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4381por Majed, Sevan Omer, Mustafa, Suhad Asad, Jalal, Paywast Jamal, Fatah, Mohammed Hassan, Miasko, Monika, Jawhar, Zanko, Karim, Abdulkarim Yasin“…Most of the mutations were found in the RBD (receptor binding domain), the region related to the escape from humoral immunity. …”
Publicado 2023
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4382por Jangra, Sonia, Landers, Jeffrey J., Laghlali, Gabriel, Rathnasinghe, Raveen, O’Konek, Jessica. J., Janczak, Katarzyna W., García-Sastre, Adolfo, Baker, James R., Schotsaert, Michael, Wong, Pamela T.“…We now demonstrate that NE/IVT with the SARS-CoV-2 receptor binding domain (RBD), induces robust and durable humoral, mucosal, and cellular immune responses of equivalent magnitude and quality in young and aged mice. …”
Publicado 2023
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4383por Christensen, Dennis, Polacek, Charlotta, Sheward, Daniel J., Hanke, Leo, McInerney, Gerald, Murrell, Ben, Hartmann, Katrine Top, Jensen, Henrik Elvang, Zimmermann, Julie, Jungersen, Gregers, Illigen, Kristin Engelhart, Isling, Louise Krag, Fernandez-Antunez, Carlota, Ramirez, Santseharay, Bukh, Jens, Pedersen, Gabriel Kristian“…Both regimens elicited spike- and RBD-specific IgG antibody responses of similar magnitude, but in vitro virus neutralization was low or undetectable. …”
Publicado 2023
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4384por Johansson, Martin E., van Lier, Nina M., Kessels, Roy P. C., Bloem, Bastiaan R., Helmich, Rick C.“…A recent subtyping scheme classifies de novo PD patients into three subtypes: mild-motor predominant, intermediate, or diffuse-malignant, based on motor impairment, cognitive function, rapid eye movement sleep behavior disorder (RBD) symptoms, and autonomic symptoms. We aimed to validate this approach in a large longitudinal cohort of early-to-moderate PD (n = 499) by assessing the influence of subtyping on clinical characteristics at baseline and on two-year progression. …”
Publicado 2023
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4385por Kodde, Cathrin, Tafelski, Sascha, Balamitsa, Efthimia, Nachtigall, Irit, Bonsignore, Marzia“…Subsequently, the level of anti-receptor binding domain (RBD) IgG antibody against SARS-CoV-2′s spike protein through blood samples was measured. …”
Publicado 2023
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4386por Xia, Shuai, Wang, Lijue, Jiao, Fanke, Yu, Xueying, Xu, Wei, Huang, Ziqi, Li, Xicheng, Wang, Qian, Zhu, Yun, Man, Qiuhong, Jiang, Shibo, Lu, Lu“…Additionally, either immune sera induced by wild-type (WT) SARS-CoV-2 RBD-based vaccine or BA.2 convalescent sera showed potent synergism with EK1 against both WT SARS-CoV-2 and various Omicron subvariants, further suggesting that EK1-based fusion inhibitors are promising candidates for development as clinical antiviral agents against the currently circulating Omicron subvariants.…”
Publicado 2023
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4387por Hidayat, Rakhmad, Mustika, Alyssa Putri, Avisha, Fhathia, Djuliannisaa, Zlatikha, Winari, Dinisa Diah, Putri, Ria Amiliah, Lisman, Heydi Marizky, Davin, Vandra, Fathi, Gemia Clarisa, Widhani, Alvina, Aini, Muhammad Hafiz, Yudhistira, Azizah, Siti, Rahmadani, Meilisa, Istanti, Novita Dwi, Giantini, Astuti“…An Immunology Analyzer with Chemiluminescence Immunoassay (CLIA) test was used to examine Anti SARS-CoV-2 S-RBD levels. Antibody levels were classified into two systems (3 categories, and 2 categories). …”
Publicado 2022
