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4521por Chang, Xinyue, Zeltins, Andris, Mohsen, Mona O., Gharailoo, Zahra, Zha, Lisha, Liu, Xuelan, Walton, Senta, Vogel, Monique, Bachmann, Martin F.“…Both CuMV(TT)-FP and CuMV(TT)-DF vaccines induced high levels of high avidity IgG antibodies as well as IgA recognizing spike and RBD in the case of CuMV(TT)-DF. Both vaccine candidates induced virus-neutralizing antibodies indicating that the fusion peptide can independently induce virus-neutralizing antibodies. …”
Publicado 2021
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4522por Sharma, Peeyush, Abrol, Vikas, Sharma, Vikas, Chaddha, Shubham, Srinivasa Rao, Ch., Ganie, A.Q., Ingo Hefft, Daniel, El-Sheikh, Mohamed A., Mansoor, Sheikh“…Each treatment was replicated three times in factorial randomized block design (RBD). The objective of this research was to determine the effects of biochar and compost on soil hydro-physical properties, water use efficiency, monetary returns and yield of knolkhol (Brassica oleracea var. gongyloides L.) under sub-tropics of North West India. …”
Publicado 2021
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4523por Mattioli, Isabela A., Castro, Karla R., Macedo, Lucyano J.A., Sedenho, Graziela C., Oliveira, Mona N., Todeschini, Iris, Vitale, Phelipe M., Ferreira, Suzete Cleusa, Manuli, Erika R., Pereira, Geovana M., Sabino, Ester C., Crespilho, Frank N.“…EEVD uses serologic IgG quantifications on SARS-CoV-2 Receptor Binding Domain (RBD) bioconjugate immobilized onto device surface. …”
Publicado 2022
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4524por Wu, Meng-Li, Liu, Feng-Liang, Sun, Jing, Li, Xin, He, Xiao-Yan, Zheng, Hong-Yi, Zhou, Yan-Heng, Yan, Qihong, Chen, Ling, Yu, Guo-Ying, Chang, Junbiao, Jin, Xia, Zhao, Jincun, Chen, Xin-Wen, Zheng, Yong-Tang, Wang, Jian-Hua“…SARS-CoV-2 challenge induced MC degranulation in ACE-2 humanized mice and rhesus macaques, and a rapid MC degranulation could be recapitulated with Spike-RBD binding to ACE2 in cells; MC degranulation altered various signaling pathways in alveolar epithelial cells, particularly, the induction of pro-inflammatory factors and consequential disruption of tight junctions. …”
Publicado 2021
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4525“…METHODS: The various mutants (MTs) of SpikeS1 receptor binding domain (RBD) of highly infectious SARS-CoV2 strains were manifested and elucidated the protein structure and binding strength using molecular dynamics (MD) simulation and protein-protein docking approaches. …”
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4526por Brockman, Mark A, Mwimanzi, Francis, Lapointe, Hope R, Sang, Yurou, Agafitei, Olga, Cheung, Peter K, Ennis, Siobhan, Ng, Kurtis, Basra, Simran, Lim, Li Yi, Yaseen, Fatima, Young, Landon, Umviligihozo, Gisele, Omondi, F Harrison, Kalikawe, Rebecca, Burns, Laura, Brumme, Chanson J, Leung, Victor, Montaner, Julio S G, Holmes, Daniel, DeMarco, Mari L, Simons, Janet, Pantophlet, Ralph, Niikura, Masahiro, Romney, Marc G, Brumme, Zabrina L“…METHODS: Anti-spike receptor-binding domain (RBD) antibodies, angiotensin-converting enzyme 2 (ACE2) competition, and virus neutralizing activities were assessed in plasma from 151 health care workers and older adults (range, 24–98 years of age) 1 month following the first vaccine dose, and 1 and 3 months following the second dose. …”
Publicado 2021
