-
4621por Bianchini, Filippo, Crivelli, Virginia, Abernathy, Morgan E., Guerra, Concetta, Palus, Martin, Muri, Jonathan, Marcotte, Harold, Piralla, Antonio, Pedotti, Mattia, De Gasparo, Raoul, Simonelli, Luca, Matkovic, Milos, Toscano, Chiara, Biggiogero, Maira, Calvaruso, Veronica, Svoboda, Pavel, Rincón, Tomás Cervantes, Fava, Tommaso, Podešvová, Lucie, Shanbhag, Akanksha A., Celoria, Andrea, Sgrignani, Jacopo, Stefanik, Michal, Hönig, Vaclav, Pranclova, Veronika, Michalcikova, Tereza, Prochazka, Jan, Guerrini, Giuditta, Mehn, Dora, Ciabattini, Annalisa, Abolhassani, Hassan, Jarrossay, David, Uguccioni, Mariagrazia, Medaglini, Donata, Pan-Hammarström, Qiang, Calzolai, Luigi, Fernandez, Daniel, Baldanti, Fausto, Franzetti-Pellanda, Alessandra, Garzoni, Christian, Sedlacek, Radislav, Ruzek, Daniel, Varani, Luca, Cavalli, Andrea, Barnes, Christopher O., Robbiani, Davide F.“…Antibody sd1.040 binds to subdomain 1, synergizes with antibody rbd.042 for neutralization and, like fp.006 and hr2.016, protects mice when present as bispecific antibody. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4622por Wang, Aiping, Zhu, Xifang, Chen, Yumei, Sun, Yaning, Liu, Hongliang, Ding, Peiyang, Zhou, Jingming, Liu, Yankai, Liang, Chao, Yin, Jiajia, Zhang, Gaiping“…All sera were tested for SARS-CoV-2 IgG antibodies using an indirect enzyme linked immunosorbent assay (ELISA) based on the receptor binding domain (RBD) of spike protein. This late survey takes advantage of the short duration of the serological response in these animals to track recent episode of transmission. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4623por Sharfin Rahman, Monica, De Alwis Watuthanthrige, Nethmi, Chandrarathne, Bhagya M., Page, Richard C., Konkolewicz, Dominik“…Hence, this study provides a detailed view of the effect specific type of modification using a library of polymers with different functionalities in interrupting RBD-ACE2 interaction.…”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4624por Tohari, Taufik Ramdani, Anshori, Isa, Baroroh, Umi, Nugroho, Antonius Eko, Gumilar, Gilang, Kusumawardani, Shinta, Syahruni, Sari, Yuliarto, Brian, Arnafia, Wyanda, Faizal, Irvan, Hartati, Yeni Wahyuni, Subroto, Toto, Yusuf, Muhammad“…The binding activity toward Spike Receptor Binding Domain (RBD) SARS-CoV-2 was confirmed with a spot-test, and the experimental binding free energy of −10.82 kcal/mol was determined using portable SPR spectroscopy. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4625por Davidov, Yana, Indenbaum, Victoria, Atari, Nofar, Kliker, Limor, Tsaraf, Keren, Asraf, Keren, Cohen-Ezra, Oranit, Likhter, Mariya, Mor, Orna, Doolman, Ram, Weiss-Ottolenghi, Yael, Hod, Tammy, Afek, Arnon, Kreiss, Yitshak, Lustig, Yaniv, Regev-Yochay, Gili, Mandelboim, Michal, Ben-Ari, Ziv“…Receptor-binding domain (RBD) IgG and Omicron BA.1 and BA.2 neutralizing antibodies were determined at a median of 132 and 29 days after the third and fourth vaccines. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4626por Ebrahim, Fawzi, Tabal, Salah, Lamami, Yosra, Alhudiri, Inas M., El Meshri, Salah Edin, Al Dwigen, Samira, Arfa, Ramadan, Alboeshi, Asma, Alemam, Hafsa A., Abuhtna, Fauzia, Altrhouni, Rabeeah, Milad, Mohamed B., Elgriw, Nada A., Ruaua, Mahmoud A., Abusrewil, Zakarya, Harroush, Warda, Jallul, Mwada, Ali, Fouziyah S., Eltaib, Farag, Elzagheid, Adam“…We investigated anti-spike RBD IgG antibody responses in 10,000 individuals, both following infection with SARS-CoV-2 and immunization with SARS-COV-2 AstraZeneca, Sputnik V, Sinopharm, and Sinovac. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4627por Wang, Zeng, Zhong, Kunhong, Wang, Guoqing, Lu, Qizhong, Li, Hexian, Wu, Zhiguo, Zhang, Zongliang, Yang, Nian, Zheng, Meijun, Wang, Yuelong, Nie, Chunlai, Zhou, Liangxue, Tong, Aiping“…Finally, pseudotyped S(Fko) particles were successfully used to detect neutralizing antibodies in RBD protein-immunized mouse serum. CONCLUSION: Overall, our study indicates a series of modifications that result in the production of relatively high-titer SARS-COV-2 pseudo-particles that may be suitable for the detection of neutralizing antibodies from COVID-19 patients.