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4301por Ruetalo, Natalia, Flehmig, Bertram, Schindler, Michael, Pridzun, Lutz, Haage, Angelika, Reichenbächer, Marija, Kirchner, Thomas, Kirchner, Teresa, Klingel, Karin, Ranke, Michael B., Normann, Andrea“…Furthermore, in two individuals, the effects of an additional vaccination with a mRNA vaccine containing the S1-RBD sequence on these antibodies were examined. …”
Publicado 2021
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4302por Xiao-ling, Qin, Yin-zhen, Du, Xue-kui, Liu, Xue, Li, Gang, Cheng, Zai-li, Li, Dian-shuai, Gao“…There were no significant differences in PQSI, ESS, RLS, RBD, HAMA, HAMD, and MoCA scores between the two groups. …”
Publicado 2021
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4303por Nayrac, Manon, Dubé, Mathieu, Sannier, Gérémy, Nicolas, Alexandre, Marchitto, Lorie, Tastet, Olivier, Tauzin, Alexandra, Brassard, Nathalie, Beaudoin-Bussières, Guillaume, Vézina, Dani, Gong, Shang Yu, Benlarbi, Mehdi, Gasser, Romain, Laumaea, Annemarie, Bourassa, Catherine, Gendron-Lepage, Gabrielle, Medjahed, Halima, Goyette, Guillaume, Ortega-Delgado, Gloria-Gabrielle, Laporte, Mélanie, Niessl, Julia, Gokool, Laurie, Morrisseau, Chantal, Arlotto, Pascale, Richard, Jonathan, Tremblay, Cécile, Martel-Laferrière, Valérie, Finzi, Andrés, Kaufmann, Daniel E.“…This regimen elicited robust RBD-specific B cell responses whose kinetics differed between cohorts, the second dose leading to increased magnitude in naïve participants only. …”
Publicado 2021
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4304por Tanguay, Mégane, Boutin, Marianne, Laumaea, Annemarie, Salaciak, Matthew, Mendoza, Alma, Cassis, Chantal, Ajjamada, Lissa, Assouline, Sarit, Patenaude, François, Clark, Michael Webster, Finzi, Andrés, Johnson, Nathalie A.“…We investigated the relationship between B cell cytopenia and the SARS-CoV-2 vaccine response in B-NHL patients. We measured anti-RBD antibodies and the lymphocyte immunophenotype in 19 controls, 22 lymphoma patients on observation (cohort 1) and 55 lymphoma patients receiving their vaccines post B-cell depleting therapy (cohort 2). …”
Publicado 2022
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4305por Cui, Zhen, Liu, Pan, Wang, Nan, Wang, Lei, Fan, Kaiyue, Zhu, Qianhui, Wang, Kang, Chen, Ruihong, Feng, Rui, Jia, Zijing, Yang, Minnan, Xu, Ge, Zhu, Boling, Fu, Wangjun, Chu, Tianming, Feng, Leilei, Wang, Yide, Pei, Xinran, Yang, Peng, Xie, Xiaoliang Sunney, Cao, Lei, Cao, Yunlong, Wang, Xiangxi“…Alterations in local conformation, charge, and hydrophobic microenvironments underpin the modulation of the epitopes such that they are not recognized by most NTD- and RBD-antibodies, facilitating viral immune escape. …”
Publicado 2022
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4306por Siddiqui, Sameed M., Bowman, Kathryn A., Zhu, Alex L., Fischinger, Stephanie, Beger, Samuel, Maron, Jenny S., Bartsch, Yannic C., Atyeo, Caroline, Gorman, Matthew J., Yanis, Ahmad, Hultquist, Judd F., Lorenzo-Redondo, Ramon, Ozer, Egon A., Simons, Lacy M., Talj, Rana, Rankin, Danielle A., Chapman, Lindsay, Meade, Kyle, Steinhart, Jordan, Mullane, Sean, Siebert, Suzanne, Streeck, Hendrik, Sabeti, Pardis, Halasa, Natasha, Musk, Elon R., Barouch, Dan H., Menon, Anil S., Nilles, Eric J., Lauffenburger, Douglas A., Alter, Galit“…In this study, we identify simple, rapid immune biomarkers of reinfection in rhesus macaques, including IgG3 antibody levels against nucleocapsid and FcγR2A receptor binding activity of anti-RBD antibodies, that are recapitulated in human reinfection cases. …”
Publicado 2022
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4307por Fresco-Taboada, Alba, García-Durán, Marga, Aira, Cristina, López, Lissett, Sastre, Patricia, van der Hoek, Lia, van Gils, Marit J., Brouwer, Philip J.M., Sanders, Rogier W., Holzer, Barbara, Zimpernikc, Irene, López-Collazo, Eduardo, Muñoz, Patricia, Rueda, Paloma, Vela, Carmen“…An Enzyme-Linked Immunosorbent Assay (ELISA) and a Lateral Flow Assay (LFA) have been developed based on the SARS-CoV-2 recombinant Receptor Binding Domain (RBD) and the combination of Spike and Nucleoprotein, respectively. …”
