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441por Amouzadeh Tabrizi, Mahmoud, Fernández-Blázquez, Juan P., Medina, Dahiana Mojena, Acedo, Pablo“…During the fabrication process, the SARS-CoV-2-RBD molecules were embedded in the polymer matrix. …”
Publicado 2022
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442por Salinas, Facundo, Marelli, Belkis E., Sanguineti, Santiago, Goldbaum, Fernando, Muñoz, Luciana, Etchevers, Lucas, Silvestrini, Paula, Notaro, Ulises S., Salvetti, Natalia R., Zylberman, Vanesa, Ortega, Hugo H.“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has required the urgent development of new therapies, among which passive immunotherapy is contemplated. CoviFab (INM005) is a RBD-specific F(ab′)2 fragment derived from equine polyclonal antibodies. …”
Publicado 2022
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443por Blanco, Omar R., Dorta, Dayamí, Hernández, Carlos A., Abreu, Daymí, Domínguez, Andy G., Luna, Yaramis, Valdivia, Onel, Pérez-Bernal, Maylín, Tamayo, Celia, Lemos, Gilda, Pasarón, Ivis M., Pérez, Joel J., Benítez, Liudmila, Bequet-Romero, Mónica, Fragas, Anitza, Cabrera, Yeosvany, Pérez, Enrique R.“…In this work, nine murine MAbs against the RBD of the SARS-CoV-2 spike protein were obtained by hybridoma technology. …”
Publicado 2022
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444por Mamedov, Tarlan, Yuksel, Damla, Ilgın, Merve, Gürbüzaslan, Irem, Gulec, Burcu, Mammadova, Gulshan, Ozdarendeli, Aykut, Yetiskin, Hazel, Kaplan, Busra, Islam Pavel, Shaikh Terkis, Uygut, Muhammet Ali, Hasanova, Gulnara“…Recently, we successfully produced receptor-binding domain (RBD) variants in the Nicotiana benthamiana plant as promising vaccine candidates against COVID-19 and demonstrated that mice immunized with these antigens elicited a high titer of RBD-specific antibodies with potent neutralizing activity against SARS-CoV-2. …”
Publicado 2021
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445por Tani, Chiara, Pratesi, Federico, Talarico, Rosaria, Cardelli, Chiara, Caruso, Teresita, Di Cianni, Federica, Laurino, Elenia, Italiano, Nazzareno, Moretti, Michele, Manca, Maria Laura, Migliorini, Paola, Mosca, Marta“…The aim of this study is to evaluate the immune response elicited by vaccination with mRNA vaccine, testing IgM, IgA and IgG antibodies to SARS-CoV-2 receptor-binding domain (RBD) and measuring neutralising antibodies. METHODS: IgG, IgM and IgA anti-RBD antibodies were measured in 101 patients with SARDs. …”
Publicado 2021
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446“…As it is urgently necessary it is assumed that some blockers/inhibitors of ACE2 could be helpful to resist the binding of viral-spike Receptor-Binding-Domain (RBD). METHODS: Here, conserved RBD from 186-countries were compared with WUHAN-Hu-1 wild-type (CLUSTAL-X2/Pymol). …”
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447por Pérez-Rodríguez, Sonia, de la Caridad Rodríguez-González, Meiby, Ochoa-Azze, Rolando, Climent-Ruiz, Yanet, Alberto González-Delgado, Carlos, Paredes-Moreno, Beatriz, Valenzuela-Silva, Carmen, Rodríguez-Noda, Laura, Perez-Nicado, Rocmira, González-Mugica, Raúl, Martínez-Pérez, Marisel, Sánchez-Ramírez, Belinda, Hernández-García, Tays, Díaz-Machado, Alina, Tamayo-Rodríguez, Maura, Martín-Trujillo, Alis, Rubino-Moreno, Jorman, Suárez-Batista, Anamary, Dubed-Echevarría, Marta, Teresa Pérez-Guevara, María, Amoroto-Roig, Mayté, Chappi-Estévez, Yanet, Bergado-Báez, Gretchen, Pi-Estopiñán, Franciscary, Chen, Guang-Wu, Valdés-Balbín, Yury, García-Rivera, Dagmar, Verez-Bencomo, Vicente“…BACKGROUND: The Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein is the target for many COVID-19 vaccines. …”
Publicado 2022
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448“…Although iRBD and PD without RBD (nRBD-PD) are both α-synucleinopathies, whether they share the same neurodegeneration process is not clear enough. …”
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449por Shahdeo, Deepshikha, Roberts, Akanksha, Archana, G.J., Shrikrishna, Narlawar Sagar, Mahari, Subhasis, Nagamani, K., Gandhi, Sonu“…Here, we report a label free electrochemical Fluorine-Doped Tin Oxide (FTO) Immunosensor coupled with gold nanorods (GNRs) as an electron carrier for ultrasensitive detection of the Receptor Binding Domain (RBD) of SARS CoV-2 Spike protein. The RBD gene was cloned, and expressed in-house with confirmed molecular weight of ∼31 kDa via Sodium Dodecyl Sulphate-Polyacrylamide Gel Electrophoresis (SDS-PAGE) and Matrix-Assisted Laser Desorption/Ionization-Time of Flight (MALDI-TOF). …”
Publicado 2022
