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4541por AlMalki, Faizah A., Albukhaty, Salim, Alyamani, Amal A., Khalaf, Moayad N., Thomas, Sabu“…The viral spike protein (S) significantly contributes to host cell entry, and mutations associated with it, particularly in the receptor-binding protein (RBD), either facilitate the escape of virus from neutralizing antibodies or enhance its transmission by increasing the affinity for cell entry receptor, angiotensin-converting enzyme 2 (ACE2). …”
Publicado 2022
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4542por Girl, Philipp, Zwirglmaier, Katrin, von Buttlar, Heiner, Wölfel, Roman, Müller, Katharina“…We evaluated the performance of four commercially available tests, i.e. two lateral flow assays (Coris BioConcept COVID-19 Sero NP/RBD and Concile InfectCheck COVID-19 NAb) and two surrogate ELISA (sELISA) tests (EUROIMMUN SARS-CoV-2 NeutraLISA and AdipoGen SARS-CoV-2 Neutralizing Antibodies Detection Kit) in comparison with an in-house SARS-CoV-2 micro neutralization test as reference. …”
Publicado 2022
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4543por Chakraborty, Chiranjib, Sharma, Ashish Ranjan, Bhattacharya, Manojit, Lee, Sang-Soo“…Simultaneously we have discussed the significant mutations related to emerging variants and immune escape, such as mutations in the RBD region (N439K, L452R, E484K, N501Y, K444R) and other parts (D614G, P681R) of the S-glycoprotein. …”
Publicado 2022
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4544por Tabynov, Kairat, Turebekov, Nurkeldi, Babayeva, Meruert, Fomin, Gleb, Yerubayev, Toktassyn, Yespolov, Tlektes, Li, Lei, Renukaradhya, Gourapura J., Petrovsky, Nikolai, Tabynov, Kaissar“…The results contrasted with only weak protection seen with a monomeric spike receptor-binding domain (RBD) vaccine even when formulated with the same adjuvant. …”
Publicado 2022
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4545por Đaković Rode, Oktavija, Bodulić, Kristian, Zember, Sanja, Cetinić Balent, Nataša, Novokmet, Anđa, Čulo, Marija, Rašić, Željka, Mikulić, Radojka, Markotić, Alemka“…We studied anti-SARS-CoV-2 Spike RBD IgG levels in 587 healthcare workers (2038 sera) who completed BNT162b2 vaccination. …”
Publicado 2022
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4546por Cheng, Chung-Yi, Fang, Te-Chao, Liao, Hung-Wei, Chen, Tso-Hsiao, Chang, Jer-Hwa, Lin, Yen-Chung, Kao, Chih-Chin, Liu, Ming-Che, Chang, Hui-Wen, Hung, Ching-Sheng, Wang, Jude Chu-Chun, Hsiao, Shih-Hsin, Sue, Yuh-Mou“…Blood tests using an antibody against the receptor-binding domain (RBD) of the S1 subunit of the SARS-CoV-2 spike protein had performed at four designed time points before and after the first and second vaccine. …”
Publicado 2022
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4547Differential escape of neutralizing antibodies by SARS-CoV-2 Omicron and pre-emergent sarbecovirusespor Wang, Lin-Fa, Tan, Chee Wah, Chia, Wan Ni, Zhu, Feng, Young, Barnaby, Chantasrisawad, Napaporn, Hwa, Shi-Hsia, Yeoh, Aileen Ying-Yan, Lim, Beng Lee, Yap, Wee Chee, Pada, Surinder Kaur, Tan, Seow Yen, Jantarabenjakul, Watsamon, Chen, Shiwei, Zhang, Jinyan, Mah, Yun Yan, Chen, Vivian, Chen, Mark, Wacharapluesadee, Supaporn, Putcharoen, Opass, Lye, David“…The SARS-CoV-2 B.1.1.529 lineage, Omicron variant, was first detected in November 2021 and carries 32 amino acid mutations in the spike protein (15 in RBD) and exhibits significant escape of neutralizing antibodies targeting the parental SARS-CoV-2 virus. …”
Publicado 2022
