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4461por Shanmugaraj, Balamurugan, Rattanapisit, Kaewta, Manopwisedjaroen, Suwimon, Thitithanyanont, Arunee, Phoolcharoen, Waranyoo“…Both plant-produced mAbs demonstrated specific binding to receptor binding domain (RBD) of SARS-CoV-2 and exhibited efficient virus neutralization activity in vitro. …”
Publicado 2020
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4462por Ren, Lili, Zhang, Lulu, Chang, De, Wang, Junwen, Hu, Yongfeng, Chen, Hong, Guo, Li, Wu, Chao, Wang, Conghui, Wang, Yingying, Wang, Ying, Wang, Geng, Yang, Siyuan, Dela Cruz, Charles S., Sharma, Lokesh, Wang, Linghang, Zhang, Dingyu, Wang, Jianwei“…Here we profiled the humoral response against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by measuring immunoglobulin (Ig) A, IgM, and IgG against nucleocapsid and spike proteins, along with IgM and IgG antibodies against receptor-binding domain (RBD) of the spike protein and total neutralizing antibodies (NAbs). …”
Publicado 2020
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4463por Patil, Rajesh, Chikhale, Rupesh, Khanal, Pukar, Gurav, Nilambari, Ayyanar, Muniappan, Sinha, Saurabh, Prasad, Satyendra, Dey, Yadu Nandan, Wanjari, Manish, Gurav, Shailendra S.“…Molecular docking studies for 15 flavonoids on the three SARS CoV-2 proteins, non-structural protein-15 Endoribonuclease (NSP15), the receptor-binding domain of spike protein (RBD of S protein), and main protease (M(pro)/3CL(pro)) were performed and selected protein-ligand complexes were subjected to Molecular Dynamics simulations. …”
Publicado 2021
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4464por Figueiredo‐Campos, Patrícia, Blankenhaus, Birte, Mota, Catarina, Gomes, Andreia, Serrano, Marta, Ariotti, Silvia, Costa, Catarina, Nunes‐Cabaço, Helena, Mendes, António M., Gaspar, Pedro, Pereira‐Santos, M. Conceição, Rodrigues, Fabiana, Condeço, Jorge, Escoval, M. Antonia, Santos, Matilde, Ramirez, Mario, Melo‐Cristino, José, Simas, J. Pedro, Vasconcelos, Eugenia, Afonso, Ângela, Veldhoen, Marc“…We quantified IgM, IgG, and IgA antibodies recognizing the SARS‐CoV‐2 receptor‐binding domain (RBD) or the Spike (S) protein over a period of 6 months following COVID‐19 onset. …”
Publicado 2020
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4465“…This type of coronavirus binds to the human receptor through the Spike glycoprotein (S) Receptor Binding Domain (RBD). The spike protein is found in inaccessible (closed) or accessible (open) conformations in which the accessible conformation causes severe infection. …”
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4466por Lucas, Carolina, Klein, Jon, Sundaram, Maria, Liu, Feimei, Wong, Patrick, Silva, Julio, Mao, Tianyang, Oh, Ji Eun, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Park, Annsea, Israelow, Benjamin, Wyllie, Anne L., Vogels, Chantal B. F., Muenker, M. Catherine, Casanovas-Massana, Arnau, Schulz, Wade L., Zell, Joseph, Campbell, Melissa, Fournier, John B., Grubaugh, Nathan D., Farhadian, Shelli, Wisnewski, Adam V., Cruz, Charles Dela, Omer, Saad, Ko, Albert I., Ring, Aaron, Iwasaki, Akiko“…However, they mounted a robust, yet delayed response, measured by anti-S, anti-RBD IgG, and neutralizing antibody (NAb) levels, compared to survivors. …”
Publicado 2020
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4467por Kaur, Satinder, Kaur, Jaspreet, Mavi, G. S., Dhillon, Guriqbal Singh, Sharma, Achla, Singh, Rohtas, Devi, Urmila, Chhuneja, Parveen“…In the background of PBW343 and PBW550, an increase in TGW upto 27.34 and 18% was observed, respectively (with respect to recipient parents), through conventional backcross breeding with phenotypic selections in 3 years replicated RBD trials. Resistance to leaf rust and stripe rust has been incorporated in the high TGW version of PBW550 through marker assisted pyramiding of stripe rust resistance gene Yr15 using marker Xuhw302, and a pair of linked leaf rust and stripe rust resistance genes Lr57-Yr40 using marker Ta5DS-2754099_kasp23. …”
