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4061por To, Kelvin Kai-Wang, Cheng, Vincent Chi-Chung, Cai, Jian-Piao, Chan, Kwok-Hung, Chen, Lin-Lei, Wong, Lok-Hin, Choi, Charlotte Yee-Ki, Fong, Carol Ho-Yan, Ng, Anthony Chin-Ki, Lu, Lu, Luo, Cui-Ting, Situ, Jianwen, Chung, Tom Wai-Hin, Wong, Shuk-Ching, Kwan, Grace See-Wai, Sridhar, Siddharth, Chan, Jasper Fuk-Woo, Fan, Cecilia Yuen-Man, Chuang, Vivien W M, Kok, Kin-Hang, Hung, Ivan Fan-Ngai, Yuen, Kwok-Yung“…The sensitivity was 91·1% (41 of 45 [95% CI 78·8–97·5]) for the microneutralisation assay, 57·8% (26 of 45 [42·2–72·3]) for anti-nucleoprotein IgG, 66·7% (30 of 45 [51·1–80·0]) for anti-spike protein receptor binding domain (RBD) IgG, and 73·3% (33 of 45 [58·1–85·4]) for enzyme immunoassay (either positive for anti-nucleoprotein or anti-RBD IgG). …”
Publicado 2020
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4062por Singh, Aditi, Salaytah, Natali, Lebovic, Daniel, Sako, Zeyad, Pounders, Zachary, Kohler, Laura, Kafri, Zyad, Saravolatz, Louis, Coyle, Meredith, Patel, Hemang“…Most interesting pattern was noted in the context of antibodies against spike protein S1 receptor-binding domain (S1RBD) where patients in cohort 2 developed minimal S1RBD antibodies. …”
Publicado 2021
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4063por Ahn, Jin Young, Lee, Jeongsoo, Suh, You Suk, Song, Young Goo, Choi, Yoon-Jeong, Lee, Kyoung Hwa, Seo, Sang Hwan, Song, Manki, Oh, Jong-Won, Kim, Minwoo, Seo, Han Young, Kwak, Jeong-Eun, Youn, Jin Won, Woo, Jung Won, Shin, Eui-Cheol, Sung, Young Chul, Park, Su-Hyung, Choi, Jun Yong“…BACKGROUND: We assessed the safety and immunogenicity of two recombinant DNA vaccines for COVID-19: GX-19 containing plasmid DNA encoding the SARS-CoV-2 spike protein, and GX-19N containing plasmid DNA encoding the SARS-CoV-2 receptor-binding domain (RBD) foldon, nucleocapsid protein, and plasmid DNA encoding the spike protein. …”
Publicado 2022
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4064por Bjørlykke, Kristin H, Ørbo, Hilde S, Tveter, Anne T, Jyssum, Ingrid, Sexton, Joseph, Tran, Trung T, Christensen, Ingrid E, Kro, Grete Birkeland, Kvien, Tore K, Jahnsen, Jørgen, Munthe, Ludvig A, Chopra, Adity, Warren, David J, Mjaaland, Siri, Haavardsholm, Espen A, Grødeland, Gunnveig, Provan, Sella A, Vaage, John T, Syversen, Silje Watterdal, Goll, Guro Løvik, Jørgensen, Kristin Kaasen“…Antibodies to the receptor-binding domain of SARS-CoV-2 spike protein (anti-RBD antibodies) were assessed 2–4 weeks following vaccination or COVID-19. …”
Publicado 2023
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4065por Das, Nabarun Chandra, Chakraborty, Pritha, Bayry, Jagadeesh, Mukherjee, Suprabhat“…Herein, we have explored the efficiency of twelve therapeutic monoclonal antibodies (mAbs) targeting the RBD region of the spike glycoprotein against all the Omicron variants bearing a mutation in spike protein through molecular docking and molecular dynamics simulation. …”
Publicado 2023
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4066por Desheva, Yulia, Lerner, Anna, Shvedova, Tamara, Kopteva, Olga, Kudar, Polina, Koroleva, Irina, Leontieva, Galina, Suvorov, Alexander“…The serum IgG to S-protein one week after hospitalization demonstrated a high-power relationship (r(s) = 0.75) with the level of RBD antibodies. There was a medium strength relationship between the levels of CRP and IgG (r(s) = 0.43). …”
Publicado 2023
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4067“…We showed that the SARS-CoV-2 spike protein S1 receptor-binding domain (RBD) is sufficient to induce endothelial permeability and vWF-secretion through the angiotensin-converting enzyme (ACE)2 in an ADP-ribosylation factor (ARF)6 activation-dependent manner. …”
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4068por Masetti, Marco, Scuppa, Maria Francesca, Aloisio, Alessio, Giovannini, Laura, Borgese, Laura, Manno, Stefania, Tazza, Beatrice, Pascale, Renato, Bonazzetti, Cecilia, Caroccia, Natascia, Sabatino, Mario, Spitaleri, Giosafat, Viale, Pierluigi, Giannella, Maddalena, Potena, Luciano“…Patients on MMF had lower levels of anti-RBD antibodies, and a positive antibody response after the third dose was associated with a lower probability of infection. …”
Publicado 2023
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4069“…The receptor-binding domain (RBD) of the spike (S) protein is involved in virus-cell binding, where virus-neutralizing antibodies (NAbs) react. …”
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4070Heterogeneity in Vaccinal Immunity to SARS-CoV-2 Can Be Addressed by a Personalized Booster Strategypor Stoddard, Madison, Yuan, Lin, Sarkar, Sharanya, Mangalaganesh, Shruthi, Nolan, Ryan P., Bottino, Dean, Hather, Greg, Hochberg, Natasha S., White, Laura F., Chakravarty, Arijit“…Our analysis shows that the ECLIA RBD binding assay strongly predicts neutralization of sequence-matched pseudoviruses. …”
Publicado 2023
