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4121por Calvo-Lozano, Olalla, Sierra, Miquel, Soler, Maria, Estévez, Maria Carmen, Chiscano-Camón, Luis, Ruiz-Sanmartin, Adolfo, Ruiz-Rodriguez, Juan Carlos, Ferrer, Ricard, González-López, Juan José, Esperalba, Juliana, Fernández-Naval, Candela, Bueno, Leticia, López-Aladid, Ruben, Torres, Antoni, Fernández-Barat, Laia, Attoumani, Sarah, Charrel, Rémi, Coutard, Bruno, Lechuga, Laura M.“…The portable plasmonic device employs a custom-designed multiantigen (RBD peptide and N protein) sensor biochip and reaches detection limits in the low ng mL(–1) range employing polyclonal antibodies. …”
Publicado 2021
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4122por Brochot, Etienne, Souplet, Vianney, Follet, Pauline, Ponthieu, Pauline, Olivier, Christophe, Even, Gaël, Audebert, Christophe, Malbec, Rémi“…Here we use a combination of the Nucleoprotein (NP), the Spike 1 (S1) and Spike 2 (S2) subunits, and the receptor binding domain (RBD) and N-terminal domain (NTD) of the Spike antigens from the CoViDiag(®) multiplex IgG assay, to follow the immune response to SARS-CoV-2 infection over a long time period and depending on disease severity. …”
Publicado 2022
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4123por Boukhari, Rachida, Breiman, Adrien, Jazat, Jennifer, Ruvoën-Clouet, Nathalie, Martinez, Salima, Damais-Cepitelli, Anne, Le Niger, Catherine, Devie-Hubert, Isabelle, Penasse, Fanny, Mauriere, Dominique, Sébille, Véronique, Dürrbach, Antoine, Le Pendu, Jacques“…For the second hypothesis, we detected no binding of recombinant SARS-CoV-2 RBD to blood group-containing glycans. Thus, although no intrinsic differences in susceptibility according to ABO blood type were detected, ABO incompatibility strongly decreased the risk of COVID-19 transmission, suggesting that anti-ABO antibodies contribute to virus neutralization.…”
Publicado 2022
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4124por Ding, Shilei, Adam, Damien, Beaudoin-Bussières, Guillaume, Tauzin, Alexandra, Gong, Shang Yu, Gasser, Romain, Laumaea, Annemarie, Anand, Sai Priya, Privé, Anik, Bourassa, Catherine, Medjahed, Halima, Prévost, Jérémie, Charest, Hugues, Richard, Jonathan, Brochiero, Emmanuelle, Finzi, Andrés“…Due to the intrinsic difficulty of working with SARS-CoV-2 authentic virus, most serological assays use recombinant forms of the Spike glycoprotein or its receptor binding domain (RBD). Cell-based assays expressing different forms of the Spike, as well as pseudoviral assays, are also widely used. …”
Publicado 2021
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4125por Jawalagatti, Vijayakumar, Kirthika, Perumalraja, Hewawaduge, Chamith, Yang, Myeon-sik, Park, Ji-Young, Oh, Byungkwan, Lee, John Hwa“…Herein we developed a multivalent Semliki Forest virus replicon-based mRNA vaccine targeting the receptor binding domain (RBD), heptad repeat domain (HR), membrane protein (M), and epitopes of non-structural protein 13 (nsp13) of SARS-CoV-2. …”
Publicado 2022
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4126por Burns, Madeleine D, Boribong, Brittany P, Bartsch, Yannic C, Loiselle, Maggie, Davis, Jameson P, Lima, Rosiane, Edlow, Andrea G, Fasano, Alessio, Alter, Galit, Yonker, Lael M“…After completion of a two-vaccine series, cross-reactivity against Omicron-specific receptor-binding domain (RBD) was seen. Evidence of waning mRNA-induced vaccine immunity underscores vulnerabilities in long-term pediatric protection against SARS-CoV-2 infection, while cross-reactivity highlights the additional benefits of vaccination. …”
Publicado 2022
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4127por Wu, Chung-Yi, Cheng, Cheng-Wei, Kung, Chih-Chuan, Liao, Kuo-Shiang, Jan, Jia-Tsrong, Ma, Che, Wong, Chi-Huey“…Here, we showed that the mRNA vaccine of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein with deletion of glycosites in the receptor-binding domain (RBD) or especially the subunit 2 (S2) domain to expose more conserved epitopes elicited stronger antibody and CD8(+) T cell responses with broader protection against the alpha, beta, gamma, delta, and omicron variants, compared to the unmodified mRNA. …”
Publicado 2022
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4128por Mishra, Tarun, Dalavi, Rishikesh, Joshi, Garima, Kumar, Atul, Pandey, Pankaj, Shukla, Sanjeev, Mishra, Ram K, Chande, Ajit“…Our study underscores the importance of non-RBD changes in determining infectivity and immune escape.…”
Publicado 2022
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4129por Pattinson, David, Jester, Peter, Guan, Lizheng, Yamayoshi, Seiya, Chiba, Shiho, Presler, Robert, Rao, Hongyu, Iwatsuki-Horimoto, Kiyoko, Ikeda, Nobuhiro, Hagihara, Masao, Uchida, Tomoyuki, Mitamura, Keiko, Halfmann, Peter, Neumann, Gabriele, Kawaoka, Yoshihiro“…Inflection titers for SARS-CoV-2 full-length spike protein (S1S2), spike protein receptor-binding domain (RBD), and nucleoprotein (N) inferred from 3 spread-out dilutions correlated with those inferred from 8 consecutive dilutions with an R(2) value of 0.97 or higher. …”
Publicado 2022