Publicado 2020
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4468por Baisa, Gary, Rancour, David, Mansfield, Keith, Burns, Monika, Martin, Lori, Cunha, Daise, Fischer, Jessica, Muecksch, Frauke, Hatziioannou, Theodora, Bieniasz, Paul D., Schomburg, Fritz, Luke, Kimberly“…Sera from animals immunized with antigens derived from the RBD were able to prevent binding of soluble spike proteins to the ACE2 receptor, shown by in vitro binding assays, while sera from animals immunized with the N-terminal domain alone lacked this activity. …”
Publicado 2021
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4469por Calcagnile, Matteo, Forgez, Patricia, Iannelli, Antonio, Bucci, Cecilia, Alifano, Marco, Alifano, Pietro“…HDOCK and FireDock simulations identified 6 ACE2 missense variants (I21T, A25T, K26R, E37K, T55A, E75G) with higher affinity for SARS-CoV-2 Spike protein receptor binding domain (RBD) with respect to wild type ACE2, and 11 variants (I21V, E23K, K26E, T27A, E35K, S43R, Y50F, N51D, N58H, K68E, M82I) with lower affinity. …”
Publicado 2021
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4470por Oladunni, Fatai S., Park, Jun-Gyu, Chiem, Kevin, Ye, Chengjin, Pipenbrink, Michael, Walter, Mark R., Kobie, James, Martinez-Sobrido, Luis“…Studies investigating natural or mNAb-induced antigenic variability in the receptor binding domain (RBD) of SARS-CoV-2 Spike (S) glycoprotein, and their effects on viral fitness are still rudimentary. …”
Publicado 2021
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4471por Song, Nan, Chen, Lihong, Ren, Xingmei, Waterfield, Nicholas R., Yang, Jian, Yang, Guowei“…We found that TcdA1 form Photorhabdus luminescens W14 (TcdA1(W14)) can recognize N-glycans via the RBD-D domain, corroborating previous findings. Knockout of N-glycan processing enzymes specifically blocks the intoxication of TcdA1(W14)-assembled Tc toxin. …”
Publicado 2021
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4472por Linsky, Thomas W., Vergara, Renan, Codina, Nuria, Nelson, Jorgen W., Walker, Matthew J., Su, Wen, Barnes, Christopher O., Hsiang, Tien-Ying, Esser-Nobis, Katharina, Yu, Kevin, Reneer, Z. Beau, Hou, Yixuan J., Priya, Tanu, Mitsumoto, Masaya, Pong, Avery, Lau, Uland Y., Mason, Marsha L., Chen, Jerry, Chen, Alex, Berrocal, Tania, Peng, Hong, Clairmont, Nicole S., Castellanos, Javier, Lin, Yu-Ru, Josephson-Day, Anna, Baric, Ralph S., Fuller, Deborah H., Walkey, Carl D., Ross, Ted M., Swanson, Ryan, Bjorkman, Pamela J., Gale, Michael, Blancas-Mejia, Luis M., Yen, Hui-Ling, Silva, Daniel-Adriano“…The best monovalent decoy, CTC-445.2, bound with low nanomolar affinity and high specificity to the receptor-binding domain (RBD) of the spike protein. Cryo–electron microscopy (cryo-EM) showed that the design is accurate and can simultaneously bind to all three RBDs of a single spike protein. …”
Publicado 2020
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4473por Thomas, Archana, Messer, William B, Hansel, Donna E, Streblow, Daniel N, Kazmierczak, Steven C, Lyski, Zoe L, Lu, Zhengchun, Slifka, Mark K“…METHODS: To overcome these obstacles, we developed a quantitative enzyme-linked immunosorbent assay based on an optimized 2-dimensional screening assay that utilizes SARS-CoV-2 receptor binding domain (RBD) of spike protein and SARS-CoV-2 spike S1 subunit. …”
Publicado 2021
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4474“…In performing target-based ligand screening utilizing the RBD-SARS-CoV-2 sequence, we observed that polyunsaturated fatty acids most effectively interfere with binding to hACE2, the receptor for SARS-CoV-2. …”
