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4341por Saltoğlu, Neşe, Dinç, Harika Öykü, Balkan, İlker İnanç, Can, Günay, Özbey, Doğukan, Beytur, Ayşe Nur, Keskin, Elif, Budak, Beyhan, Aydoğan, Okan, Mete, Bilgül, Karaali, Rıdvan, Ergin, Sevgi, Kocazeybek, Bekir“…The study included 318 HCWs vaccinated with inactive CoronaVac SARS-CoV-2 vaccine in 2 doses. Anti-spike/RBD IgG levels were measured immediately before and 1 month after the booster dose. …”
Publicado 2022
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4342por Cho, Alice, Muecksch, Frauke, Wang, Zijun, Ben Tanfous, Tarek, DaSilva, Justin, Raspe, Raphael, Johnson, Brianna, Bednarski, Eva, Ramos, Victor, Schaefer-Babajew, Dennis, Shimeliovich, Irina, Dizon, Juan P., Yao, Kai-Hui, Schmidt, Fabian, Millard, Katrina G., Turroja, Martina, Jankovic, Mila, Oliveira, Thiago Y., Gazumyan, Anna, Gaebler, Christian, Caskey, Marina, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C.“…Compared with mRNA vaccines, Ad.26.COV.2 recipients had significantly lower numbers of RBD-specific memory B cells 1.5 or 6 mo after vaccination. …”
Publicado 2022
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4343por Chen, Chuan, Saville, James W., Marti, Michelle M., Schäfer, Alexandra, Cheng, Mary Hongying, Mannar, Dhiraj, Zhu, Xing, Berezuk, Alison M., Banerjee, Anupam, Sobolewski, Michele D., Kim, Andrew, Treat, Benjamin R., Da Silva Castanha, Priscila Mayrelle, Enick, Nathan, McCormick, Kevin D., Liu, Xianglei, Adams, Cynthia, Hines, Margaret Grace, Sun, Zehua, Chen, Weizao, Jacobs, Jana L., Barratt-Boyes, Simon M., Mellors, John W., Baric, Ralph S., Bahar, Ivet, Dimitrov, Dimiter S., Subramaniam, Sriram, Martinez, David R., Li, Wei“…Cryo-EM analyses reveal that F6 has a unique binding mode that spans a broad surface of the RBD and involves the antibody framework region. …”
Publicado 2022
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4344por Yu, Esther Dawen, Narowski, Tara M., Wang, Eric, Garrigan, Emily, Mateus, Jose, Frazier, April, Weiskopf, Daniela, Grifoni, Alba, Premkumar, Lakshmanane, da Silva Antunes, Ricardo, Sette, Alessandro“…Similarly, CCC-specific and spike RBD-specific IgG responses were stable in time. …”
Publicado 2022
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4345por Brehm, Thomas Theo, Ullrich, Felix, Thompson, Michelle, Küchen, Julia, Schwinge, Dorothee, Spier, Anthea, Huber, Samuel, Knobloch, Johannes K., Aepfelbacher, Martin, Addo, Marylyn M., Lohse, Ansgar W., Lütgehetmann, Marc, Schulze zur Wiesch, Julian“…All vaccinated individuals had detectable anti-S1-RBD-SARS-CoV-2 antibodies (median AU/mL [IQR]: 13,891 [8505–23,543]), indicating strong protection against severe COVID-19. …”
Publicado 2022
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4346por Short, Kristopher K., Lathrop, Stephanie K., Davison, Clara J., Partlow, Haley A., Kaiser, Johnathan A., Tee, Rebekah D., Lorentz, Elizabeth B., Evans, Jay T., Burkhart, David J.“…Here, subunit vaccines were made with squalene-based emulsions containing novel, synthetic toll-like receptor (TLR) agonists, INI-2002 (TLR4 agonist) and INI-4001 (TLR7/8 agonist), using the recombinant receptor-binding domain (RBD) of SARS-CoV-2 S protein as an antigen. The addition of the TLR4 and TLR7/8 agonists, alone or in combination, maintained the formulation characteristics of squalene-based emulsions, including a sterile filterable droplet size (<220 nm), high homogeneity, and colloidal stability after months of storage at 4, 25, and 40 °C. …”
Publicado 2022