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4071por Campbell, Elliot, Dobkin, Julie, Osorio, Louis J., Kolloli, Afsal, Ramasamy, Santhamani, Kumar, Ranjeet, Sant’Angelo, Derek B., Subbian, Selvakumar, Denzin, Lisa K., Anderson, Stephen“…Here, we describe a novel protein component vaccine candidate, MT-001, based on a fragment of the SARS-CoV-2 spike protein that encompasses the receptor binding domain (RBD). Mice and hamsters immunized with a prime-boost regimen of MT-001 demonstrated extremely high anti-spike IgG titers, and remarkably this humoral response did not appreciably wane for up to 12 months following vaccination. …”
Publicado 2023
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4072por Lamara Mahammed, Lydia, Bensaid, Kahina, Ait-Seddik, Sarah, Larinouna, Amel, Brahimi, Ghania, Belkaid, Rosa, Hamzaoui, Ouassila, Rouaki, Soumia Meriem, Idder, Cherifa, Allam, Ines, Djidjik, Reda“…Interestingly, in a healthy unvaccinated case and three convalescents with negative IgG-RBD, we detected a positive QuantiFERON test after stimulation with Ag3. …”
Publicado 2023
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4073por Xia, Xuhua“…Identification of the interaction between the host membrane receptor and viral receptor-binding domain (RBD) represents a crucial step for understanding viral pathophysiology and for developing drugs against pathogenic viruses. …”
Publicado 2023
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4074por Beeg, Marten, Baroni, Sara, Piotti, Arianna, Porta, Alessia, De Luigi, Ada, Cagnotto, Alfredo, Gobbi, Marco, Diomede, Luisa, Salmona, Mario“…We generated a cyclic peptide library derived from the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein and the angiotensin-converting enzyme 2 (ACE2) receptor. …”
Publicado 2023
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4075por Gargantilla, Marta, Francés, Clara, Adhav, Anmol, Forcada-Nadal, Alicia, Martínez-Gualda, Belén, Martí-Marí, Olaia, López-Redondo, María Luisa, Melero, Roberto, Marco-Marín, Clara, Gougeard, Nadine, Espinosa, Carolina, Rubio-del-Campo, Antonio, Ruiz-Partida, Rafael, Hernández-Sierra, María del Pilar, Villamayor-Belinchón, Laura, Bravo, Jerónimo, Llacer, José-Luis, Marina, Alberto, Rubio, Vicente, San-Félix, Ana, Geller, Ron, Pérez-Pérez, María-Jesús“…Thermofluor and microscale thermophoresis studies revealed their binding to S and to its isolated receptor binding domain (RBD), interfering with the interaction with ACE2. …”
Publicado 2023
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4076por Viriyakitkosol, Ratchanont, Wanitchang, Asawin, Srisutthisamphan, Kanjana, Saenboonreung, Janya, Boonkrai, Chatikorn, Pisitkun, Trairak, Jongkaewwattana, Anan“…In this study, we investigated the potential of two SARS-CoV-2 variants, BA.2 and BA.5, to evade neutralization by a human monoclonal antibody targeting the virus’s spike RBD (mAb 1D1). By subjecting the viruses to serial propagation in the presence of the antibody, we found that BA.2 exhibited poor growth, whereas BA.5 regained robust growth with significantly higher kinetics than the parental virus. …”
Publicado 2023
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4077por Rana, Neha, Sharma, Akhilesh, Rana, Ranbir Singh, Lata, Hem, Bansuli, Thakur, Alisha, Singh, Vivek, Sood, Aditya“…Keeping in view, the current investigation was undertaken to assess the agro-morphological and molecular diversity involving 36 diverse mid-late and late cauliflower genotypes following α-RBD design during winter season 2021–22. Six morphological descriptors predicted as polymorphic using Shannon diversity index with maximum for leaf margin (0.94). …”
Publicado 2023
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4078por Sukhova, Maria, Byazrova, Maria, Mikhailov, Artem, Yusubalieva, Gaukhar, Maslova, Irina, Belovezhets, Tatyana, Chikaev, Nikolay, Vorobiev, Ivan, Baklaushev, Vladimir, Filatov, Alexander“…We found that serum samples from the D614G period demonstrated 3.9- and 1.6-fold increases in RBD- and spike-specific IgG binding with wild-type antigens compared with Delta variant antigens (p < 0.01). …”
Publicado 2023
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4079por Dotaniya, C. K., Lakaria, B. L., Sharma, Yogesh, Meena, B. P., Wanjari, R. H., Shirale, A. O., Dotaniya, M. L., Aher, Satish B., Gurav, Priya, Jha, Pramod, Biswas, A. K., Yadav, S. R., Kumar, Kuldeep, Doutaniya, R. K., Reager, M. L., Lata, Manju, Sanwal, R. C.“…The experiment comprised with twelve treatments laid out in randomized block design (RBD) with three replications under maize-chickpea cropping sequence. …”
Publicado 2023
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4080por Hochmayr, Christoph, Hammerl, Marlene, Winkler, Ira, Schweigmann, Gisela, Kiechl-Kohlendorfer, Ursula, Griesmaier, Elke, Posod, Anna“…IgG, but not IgM antibodies against spike protein S1 receptor-binding domain (S1RBD) epitope were detectable in umbilical cord blood and neonatal serum collected at 48 hours of life. …”
Publicado 2023
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