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4527por Reyes, Raphael A., Clarke, Kathleen, Gonzales, S. Jake, Cantwell, Angelene M., Garza, Rolando, Catano, Gabriel, Tragus, Robin E., Patterson, Thomas F., Bol, Sebastiaan, Bunnik, Evelien M.“…Using high-parameter spectral flow cytometry, we analyzed the phenotype of memory B cells with reactivity against the SARS-CoV-2 spike protein or the spike receptor binding domain (RBD) in recovered individuals who had been hospitalized with non-severe (n = 8) or severe (n = 5) COVID-19. …”
Publicado 2021
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4528por Hossain, Mohammad Enayet, Rahman, Md. Mahfuzur, Alam, Md. Shaheen, Sarmin, Monira, Karim, Yeasir, Hasan, Mehedi, Hoque, Ananya Ferdous, Hasan, Md. Mahmudul, Rahman, Mohammed Ziaur, Chisti, Mohammod Jobayer, Rahman, Mustafizur“…Among them, eight mutations were identified in the receptor-binding domain (RBD). Conclusion: Our findings concern whether the immunity acquired by natural infection or mass vaccination could confer adequate protection against the constantly evolving SARS-CoV-2. …”
Publicado 2021
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4529por Sobitan, Adebiyi, Mahase, Vidhyanand, Rhoades, Raina, Williams, Dejaun, Liu, Dongxiao, Xie, Yixin, Li, Lin, Tang, Qiyi, Teng, Shaolei“…Severe Acute respiratory syndrome coronavirus (SARS-CoV-1) attaches to the host cell surface to initiate the interaction between the receptor-binding domain (RBD) of its spike glycoprotein (S) and the human Angiotensin-converting enzyme (hACE2) receptor. …”
Publicado 2021
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4530por Sivasubramanian, Srinivasan, Gopalan, Vidya, Ramesh, Kiruba, Padmanabhan, Padmapriya, Mone, Kiruthiga, Govindan, Karthikeyan, Velladurai, Selvakumar, Dhandapani, Prabu, Krishnasamy, Kaveri, Kitambi, Satish Srinivas“…Mutation score prediction analyses reveal that there are several mutations in S-protein including the RBD and NTD regions that can influence the virulence of virus. …”
Publicado 2021
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4531por Intapiboon, Porntip, Seepathomnarong, Purilap, Ongarj, Jomkwan, Surasombatpattana, Smonrapat, Uppanisakorn, Supattra, Mahasirimongkol, Surakameth, Sawaengdee, Waritta, Phumiamorn, Supaporn, Sapsutthipas, Sompong, Sangsupawanich, Pasuree, Chusri, Sarunyou, Pinpathomrat, Nawamin“…In the intradermal group after receiving only one fifth of the conventional dosage, serum Anti-RBD IgG was halved compared to the full dose of an intramuscular injection. …”
Publicado 2021
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4532por Greenberg, Ross S., Ruddy, Jake A., Boyarsky, Brian J., Werbel, William A., Garonzik-Wang, Jacqueline M., Segev, Dorry L., Imus, Philip H.“…Among those on MM therapy, 93% developed detectable anti-receptor binding domain (RBD) antibodies after dose 2, while 94% of patients not on MM therapy seroconverted. …”
Publicado 2021
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4533por Wang, Sheng, Liu, Lizhen, Wang, Can, Wang, Ziqiang, Duan, Xuhua, Chen, Gang, Zhou, Hu, Shao, Hong“…Furthermore, the neutralization ability of two antibodies targeted receptor-binding domain (RBD) of SARS-CoV-2 spike protein (S) was evaluated, which showed different inhibition dose–effect curves among four types of S pseudovirus. …”
Publicado 2022