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4475por Shen, Xiaoying, Tang, Haili, McDanal, Charlene, Wagh, Kshitij, Fischer, William, Theiler, James, Yoon, Hyejin, Li, Dapeng, Haynes, Barton F., Sanders, Kevin O., Gnanakaran, Sandrasegaram, Hengartner, Nick, Pajon, Rolando, Smith, Gale, Glenn, Gregory M., Korber, Bette, Montefiori, David C.“…A subset of monoclonal antibodies to the receptor binding domain (RBD) of spike are less effective against the variant, while others are largely unaffected. …”
Publicado 2021
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4476por Li, Yang, Ma, Ming-liang, Lei, Qing, Wang, Feng, Hong, Wei, Lai, Dan-yun, Hou, Hongyan, Xu, Zhao-wei, Zhang, Bo, Chen, Hong, Yu, Caizheng, Xue, Jun-biao, Zheng, Yun-xiao, Wang, Xue-ning, Jiang, He-wei, Zhang, Hai-nan, Qi, Huan, Guo, Shu-juan, Zhang, Yandi, Lin, Xiaosong, Yao, Zongjie, Wu, Jiaoxiang, Sheng, Huiming, Zhang, Yanan, Wei, Hongping, Sun, Ziyong, Fan, Xionglin, Tao, Sheng-ce“…Unexpectedly, we find that the receptor binding domain (RBD) lacks linear epitope. We reveal that the number of responsive peptides is highly variable among patients and correlates with disease severity. …”
Publicado 2021
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4477por Prompetchara, Eakachai, Ketloy, Chutitorn, Tharakhet, Kittipan, Kaewpang, Papatsara, Buranapraditkun, Supranee, Techawiwattanaboon, Teerasit, Sathean-anan-kun, Suwitra, Pitakpolrat, Patrawadee, Watcharaplueksadee, Supaporn, Phumiamorn, Supaporn, Wijagkanalan, Wassana, Patarakul, Kanitha, Palaga, Tanapat, Ruxrungtham, Kiat“…However, only the sera from mice vaccinated with pCMKkan-S or -S1 DNA vaccines could inhibit viral RBD and ACE2 interaction. The highest neutralizing antibody (NAb) titer was found in pCMVkan-S group, followed by -S1, while -S2 showed the lowest PRNT50 titers. …”
Publicado 2021
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4478por Sokal, Aurélien, Chappert, Pascal, Barba-Spaeth, Giovanna, Roeser, Anais, Fourati, Slim, Azzaoui, Imane, Vandenberghe, Alexis, Fernandez, Ignacio, Meola, Annalisa, Bouvier-Alias, Magali, Crickx, Etienne, Beldi-Ferchiou, Asma, Hue, Sophie, Languille, Laetitia, Michel, Marc, Baloul, Samia, Noizat-Pirenne, France, Luka, Marine, Mégret, Jérôme, Ménager, Mickaël, Pawlotsky, Jean-Michel, Fillatreau, Simon, Rey, Felix A., Weill, Jean-Claude, Reynaud, Claude-Agnès, Mahévas, Matthieu“…While highly mutated memory B cells, including pre-existing cross-reactive seasonal Betacoronavirus-specific clones, were recruited early in the response, neutralizing SARS-CoV-2 RBD-specific clones accumulated with time and largely contributed to the late, remarkably stable, memory B cell pool. …”
Publicado 2021
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4479por Klaus, Julia, Meli, Marina L., Willi, Barbara, Nadeau, Sarah, Beisel, Christian, Stadler, Tanja, Egberink, Herman, Zhao, Shan, Lutz, Hans, Riond, Barbara, Rösinger, Nina, Stalder, Hanspeter, Renzullo, Sandra, Hofmann-Lehmann, Regina“…The infection of Cat 1 was confirmed by positive SARS-CoV-2 S1 receptor binding domain (RBD) antibody testing and neutralizing activity in a surrogate assay. …”
Publicado 2021
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4480por Klaus, Julia, Palizzotto, Carlo, Zini, Eric, Meli, Marina L., Leo, Chiara, Egberink, Herman, Zhao, Shan, Hofmann-Lehmann, Regina“…Five and six months after positive molecular results, the serological testing substantiated the presence of a SARS-CoV-2 infection in the cat with the detection of anti-SARS-CoV-2 receptor binding domain (RBD) immunoglobulin (IgG) antibodies and neutralizing activity in a surrogate virus neutralization assay (sVNT). …”
Publicado 2021
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