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4388por Du, Wenjuan, Janssens, Rick, Mykytyn, Anna Z., Li, Wentao, Drabek, Dubravka, van Haperen, Rien, Chatziandreou, Marianthi, Rissmann, Melanie, van der Lee, Joline, van Dortmondt, Melissa, Martin, Itziar Serna, van Kuppeveld, Frank J. M., Hurdiss, Daniel L., Haagmans, Bart L., Grosveld, Frank, Bosch, Berend-Jan“…Here we describe the design of a biparatopic heavy-chain-only antibody consisting of six antigen binding sites recognizing two distinct epitopes in the spike protein NTD and RBD. The hexavalent antibody showed potent neutralizing activity against SARS-CoV-2 and variants of concern, including the Omicron sub-lineages BA.1, BA.2, BA.4 and BA.5, whereas the parental components had lost Omicron neutralization potency. …”
Publicado 2023
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4389por Frans, Glynis, Dillaerts, Doreen, Dehaemers, Tom, Van Elslande, Jan, De Leeuw, Jonas, Boon, Lise, Maes, Wim, Callewaert, Nico, Calcoen, Bas, Ancheva, Lina, Cockx, Maaike, Geukens, Nick, Arat, Kusay, Derua, Rita, Vermeersch, Pieter, Carpentier, Sebastien Christian, Bossuyt, Xavier“…In order to understand ‘hybrid immunity’ at the molecular level we studied the complementarity determining regions (CDR) of anti-RBD (receptor binding domain) antibodies isolated from individuals with ‘hybrid immunity’ as well as from ‘naive’ (not SARS-CoV-2 infected) vaccinated individuals. …”
Publicado 2023
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4390por Zhu, Feng-Cai, Guan, Xu-Hua, Li, Yu-Hua, Huang, Jian-Ying, Jiang, Tao, Hou, Li-Hua, Li, Jing-Xin, Yang, Bei-Fang, Wang, Ling, Wang, Wen-Juan, Wu, Shi-Po, Wang, Zhao, Wu, Xiao-Hong, Xu, Jun-Jie, Zhang, Zhe, Jia, Si-Yue, Wang, Bu-Sen, Hu, Yi, Liu, Jing-Jing, Zhang, Jun, Qian, Xiao-Ai, Li, Qiong, Pan, Hong-Xing, Jiang, Hu-Dachuan, Deng, Peng, Gou, Jin-Bo, Wang, Xue-Wen, Wang, Xing-Huan, Chen, Wei“…The primary endpoints for immunogenicity were the geometric mean titres (GMTs) of specific ELISA antibody responses to the receptor binding domain (RBD) and neutralising antibody responses at day 28. …”
Publicado 2020
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4391por Rose, Ruben, Neumann, Franziska, Grobe, Olaf, Lorentz, Thomas, Fickenscher, Helmut, Krumbholz, Andi“…The booster vaccination resulted in 100% seroconversion and the occurrence of highly avid IgG, which is directed against the S-protein subunit 1 and the RBD, as well as VNA against VOC B.1.1.7, while anti-NP IgGs were not detected. …”
Publicado 2022
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4392por Skaria, Teny Grace, Sreeprakash, Anu, Umesh, Rashwith, Joseph, Sneha, Mohan, Manju, Ahmed, Sakir, Mehta, Pankti, Oommen, Seena Elsa, Benny, Jannet, Paulose, Anagha, Paul, Aby, George, Justin, Sukumaran, Aswathy, Babu, Sageer S, Navas, Safna, Vijayan, Anuroopa, Joseph, Sanjana, Nalianda, Kaveri K, Narayanan, Krishnan, Shenoy, Padmanabha“…The primary outcome for both MIVAC I and MIVAC II was the titre (absolute value) of anti-receptor binding domain (RBD) antibody measured 4 weeks after the second dose of vaccine. …”
Publicado 2022
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4393por Tatsuma, Tetsu, Nakakido, Makoto, Ichinohe, Takeshi, Kuroiwa, Yoshinori, Tomioka, Kengo, Liu, Chang, Miyamae, Nobuhiro, Onuki, Tatsuya, Tsumoto, Kouhei, Hashimoto, Kazuhito, Wakihara, Toru“…The photocatalysts greatly suppressed binding ability of the receptor binding domain (RBD) of coronavirus (the original, alpha and delta variants) spike protein to the receptor of human cells. …”
Publicado 2023
