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4501por Riahi, Saleh, Lee, Jae Hyeon, Wei, Shuai, Cost, Robert, Masiero, Alessandro, Prades, Catherine, Olfati-Saber, Reza, Wendt, Maria, Park, Anna, Qiu, Yu, Zhou, Yanfeng“…Structures of variable fragment (Fv) in complex with receptor binding domain (RBD) from SARS-CoV or SARS-CoV-2 were subjected to our established in silico antibody engineering platform to improve their binding affinity to SARS-CoV-2 and developability profiles. …”
Publicado 2021
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4502por Zollner, Andreas, Watschinger, Christina, Rössler, Annika, Farcet, Maria R., Penner, Agnes, Böhm, Vincent, Kiechl, Sophia J., Stampfel, Gerald, Hintenberger, Rainer, Tilg, Herbert, Koch, Robert, Antlanger, Marlies, Kreil, Thomas R., Kimpel, Janine, Moschen, Alexander R.“…This translated into more efficient neutralisation of virus particles, even more pronounced than expected from the RBD ELISA results. Furthermore, T cell responses were stronger in convalescents and particularly strong against the SARS-CoV-2 nucleocapsid protein. …”
Publicado 2021
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4503por Jörrißen, Philipp, Schütz, Paula, Weiand, Matthias, Vollenberg, Richard, Schrempf, Inga Marie, Ochs, Kevin, Frömmel, Christopher, Tepasse, Phil-Robin, Schmidt, Hartmut, Zibert, Andree“…A fusion protein encoding major parts of RBD also showed higher rates of recognition during acute (50.0%) and lower rates in the convalescent phase (23.3%). …”
Publicado 2021
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4504por Abrego-Martinez, Juan Carlos, Jafari, Maziar, Chergui, Siham, Pavel, Catalin, Che, Diping, Siaj, Mohamed“…The aptasensor relies on an aptamer targeting the receptor-binding domain (RBD) in the spike protein (S-protein) of the SARS-CoV-2. …”
Publicado 2022
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4505por Sun, Cheng-Pu, Jan, Jia-Tsrong, Wang, I-Hsuan, Ma, Hsiu-Hua, Ko, Hui-Ying, Wu, Ping-Yi, Kuo, Tzu-Jiun, Liao, Hsin-Ni, Lan, Yu-Hua, Sie, Zong-Lin, Chen, Yen-Hui, Ko, Yi-An, Liao, Chun-Che, Chen, Liang-Yu, Lee, I-Jung, Tsung, Szu-I, Lai, Yun-Ju, Chiang, Ming-Tsai, Liang, Jian-Jong, Liu, Wen-Chun, Wang, Jing-Rong, Yuan, Joyce Pei-Yi, Lin, Yin-Shiou, Tsai, Yi-Ching, Hsieh, Shie-Liang, Li, Chia-Wei, Wu, Han-Chung, Ko, Tai-Ming, Lin, Yi-Ling, Tao, Mi-Hua“…The efficacy of a novel therapeutic antibody cocktail RBD-chAbs for COVID-19 was tested and confirmed by using this AAV/hACE2 mouse model, further demonstrating its successful application in drug development.…”
Publicado 2021
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4506por Struck, Friedhelm, Schreiner, Patrick, Staschik, Eva, Wochinz‐Richter, Karin, Schulz, Sarah, Soutschek, Erwin, Motz, Manfred, Bauer, Georg“…We confirm and extend data on incomplete avidity maturation of IgG toward severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) nucleoprotein (NP), spike protein‐1 (S1), and its receptor‐binding domain (RBD) in coronavirus disease 2019 (COVID‐19) patients. …”
Publicado 2021
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4507por Broszeit, Frederik, van Beek, Rosanne J., Unione, Luca, Bestebroer, Theo M., Chapla, Digantkumar, Yang, Jeong-Yeh, Moremen, Kelley W., Herfst, Sander, Fouchier, Ron A. M., de Vries, Robert P., Boons, Geert-Jan“…Computational analysis of HAs in complex with sialosides having extended LacNAc moieties reveals that mutations distal to the RBD reoriented the Y159 side chain resulting in an extended receptor binding site.…”
Publicado 2021
