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4421por Lai, Chien-Hsien, Huang, Yu-Chuan, Lee, Jenq-Chang, Tseng, Joseph Ta-Chien, Chang, Kung-Chao, Chen, Yen-Ju, Ding, Nai-Jhu, Huang, Pao-Hsuan, Chang, Wen-Chang, Lin, Bo-Wen, Chen, Ruo-Yu, Wang, Yu-Chu, Lai, Yi-Chien, Hung, Liang-Yi“…Overexpression of hnRNP Q1 promotes cell proliferation and tumor growth. HnRNP Q1/ΔRBD23-truncated mutant, which loses the binding ability and translational regulation of Aurora-A mRNA, has no effect on promoting tumor growth. …”
Publicado 2017
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4422por Kim, Felix J, Manel, Nicolas, Garrido, Edith N, Valle, Carine, Sitbon, Marc, Battini, Jean-Luc“…Therefore, the HTLV receptor-binding domain (RBD) lies in the amino terminus of the SU, immediately upstream of a central immunodominant proline rich region (Env residues 180 to 205), that we show to be dispensible for receptor-binding and interference. …”
Publicado 2004
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4423por Wang, Yuanze, van Oosterwijk, Niels, Ali, Ameena M., Adawy, Alaa, Anindya, Atsarina L., Dömling, Alexander S. S., Groves, Matthew R.“…Four different proteins: HA-RBD, MDM2, IL-17A and PD-L1 were used to validate our refolding approach. …”
Publicado 2017
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4424por San Luciano, Marta, Wang, Cuiling, Ortega, Roberto A., Giladi, Nir, Marder, Karen, Bressman, Susan, Saunders‐Pullman, Rachel“…LRRK2 men demonstrated lower motor and higher cognitive, RBD and thermoregulation scores than IPD men and LRRK2 women had greater UDPRS‐IV and rates of dyskinesia. …”
Publicado 2017
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4425por Glize, Bertrand, Lunven, Marine, Rossetti, Yves, Revol, Patrice, Jacquin-Courtois, Sophie, Klinger, Evelyne, Joseph, Pierre-Alain, Rode, Gilles“…Seven right brain-damaged (RBD) patients with chronic neglect were included. …”
Publicado 2017
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4426“…Fifty one subacute stroke patients with left (LBD) or right (RBD) brain damage were investigated including patients with and without CTU-apraxia. …”
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4427por Pieczynski, Marcin, Kruszka, Katarzyna, Bielewicz, Dawid, Dolata, Jakub, Szczesniak, Michal, Karlowski, Wojciech, Jarmolowski, Artur, Szweykowska-Kulinska, Zofia“…This highly conserved U12 intron always divides the plant CBP20 gene into two parts: one part encodes the core domain containing the RNA binding domain (RBD), and the second part encodes the tail domain with a nuclear localization signal (NLS). …”
Publicado 2018
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4428por Jia, Wenxu, Channappanavar, Rudragouda, Zhang, Chao, Li, Mingxi, Zhou, Haixia, Zhang, Shuyuan, Zhou, Panpan, Xu, Jiuyang, Shan, Sisi, Shi, Xuanling, Wang, Xinquan, Zhao, Jincun, Zhou, Dongming, Perlman, Stanley, Zhang, Linqi“…Analysis of sera absorption and isolated monoclonal antibodies from immunized mice demonstrated that the potent and broad neutralizing activity was largely attributed to antibodies targeting the receptor binding domain (RBD) of the S protein. These results show that AdC68-S can induce protective immune responses in mice and represent a promising candidate for further development against MERS-CoV infection in both dromedaries and humans.…”
Publicado 2019
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4429“…Here, we designed recombinant replication-deficient adenovirus-based vaccines expressing the N-terminal domain (rAd/NTD) and receptor-binding domain (rAd/RBD) of the MERS-CoV S1 subunit and full-length Spike protein (rAd/Spike). …”
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4430“…Linear correlations with R values as large as 0.6 where observed for the full sequence homology and the homology of the RBD domains of the proteins. The correlations with the other protein domains were significant lower. …”
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4431por Zhou, Hong, Chen, Xing, Hu, Tao, Li, Juan, Song, Hao, Liu, Yanran, Wang, Peihan, Liu, Di, Yang, Jing, Holmes, Edward C., Hughes, Alice C., Bi, Yuhai, Shi, Weifeng“…In contrast, RmYN02 showed low sequence identity (61.3%) to SARS-CoV-2 in the receptor-binding domain (RBD) and might not bind to angiotensin-converting enzyme 2 (ACE2). …”
Publicado 2020
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4432por Weiss, Svenja, Klingler, Jéromine, Hioe, Catarina, Amanat, Fatima, Baine, Ian, Kojic, Erna Milunka, Stoever, Jonathan, Liu, Sean, Jurczyszak, Denise, Bermudez-Gonzalez, Maria, Simon, Viviana, Krammer, Florian, Zolla-Pazner, Susan“…Fluorochrome-labeled beads were coated with a recombinant soluble stabilized trimeric SARS-CoV-2 S protein ectodomain or its central portion, the receptor binding domain (RBD). Coated beads were incubated with sera, followed by incubation with biotinylated anti-human total Ig antibodies and phycoerythrin (PE)-labeled streptavidin. …”
