-
401por Salzer, Ralf, Clark, Jordan J., Vaysburd, Marina, Chang, Veronica T., Albecka, Anna, Kiss, Leo, Sharma, Parul, Gonzalez Llamazares, Andres, Kipar, Anja, Hiscox, Julian A., Owen, Andrew, Aricescu, A. Radu, Stewart, James P., James, Leo C., Löwe, Jan“…Immunisation experiments in mice demonstrated that the SARS‐CoV‐2 receptor binding domain (RBD) coupled to Dps (RBD‐S‐Dps) elicited a higher antibody titre and an enhanced neutralising antibody response compared to monomeric RBD. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
402por Barton, Michael I, MacGowan, Stuart A, Kutuzov, Mikhail A, Dushek, Omer, Barton, Geoffrey John, van der Merwe, P Anton“…The interaction between the SARS-CoV-2 virus Spike protein receptor binding domain (RBD) and the ACE2 cell surface protein is required for viral infection of cells. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
403por Conforti, Antonella, Marra, Emanuele, Palombo, Fabio, Roscilli, Giuseppe, Ravà, Micol, Fumagalli, Valeria, Muzi, Alessia, Maffei, Mariano, Luberto, Laura, Lione, Lucia, Salvatori, Erika, Compagnone, Mirco, Pinto, Eleonora, Pavoni, Emiliano, Bucci, Federica, Vitagliano, Grazia, Stoppoloni, Daniela, Pacello, Maria Lucrezia, Cappelletti, Manuela, Ferrara, Fabiana Fosca, D’Acunto, Emanuela, Chiarini, Valerio, Arriga, Roberto, Nyska, Abraham, Di Lucia, Pietro, Marotta, Davide, Bono, Elisa, Giustini, Leonardo, Sala, Eleonora, Perucchini, Chiara, Paterson, Jemma, Ryan, Kathryn Ann, Challis, Amy-Rose, Matusali, Giulia, Colavita, Francesca, Caselli, Gianfranco, Criscuolo, Elena, Clementi, Nicola, Mancini, Nicasio, Groß, Rüdiger, Seidel, Alina, Wettstein, Lukas, Münch, Jan, Donnici, Lorena, Conti, Matteo, De Francesco, Raffaele, Kuka, Mirela, Ciliberto, Gennaro, Castilletti, Concetta, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Guidotti, Luca G., Rovati, Lucio, Iannacone, Matteo, Aurisicchio, Luigi“…Among them, COVID-eVax—a DNA plasmid encoding a secreted monomeric form of SARS-CoV-2 S protein receptor-binding domain (RBD)—induced the most potent anti-SARS-CoV-2 neutralizing antibody responses (including against the current most common variants of concern) and a robust T cell response. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
404por Chen, Chen, Boorla, Veda Sheersh, Banerjee, Deepro, Chowdhury, Ratul, Cavener, Victoria S., Nissly, Ruth H., Gontu, Abhinay, Boyle, Nina R., Vandegrift, Kurt, Nair, Meera Surendran, Kuchipudi, Suresh V., Maranas, Costas D.“…The association of the receptor binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein with human angiotensin-converting enzyme 2 (hACE2) represents the first required step for cellular entry. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
405por Duan, Xuejun, Shi, Yijun, Zhang, Xudong, Ge, Xiaoxiao, Fan, Rong, Guo, Jinghan, Li, Yubin, Li, Guoge, Ding, Yaowei, Osman, Rasha Alsamani, Jiang, Wencan, Sun, Jialu, Luan, Xin, Zhang, Guojun“…Thus, this assay is based on the inhibition of binding between ACE2 and the RBD of the SARS-CoV-2 spike protein by neutralizing antibodies, and the affinity of anti-human immunoglobulins for these neutralizing antibodies. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
406por Wu, Leyun, Zhou, Liping, Mo, Mengxia, Liu, Tingting, Wu, Chengkun, Gong, Chunye, Lu, Kai, Gong, Likun, Zhu, Weiliang, Xu, ZhijianEnlace del recurso
Publicado 2022
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