Publicado 2022
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4308por Ogundipe, H.D.“…As research towards generating effective vaccines against SARS-CoV-2 are in advanced stages, there is need for continued robust review of the available data from various studies on the antibody response from natural SARS-COV-2 infection as regards the potential for immunity against re-infection following exposure to the antigens of this virus. Antibodies against RBD of the spike protein of SARS-CoV-2 were detected in majority of patients, appearing within the first week, peaking by 3rd week. …”
Publicado 2021
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4309por Chunchu, Srinivasa Rao, Ravula, Ushasree, Gente, Vikram Kumar, Bacchu, Srinivas, Pandu Ranga Rao, S., Mooli, Srujaleswari“…The current study aimed to estimate the seroprevalence of SARS-CoV-2 IgG (S-protein) antibodies along with neutralizing assay (RBD-domain) among the whole blood donors without any prior Covid-19 history or symptoms visiting Blood Centre at a Tertiary care institution, South India amidst the ongoing pandemic. …”
Publicado 2022
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4310por Ku, Zhiqiang, Xie, Xuping, Lin, Jianqing, Gao, Peng, El Sahili, Abbas, Su, Hang, Liu, Yang, Ye, Xiaohua, Li, Xin, Fan, Xuejun, Goh, Boon Chong, Xiong, Wei, Boyd, Hannah, Muruato, Antonio E., Deng, Hui, Xia, Hongjie, Jing, Zou, Kalveram, Birte K., Menachery, Vineet D., Zhang, Ningyan, Lescar, Julien, Shi, Pei-Yong, An, Zhiqiang“…Single molecules of both bsAbs block the two epitopes targeted by parental antibodies on the receptor-binding domain (RBD). However, bsAb with the IgG-(scFv)(2) design (14-H-06) but not the CrossMAb design (14-crs-06) increases antigen-binding and virus-neutralizing activities and spectrum against multiple SARS-CoV-2 variants including the Omicron, than the cocktail. …”
Publicado 2022
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4311por Wang, Xun, Zhao, Xiaoyu, Song, Jieyu, Wu, Jing, Zhu, Yuqi, Li, Minghui, Cui, Yuchen, Chen, Yanjia, Yang, Lulu, Liu, Jun, Zhu, Huanzhang, Jiang, Shibo, Wang, Pengfei“…Omicron resists seven of eight authorized/approved mAbs, as well as most of the other mAbs targeting distinct epitopes on RBD and NTD. Taken together, our results suggest the urgency to push forward the booster vaccination to combat the emerging SARS-CoV-2 variants.…”
Publicado 2022
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4312por GOC, ANNA, NIEDZWIECKI, ALEKSANDRA, IVANOV, VADIM, IVANOVA, SVETLANA, RATH, MATTHIAS“…The composition containing vitamin C, N-acetylcysteine, resveratrol, theaflavin, curcumin, quercetin, naringenin, baicalin, and broccoli extract demonstrated a highest efficacy by inhibiting the receptor-binding domain (RBD) binding of SARS-CoV-2 to its cellular ACE2 receptor by 90%. …”
Publicado 2022
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4313por Yu, Jie-Mei, Zhang, Li-Shu, Fu, Yuan-Hui, Ji, Feng-Min, Xu, Han-Li, Huang, Jia-Qiang, Peng, Xiang-Lei, Zheng, Yan-Peng, Zhang, Ying, He, Jin-Sheng“…Two mutations were found in the receptor-binding domain (RBD) but outside the receptor-binding motif (RBM), indicating that mutations may only have marginal biological effects but merit further attention. …”
Publicado 2020
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4314por Wei, Nana, Wang, Qiujing, Lin, Zhibing, Xu, Liyun, Zhang, Zheen, Wang, Yan, Yang, Zhejuan, Li, Lue, Zhao, Tingxiao, Wang, Lu, Lou, Haifei, Han, Mingfang, Ma, Mingliang, Jiang, Yaosheng, Lu, Jinmiao, Zhu, Shilan, Cui, Li, Li, Shibo“…Five epitopes were identified to be associated with the clinical adverse events, and three peptides located in RBD. Overall, this study presents a systemic view of the SARS-CoV-2 specific IgG and IgM responses between AS and S recovered patients and provide insights to promote precise development of SARS-CoV-2 vaccines.…”
