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4581por Peddireddy, Sai Preetham, Rahman, Syed A., Cillo, Anthony R., Vijay, Godhev Manakkat, Somasundaram, Ashwin, Workman, Creg J., Bain, William, McVerry, Bryan J., Methe, Barbara, Lee, Janet S., Ray, Prabir, Ray, Anuradha, Bruno, Tullia C., Vignali, Dario A.A., Kitsios, Georgios D., Morris, Alison, Singh, Harinder, Sarkar, Aniruddh, Das, Jishnu“…The profiles included canonical (spike [S], receptor-binding domain [RBD], and nucleocapsid [N]) and non-canonical (orf3a, orf8, nsp3, nsp13, and membrane [M]) antigenic specificities. …”
Publicado 2022
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4582por Petrone, Linda, Tortorella, Carla, Aiello, Alessandra, Farroni, Chiara, Ruggieri, Serena, Castilletti, Concetta, Meschi, Silvia, Cuzzi, Gilda, Vanini, Valentina, Palmieri, Fabrizio, Prosperini, Luca, Haggiag, Shalom, Galgani, Simona, Grifoni, Alba, Sette, Alessandro, Gasperini, Claudio, Nicastri, Emanuele, Goletti, Delia“…Anti-Receptor Binding Domain (RBD) IgG were also evaluated. RESULTS: No significant differences were found comparing the IFN-γ-specific immune response between MS and “no MS” subjects to the ancestral (P = 0.62) or Delta peptide pools (P = 0.68). …”
Publicado 2022
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4583por Durstenfeld, Matthew S., Peluso, Michael J., Kelly, J. Daniel, Win, Sithu, Swaminathan, Shreya, Li, Danny, Arechiga, Victor M., Zepeda, Victor, Sun, Kaiwen, Shao, Shirley, Hill, Christopher, Arreguin, Mireya I., Lu, Scott, Hoh, Rebecca, Tai, Viva, Chenna, Ahmed, Yee, Brandon C., Winslow, John W., Petropoulos, Christos J., Kornak, John, Henrich, Timothy J., Martin, Jeffrey N., Deeks, Steven G., Hsue, Priscilla Y.“…Among adults more than 8 weeks after SARS-CoV-2 infection, SARS-CoV-2 RBD antibodies, markers of inflammation, and, possibly, pericardial effusions are associated with cardiopulmonary symptoms. …”
Publicado 2022
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4584por Pietrasanta, Carlo, Darwich, Abbass, Ronchi, Andrea, Crippa, Beatrice, Spada, Elena, Mosca, Fabio, Pugni, Lorenza, Rescigno, Maria“…Here, we quantified anti-S and anti-RBD IgG, IgA, IgA1, and IgA2 in maternal serum, maternal saliva, BM, infant buccal swabs, and infant feces up to 90 days after the second maternal vaccine dose. …”
Publicado 2022
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4585por Yu, Ge, Liang, Zhihui, Yu, Zilan, Li, Min, Yang, Wenqi, Zhang, Yawei, Zhao, Yuhang, Yang, Cheng, Xue, Changying, Shi, Li, Sun, Bingbing“…Here, we engineered aluminum oxyhydroxide (AlOOH) nanorods and used a variety of antigens including hepatitis B surface antigen (HBsAg), SARS-CoV-2 spike protein receptor-binding domain (RBD), bovine serum albumin (BSA) and ovalbumin (OVA) to identify the key physicochemical properties of adjuvant that determine the antigen adsorption at the nano-bio interface between selected antigen and AlOOH nanorod adjuvant. …”
Publicado 2022
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4586por Maeda, Ryota, Fujita, Junso, Konishi, Yoshinobu, Kazuma, Yasuhiro, Yamazaki, Hiroyuki, Anzai, Itsuki, Watanabe, Tokiko, Yamaguchi, Keishi, Kasai, Kazuki, Nagata, Kayoko, Yamaoka, Yutaro, Miyakawa, Kei, Ryo, Akihide, Shirakawa, Kotaro, Sato, Kei, Makino, Fumiaki, Matsuura, Yoshiharu, Inoue, Tsuyoshi, Imura, Akihiro, Namba, Keiichi, Takaori-Kondo, Akifumi“…Structural analyses show that the P86 clone targets epitopes that are conserved yet unclassified on the receptor-binding domain (RBD) and contacts the N-terminal domain (NTD). Human antibodies rarely access both regions; consequently, the clone buries hidden crevasses of SARS-CoV-2 spike proteins that go undetected by conventional antibodies.…”
Publicado 2022
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4587por Choudhury, Nila Roy, Trus, Ivan, Heikel, Gregory, Wolczyk, Magdalena, Szymanski, Jacek, Bolembach, Agnieszka, Dos Santos Pinto, Rute Maria, Smith, Nikki, Trubitsyna, Maryia, Gaunt, Eleanor, Digard, Paul, Michlewski, Gracjan“…Surprisingly, previously identified RNA-binding deficient mutant TRIM25ΔRBD and E3 ubiquitin ligase mutant TRIM25ΔRING, which lack E3 ubiquitin ligase activity, still inhibited IAV replication. …”
Publicado 2022