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4130“…Thus, the phenomenon of breaking the cross-species barrier is mainly associated with mutations in the receptor-binding domain (RBD) of the spike (S) protein that interacts with ACE2. …”
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4131“…So far, panels of binders have been isolated against different viral and tumor targets, including the SARS-CoV-2 RBD, HIV-1 ENV protein, mesothelin and FLT3. In the present study, we discuss domain library construction, characterize novel VH binders against human CD22 and PD-L1, and define our design process for antibody domain drug conjugation (DDC) as tumoricidal reagents. …”
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4132por Broseta, José Jesús, Rodríguez-Espinosa, Diana, Cuadrado, Elena, Rodríguez, Néstor, Bedini, José Luis, Maduell, Francisco“…This observational, prospective, multi-center study evaluated the humoral response in terms of presence and levels of IgG antibodies to the receptor-binding domain of the S1 spike antigen of SARS-CoV-2 (anti-S1-RBD IgG) to the third dose of SARS-CoV-2 mRNA vaccines, either the mRNA-1273 (Moderna) or BNT162b2 (Pfizer), in 153 patients from three dialysis units affiliated to Hospital Clínic of Barcelona (Spain). …”
Publicado 2022
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4133por Burns, Madeleine D., Boribong, Brittany P., Bartsch, Yannic C., Loiselle, Maggie, St. Denis, Kerri J., Sheehan, Maegan L., Chen, Jessica W., Davis, Jameson P., Lima, Rosiane, Edlow, Andrea G., Fasano, Alessio, Balazs, Alejandro B., Alter, Galit, Yonker, Lael M.“…After completion of a two-vaccine series, cross-reactivity against Omicron-specific receptor-binding domain (RBD) was seen. Functional humoral activation against wild type and Omicron SARS-CoV-2 also declines over time in vaccinated adolescent children. …”
Publicado 2022
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4134por Baj, Andreina, Gasperina, Daniela Dalla, Focosi, Daniele, Forlani, Greta, Ferrante, Francesca Drago, Novazzi, Federica, Azzi, Lorenzo, Maggi, Fabrizio“…Anti-Spike IgG and Anti-Receptor Binding Domain (RBD) Neutralizing Antibodies (NAb) in serum was assessed in 64 immunocompetent healthcare workers (HCW) before and 14 days post the third dose of BNT162b2 vaccine (Comirnaty®, Pfizer/BioNTech) or BNT162b2 plus quadrivalent flu vaccine (Vaxigript Tetra ®Sanofi Pasteur) on the same day. …”
Publicado 2022
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4135“…METHODS: In silico tools were used to design spike‐based subunit recombinant proteins (RBD (P(1)), fusion peptide (P(2)), and S1/S2 cleavage site (P(3))). …”
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4136por Choi, Kwang-Eun, Kim, Jeong-Min, Rhee, Jee Eun, Park, Ae Kyung, Kim, Eun-Jin, Yoo, Cheon Kwon, Kang, Nam Sook“…The structural stability of the variant types was analyzed based on the distance between the receptor-binding domain (RBD) of each chain in the spike protein and the binding free energy between the spike protein and bound ACE2 in the one-, two-, and three-open-complex forms using molecular dynamics (MD) simulation. …”
Publicado 2022
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4137por Branković, Jovica, Milovanović, Vesna M., Simijonović, Dušica, Novaković, Slađana, Petrović, Zorica D., Trifunović, Snežana S., Bogdanović, Goran A., Petrović, Vladimir P.“…Also, the investigations were performed on ACE2 and the spike RBD-ACE2 complex. The obtained results for these proteins suggest that selected compounds could express antiviral properties by blocking the binding to the host cell and viral spreading, also. …”
Publicado 2022
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4138por Jiaranaikulwanitch, Jutamas, Yooin, Wipawadee, Chutiwitoonchai, Nopporn, Thitikornpong, Worathat, Sritularak, Boonchoo, Rojsitthisak, Pornchai, Vajragupta, Opa“…Herein, in silico screening of 83 compounds from Dendrobium sp. by using the SARS-CoV-2 spike protein receptor-binding domain (RBD) as a drug target was performed in searching for a new lead compound against SARS-CoV-2 infection. …”
Publicado 2022
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4139por Forgacs, David, Silva-Moraes, Vanessa, Sautto, Giuseppe A., Hanley, Hannah B., Gattiker, Jasper L., Jefferson, Alexandria M., Kolhe, Ravindra, Ross, Ted M.“…In order to longitudinally track SARS-CoV-2 antibody levels after vaccination or infection, we assessed anti-RBD antibody levels in over 1000 people and found no significant decrease in antibody levels during the first 14 months after infection in unvaccinated participants, however, a significant waning of antibody levels was observed following vaccination. …”
Publicado 2022
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4140por Schipani, Maria Caterina, Tomassetti, Flaminia, Polidori, Isabella, Ricci, Paola, Frassanito, Maria Loredana, Seraceni, Silva, Morello, Maria, Nicolai, Eleonora, Aquaro, Stefano, Bernardini, Sergio, Pieri, Massimo, Calugi, Graziella“…Our focus was to investigate and compare different vaccination schedules, monitoring circulating S-RBD Ab (antibodies anti—Spike protein—Receptor Binding Domain) levels after administering two doses in naïve patients. …”
Publicado 2022
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