisal, José Leopoldo, Vázquez-Pérez, Joel Armando“…We observed a significant decrease in the median of neutralization in patients infected with viral variants with changes in RBD of the spike protein. Our results suggest that developing an early and robust neutralizing response against SARS-CoV-2 may increase survival probability in critical patients.…”
Publicado 2022
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4052por Nicolas, Alexandre, Sannier, Gérémy, Dubé, Mathieu, Nayrac, Manon, Tauzin, Alexandra, Painter, Mark M., Goel, Rishi R., Laporte, Mélanie, Gendron-Lepage, Gabrielle, Medjahed, Halima, Williams, Justine C., Brassard, Nathalie, Niessl, Julia, Gokool, Laurie, Morrisseau, Chantal, Arlotto, Pascale, Tremblay, Cécile, Martel-Laferrière, Valérie, Finzi, Andrés, Greenplate, Allison R., Wherry, E. John, Kaufmann, Daniel E.“…After boost, the longer interval results in a higher magnitude and a more mature phenotype of RBD-specific B cells. While the two geographically distinct cohorts present quantitative and qualitative differences in T cell responses at baseline and after priming, the second dose led to convergent features with overall similar magnitude, phenotype, and function of CD4(+) and CD8(+) T cell responses at post-boost memory time points. …”
Publicado 2022
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4053“…Based on clinical evaluation and nocturnal hospital-based polysomnography (PSG), the patient had severe PLMD (PSG showed severe periodic leg movements), excessive daytime sleepiness (EDS, the score of the ESS is 16), and probable rapid eye movement sleep disorder (RBD). Parkinson's disease sleep scale (PDSS) score, Pittsburgh sleep quality index (PSQI), and periodic leg movements index were 93, 11, and 135.2, respectively. …”
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4054por Borgoyakova, M. B., Karpenko, L. I., Merkulyeva, I. A., Shcherbakov, D. N., Rudometov, A. P., Starostina, E. V., Shanshin, D. V., Isaeva, A. A., Nesmeyanova, V. S., Volkova, N. V., Belenkaya, S. V., Volosnikova, E. A., Zadorozhny, A. M., Orlova, L. A., Zaykovskaya, A. V., Pyankov, O. V., Bazhan, S. I., Ilyichev, A. A.“…For the creation of DNA vaccine, we chose the full-length spike protein (S) of the SARS-CoV-2 virus and used the recombinant receptor-binding domain (RBD) of the S protein produced in CHO-K1 cells as a protein component. …”
Publicado 2023
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4055“…Molecular docking calculations were performed between panduratin A and five important proteins, i.e., main protease (Mpro), papain-like protease (PLpro), receptor binding domain (RBD) of spike proteins, RNA-dependent-RNA-polymerase (RdRp), and 2′-O-methyltransferase (MTase). …”
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4056por Nehring, Mary, Pugh, Sierra, Dihle, Tina, Gallichotte, Emily, Nett, Terry, Weber, Eric, Mayo, Christie, Lynn, Lori, Ebel, Greg, Fosdick, Bailey K., VandeWoude, Sue“…We found that laboratory-based receptor binding domain (RBD) binding assays had equivalent or superior sensitivity and specificity compared to commercially available tests. …”
Publicado 2022
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4057“…The Clungene test principle is based on the receptor-binding domain (RBD) of the spike protein. Antibodies targeting the spike protein are considered an appropriate measure of humoral response from spike-based vaccines. …”
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4058por van Kempen, Zoé L. E., Hogenboom, Laura, Toorop, Alyssa A., Steenhuis, Maurice, Stalman, Eileen W., Kummer, Laura Y. L., van Dam, Koos P. J., Bloem, Karien, ten Brinke, Anja, van Ham, S. Marieke, Kuijpers, Taco W., Wolbink, Gerrit J., Loeff, Floris C., Wieske, Luuk, Eftimov, Filip, Rispens, Theo, Strijbis, Eva M. M., Killestein, Joep“…In 52 patients with MS, we found ocrelizumab concentration at the time of vaccination to be a good predictor for SARS‐CoV‐2 IgG anti‐RBD titers after vaccination (comparable to B‐cell count). …”
Publicado 2022
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4059“…The first one is the use of competitive peptidomimetic inhibitors that can selectively bind to the receptor binding domain (RBD) of the Spike glycoprotein with much higher affinity than the cell surface receptor itself. …”
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4060por Oyebanji, Oladayo A, Ragavapuram, Vaishnavi, Sundheimer, Nicholas, Bosch, Jürgen, Wilson, Brigid, Gravenstein, Stefan, King, Christopher, Canaday, David“…RESULTS: After the primary series, anti-spike and RBD titers increased significantly to all 3 strains in both NHR and HCW. …”
Publicado 2023
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