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4394por Calvaresi, Valeria, Wrobel, Antoni G., Toporowska, Joanna, Hammerschmid, Dietmar, Doores, Katie J., Bradshaw, Richard T., Parsons, Ricardo B., Benton, Donald J., Roustan, Chloë, Reading, Eamonn, Malim, Michael H., Gamblin, Steve J., Politis, Argyris“…Here, using HDX-MS, we identified changes in spike dynamics that we associate with the transition from closed to open conformations, to ACE2 binding, and to specific mutations in VOCs. We show that the RBD-associated subdomain plays a role in spike opening, whereas the NTD acts as a hotspot of conformational divergence of VOC spikes driving immune evasion. …”
Publicado 2023
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4395“…In particular we focus on in vitro infection assays and molecular interaction assays studying the binding of the receptor binding domain (RBD) with its cognate cellular receptor ACE2. These assays, but not the measurement of SARS-CoV-2-specific antibodies per se, can inform us of whether antibodies produced by convalescent or vaccinated subjects may protect against the infection and thus have the potential to predict the risk of becoming newly infected. …”
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4396por Nah, Eun-Hee, Cho, Seon, Park, Hyeran, Kim, Suyoung, Noh, Dongwon, Kwon, Eunjoo, Cho, Han-Ik“…At T3-3, antibody levels had decreased by 29.1% in the BNT/BNT group and by 45.3% in the ChAd/ChAd group compared with the antibody levels at T3-1. The anti-SARS-CoV-2 S-RBD IgG levels at T3-1 were significantly associated with having received mRNA vaccines as the two primary doses (p < 0.001). …”
Publicado 2023
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4397por Guo, Hangtian, Yang, Yixuan, Zhao, Tiantian, Lu, Yuchi, Gao, Yan, Li, Tinghan, Xiao, Hang, Chu, Xiaoyu, Zheng, Le, Li, Wanting, Cheng, Hao, Huang, Haibin, Liu, Yang, Lou, Yang, Nguyen, Henry C., Wu, Chao, Chen, Yuxin, Yang, Haitao, Ji, Xiaoyun“…Cryo-electron microscopy (cryo-EM) structure determination of the BA.1 spike-1H1 Fab complexes shows that 1H1 targets a highly conserved region of RBD and avoids most of the circulating Omicron mutations, explaining its broad-spectrum neutralization potency. …”
Publicado 2023
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4398por Chu, Xiaoyu, Ding, Xinyu, Yang, Yixuan, Lu, Yuchi, Li, Tinghan, Gao, Yan, Zheng, Le, Xiao, Hang, Yang, Tingting, Cheng, Hao, Huang, Haibin, Liu, Yang, Lou, Yang, Wu, Chao, Chen, Yuxin, Yang, Haitao, Ji, Xiaoyun, Guo, Hangtian“…Our structural analysis shows that 9H1 interacts with the receptor-binding motif (RBM) region of the receptor-binding domain (RBD) on the spike protein and by directly competing with angiotensin-converting enzyme 2 (ACE2), it blocks the binding of the virus to the receptor and achieves neutralization. …”
Publicado 2023
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4399por Chen, Fangfang, Huang, Yuhan, Huang, Zhengyu, Jiang, Tingting, Yang, Zailin, Zeng, Jie, Jin, Aishun, Zuo, Hua, Huang, Cheng Zhi, Mao, Chengde“…Here, we report a molecular vaccine design principle that maximally drives potent SARS-CoV-2 RBD subunit vaccine on DNA duplex to induce robust and efficacious immune responses in vivo. …”
Publicado 2023
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4400por Shen, Ching-Fen, Fu, Yi-Chen, Ho, Tzong-Shiann, Chen, Po-Lin, Lee, Nan-Yao, Tsai, Bo-Yang, Tsai, Pei-Jane, Ko, Wen-Chien, Liu, Ching-Chuan, Cheng, Chao-Min, Shieh, Chi-Chang“…Assay used: anti-spike RBD antibody, surrogate virus neutralizing antibody and interferon-γ release assay. …”
Publicado 2023
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