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4508por Fenwick, Craig, Turelli, Priscilla, Perez, Laurent, Pellaton, Céline, Esteves-Leuenberger, Line, Farina, Alex, Campos, Jérémy, Lana, Erica, Fiscalini, Flurin, Raclot, Charlène, Pojer, Florence, Lau, Kelvin, Demurtas, Davide, Descatoire, Marc, Joo, Victor S., Foglierini, Mathilde, Noto, Alessandra, Abdelnabi, Rana, Foo, Caroline S., Vangeel, Laura, Neyts, Johan, Du, Wenjuan, Bosch, Berend-Jan, Veldman, Geertruida, Leyssen, Pieter, Thiel, Volker, LeGrand, Roger, Lévy, Yves, Trono, Didier, Pantaleo, Giuseppe“…Structural characterization of P5C3 Fab in complex with the spike demonstrates a neutralizing activity defined by a large buried surface area, highly overlapping with the receptor-binding domain (RBD) surface necessary for ACE2 interaction. We further demonstrate that P5C3 shows complete prophylactic protection in the SARS-CoV-2-infected hamster challenge model. …”
Publicado 2021
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4509por Lijeskić, Olivera, Klun, Ivana, Stamenov Djaković, Marija, Gligorić, Nenad, Štajner, Tijana, Srbljanović, Jelena, Djurković-Djaković, Olgica“…We here present the rates of detection and levels of antibodies specific for the SARS-CoV-2 spike protein RBD (receptor binding domain) elicited by four vaccines available in Serbia, including BNT-162b2 (BioNTech/Pfizer), BBIBP-CorV (Sinopharm), Gam-COVID-Vac (Gamaleya Research Institute) and ChAdOx1-S (AstraZeneca), compared with those after documented COVID-19, at 6 weeks and 3 months post first vaccine dose or post-infection. …”
Publicado 2021
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4510por Guo, Yong, Meng, Jie-Ru, Liu, Jia-Zheng, Xu, Ting, Zheng, Zhi-Yuan, Jiang, Zhi-Hong, Bai, Li-Ping“…A competitive ELISA assay confirmed the inhibitory effect of 6p on SARS-CoV-2 spike RBD’s binding with ACE2. Importantly, 6a and 6p (TC(50) > 100 μM) also had higher biological safety for host cells than honokiol (TC(50) of 48.23 μM). …”
Publicado 2021
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4511por Salvaggio, Marcello, Fusina, Federica, Albani, Filippo, Salvaggio, Maurizio, Beschi, Rasula, Ferrari, Emanuela, Costa, Alberto, Agnoletti, Laura, Facchi, Emanuela, Natalini, Giuseppe“…Data were retrospectively collected from the clinical documentation of 337 healthcare workers who underwent SARS-CoV-2 testing before and after BNT162b2. Total anti RBD (receptor-binding domain) antibodies against SARS-CoV-2′s spike protein were measured before and 21 days after the first dose, and 12 days after the second dose of BNT162b2. …”
Publicado 2021
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4512por Patel, Ami, Walters, Jewell N., Reuschel, Emma L., Schultheis, Katherine, Parzych, Elizabeth, Gary, Ebony N., Maricic, Igor, Purwar, Mansi, Eblimit, Zeena, Walker, Susanne N., Guimet, Diana, Bhojnagarwala, Pratik, Adeniji, Opeyemi S., Doan, Arthur, Xu, Ziyang, Elwood, Dustin, Reeder, Sophia M., Pessaint, Laurent, Kim, Kevin Y., Cook, Anthony, Chokkalingam, Neethu, Finneyfrock, Brad, Tello-Ruiz, Edgar, Dodson, Alan, Choi, Jihae, Generotti, Alison, Harrison, John, Tursi, Nicholas J., Andrade, Viviane M., Dia, Yaya, Zaidi, Faraz I., Andersen, Hanne, Abdel-Mohsen, Mohamed, Lewis, Mark G., Muthumani, Kar, Kim, J. Joseph, Kulp, Daniel W., Humeau, Laurent M., Ramos, Stephanie J., Smith, Trevor R.F., Weiner, David B., Broderick, Kate E.“…Vaccination with INO-4800 induced T cell responses and induced spike antigen and RBD binding antibodies with ADCP and ADCD activity. …”
Publicado 2021
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4513“…BACKGROUND: Measurement of anti-SARS-CoV-2 RBD Ig G antibody response is very important to define the dynamics of immunization in vaccine COVID-19 recipients. …”