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4534por Tarke, Alison, Coelho, Camila H., Zhang, Zeli, Dan, Jennifer M., Yu, Esther Dawen, Methot, Nils, Bloom, Nathaniel I., Goodwin, Benjamin, Phillips, Elizabeth, Mallal, Simon, Sidney, John, Filaci, Gilberto, Weiskopf, Daniela, da Silva Antunes, Ricardo, Crotty, Shane, Grifoni, Alba, Sette, Alessandro“…In subjects ∼6 months post-vaccination, 90% (CD4(+)) and 87% (CD8(+)) of memory T cell responses were preserved against variants on average by AIM assay, and 84% (CD4(+)) and 85% (CD8(+)) preserved against Omicron. Omicron RBD memory B cell recognition was substantially reduced to 42% compared with other variants. …”
Publicado 2022
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4535por Chen, Gang, Du, Yinzhen, Li, Xue, Kambey, Piniel Alphayo, Wang, Li, Xia, Ying, Tang, Chuanxi, Shi, Mingyu, Zai-li, Li, Zai-e, Xin, Xiao-ling, Qin, Dian-shuai, Gao“…Relative to the nCons-PD group, Cons-Clinic-PD had higher NMSS scores, lower MoCA and PDSS scores, and were more likely to have RBD. Conclusions: GDNF serum levels are lower in patients with PD who are constipated. …”
Publicado 2022
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4536por Maranci, Jean-Baptiste, Nigam, Milan, Masset, Luc, Msika, Eva-Flore, Vionnet, Marie Charlotte, Chaumereil, Charlotte, Vidailhet, Marie, Leu-Semenescu, Smaranda, Arnulf, Isabelle“…To highlight this association, we studied the REM sleep during video-polysomnography of 20 subjects with REM sleep behaviour disorder (RBD), a model of enacted dreams offering direct access to the emotional content of the sleeper (face expression, speeches, behaviour). …”
Publicado 2022
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4537por Qin, Hongbo, Qiu, Hengju, He, Shi-Ting, Hong, Bixia, Liu, Ke, Lou, Fuxing, Li, Maochen, Hu, Pan, Kong, Xianghao, Song, Yujie, Liu, Yuchen, Pu, Mingfang, Han, Pengjun, Li, Mengzhe, An, Xiaoping, Song, Lihua, Tong, Yigang, Fan, Huahao, Wang, Ruixue“…We identified four dominant short-lived reactive species, ONOO(-), (1)O(2), O(2)(-) and·OH, generated in response to CAP and distinguished their roles in the inactivation of GX_P2V and SARS-CoV-2 spike protein receptor binding domain (RBD), which is responsible for recognition and binding to human angiotensin-converting enzyme 2 (hACE2). …”
Publicado 2022
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4538por Saville, James W., Mannar, Dhiraj, Zhu, Xing, Srivastava, Shanti S., Berezuk, Alison M., Demers, Jean-Philippe, Zhou, Steven, Tuttle, Katharine S., Sekirov, Inna, Kim, Andrew, Li, Wei, Dimitrov, Dimiter S., Subramaniam, Sriram“…Compared to wild-type and Kappa lineages, Delta variant spike proteins show modest increase in ACE2 affinity, likely due to enhanced electrostatic complementarity at the RBD-ACE2 interface, which we characterize by cryo-EM. …”
Publicado 2022
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4539por Lázaro-Frías, Adrián, Pérez, Patricia, Zamora, Carmen, Sánchez-Cordón, Pedro J., Guzmán, María, Luczkowiak, Joanna, Delgado, Rafael, Casasnovas, José M., Esteban, Mariano, García-Arriaza, Juan“…High titers of IgG antibodies against S and receptor-binding domain (RBD) proteins and of neutralizing antibodies were induced against parental virus and variants of concern, markers that correlated with protection. …”
Publicado 2022
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4540“…The docking study showed that the multiple epitopes on the IgY-scFv interacted with multiple residues on SARS-CoV-2 S1 RBD to form hydrogen bonds. This preliminary study suggests that IgY and IgY-scFv are suitable candidates for the development of immunoassay and passive immunotherapy for COVID-19 to humans and animals.…”
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