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421por Qiao, Yidan, Zhan, Yikang, Zhang, Yongli, Deng, Jieyi, Chen, Achun, Liu, Bingfeng, Zhang, Yiwen, Pan, Ting, Zhang, Wangjian, Zhang, Hui, He, Xin“…Herein, we further improved the RBD production in the eukaryote system by in situ Crispr/Cas9-engineered CHO cells. …”
Publicado 2022
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422“…There are many scientific reports on the interaction of the SARS‐CoV‐2 virus S protein (and its RBD) with the human ACE2 receptor protein. However, there are no reliable data on how this interaction differs from the interaction of the receptor binding domain of SARS‐CoV‐1 with ACE2, in terms of binding strength and changes in reaction enthalpy and entropy. …”
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423por Bigenwald, Camille, Haddad, Yacine, Thelemaque, Cassandra, Carrier, Agathe, Birebent, Roxanne, Ly, Pierre, Flament, Caroline, Lahmar, Imran, de Sousa, Eric, Maeurer, Markus, Miyara, Makoto, Assi, Tarek, Castilla-Llorente, Cristina, Willekens, Christophe, Fayemi, Céline, Lazarovici, Julien, Marabelle, Aurélien, Derosa, Lisa, Ribrag, Vincent, Zitvogel, Laurence“…Finally, 16 patients were infected with SARS-CoV-2, of whom 6 developed a severe infection. Only S1-RBD-specific Th1 responses were associated with protection against SARS-CoV2 infection, while Th2 responses or anti-S1-RBD IgG titers failed to correlate with protection. …”
Publicado 2023
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424por Nanishi, Etsuro, Borriello, Francesco, Seo, Hyuk-Soo, O’Meara, Timothy R., McGrath, Marisa E., Saito, Yoshine, Chen, Jing, Diray-Arce, Joann, Song, Kijun, Xu, Andrew Z., Barman, Soumik, Menon, Manisha, Dong, Danica, Caradonna, Timothy M., Feldman, Jared, Hauser, Blake M., Schmidt, Aaron G., Baden, Lindsey R., Ernst, Robert K., Dillen, Carly, Yu, Jingyou, Chang, Aiquan, Hilgers, Luuk, Platenburg, Peter Paul, Dhe-Paganon, Sirano, Barouch, Dan H., Ozonoff, Al, Zanoni, Ivan, Frieman, Matthew B., Dowling, David J., Levy, Ofer“…While demonstrating superior immunogenicity to soluble receptor-binding domain (RBD), RBD displayed as a protein nanoparticle (RBD-NP) generated limited antibody responses. …”
Publicado 2023
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425por Raoufi, Ehsan, Hosseini, Fatemeh, Onagh, Bahman, Salehi-Shadkami, Mohammad, Mehrali, Marjan, Mohsenzadegan, Monireh, Ho, Jim Q., Bigdelou, Banafsheh, Sepand, Mohammad Reza, Webster, Thomas J., Zanganeh, Steven, Farajollahi, Mohammad M.“…METHODS: A recombinant-RBD comprising 283 residues (31 kDa) was constructed after epitope analyses. …”
Publicado 2023
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426por Tambunan, Betty A., Ugrasena, I. Dewa G., Nugraha, Jusak, Fitriah, Munawaroh, Permatasari, Cynthia A., Moses, Emmanuel J., Yusoff, Narazah M., Aryati“…Studies evaluating the levels of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) anti-spike protein receptor-binding domain (S-RBD) immunoglobulin G (IgG) antibodies in vaccinated healthcare workers in Indonesia are limited. …”
Publicado 2023
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427por Magen, Hila, Avigdor, Abraham, Nevo, Lee, Fried, Shalev, Gibori, Amit, Levin, Einav G., Lustig, Yaniv, Shkury, Eden, Rahav, Galia“…In the control group 210 (98.9%) developed anti-RBD-IgG antibodies after a median of 21 days, with a GMT of 5.17 (95%CI, 4.8–5.6), p<0.0001. …”