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4514por Reyes, Raphael A., Clarke, Kathleen, Gonzales, S. Jake, Cantwell, Angelene M., Garza, Rolando, Catano, Gabriel, Tragus, Robin E., Patterson, Thomas F., Bol, Sebastiaan, Bunnik, Evelien M.“…Using high-parameter spectral flow cytometry, we analyzed the phenotype of memory B cells with reactivity against the SARS-CoV-2 spike protein or the spike receptor binding domain (RBD) in recovered individuals who had been hospitalized with non-severe (n=8) or severe (n=5) COVID-19. …”
Publicado 2021
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4515por Lam, Brandon, Kung, Yu Jui, Lin, John, Tseng, Ssu-Hsueh, Tsai, Ya Chea, He, Liangmei, Castiglione, Gianni, Egbert, Emily, Duh, Elia J., Bloch, Evan M., Tobian, Aaron A.R., Milstone, Aaron M., Roden, Richard B.S., Wu, Tzyy-Choou, Hung, Chien-Fu“…Human coronavirus disease 2019 (COVID-19)+ or vaccinated antibody isotypes, titers, variant receptor binding domain (RBD) binding, and neutralization potential are studied, revealing numerous significant correlations. …”
Publicado 2021
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4516por Moerman, Alena, Vernelen, Kris, China, Bernard, Capron, Arnaud, Bossche, Dorien Van Den, Mariën, Joachim, Ariën, Kevin K., Van Acker, Jos, Delforge, Marie-Luce, Reynders, Marijke, Boel, An, Depypere, Melissa, Van Gasse, Natasja, Vijgen, Sara, Brauner, Jonathan, Dujardin, Barbara, Padalko, Elizaveta“…All tests against S1/S2 (Liaison, Diasorin) resulted in a signal above cutoff. Assays against RBD, mostly generate a negative result. An exception are the Wantai SARS-CoV-2 ELISA's. …”
Publicado 2022
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4517por Ciabattini, Annalisa, Pastore, Gabiria, Fiorino, Fabio, Polvere, Jacopo, Lucchesi, Simone, Pettini, Elena, Auddino, Stefano, Rancan, Ilaria, Durante, Miriam, Miscia, Michele, Rossetti, Barbara, Fabbiani, Massimiliano, Montagnani, Francesca, Medaglini, Donata“…Spike-specific antibodies peaked 7 days after the second dose and significant antibody titers and ACE2/RBD binding inhibiting activity were still observed after 6 months, despite a progressive decline over time. …”
Publicado 2021
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4518“…INTRODUCTION: We evaluated the Roche Elecsys Anti-SARS-CoV-2 and Snibe SARS-CoV-2 S-RBD IgG spike chemiluminescent immunoassays and compared them to existing Roche/Abbott nucleocapsid and Abbott IgM spike assays. …”
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4519por Bichara, Carlos David Araújo, Queiroz, Maria Alice Freitas, da Silva Graça Amoras, Ednelza, Vaz, Gergiane Lopes, Vallinoto, Izaura Maria Vieira Cayres, Bichara, Cléa Nazaré Carneiro, do Amaral, Isabella Pinheiro Costa, Ishak, Ricardo, Vallinoto, Antonio Carlos Rosário“…The present study evaluated the frequency of seropositivity for anti-SARS-CoV-2 (S1 and S2) total antibodies and anti-SARS-CoV-2 (receptor binding domain-RBD-S1) neutralizing antibodies in individuals vaccinated with the immunizing agent Coronavac. …”
Publicado 2021
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4520por Boon, Siaw Shi, Xia, Chichao, Wang, Maggie Haitian, Yip, Ka Lai, Luk, Ho Yin, Li, Sile, Ng, Rita W. Y., Lai, Christopher K. C., Chan, Paul Kay Sheung, Chen, Zigui“…Through in silico protein structure prediction and immunoinformatics tools, we discovered D614G is the key determinant to S protein conformational change, while variations of N439K, T478I, E484K, and N501Y in S1-RBD also had an impact on S protein binding affinity to hACE2 and antigenicity. …”
Publicado 2021
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