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4548por Liang, Zhihui, Wang, Xin, Yu, Ge, Li, Min, Shi, Shuting, Bao, Hang, Chen, Chen, Fu, Duo, Ma, Wei, Xue, Changying, Sun, Bingbing“…By using hepatitis B surface antigen (HBsAg) virus-like particles (VLPs) or SARS-CoV-2 spike protein receptor-binding domain (RBD) as model antigens, AlOOH nanorods with higher aspect ratio were determined to elicit more potent humoral immune responses, which could be attributed to the enhanced DC activation and the efficient antigen trafficking to the draining lymph nodes. …”
Publicado 2022
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4549por Hauser, Blake M., Sangesland, Maya, St. Denis, Kerri J., Lam, Evan C., Case, James Brett, Windsor, Ian W., Feldman, Jared, Caradonna, Timothy M., Kannegieter, Ty, Diamond, Michael S., Balazs, Alejandro B., Lingwood, Daniel, Schmidt, Aaron G.“…Using glycan engineering and epitope scaffolding in boosting immunogens, we focus murine serum antibody responses to conserved receptor binding motif (RBM) and receptor binding domain (RBD) epitopes following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike imprinting. …”
Publicado 2022
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4550por Tay, Matthew Zirui, Rouers, Angeline, Fong, Siew‐Wai, Goh, Yun Shan, Chan, Yi‐Hao, Chang, Zi Wei, Xu, Weili, Tan, Chee Wah, Chia, Wan Ni, Torres‐Ruesta, Anthony, Amrun, Siti Naqiah, Huang, Yuling, Hor, Pei Xiang, Loh, Chiew Yee, Yeo, Nicholas Kim‐Wah, Wang, Bei, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Chavatte, Jean‐Marc, Lim, Alicia Jieling, Maurer‐Stroh, Sebastian, Wang, Lin‐Fa, Lin, Raymond Valentine Tzer Pin, Wang, Cheng‐I, Tan, Seow‐Yen, Young, Barnaby Edward, Leo, Yee‐Sin, Lye, David C, Renia, Laurent, Ng, Lisa FP“…Vaccine breakthrough cases showed lower memory B cell frequencies against SARS‐CoV‐2 receptor‐binding domain (RBD). Compared to plasma antibodies, antibodies secreted by memory B cells retained a higher fraction of neutralizing properties against the Delta variant. …”
Publicado 2022
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4551por George, Carolin Elizabeth, Inbaraj, Leeberk Raja, Rajukutty, Shon, Joan, Roshni Florina, Suseeladevi, Arun Karthikeyan, Muthuraj, Sangeetha, Chandrasingh, Sindhulina“…We tested samples for the presence of antibodies (including IgG & IgM) to SARS CoV-2 using the Roche Elecsys SARS-CoV-2 –S assay that quantifies antibodies against the receptor-binding domain (RBD) of the spike (S) protein. RESULTS: We estimated an overall prevalence of 62.7% (95% CI: 59.3–66.0) and an age-and gender-adjusted seroprevalence of 44.9% (95% CI: 42.5–47.4). …”
Publicado 2022
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4552por Rodda, Lauren B., Morawski, Peter A., Pruner, Kurt B., Fahning, Mitchell L., Howard, Christian A., Franko, Nicholas, Logue, Jennifer, Eggenberger, Julie, Stokes, Caleb, Golez, Inah, Hale, Malika, Gale, Michael, Chu, Helen Y., Campbell, Daniel J., Pepper, Marion“…We found that following vaccination, previously infected individuals generated more SARS-CoV-2 RBD-specific memory B cells and variant-neutralizing antibodies and a distinct population of IFN-γ and IL-10-expressing memory SARS-CoV-2 spike-specific CD4(+) T cells than previously naive individuals. …”
Publicado 2022
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4553por Zhao, Zhuxiang, Cui, Tingting, Huang, Mingzhu, Liu, Shuo, Su, Xiaoling, Li, Guichang, Song, Tao, Li, Weidong, Zhong, Nanshan, Xu, Miao, Yang, Xiaoyun, Huang, WeiJin, Wang, Zhongfang“…Here, we showed that humoral immunity components, including anti-S + N, anti-RBD IgG, and neutralizing antibodies (NAbs), gradually waned and decreased the neutralizing capacity against emerging Omicron variants at 3 and 6 months after two inactivated COVID-19 vaccinations. …”
Publicado 2022