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4588por Kared, Hassen, Wolf, Asia-Sophia, Alirezaylavasani, Amin, Ravussin, Anthony, Solum, Guri, Tran, Trung The, Lund-Johansen, Fridtjof, Vaage, John Torgils, Nissen-Meyer, Lise Sofie, Nygaard, Unni C., Hungnes, Olav, Robertson, Anna H., Næss, Lisbeth Meyer, Trogstad, Lill, Magnus, Per, Munthe, Ludvig A., Mjaaland, Siri“…Individuals with Omicron SARS-CoV-2 breakthrough infections have significantly increased activated SARS-CoV-2 wild type Spike-specific cytotoxic T cells, activated follicular helper (T(FH)) cells, functional T cell responses, boosted humoral responses, and rapid release of Spike and RBD-specific IgG(+) B cell plasmablasts and memory B cells into circulation. …”
Publicado 2022
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4589por Benotmane, Ilies, Gautier-Vargas, Gabriela, Cognard, Noëlle, Olagne, Jérôme, Heibel, Françoise, Braun-Parvez, Laura, Martzloff, Jonas, Perrin, Peggy, Pszczolinski, Romain, Moulin, Bruno, Fafi-Kremer, Samira, Caillard, Sophie“…The study population consisted of 564 KTRs who received at least two doses of the mRNA-1273 vaccine. Anti-RBD IgG titers were quantified one month after each vaccine dose and until six months thereafter. …”
Publicado 2022
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4590por Boongird, Sarinya, Setthaudom, Chavachol, Kitpermkiat, Rungthiwa, Prasongtanakij, Somsak, Srisala, Supanart, Chuengsaman, Piyatida, Nongnuch, Arkom, Assanatham, Montira, Kiertiburanakul, Sasisopin, Malathum, Kumthorn, Phuphuakrat, Angsana, Bruminhent, Jackrapong“…At 6 months, median anti-RBD IgG titers (IQR) significantly declined from baseline in the HD (1741 (1136–3083) BAU/mL vs. 373 (188–607) BAU/mL) and PD (1093 (617–1911) BAU/mL vs. 180 (126–320) BAU/mL) groups, as did the mean percent inhibition of neutralizing antibodies (HD: 96% vs. 81%; PD: 95% vs. 73%) (all p < 0.01). …”
Publicado 2022
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4591por Kruse, Marlen, Altattan, Basma, Laux, Eva-Maria, Grasse, Nico, Heinig, Lars, Möser, Christin, Smith, David M., Hölzel, Ralph“…While binding of the peptide to the full-length spike protein can be observed, the subunits RBD and S1 do not exhibit binding in the employed concentrations. …”
Publicado 2022
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4592por Dacon, Cherrelle, Tucker, Courtney, Peng, Linghang, Lee, Chang-Chun D., Lin, Ting-Hui, Yuan, Meng, Cong, Yu, Wang, Lingshu, Purser, Lauren, Williams, Jazmean K., Pyo, Chul-Woo, Kosik, Ivan, Hu, Zhe, Zhao, Ming, Mohan, Divya, Cooper, Andrew J. R., Peterson, Mary, Skinner, Jeff, Dixit, Saurabh, Kollins, Erin, Huzella, Louis, Perry, Donna, Byrum, Russell, Lembirik, Sanae, Drawbaugh, David, Eaton, Brett, Zhang, Yi, Yang, Eun Sung, Chen, Man, Leung, Kwanyee, Weinberg, Rona S., Pegu, Amarendra, Geraghty, Daniel E., Davidson, Edgar, Douagi, Iyadh, Moir, Susan, Yewdell, Jonathan W., Schmaljohn, Connie, Crompton, Peter D., Holbrook, Michael R., Nemazee, David, Mascola, John R., Wilson, Ian A., Tan, Joshua“…COV44-62 and COV44-79 broadly neutralize alpha and beta coronaviruses, including SARS-CoV-2 Omicron subvariants BA.2 and BA.4/5, albeit with lower potency than RBD-specific antibodies. In crystal structures of Fabs COV44-62 and COV44-79 with the SARS-CoV-2 fusion peptide, the fusion peptide epitope adopts a helical structure and includes the arginine at the S2' cleavage site. …”
Publicado 2022
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4593por Chen, Weixin, Zhang, Lichi, Li, Juan, Bai, Shuang, Wang, Yali, Zhang, Bing, Zheng, Qun, Chen, Meng, Zhao, Wei, Wu, Jiang“…We used live SARS‐CoV‐2 virus neutralizing assay to determine neutralizing ability against the wild‐type strain and 4 variants (Beta, Gamma, Delta and Omicron) and ELISA to quantify SARS‐CoV‐2 RBD‐specific IgG subclasses. The results showed that the 2‐dose primary immunization only achieved low neutralizing ability, while a booster shot can significantly enhance neutralizing ability against the wild‐type strain, Beta, Gamma, Delta and Omicron variants. …”
Publicado 2022
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4594por Chen, Kepan, Fan, Na, Huang, Hai, Jiang, Xin, Qin, Shugang, Xiao, Wen, Zheng, Qian, Zhang, Yupei, Duan, Xing, Qin, Zeyi, Liu, Yongmei, Zeng, Jun, Wei, Yuquan, Song, Xiangrong“…Importantly, the novel vaccines have higher RBD‐specific IgG titers and neutralizing antibody titers than SM‐102‐based DS mRNA vaccine. …”