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450por Agurto-Arteaga, Andres, Poma-Acevedo, Astrid, Rios-Matos, Dora, Choque-Guevara, Ricardo, Montesinos-Millán, Ricardo, Montalván, Ángela, Isasi-Rivas, Gisela, Cauna-Orocollo, Yudith, Cauti-Mendoza, María de Grecia, Pérez-Martínez, Norma, Gutierrez-Manchay, Kristel, Ramirez-Ortiz, Ingrid, Núñez-Fernández, Dennis, Salguedo-Bohorquez, Mario I., Quiñones-Garcia, Stefany, Fernández Díaz, Manolo, Guevara Sarmiento, Luis A., Zimic, Mirko“…In the present study, IgY antibodies against a recombinant RBD protein of SARS-CoV-2 were produced in specific-pathogen-free chickens and purified from eggs using a biocompatible method. …”
Publicado 2022
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451por Zhao, Zhennan, Zhou, Jingya, Tian, Mingxiong, Huang, Min, Liu, Sheng, Xie, Yufeng, Han, Pu, Bai, Chongzhi, Han, Pengcheng, Zheng, Anqi, Fu, Lutang, Gao, Yuanzhu, Peng, Qi, Li, Ying, Chai, Yan, Zhang, Zengyuan, Zhao, Xin, Song, Hao, Qi, Jianxun, Wang, Qihui, Wang, Peiyi, Gao, George F.“…Furthermore, we found that S371L, S373P and S375F substitutions enhance the stability of the one-RBD-up conformation to prevent exposing more up-RBDs triggered by ACE2 binding. …”
Publicado 2022
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452por Hadni, Hanine, Fitri, Asmae, Benjelloun, Adil Touimi, Benzakour, Mohammed, Mcharfi, Mohammed“…With this in mind, Molecular docking of 26 natural compounds belonging to the flavonoid family with the 3CLpro and RBD sites of SARS-CoV-2 has been performed. The docking results revealed that the ligands Silibinin, Tomentin A, Tomentin B, 4′-O-methyldiplacone, Hesperidin Amentoflavone and Bilobetin act as a potential inhibitor of SARS-CoV-2 3CLpro, and that the ligands Herbacetin, Morin, Silibinin, Tomentin E, Amentoflavone, Bilobetin, Baicalein and Quercetin can be potential inhibitors of SARS-CoV-2 RBD. …”
Publicado 2022
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453
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454por Liu, Yu, Zhao, Danhua, Wang, Yichang, Chen, Zhian, Yang, Li, Li, Wenjuan, Gong, Yanqiu, Gan, Chunmei, Tang, Jieshi, Zhang, Tizhong, Tang, Dan, Dong, Xiuju, Yang, Qingzhe, Valencia, C. Alexander, Dai, Lunzhi, Qi, Shiqian, Dong, Biao, Chow, Hoi Yee, Li, Yuhua“…The wild-type RBD (wtRBD) protein was overexpressed in Pichia pastoris, and the purified protein was used as the antigen to immunize mice after formulating an aluminium hydroxide (Alum) adjuvant. …”
Publicado 2022
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455por Sherwani, Subuhi, Raafat, Mohamed, Rajendrasozhan, Saravanan, Khan, Mahvish, Saleem, Mohd, Husain, Qayyum, Khan, Saif, Alam, Noor, Khan, Mohd Wajid Ali“…Autoantibodies against in vitro reactive oxygen species (ROS) modified BSA and Lys as well as antibodies against receptor binding domain subunit S1 (S1-RBD) (S1-RBD-Abs) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were estimated using direct binding and competition ELISA. …”
Publicado 2022
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456“…METHODS: In this review, the structural details of ACE2, RBD and their interactions are discussed. In addition, some critical mutations of RBD and their impact on ACE2-RBD interactions are also discussed. …”
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457por Caruso, Teresita, Salani, Francesca, Catanese, Silvia, Pratesi, Federico, Mercinelli, Chiara, Motta, Giuseppe, Genovesi, Virginia, Bonato, Adele, Sara, Galimberti, Masi, Gianluca, Migliorini, Paola“…IgM and IgA anti-RBD antibodies were also produced in 5.3% and 21% cancer patients, respectively. …”
Publicado 2023
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458
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459por Chen, Qian, Du, Pei, Han, Yuxuan, Ma, Xuehui, Zhang, Rong, Rong, Xiaoyu, Zhao, Xu, Ma, Renyi, Yang, Huiting, Zheng, Anqi, Huang, Qingrui, Yan, Jinghua, Wang, Hui, Zhao, Xin, Dai, Lianpan, Gao, George F., Wang, Qihui“…Previously, we developed a coronavirus disease 2019 (COVID-19) protein subunit vaccine ZF2001® based on the tandem homo-prototype receptor-binding domain (RBD)-dimer of the SARS-CoV-2 spike protein. We upgraded the antigen into a hetero-chimeric prototype (PT)-Beta or Delta-BA.1 RBD-dimer to broaden the cross-protection efficacy and prove its efficiency with protein subunit and mRNA vaccine platforms. …”
Publicado 2023
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460por Kelaidonis, Konstantinos, Ligielli, Irene, Letsios, Spiros, Vidali, Veroniki P., Mavromoustakos, Thomas, Vassilaki, Niki, Moore, Graham J., Hoffmann, Weronika, Węgrzyn, Katarzyna, Ridgway, Harry, Chasapis, Christos T., Matsoukas, John M.“…The primary goal of this study was to investigate the role of tetrazole in binding and the network of amino acids of SARS-CoV-2 Spike RBD-ACE2 complex involved in interactions with sartans. …”
Publicado 2023
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