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4554por Balkan, İlker İnanc, Dinc, Harika Oyku, Can, Gunay, Karaali, Rıdvan, Ozbey, Dogukan, Caglar, Bilge, Beytur, Ayşe Nur, Keskin, Elif, Budak, Beyhan, Aydogan, Okan, Mete, Bilgül, Ergin, Sevgi, Kocazeybek, Bekir, Saltoglu, Nese“…METHODS: The study included 175 HCWs vaccinated with inactive CoronaVac (Sinovac Life Sciences, China) SARS-CoV-2 vaccine in two doses. Anti-spike/RBD IgG levels were measured first, third, and sixth months after the second dose. …”
Publicado 2022
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4555por Oliva-Hernández, Reynaldo, Fariñas-Medina, Mildrey, Hernández-Salazar, Tamara, Oyarzabal-Vera, Ambar, Infante-Bourzac, Juan F., Rodríguez-Salgueiro, Sandra, Rodríguez-Noda, Laura M., Arranguren-Masorra, Yisabel, Climent-Ruíz, Yanet, Fernández-Castillo, Sonsire, G-Rivera, Daniel, Santana-Mederos, Darielys, Sánchez-Ramírez, Belinda, García-Rivera, Dagmar, Valdés-Barbín, Yury, Vérez-Bencomo, Vicente“…Sprague Dawley rats were randomly allocated to three experimental groups: control (receiving physiological saline solution); placebo (receiving all vaccine components except antigens) and vaccine group (receiving three doses of the vaccine candidate, 37.5 µg of RBD) administered intramuscularly in hind limbs at 24 h intervals during three days. …”
Publicado 2022
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4556por Sevenich, Marc, Thul, Elena, Lakomek, Nils-Alexander, Klünemann, Thomas, Schubert, Maren, Bertoglio, Federico, van den Heuvel, Joop, Petzsch, Patrick, Mohrlüder, Jeannine, Willbold, Dieter“…Here, we used a novel and efficient next generation sequencing (NGS) supported phage display strategy for the selection of a set of SARS-CoV-2 receptor binding domain (RBD)-targeting peptide ligands that bind to the target protein with low µM to nM dissociation constants. …”
Publicado 2022
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4557por Gordon-Lipkin, Eliza M., Marcum, Christopher, Kruk, Shannon, Thompson, Elizabeth, Kelly, Sophie E.M., Kalish, Heather, Sadtler, Kaitlyn, McGuire, Peter J.“…Most samples were IgM positive for spike or RBD (70%), indicating that infection was recent. …”
Publicado 2022
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4558por Mooij, Petra, García-Arriaza, Juan, Pérez, Patricia, Lázaro-Frías, Adrian, Verstrepen, Babs E., Böszörményi, Kinga P., Mortier, Daniella, Fagrouch, Zahra, Kiemenyi-Kayere, Gwendoline, Niphuis, Henk, Acar, Roja Fidel, Meijer, Lisette, Stammes, Marieke A., Kondova, Ivanela, Verschoor, Ernst J., GeurtsvanKessel, Corine H., de Bruin, Erwin, Sikkema, Reina S., Luczkowiak, Joanna, Delgado, Rafael, Montenegro, Dolores, Puentes, Eugenia, Rodríguez, Esteban, Bogers, Willy M. J. M., Koopman, Gerrit, Esteban, Mariano“…MVA-S vaccination was well tolerated and induced S and receptor-binding domain (RBD)-binding IgG antibodies and neutralizing antibodies against SARS-CoV-2 and several variants of concern. …”
Publicado 2022
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4559“…We then validate the multiplex platform by detecting the presence of 3 monoclonal antibodies against 3 antigens (2 different hemagglutinins (HAs) from influenza viruses, and the SARS-CoV-2 Spike RBD (receptor binding domain)). We also measure the humoral response in murine sera collected before and after its immunization with the SARS-CoV-2 Spike protein, in good agreement with the results obtained by the ELISA assay. …”
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4560por Li, Yang, Wang, Xi, Shen, Xu-Rui, Geng, Rong, Xie, Nan, Han, Jun-Feng, Zhang, Qing-Miao, Shi, Zheng-Li, Zhou, Peng“…We did four-time points sampling per subject to precisely understand the kinetics of durability of SARS-CoV-2 circulating antibodies. We found that the RBD IgG levels likely reach a stable plateau at around 6 months, albeit it is waning at the first 6 months after infection. …”
Publicado 2022
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