Publicado 2022
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4595“…Next, we compared raccoons and human ACE-2 residues that are known to serve for binding with SARS-CoV-2 receptor binding domain (RBD). Interestingly, we found only 60% identity on amino acid level, which may have contributed to the absence of SARS-CoV-2 infections in raccoons. …”
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4596por Qu, Kun, Chen, Qiuluan, Ciazynska, Katarzyna A., Liu, Banghui, Zhang, Xixi, Wang, Jingjing, He, Yujie, Guan, Jiali, He, Jun, Liu, Tian, Zhang, Xiaofei, Carter, Andrew P., Xiong, Xiaoli, Briggs, John A. G.“…Analysis of the structures suggests that rigidified domain D in the locked conformations interacts with the hinge to domain C and thereby restrains RBD movement. Structural change in domain D correlates with spike conformational change. …”
Publicado 2022
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4597por Mannar, Dhiraj, Saville, James W., Sun, Zehua, Zhu, Xing, Marti, Michelle M., Srivastava, Shanti S., Berezuk, Alison M., Zhou, Steven, Tuttle, Katharine S., Sobolewski, Michele D., Kim, Andrew, Treat, Benjamin R., Da Silva Castanha, Priscila Mayrelle, Jacobs, Jana L., Barratt-Boyes, Simon M., Mellors, John W., Dimitrov, Dimiter S., Li, Wei, Subramaniam, Sriram“…Further, we provide a comparative analysis of the mutational effects within previously emerged variant spikes and identify the structural role of mutations within the NTD and RBD in evading antibody neutralization. Our analysis shows that the highly mutated Gamma N-terminal domain exhibits considerable structural rearrangements, partially explaining its decreased neutralization by convalescent sera. …”
Publicado 2022
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4598por Vergori, Alessandra, Cozzi Lepri, Alessandro, Cicalini, Stefania, Matusali, Giulia, Bordoni, Veronica, Lanini, Simone, Meschi, Silvia, Iannazzo, Roberta, Mazzotta, Valentina, Colavita, Francesca, Mastrorosa, Ilaria, Cimini, Eleonora, Mariotti, Davide, De Pascale, Lydia, Marani, Alessandra, Gallì, Paola, Garbuglia, AnnaRosa, Castilletti, Concetta, Puro, Vincenzo, Agrati, Chiara, Girardi, Enrico, Vaia, Francesco, Antinori, Andrea“…In order to investigate safety and immunogenicity of SARS-CoV-2 vaccine third dose in people living with HIV (PLWH), we analyze anti-RBD, microneutralization assay and IFN-γ production in 216 PLWH on ART with advanced disease (CD4 count <200 cell/mm(3) and/or previous AIDS) receiving the third dose of a mRNA vaccine (BNT162b2 or mRNA-1273) after a median of 142 days from the second dose. …”
Publicado 2022
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4599por Limbekar, Naina, Pham, Jonathan, Budhiraja, Rohit, Javaheri, Sogol, Epstein, Lawrence J., Batool-Anwar, Salma, Pavlova, Milena“…Comorbidities included obstructive sleep apnea (OSA) (46%), periodic limb movement syndrome (PLMS) (13%), insomnia (19%), Restless leg syndrome (RLS) (9%), epilepsy (4%), and REM behavior disorder (RBD) (9%). Initial treatment strategies include behavioral and safety counseling only (34%), pharmacological treatment (29%), treatment of any comorbidity (28%), and combined treatment of any of the above (9%). …”
Publicado 2022
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4600por Cholette, François, Fabia, Rissa, Harris, Angela, Ellis, Hannah, Cachero, Karla, Schroeder, Lukas, Mesa, Christine, Lacap, Philip, Arnold, Corey, Galipeau, Yannick, Langlois, Marc-André, Colwill, Karen, Gingras, Anne-Claude, McGeer, Allison, Giles, Elizabeth, Day, Jacqueline, Osiowy, Carla, Durocher, Yves, Hankins, Catherine, Mazer, Bruce, Drebot, Michael, Kim, John“…This may be due to our DBS panel which consisted of samples collected from convalescent COVID-19 patients with significant anti-spike, -receptor binding domain (RBD), and -nucleocapsid antibody titers. This study demonstrates that biological specimens collected as DBS coupled with one of several readily available assays are useful for large-scale COVID-19 serosurveillance.…”
Publicado 2022
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