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4361por Kleinerman, Gabriela, Gross, Saar, Topol, Shira, Ariel, Ella, Volokh, Gerry, Melloul, Sivan, Mergy, Shani Etty, Malamud, Yaakov, Gilboa, Sagi, Gal, Yoav, Weiss, Libby, Richt, Juergen A., Decaro, Nicola, Eskandar, Shadi, Arieli, Yarden, Gingis, Efrat, Sachter, Yacov, Chaim, Lavie“…Three out of 131 cats analyzed, showed IgG antibodies against SARS-CoV-2 RBD and S2P (2.3 %). None of cats were positive for SARS-CoV-2 RNA by RT-PCR. …”
Publicado 2022
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4362“…This paper has explored the infrared (IR) spectra of spike protein receptor-binding domain (RBD) for SARS-CoV-2 using molecular dynamics simulations, and the absorption bands are assigned. …”
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4363por Hutchinson, Geoffrey, Abiona, Olubukola, Ziwawo, Cynthia, Werner, Anne, Ellis, Daniel, Tsybovsky, Yaroslav, Leist, Sarah, Palandjian, Charis, West, Ande, Fritch, Ethan, Wang, Niangshuang, Wrapp, Daniel, Boyoglu-Barnum, Seyhan, Ueda, George, Baker, David, Kanekiyo, Masaru, McLellan, Jason, Baric, Ralph, King, Neil, Graham, Barney, Corbett, Kizzmekia“…However, targeting other conserved non-RBD epitopes could further limit the potential for antigenic escape. …”
Publicado 2022
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4364por Svetlova, Julia, Gustin, Dmitry, Manuvera, Valentin, Shirokov, Dmitriy, Shokina, Varvara, Prusakov, Kirill, Aldarov, Konstantin, Kharlampieva, Daria, Matyushkina, Daria, Bespyatykh, Julia, Varizhuk, Anna, Lazarev, Vassili, Vedekhina, Tatiana“…Importantly, all samples were collected in the pre-Omicron period but showed noticeable responses to the receptor-binding domain (RBD) of the Omicron spike protein. Thus, using the new express Ab-profiling system, we confirmed the inter-variant cross-reactivity of the anti-SARS-CoV-2 Abs and demonstrated the relative potency of the vaccines against new VOCs.…”
Publicado 2022
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4365por Ovchynnykova, Olha, Kapusta, Karina, Sizochenko, Natalia, Sukhyy, Kostyantyn M., Kolodziejczyk, Wojciech, Hill, Glake A., Saloni, Julia“…Here, we propose a multitarget drug discovery pipeline for identifying potential drug candidates which can efficiently inhibit the Receptor Binding Domain (RBD) of spike glycoproteins from different variants of SARS-CoV-2. …”
Publicado 2022
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4366por Shrestha, Asmita, Marahatha, Rishab, Basnet, Saroj, Regmi, Bishnu P., Katuwal, Saurav, Dahal, Salik Ram, Sharma, Khaga Raj, Adhikari, Achyut, Chandra Basnyat, Ram, Parajuli, Niranjan“…Finally, an in vitro assay indicated that about 50% reduction in the binding of hACE2 with S1-RBD in the presence of cyanidin-containing red grapes crude extract was achieved at approximately 1.25 mg/mL. …”
Publicado 2022
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4367por Toelzer, Christine, Gupta, Kapil, Yadav, Sathish K. N., Hodgson, Lorna, Williamson, Maia Kavanagh, Buzas, Dora, Borucu, Ufuk, Powers, Kyle, Stenner, Richard, Vasileiou, Kate, Garzoni, Frederic, Fitzgerald, Daniel, Payré, Christine, Gautam, Gunjan, Lambeau, Gérard, Davidson, Andrew D., Verkade, Paul, Frank, Martin, Berger, Imre, Schaffitzel, Christiane“…S receptor binding domain (RBD) comprises a free fatty acid (FFA)–binding pocket. …”
Publicado 2022
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4368por Siavash Moakhar, Roozbeh, del Real Mata, Carolina, Jalali, Mahsa, Shafique, Houda, Sanati, Alireza, de Vries, Justin, Strauss, Julia, AbdElFatah, Tamer, Ghasemi, Fahimeh, McLean, Myles, I. Hosseini, Imman, Lu, Yao, Yedire, Sripadh Guptha, Mahshid, Sahar Sadat, Tabatabaiefar, Mohammad Amin, Liang, Chen, Mahshid, Sara“…NFluidEX is validated with Influenza A H1N1 and SARS‐CoV‐2 (original strain and variants of concern), and achieves low detection limit in saliva and blood for the viral proteins and the anti‐receptor binding domain (RBD) Immunoglobulin G (IgG) and Immunoglobulin M (IgM), respectively. …”