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4347por Garcia, Laura, Woudenberg, Tom, Rosado, Jason, Dyer, Adam H., Donnadieu, Françoise, Planas, Delphine, Bruel, Timothée, Schwartz, Olivier, Prazuck, Thierry, Velay, Aurélie, Fafi-Kremer, Samira, Batten, Isabella, Reddy, Conor, Connolly, Emma, McElheron, Matt, Kennelly, Sean P., Bourke, Nollaig M., White, Michael T., Pelleau, Stéphane“…In this study, we use bead-based multiplex assays to measure IgG and IgA antibodies and IgG avidity to five SARS-CoV-2 antigens (Spike (S), receptor-binding domain (RBD), Nucleocapsid (N), S subunit 2, and Membrane-Envelope fusion (ME)). …”
Publicado 2022
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4348por Tripathi, Nancy, Goel, Bharat, Bhardwaj, Nivedita, Vishwakarma, Ram A., Jain, Shreyans K.“…For example, the glycosaminoglycans (GAGs) of host cells serve as a cofactor as they interact with the receptor-binding domain (RBD) of S-glycoprotein and play a protective role in host immune evasion via masking the viral peptide epitopes. …”
Publicado 2022
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4349por Arguni, Eggi, Dewi, Fatwa Sari Tetra, Fachiroh, Jajah, Paramita, Dewi Kartikawati, Lestari, Septi Kurnia, Wiratama, Bayu Satria, Susilaningrum, Annisa Ryan, Kharisma, Bara, Meisyarah, Yogi Hasna, Sari, Merlinda Permata, Farahdilla, Zakiya Ammalia, Siswanto, Siswanto, Sjaugi, Muhammad Farhan, Sasongko, Teguh Haryo, Lazuardi, Lutfan“…Serum samples taken at various time points will be tested for IgM anti-Spike protein of SARS-CoV-2 and IgG anti-Spike RBD of SARS-CoV-2 by using Chemiluminescent Microparticle Immunoassay (CMIA) method. …”
Publicado 2022
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4350por Mahmood, Tousif Bin, Hossan, Mohammad Imran, Mahmud, Shafi, Shimu, Mst. Sharmin Sultana, Alam, Md. Jahidul, Bhuyan, Md. Mahfuzur Rahman, Emran, Talha Bin“…The molecular docking study also revealed that L452R and T478K mutations found in the RBD domain of delta variant spike protein contributed to alter interaction with the host ACE2 receptor. …”
Publicado 2022
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4351“…The receptor binding domain (RBD) and N-terminal domain (NTD) situated on the peak of the spike protein (S-Protein) of SARS-CoV-2 are immunogenic in nature, therefore, can be targeted by neutralizing monoclonal antibodies. …”
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4352por Shim, Hyeon Woo, Shin, Jae hang, Shin, Shang Cheol, Lee, Hwa Jung, So, Kyung Soon, Lee, So Young, Jun, Jae Woo, Seo, Jeong Ku, Lee, Hwa Seop, Lee, Suk Young, Kim, Seung Hyun, Kim, Sun Jong, Kim, Kyoung-Chol, Ryu, Gyu Ha“…(1) Objective: To investigate the factors that affect rates of neutralizing antibody production and duration after vaccination using the newly developed SARS-CoV-2 POCT. (2) Methods: The production of immunoglobulin and neutralizing antibody in clinical subjects who completed various vaccines was analyzed using the POCT, the semi-quantitative was interpreted by measurement application, and the quantified neutralizing antibody titers were using the ELISA. (3) Results: According to the clinical performance analysis of the POCT, the clinical sensitivity and the specificity were 96.8% (90/93) and 97.7% (167/171), respectively, for the S1 RBD IgG antibody. The clinical sensitivity was 92.22% (83/90), and the clinical specificity was 100.00% (174/174) for neutralizing antibodies. …”
Publicado 2022