Publicado 2023
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428por Ma, Xiaoying, Liang, Jady, Zhu, Guangheng, Bhoria, Preeti, Shoara, Aron A., MacKeigan, Daniel T., Khoury, Christopher J., Slavkovic, Sladjana, Lin, Lisha, Karakas, Danielle, Chen, Ziyan, Prifti, Viktor, Liu, Zhenze, Shen, Chuanbin, Li, Yuchong, Zhang, Cheng, Dou, Jiayu, Rousseau, Zack, Zhang, Jiamin, Ni, Tiffany, Lei, Xi, Chen, Pingguo, Wu, Xiaoyu, Shaykhalishahi, Hamed, Mubareka, Samira, Connelly, Kim A., Zhang, Haibo, Rotstein, Ori, Ni, Heyu“…Both infection and vaccination utilize the spike protein receptor-binding domain (RBD) of SARS-CoV-2. We found that intravenous injection of recombinant RBD caused significant platelet clearance in mice. …”
Publicado 2023
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429por Oh, Jeein, Park, Uni, Kim, Juhyung, Jeon, Kyeongseok, Kim, Chulwoo, Cho, Nam-Hyuk, Choi, Youn Soo“…Moreover, proteolytic cleavage sites and the fusion peptide VLP immunization showed a synergistic effect on the immune protection against MERS-CoV infection elicited by immunization with VLP expressing the receptor binding domain (RBD) of the S protein. Additionally, immune evasion of MERS-CoV RBD variants from anti-RBD sera was significantly controlled by anti-proteolytic cleavage sites and the fusion peptide sera. …”
Publicado 2023
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430“…The screen revealed that the PDE RbdA is activated by Mn(2+) and is responsible for Mn(2+)-dependent attachment, inhibition of Psl production, and dispersion. …”
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431“…We show that the BA.1 NTD amplifies the immune evasion of its associated RBD. BA.1 NTD reduces neutralistion by RBD directed monoclonal antibodies, and impacts ACE2 interaction. …”
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432por Mahmoudi Azar, Lena, Öncel, Muhammed Miran, Karaman, Elif, Soysal, Levent Faruk, Fatima, Ayesha, Choi, Sy Bing, Eyupoglu, Alp Ertunga, Erman, Batu, Khan, Asif M., Uysal, Serdar“…The interaction between the receptor binding domain (RBD) of SARS-CoV-2 spike protein and the helical peptide of human angiotensin-converting enzyme-2 (ACE2) is a necessity for the initiation of viral infection. …”
Publicado 2023
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433por Ma, Xiancai, Zou, Fan, Yu, Fei, Li, Rong, Yuan, Yaochang, Zhang, Yiwen, Zhang, Xiantao, Deng, Jieyi, Chen, Tao, Song, Zheng, Qiao, Yidan, Zhan, Yikang, Liu, Jun, Zhang, Junsong, Zhang, Xu, Peng, Zhilin, Li, Yuzhuang, Lin, Yingtong, Liang, Liting, Wang, Guanwen, Chen, Yingshi, Chen, Qier, Pan, Ting, He, Xin, Zhang, Hui“…Compared to monomer vaccines, nanoparticle vaccines elicited more robust neutralizing antibodies and cellular immune responses. RBD and RBD-HR nanoparticle vaccinated hACE2 transgenic mice vaccinated with RBD and/or RBD-HR nanoparticles exhibited reduced viral load in the lungs after SARS-CoV-2 challenge. …”
Publicado 2020
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434por Zhu, Zhi-Ling, Qiu, Xiao-Dan, Wu, Shuo, Liu, Yi-Tong, Zhao, Ting, Sun, Zhong-Hao, Li, Zhuo-Rong, Shan, Guang-Zhi“…A compound 02B05 (demethylzeylasteral, CAS number: 107316-88-1) that had high affinities for S-RBD and ACE2 was discovered, and binding affinities (K(D), μM) of 02B05-ACE2 and 02B05-S-RBD were 1.736 and 1.039 μM, respectively. …”
Publicado 2020