Publicado 2022
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4369por Bergami, Federica, Arena, Francesca, Sammartino, Josè Camilla, Ferrari, Alessandro, Zavaglio, Federica, Zelini, Paola, Paolucci, Stefania, Comolli, Giuditta, Percivalle, Elena, Lilleri, Daniele, Cassaniti, Irene, Baldanti, Fausto“…Memory B cells secreting SARS-CoV-2 RBD-IgG were measured by B-spot assay. At three weeks after the third dose (T4), the frequency of subjects showing NT-Abs titer at the upper detection limit (≥640) was significantly higher than that observed at three weeks after the second dose (26/77; 33.7% vs. 9/77; 11.6%; p = 0.0018). …”
Publicado 2022
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4370por Lawton, Kaila, Keller, Stefan M., Barnum, Samantha, Arredondo-Lopez, Christina, Spann, Kennedy, Pusterla, Nicola“…Blood samples were tested for SARS-CoV-2 antibodies using an ELISA targeting the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. Further, selected prevalence factors (season, age, breed, sex, presenting complaint) were retrieved from the medical records. …”
Publicado 2022
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4371“…This step in the viral replication process is mediated by the receptor binding domain (RBD) of SP that is located on the surface of the virus. …”
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4372por Nishiwaki, Hiroshi, Ueyama, Jun, Kashihara, Kenichi, Ito, Mikako, Hamaguchi, Tomonari, Maeda, Tetsuya, Tsuboi, Yoshio, Katsuno, Masahisa, Hirayama, Masaaki, Ohno, Kinji“…Gut microbiota and fecal bile acids were analyzed in 278 patients with α-synucleinopathies, which were comprised of 28 patients with dementia with Lewy bodies (DLB), 224 patients with Parkinson’s disease (PD), and 26 patients with idiopathic rapid eye movement sleep behavior disorder (iRBD). Similarly to PD, short-chain fatty acids-producing genera were decreased in DLB. …”
Publicado 2022
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4373por Scarpa, Fabio, Sanna, Daria, Benvenuto, Domenico, Borsetti, Alessandra, Azzena, Ilenia, Casu, Marco, Fiori, Pier Luigi, Giovanetti, Marta, Maruotti, Antonello, Ceccarelli, Giancarlo, Caruso, Arnaldo, Caccuri, Francesca, Cauda, Roberto, Cassone, Antonio, Pascarella, Stefano, Ciccozzi, Massimo“…Concerning the affinity for ACE2, structure analyses (also performed by comparing the properties of BQ.1 and BA.5 RBD) indicate that the impact of the BQ.1 mutations may be modest. …”
Publicado 2022
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4374por Wang, Bo, Xu, Hua, Liang, Zi-teng, Zhao, Tian-ning, Zhang, Xin, Peng, Tian-bo, Wang, You-chun, Su, Xiao-dong“…We have determined the cryo-EM structure of the BD-218/spike protein complex to define its epitope in detail, which revealed that BD-218 interacts with a novel epitope on the receptor-binding domain (RBD) of the spike protein. We concluded that BD-218 is a highly effective and broadly active nAb against SARS-CoV-2 variants with promising potential for therapeutic development.…”
Publicado 2023
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4375por Bowen, John E., Park, Young-Jun, Stewart, Cameron, Brown, Jack T., Sharkey, William K., Walls, Alexandra C., Joshi, Anshu, Sprouse, Kaitlin R., McCallum, Matthew, Tortorici, M. Alejandra, Franko, Nicholas M., Logue, Jennifer K., Mazzitelli, Ignacio G., Nguyen, Annalee W., Silva, Rui P., Huang, Yimin, Low, Jun Siong, Jerak, Josipa, Tiles, Sasha W, Ahmed, Kumail, Shariq, Asefa, Dan, Jennifer M., Zhang, Zeli, Weiskopf, Daniela, Sette, Alessandro, Snell, Gyorgy, Posavad, Christine M., Iqbal, Najeeha Talat, Geffner, Jorge, Bandera, Alessandra, Gori, Andrea, Sallusto, Federica, Maynard, Jennifer A., Crotty, Shane, Van Voorhis, Wesley C., Simmerling, Carlos, Grifantini, Renata, Chu, Helen Y., Corti, Davide, Veesler, David“…We show that neutralizing activity is almost entirely directed to the S(1) subunit and that variant cross-neutralization is mediated solely by RBD-specific antibodies. Our data provide a quantitative framework for guiding future S engineering efforts to develop vaccines with higher resilience to the emergence of variants than current technologies.…”