Publicado 2022
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4315por Behl, Tapan, Kaur, Ishnoor, Sehgal, Aayush, Singh, Sukhbir, Sharma, Neelam, Anwer, Md Khalid, Makeen, Hafiz A., Albratty, Mohammed, Alhazmi, Hassan A., Bhatia, Saurabh, Bungau, Simona“…The large number of mutations in the receptor binding domain (RBD) of the spike protein is responsible for strengthening of the spike-angiotensin-converting enzyme 2 (ACE2) interaction, thereby explaining the elevated threat. …”
Publicado 2022
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4316por Peterhoff, David, Einhauser, Sebastian, Beileke, Stephanie, Niller, Hans-Helmut, Günther, Felix, Schachtner, Michael, Asbach, Benedikt, Steininger, Philipp, Tenbusch, Matthias, Peter, Antonia S., Gessner, Andre, Burkhardt, Ralph, Heid, Iris M., Wagner, Ralf, Überla, Klaus“…Regression analysis indicated that both increased age and increased time since vaccination independently decreased RBD binding and neutralizing antibody levels. Unvaccinated participants with detectable N-antibodies at baseline (June 2020) revealed a median ID50 of 72 at the April 2021 follow-up. …”
Publicado 2022
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4317por Singh, Vidisha, Obregon-Perko, Veronica, Lapp, Stacey A., Horner, Anna Marie, Brooks, Alyssa, Macoy, Lisa, Hussaini, Laila, Lu, Austin, Gibson, Theda, Silvestri, Guido, Grifoni, Alba, Weiskopf, Daniela, Sette, Alessandro, Anderson, Evan J., Rostad, Christina A., Chahroudi, Ann“…Serologic responses against spike receptor binding domain (RBD), full-length spike, and nucleocapsid were similar among convalescent COVID-19 and MIS-C, suggesting functional B cell responses. …”
Publicado 2022
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4318por Yu, Esther Dawen, Narowski, Tara M., Wang, Eric, Garrigan, Emily, Mateus, Jose, Frazier, April, Weiskopf, Daniela, Grifoni, Alba, Premkumar, Lakshmanane, da Silva Antunes, Ricardo, Sette, Alessandro“…CCC-specific CD4+ T cell responses were also associated with low numbers of HLA-DR+CD38+ cells and their magnitude did not correlate with yearly changes in the prevalence of CCC infections. Similarly, spike RBD-specific IgG responses for CCC were stable throughout the sampling period. …”
Publicado 2022
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4319por Lee, Youri, Grubbs, Gabrielle, Ramelli, Sabrina C., Levine, Andrea R., Bathula, Allison, Saharia, Kapil, Purcell, Madeleine, Singireddy, Shreya, Dugan, Colleen L., Kirchoff, Lindsey, Lankford, Allison, Cipriano, Sarah, Curto, Ryan A., Wu, Jocelyn, Raja, Katherine, Kelley, Emily, Herr, Daniel, Vannella, Kevin M., Ravichandran, Supriya, Tang, Juanjie, Harris, Anthony, Sajadi, Mohammad, Chertow, Daniel S., Grazioli, Alison, Khurana, Surender“…Higher antibody binding was observed against SARS-CoV-2 receptor-binding domain (RBD) mutants with key VOC amino acids when tested with post-second vaccination plasma from post-partum women compared with controls. …”
Publicado 2022
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4320por Zhou, Panpan, Song, Ge, He, Wan-ting, Beutler, Nathan, Tse, Longping V., Martinez, David R., Schäfer, Alexandra, Anzanello, Fabio, Yong, Peter, Peng, Linghang, Dueker, Katharina, Musharrafieh, Rami, Callaghan, Sean, Capozzola, Tazio, Yuan, Meng, Liu, Hejun, Limbo, Oliver, Parren, Mara, Garcia, Elijah, Rawlings, Stephen A., Smith, Davey M., Nemazee, David, Jardine, Joseph G., Wilson, Ian A., Safonova, Yana, Rogers, Thomas F., Baric, Ralph S., Gralinski, Lisa E., Burton, Dennis R., Andrabi, Raiees“…The emergence of the Omicron variant of SARS-CoV-2 has illustrated the limitations of solely targeting the receptor binding domain (RBD) of the envelope Spike (S)-protein. Here, we isolated a large panel of broadly neutralizing antibodies (bnAbs) from SARS-CoV-2 recovered-vaccinated donors that target a conserved S2 region in the fusion machinery on betacoronavirus spikes. …”
Publicado 2022
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