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  1. 4081
    “…The structural and dynamic impact of the two quasispecies was characterized by using molecular dynamics simulations, showing the conservation of the principal functional movements in the mutated systems and their capabilities to alter the structure and dynamics of the RBD, responsible for the interaction with the ACE2 human receptor. …”
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    Treatment-Emergent Cilgavimab Resistance Was Uncommon in Vaccinated Omicron BA.4/5 Outpatients
  2. 4082
    “…We found that after two doses of SARS-CoV-2 mRNA vaccine, PLWH with a CD4 count < 250/mm(3) had lower levels of anti-RBD IgG antibodies compared to PLWH with a CD4 count > 250/mm(3) (p < 0.05). …”
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    Humoral Responses Elicited by SARS-CoV-2 mRNA Vaccine in People Living with HIV
  3. 4083
    “…The structure of HicA(H24A) was solved by NMR and forms a dsRBD-like (dsRNA-binding domain-like) fold, composed of a triple-stranded β-sheet, with two helices packed against one face. …”
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    The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation
  4. 4084
    “…ADARs are modular enzymes with multiple double-stranded RNA binding domains (dsRBDs) and a catalytic domain. While dsRBD binding is understood, little is known about ADAR catalytic domain/RNA interactions. …”
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    Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2
  5. 4085
    “…Farnesylated and methylated KRAS4b is fully active in hydrolyzing GTP, binds RAF-RBD on lipid Nanodiscs and interacts with the known farnesyl-binding protein PDEδ.…”
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    Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions
  6. 4086
    “…The lead iridium(iii) compound 1 exhibited potent inhibitory activity against the H-Ras/Raf-1 interaction and its signaling pathway in vitro and in vivo, and also directly engaged both H-Ras and Raf-1-RBD in cell lysates. Moreover, 1 repressed tumor growth in a mouse renal xenograft tumor model. …”
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    Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound
  7. 4087
    “…Saccade latency was significantly associated with PD duration, Berg balance score, RBD score, and Total LEDD in PD patients. Conclusions: PD patients commonly exhibit oculomotor deficits in multiple behavioral contexts, which are associated with both motor and non-motor symptoms. …”
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    Oculomotor Performances Are Associated With Motor and Non-motor Symptoms in Parkinson's Disease
  8. 4088
    “…Here, we demonstrate that an evolutionarily conserved fragment located in the C-terminal cytoplasmic tail of BAI-aGPCRs is specifically recognized by the RBD-ARR-ELMO (RAE) supramodule of the ELMO family scaffolds. …”
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    Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds
  9. 4089
    “…Significant new information about previously reported aspects of DLB has been incorporated, with increased diagnostic weighting given to rapid eye movement (REM) sleep behavior disorder (RBD) and iodine-123-metaiodobenzylguanidine (MIBG) myocardial scintigraphy. …”
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    Diagnostic Criteria for Dementia with Lewy Bodies: Updates and Future Directions
  10. 4090
    “…Here we discuss the most recent studies on the structure of the MERS-CoV spike protein and its role in virus binding and entry, and the development of MERS-CoV entry/fusion inhibitors targeting the S1 subunit, particularly the receptor-binding domain (RBD), and the S2 subunit, especially the HR1 region, of the MERS-CoV spike protein. …”
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    Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein
  11. 4091
    “…Our computation also suggested that the RBD-ACE2 binding for SARS-CoV-2 is much more temperature-sensitive than that for SARS-CoV. …”
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    Molecular Mechanism of Evolution and Human Infection with SARS-CoV-2
  12. 4092
    “…Viral entry into the host cell is a multistep process in which SARS-CoV-2 utilizes the receptor-binding domain (RBD) of the spike (S) glycoprotein to recognize angiotensin-converting enzyme 2 (ACE2) receptors on the human cells; this initiates host-cell entry by promoting viral–host cell membrane fusion through large-scale conformational changes in the S protein. …”
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    COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2
  13. 4093
    “…We have disclosed 28 main consensus druggable pockets within the Spike. The RBD and SD1 (S1 subunit); and the CR, HR1 and CH (S2 subunit) represent the most promising conserved druggable regions. …”
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    Unlocking COVID therapeutic targets: A structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike
  14. 4094
    “…Therefore, mutations in the gene encoding the S glycoprotein and especially the possible variations in the receptor binding domain (RBD) in S gene are important issues to be emphasized. …”
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    Mutations Observed in the SARS-CoV-2 Spike Glycoprotein and Their Effects in the Interaction of Virus with ACE-2 Receptor
  15. 4095
    “…Hantavirus infection is a rodent-borne disease (RBD) transmitted by urine or feces (as the natural reservoirs) with an annual estimated worldwide incidence of ~150,000 cases. …”
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    Association between predator species richness and human hantavirus infection emergence in Brazil
  16. 4096
    “…Using a recombinant chimeric VSV/SARS-CoV-2 reporter virus, we show that functional SARS-CoV-2 S protein variants with mutations in the receptor-binding domain (RBD) and N-terminal domain that confer resistance to monoclonal antibodies or convalescent plasma can be readily selected. …”
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    Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants
  17. 4097
    por Azad, Gajendra Kumar
    Publicado 2021
    “…The RNA-binding domain (RBD) and dimerization domain of N-protein also have mutations at key residues. …”
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    Identification and molecular characterization of mutations in nucleocapsid phosphoprotein of SARS-CoV-2
  18. 4098
    “…Fusarium species are important seedborne pathogens that cause rice bakanae disease (RBD). In this study, 421 strains were isolated from 25 rice samples collected from Zhejiang, Anhui, and Jiangxi provinces of China. …”
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    Identification of Rice Seed-Derived Fusarium spp. and Development of LAMP Assay against Fusarium fujikuroi
  19. 4099
    por Lu, Jinghua, Sun, Peter D.
    Publicado 2020
    “…The enhancement in ACE2 enzymatic function was mediated by the binding of SARS-CoV-2 spike RBD domain. These results highlighted the potential for SARS-CoV-2 infection to enhance ACE2 activity, which may be relevant to the cardiovascular symptoms associated with COVID-19.…”
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    High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity
  20. 4100
    “…In order to reduce the disease spread, 16 monoclonal antibodies (McAbs) again SARS-CoV-2 were generated by immunized mice with the spike protein receptor binding domain (RBD), which was expressed in Chinese hamster ovary cell (CHO). …”
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    Development of a Colloidal Gold-Based Immunochromatographic Strip for Rapid Detection of Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein
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