Publicado 2022
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4376por Marot, Stephane, Bocar Fofana, Djeneba, Flandre, Philippe, Malet, Isabelle, Zafilaza, Karen, Leducq, Valentin, Vivien, Diane, Mrabet, Sarah, Poignon, Corentin, Calvez, Vincent, Morand-Joubert, Laurence, Marcelin, Anne-Geneviève, Gozlan, Joel“…We analyzed, in 105 patients with various histories of SARS-CoV-2 infection and/or vaccination, the neutralizing response using a virus neutralization test (VNT) against B.1, Alpha, Beta and Omicron variants, and compared the results with two surrogate assays based on antibody-mediated blockage of the ACE2-RBD interaction (Lateral Flow Boditech and ELISA Genscript). …”
Publicado 2022
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4377por Fryer, Holly A., Hartley, Gemma E., Edwards, Emily S.J., O'Hehir, Robyn E., van Zelm, Menno C.“…However, all vaccines induce Spike- and RBD-specific Bmem, which are vital in providing long-lasting protection in the form of rapid recall responses to subsequent infections. …”
Publicado 2022
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4378por Aurisicchio, Luigi, Brambilla, Nadia, Cazzaniga, Marina E., Bonfanti, Paolo, Milleri, Stefano, Ascierto, Paolo A., Capici, Serena, Vitalini, Cristina, Girolami, Federica, Giacovelli, Giampaolo, Caselli, Gianfranco, Visintin, Michela, Fanti, Francesca, Ghirri, Matteo, Conforti, Antonella, Compagnone, Mirco, Lione, Lucia, Salvatori, Erika, Pinto, Eleonora, Muzi, Alessia, Marra, Emanuele, Palombo, Fabio, Roscilli, Giuseppe, Manenti, Alessandro, Montomoli, Emanuele, Cadossi, Matteo, Rovati, Lucio C.“…Here we report the findings from the phase 1, first-in-human, dose-escalation study of COVID-eVax, a DNA vaccine encoding the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. Sixty-eight healthy adults received two doses of 0.5, 1, or 2 mg 28 days apart, or a single 2-mg dose, via intramuscular injection followed by electroporation, and they were monitored for 6 months. …”
Publicado 2023
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4379por Zaccaria, Marco, Genovese, Luigi, Dawson, William, Cristiglio, Viviana, Nakajima, Takahito, Johnson, Welkin, Farzan, Michael, Momeni, Babak“…We employ a recently developed complexity-reduction quantum mechanical (QM-CR) approach, based on complexity reduction of density functional theory calculations, to characterize the interactions of the SARS-CoV-2 spike receptor binding domain (RBD) with ACE2 host receptors and antibodies. QM-CR operates via ab initio identification of individual amino acid residue’s contributions to chemical binding and leads to the identification of the impact of point mutations. …”
Publicado 2022
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4380por Luo, Mengxiao, Zhou, Biao, Reddem, Eswar R., Tang, Bingjie, Chen, Bohao, Zhou, Runhong, Liu, Hang, Liu, Lihong, Katsamba, Phinikoula S., Au, Ka-Kit, Man, Hiu-On, To, Kelvin Kai-Wang, Yuen, Kwok-Yung, Shapiro, Lawrence, Dang, Shangyu, Ho, David D., Chen, Zhiwei“…The infection activates diverse memory B cell clonotypes for generating potent class I/II and III bNAbs with new epitopes mapped to the receptor-binding domain (RBD). The top eight bNAbs neutralize wildtype and BA.1 potently but display divergent IgH/IgL sequences and neuralization profiles against other variants of concern (VOCs). …”
Publicado 2023
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