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435por Bertoglio, Federico, Meier, Doris, Langreder, Nora, Steinke, Stephan, Rand, Ulfert, Simonelli, Luca, Heine, Philip Alexander, Ballmann, Rico, Schneider, Kai-Thomas, Roth, Kristian Daniel Ralph, Ruschig, Maximilian, Riese, Peggy, Eschke, Kathrin, Kim, Yeonsu, Schäckermann, Dorina, Pedotti, Mattia, Kuhn, Philipp, Zock-Emmenthal, Susanne, Wöhrle, Johannes, Kilb, Normann, Herz, Tobias, Becker, Marlies, Grasshoff, Martina, Wenzel, Esther Veronika, Russo, Giulio, Kröger, Andrea, Brunotte, Linda, Ludwig, Stephan, Fühner, Viola, Krämer, Stefan Daniel, Dübel, Stefan, Varani, Luca, Roth, Günter, Čičin-Šain, Luka, Schubert, Maren, Hust, Michael“…This virus uses the human ACE2 enzyme as receptor for cell entry, recognizing it with the receptor binding domain (RBD) of the S1 subunit of the viral spike protein. …”
Publicado 2021
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436por Chen, Rui Hong, Yang, Li Jun, Hamdoun, Sami, Chung, Sookja Kim, Lam, Christopher Wai-kei, Zhang, Kai Xi, Guo, Xiaoling, Xia, Chenglai, Law, Betty Yuen Kwan, Wong, Vincent Kam Wai“…BLI assay further confirmed that PGG exhibits a relatively strong binding affinity to SARS-CoV-2-RBD protein in comparison to hACE2. In addition, both ELISA and immunocytochemistry assay proved that PGG blocks SARS-CoV-2-RBD binding to hACE2 dose dependently in cellular level. …”
Publicado 2021
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437“…Further studies show that subdomains from SARS-CoV 2 RBD Pro(322)-Thr(581), SARS-CoV RBD Pro(309)-Pro(575), BtRsRaTG13 RBD Thr(581)-Thr(323), BtRsBeta-CoV RBD Ser(311)-Thr(568), BtRsCoV-related Arg(306)-Pro(575) and PCoV RBD Gln(319)-Ser(589) show binding conformations with ACE2 like their full-length structures of spike proteins. …”
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438por Liu, Junli, Chen, Qi, Yang, Shumin, Li, Ying, Dou, Yang, Deng, Yong-Qiang, Bi, Jinpeng, Tan, Yongcong, Wang, Hongfan, Gong, Wei, Xu, Xiaoyu, Li, Zhenhu, Lang, Guojun, Qin, Cheng-Feng, Lu, Bai, Jiang, WeidongEnlace del recurso
Publicado 2021
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439por Lo Sasso, Bruna, Giglio, Rosaria Vincenza, Vidali, Matteo, Scazzone, Concetta, Bivona, Giulia, Gambino, Caterina Maria, Ciaccio, Anna Maria, Agnello, Luisa, Ciaccio, Marcello“…(1) Background: The evaluation of anti-spike protein receptor-binding domain (S-RBD) antibodies represents a useful tool to estimate the individual protection against Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection; (2) Methods: We evaluated anti S-RBD IgG levels by indirect chemiluminescence immunoassay on Maglumi 800 (SNIBE, California) in 2248 vaccinated subjects without previous SARS-CoV-2 infection, 91 vaccinated individuals recovered from COVID-19, and 268 individuals recovered from COVID-19 who had not been vaccinated. …”
Publicado 2021
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440por Ding, Chengchao, He, Jun, Zhang, Xiangyu, Jiang, Chengcheng, Sun, Yong, Zhang, Yuqing, Chen, Qingqing, He, Hongliang, Li, Wenting, Xie, Jiajia, Liu, Zhirong, Gao, Yong“…To identify crucial mutations in spike protein that escape humoral immune response, we evaluated the cross-neutralization of convalescent plasmas and RBD-specific monoclonal antibodies (mAbs) against various spike protein-based pseudoviruses. …”
Publicado 2021
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