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4353por Brehm, Jessica, Spaeth, Alexander, Dreßler, Lars, Masetto, Thomas, Dannenberg, Rainer, Peter, Christoph, Grimmler, Matthias“…All common immune methods (ELISA, CLIA, PETIA) and SARS-CoV-2 specific antigens (N-, S1- and RBD-) were specifically tracked and directly compared for up to 455 days. …”
Publicado 2022
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4354por Wang, Hsi-Hao, Wu, Jia-Ling, Chang, Min-Yu, Wu, Hsin-Mian, Ho, Li-Chun, Chi, Po-Jui, Wu, Ching-Fang, Lee, Wan-Chia, Liou, Hung-Hsiang, Hung, Shih-Yuan, Lee, Yi-Che“…Patients receiving hemodialysis (HD, n = 204) or peritoneal dialysis (PD, n = 116) were enrolled alongside healthy subjects (control, n = 34). Anti-SARS-CoV-2 S1 RBD IgG antibodies were measured before the first vaccination (T0), four to six weeks afterwards (T1), one week before the second dose (T2), and four to six weeks afterwards (T3). …”
Publicado 2022
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4355“…RESULTS: According to our in silico studies, the amino acid residues Asn487, Tyr489, Gln493, Lys417, and Tyr505 of the receptor binding domain (RBD) of SARS-CoV-2 formed an interaction with the model lectin Lablab purpureus lectin. …”
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4356por Pimentel, Vitor, Mariano, Diego, Cantão, Letícia Xavier Silva, Bastos, Luana Luiza, Fischer, Pedro, de Lima, Leonardo Henrique Franca, Fassio, Alexandre Victor, de Melo-Minardi, Raquel Cardoso“…To evaluate our tool, we proposed three case studies: we 1) compared vertebrate myoglobin and truncated invertebrate hemoglobin; 2) analyzed interactions between the spike protein RBD of SARS-CoV-2 and the cell receptor ACE2; and 3) compared a glucose-tolerant and a non-tolerant β-glucosidase enzyme used for biofuel production. …”
Publicado 2021
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4357por Valdovino-Navarro, Blanca J., Dueñas, Salvador, Flores-Acosta, G. Isaí, Gasperin-Bulbarela, Jahaziel, Bernaldez-Sarabia, Johanna, Cabanillas-Bernal, Olivia, Cervantes-Luevano, Karla E., Licea-Navarro, Alexei F.“…In the phage display, a plasma with high antibody titers against SARS-CoV-2 was used to selectively displace the VNAR antibodies bound to the antigen SARS-CoV-2 receptor binding domain (RBD). In silico data suggested that the SP240 binding epitopes are located within the ACE2 binding interface. …”
Publicado 2022
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4358por Moreira, David, Leitão, Daniela, Lopes-Nunes, Jéssica, Santos, Tiago, Figueiredo, Joana, Miranda, André, Alexandre, Daniela, Tomaz, Cândida, Mergny, Jean-Louis, Cruz, Carla“…In silico studies suggest that four ligands bind to the AT11-L2 G4 structure by stacking interactions, while the RBD1,2 domains of NCL interact preferentially with the thymines of AT11-L2 G4. …”
Publicado 2022
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4359por Wallon, Lauren, Khan, Imran, Teng, Kai Wen, Koide, Akiko, Zuberi, Mariyam, Li, Jianping, Ketavarapu, Gayatri, Traaseth, Nathaniel J., O’Bryan, John P., Koide, Shohei“…Furthermore, JAM20 directly competed with both the RAF(RBD) and BI-2852. These results provide direct validation of targeting the Switch I/II pocket for inhibiting RAS-driven tumorigenesis. …”
Publicado 2022
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4360por Agallou, Maria, Koutsoni, Olga S, Michail, Maria, Zisimopoulou, Paraskevi, Tsitsilonis, Ourania E, Karagouni, Evdokia“…RESULTS: Both mRNA vaccines induced faster and stronger humoral responses as assessed by high spike- and RBD-specific antibody titers and neutralizing efficacy in comparison to ChAdOx1-nCoV-19 vaccine. …”
Publicado 2022
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