Publicado 2020
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4433por Kim, Jun-Sub, Jang, Jun-Hyeong, Kim, Jeong-Min, Chung, Yoon-Seok, Yoo, Cheon-Kwon, Han, Myung-Guk“…In the receptor-binding domain (RBD) of the S gene, 11 non-synonymous mutations were observed in the region adjacent to the angiotensin converting enzyme 2 (ACE2) binding site. …”
Publicado 2020
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4434“…Furthermore, none of the antimalarial drugs showed strong binding affinity for either protease or the receptor binding domain (RBD).…”
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4435“…Thereto, high throughput virtual screening approach was used to investigate FDA approved LOPAC library drugs against both the receptor binding domain of spike protein (S-RBD) and ACE2 host cell receptor. Primary screening identified a few promising molecules for both the targets, which were further analyzed in details by their binding energy, binding modes through molecular docking, dynamics and simulations. …”
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4436por Yang, Ren, Lan, Jiaming, Huang, Baoying, A, Ruhan, Lu, Mingqing, Wang, Wen, Wang, Wenling, Li, Wenhui, Deng, Yao, Wong, Gary, Tan, Wenjie“…FINDINGS: We confirmed that SARS-CoV-2 infects cells via angiotensin converting enzyme 2 (ACE2), the functional receptor for SARS-CoV, and we also found that the recombinant receptor binding domain (RBD) of the S protein of SARS-CoV effectively inhibits ppSARS-2 entry in Huh7.5 cells. …”
Publicado 2020
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4437por Wang, Bei, Asarnow, Daniel, Lee, Wen-Hsin, Huang, Ching-Wen, Faust, Bryan, Ng, Patricia Miang Lon, Ngoh, Eve Zi Xian, Bohn, Markus, Bulkley, David, Pizzorno, Andrés, Tan, Hwee Ching, Lee, Chia Yin, Minhat, Rabiatul Adawiyah, Terrier, Olivier, Soh, Mun Kuen, Teo, Frannie Jiuyi, Yeap, Yvonne Yee Chin, Hu, Yuanyu, Seah, Shirley Gek Kheng, Maurer-Stroh, Sebastian, Renia, Laurent, Hanson, Brendon John, Rosa-Calatrava, Manuel, Manglik, Aashish, Cheng, Yifan, Craik, Charles S., Wang, Cheng-I“…Lead antibody 5A6 blocks the receptor binding domain (RBD) of the viral spike from binding to the host receptor angiotensin converting enzyme 2 (ACE2), neutralizes SARS-CoV-2 infection of Vero E6 cells, and reduces viral replication in reconstituted human nasal and bronchial epithelium models. 5A6 has a high occupancy on the viral surface and exerts its neutralization activity via a bivalent binding mode to the tip of two neighbouring RBDs at the ACE2 interaction interface, one in the “up” and the other in the “down” position, explaining its superior neutralization capacity. …”
Publicado 2020
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4438por Zhang, Na-Na, Li, Xiao-Feng, Deng, Yong-Qiang, Zhao, Hui, Huang, Yi-Jiao, Yang, Guan, Huang, Wei-Jin, Gao, Peng, Zhou, Chao, Zhang, Rong-Rong, Guo, Yan, Sun, Shi-Hui, Fan, Hang, Zu, Shu-Long, Chen, Qi, He, Qi, Cao, Tian-Shu, Huang, Xing-Yao, Qiu, Hong-Ying, Nie, Jian-Hui, Jiang, Yuhang, Yan, Hua-Yuan, Ye, Qing, Zhong, Xia, Xue, Xia-Lin, Zha, Zhen-Yu, Zhou, Dongsheng, Yang, Xiao, Wang, You-Chun, Ying, Bo, Qin, Cheng-Feng“…Here, we developed a lipid nanoparticle-encapsulated mRNA (mRNA-LNP) encoding the receptor binding domain (RBD) of SARS-CoV-2 as a vaccine candidate (called ARCoV). …”
Publicado 2020
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4439por Silva-Filho, José Caetano, Melo, Cynthia Germoglio Farias de, Oliveira, Janaína Lima de“…S1 is subdivided in domains S1A (or NTD) and S1B (or RBD), with experimental and in silico studies suggesting that the former binds to sialic acid-containing glycoproteins, such as CD147, whereas the latter binds to ACE2 receptor. …”
Publicado 2020
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4440por Hermann, Wiebke, Schmitz-Peiffer, Henning, Kasper, Elisabeth, Fauser, Mareike, Franke, Christiana, Wienecke, Miriam, Otto, Karolin, Löhle, Matthias, Brandt, Moritz D., Reichmann, Heinz, Storch, Alexander“…RESULTS: We did not detect differences in cognitive performance between patients with and without rapid eye movement (REM) sleep behavior disorder (RBD). Instead, cognitive impairment, particularly affecting cognitive domains attention, executive function/working memory, and semantic memory, was associated with impaired PSG-measured sleep quality (e.g., sleep efficiency) and sleep disordered breathing (SDB) (Apnea-Hypopnea Index > 5/h). …”
Publicado 2020
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