407por Zhang, Guo-Qiang, Gao, Zhiyuan, Zhang, Jingtian, Ou, Hanlin, Gao, Heqi, Kwok, Ryan T.K., Ding, Dan, Tang, Ben Zhong“…Here, two kinds of test strips for receptor binding domain (RBD) and N antigens of SARS-CoV-2 are established with high sensitivity and specificity, in which AIE luminogens (AIEgens) are utilized as reporters. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
408por Mi, Taotao, Wang, Tiantian, Xu, Huifang, Sun, Peng, Hou, Xuchen, Zhang, Xinwei, Ke, Qian, Liu, Jiawen, Hu, Shengwei, Wu, Jun, Liu, Bo“…Our previous study revealed that the wild-type RBD (WT-RBD) formulated with aluminum hydroxide and CpG 2006 adjuvant effectively induces neutralizing antibodies in BALB/c mice. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
409por Chen, Chen, Boorla, Veda Sheersh, Chowdhury, Ratul, Nissly, Ruth H., Gontu, Abhinay, Chothe, Shubhada K., LaBella, Lindsey, Jakka, Padmaja, Ramasamy, Santhamani, Vandegrift, Kurt J., Nair, Meera Surendran, Kuchipudi, Suresh V., Maranas, Costas D.“…The cellular entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) involves the association of its receptor binding domain (RBD) with human angiotensin converting enzyme 2 (hACE2) as the first crucial step. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
410por Chen, Ran, Zhang, Xiantao, Yuan, Yaochang, Deng, Xiaohui, Wu, Bolin, Xi, Zhihui, Wang, Guanwen, Lin, Yingtong, Li, Rong, Wang, Xuemei, Zou, Fan, Liang, Liting, Yan, Haiping, Liang, Chaofeng, Li, Yuzhuang, Wu, Shijian, Deng, Jieyi, Zhou, Mo, Zhang, Xu, Li, Congrong, Bu, Xiuqing, Peng, Yi, Ke, Changwen, Deng, Kai, He, Xin, Zhang, Yiwen, Zhang, Zhenhai, Pan, Ting, Zhang, Hui“…Here, receptor binding domain (RBD)‐conjugated nanoparticle vaccines targeting the Delta variant, as well as the early and Beta/Gamma strains, are developed. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
411por Meena, Jairam, Singhvi, Priyank, Srichandan, Sudeepa, Dandotiya, Jyotsna, Verma, Juhi, Singh, Mamta, Ahuja, Rahul, Panwar, Neha, Wani, Tabiya Qayoom, Khatri, Ritika, Siddiqui, Gazala, Gupta, Anuradha, Samal, Sweety, Panda, Amulya Kumar“…Moreover, challenge with 1 µg of RBD alone was able to generate secondary antibody response, suggesting that immunization with RBD-PLA nanoparticles has the ability to elicit memory antibody against RBD. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
412por Lei, Hong, Alu, Aqu, Yang, Jingyun, Ren, Wenyan, He, Cai, Lan, Tianxia, He, Xuemei, Yang, Li, Li, Jiong, Wang, Zhenling, Song, Xiangrong, Wang, Wei, Lu, Guangwen, Wei, Xiawei“…Here, we developed an adjuvanted intranasal RBD vaccine and monitored its long-term immunogenicity against both wild-type and mutant strains of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), including Omicron variants, in mice. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
413por Miao, Lu, Zhou, Wei, Yan, Chunyu, Zhang, Yuebin, Qiao, Qinglong, Zhou, Xuelian, Chen, Yingzhu, Wang, Guangying, Guo, Zhendong, Liu, Jun, Piao, Hailong, Pan, Xia, Yan, Mengxue, Zhao, Weijie, Li, Guohui, Li, Yueqing, Xu, ZhaochaoEnlace del recurso
Publicado 2022
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
414por Madanat, Luai, Sager, Melinda, O’Connor, Daniel, Thapa, Bijaya, Aggarwal, Nishant, Ghimire, Bipin, Lauter, Carl, Maine, Gabriel N, Sims, Matthew, Halalau, Alexandra“…Anti-nucleocapsid IgG (anti-N) and Anti-RBD levels were measured. Anti-RBD level of 500 AU/mL was used as a cutoff to stratify patients. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
415por Bommireddy, Ramireddy, Stone, Shannon, Bhatnagar, Noopur, Kumari, Pratima, Munoz, Luis E., Oh, Judy, Kim, Ki-Hye, Berry, Jameson T. L., Jacobsen, Kristen M., Jaafar, Lahcen, Naing, Swe-Htet, Blackerby, Allison N., der Gaag, Tori Van, Wright, Chloe N., Lai, Lilin, Pack, Christopher D., Ramachandiran, Sampath, Suthar, Mehul S., Kang, Sang-Moo, Kumar, Mukesh, Reddy, Shaker J. C., Selvaraj, Periasamy“…We have developed a hybrid vaccine for SARS-CoV-2 and influenza viruses using influenza virus-like particles (VLP) incorporated by protein transfer with glycosylphosphatidylinositol (GPI)-anchored SARS-CoV-2 RBD fused to GM-CSF as an adjuvant. GPI-RBD-GM-CSF fusion protein was expressed in CHO-S cells, purified and incorporated onto influenza VLPs to develop the hybrid vaccine. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
416por Castro, Julia T., Azevedo, Patrick, Fumagalli, Marcílio J., Hojo-Souza, Natalia S., Salazar, Natalia, Almeida, Gregório G., Oliveira, Livia I., Faustino, Lídia, Antonelli, Lis R., Marçal, Tomas G., Augusto, Marconi, Valiate, Bruno, Fiorini, Alex, Rattis, Bruna, Ramos, Simone G., Piccin, Mariela, Nonato, Osvaldo Campos, Benevides, Luciana, Magalhães, Rubens, Cassaro, Bruno, Burle, Gabriela, Doro, Daniel, Kalil, Jorge, Durigon, Edson, Salazar, Andrés, Caballero, Otávia, Santiago, Helton, Machado, Alexandre, Silva, João S., da Fonseca, Flávio, Fernandes, Ana Paula, Teixeira, Santuza R., Gazzinelli, Ricardo T.“…Here, we generate a chimeric protein (SpiN) that comprises the receptor binding domain (RBD) from Spike (S) and the nucleocapsid (N) antigens from SARS-CoV-2. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
417por Chen, Xi, Wang, Ziyuan, Wang, Jing, Yao, Yifan, Wang, Qian, Huang, Jiahao, Xiang, Xianping, Zhou, Yifan, Xue, Yintong, Li, Yan, Gao, Xiang, Wang, Lijun, Chu, Ming, Wang, Yuedan“…A total of 20 drugs were retrieved as S-RBD-hACE2 inhibitors, of which 16 drugs were identified to bind to S-RBD or hACE2. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
418por Walker, Melanie R., Podlekareva, Daria, Johnsen, Stine, Leerhøy, Bonna, Fougeroux, Cyrielle, Søgaard, Max, Salanti, Ali, Ditlev, Sisse Bolm, Barfod, Lea“…After vaccination, receptor binding domain (RBD)-specific IgG binding increased by at least 3.5-fold and inhibition of ACE2 increased by at least 2-fold. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
419por Li, Yuanyuan, Wang, Chunyi, Luo, Ningdi, Chen, Fangzheng, Zhou, Liche, Niu, Mengyue, Kang, Wenyan, Liu, Jun“…BACKGROUND: As the strongest prodromal marker of α-synuclein-specific neurodegeneration, idiopathic REM sleep behavior disorder (iRBD) is becoming a focus of interest in disease-modifying therapy. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
420por Wang, Shixia, Wang, Chang Yi, Kuo, Hui-Kai, Peng, Wen-Jiun, Huang, Juin-Hua, Kuo, Be-Shen, Lin, Feng, Liu, Yaw-Jen, Liu, Zhi, Wu, Huang-Ting, Ding, Shuang, Hou, Kou-Liang, Cheng, Jennifer, Yang, Ya-Ting, Jiang, Ming-Han, Wang, Min-Sheng, Chen, Tony, Xia, Wei Guo, Lin, Ed, Hung, Chung Ho, Chen, Hui-Jung, Shih, Zhonghao, Lin, Yi Ling, Ryan, Valorie, Hu, Mei Mei, Heppner, D. Gray, Malherbe, Delphine C., Periasamy, Sivakumar, Kuzmina, Natalia, Subramani, Chandru, Hellerstein, Michael, Monath, Thomas P., Rumyantsev, Alexander, Bukreyev, Alexander, Guirakhoo, FarshadEnlace del recurso
Publicado 2022
Enlace del recurso
Enlace del recurso
Online Artículo Texto