…”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4628por El Ouafi, Zainab, Rhalem, Wajih, Habib, Nihal, Idrissi Azami, Abdellah, Sehli, Sofia, Al Idrissi, Najib, Bakkali, Fadil, Abderrazak, Rfaki, Merzouki, Mohamed, Allali, Imane, Amzazi, Saaïd, Nejjari, Chakib, Ghazal, Hassan“…A total of 3 C. sativa active components have been found to bind to the ACE2 protein active site and could inhibit spike binding, although they do not compete directly with the receptor-binding domain (RBD) of SARS-CoV-2. 6-Prenylapigenin, cannabivarin (CBN-C3), and Δ8-tetrahydrocannabinolic acid-A (Δ8-THCA) have a greater affinity (−8.3, −8.3, and −8.0 kcal/mol, respectively) and satisfactory interaction with ACE2 than its inhibitor MLN-4760 (−7.1 kcal/mol). …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4629por Qin, Shugang, Huang, Hai, Xiao, Wen, Chen, Kepan, He, Xi, Tang, Xiaoshan, Huang, Zhiying, Zhang, Yupei, Duan, Xing, Fan, Na, Zheng, Qian, Wu, Min, Lu, Guangwen, Wei, Yuquan, Wei, Xiawei, Song, Xiangrong“…HRBD containing four heterologous RBD (Delta, Beta, Gamma, and Wild-type) can form a stable dodecameric conformation under T4 trimerization tag (Flodon, FD). …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4630por Chevaisrakul, Parawee, Lumjiaktase, Putthapoom, Kietdumrongwong, Pongtorn, Chuatrisorn, Ittiporn, Chatsangjaroen, Pongsan, Phanuphak, Nittaya“…The levels of immunity were not different between patients and close contacts. Anti-RBD IgG against SARS-CoV-2 increased in a dose-dependent manner with the number of vaccine doses. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4631Linear epitope mapping of the humoral response against SARS-CoV-2 in two independent African cohortspor Vigan-Womas, Inès, Spadoni, Jean-Louis, Poiret, Thomas, Taïeb, Fabien, Randrianarisaona, Fanirisoa, Faye, Rokhaya, Mbow, Adji Astou, Gaye, Aboubacry, Dia, Ndongo, Loucoubar, Cheikh, Ny Mioramalala, Diary Juliannie, Ratovoson, Rila, Randremanana, Rindra Vatosoa, Sall, Amadou Alpha, Seydi, Moussa, Noirel, Josselin, Moreau, Gabriel, Simon, Arnaud, Holenya, Pavlo, Meyniel, Jean-Philippe, Zagury, Jean-François, Schoenhals, Matthieu“…We found that the main 36 immunodominant linear epitopes identified were (i) similar in both countries, (ii) distributed mainly in the Spike and the Nucleocapsid proteins, (iii) located outside the RBD and NTD regions where most of the reported SARS-CoV-2 variant mutations occur, and (iv) identical to those reported in European, North American, and Asian studies. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4632por Zhu, Yuanmei, Li, Min, Liu, Nian, Wu, Tong, Han, Xuelian, Zhao, Guangyu, He, Yuxian“…We further showed that LCB1-based inhibitors had similar α-helicity and thermostability in structure and bound to the target-mimic RBD protein with high affinity, and the lipopeptides exhibited greatly enhanced binding with the viral and cellular membranes, improved inhibitory activities against emerging SARS-CoV-2 variants. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4633por Doke, Prakash P., Mhaske, Suhas T., Oka, Gauri, Kulkarni, Ruta, Muley, Vrishali, Mishra, Akhilesh Chandra, Arankalle, Vidya A.“…The receptor binding domain (RBD) sequences from vaccinated (n = 126) and non-vaccinated (n = 168) samples were used for variant analysis. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4634“…In the first, the measured data are integrated directly, for the uncertainty quantification, by means of the random balance design (RBD). In the second step, the generated stochastic data are evaluated in an iterative way to solve friction-induced vibration problem. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4635por Santos da Silva, Eveline, Servais, Jean-Yves, Kohnen, Michel, Arendt, Victor, Gilson, Georges, Staub, Therese, Seguin-Devaux, Carole, Perez-Bercoff, Danielle“…Despite similar levels of anti-Spike and anti-Receptor Binding Domain (RBD) antibodies in all groups, BTI sera had the highest cross-neutralizing ability against all Omicron sublineages and convalescent sera were the least neutralizing. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4636por Mischley, Laurie K., Shankland, Eric, Liu, Sophia Z., Bhayana, Saakshi, Fox, Devon J., Marcinek, David J.“…Exploratory analyses of mitochondrial markers and individual symptoms suggested that higher ATPmax was associated with a greater sense of motivation and engagement and less REM sleep behavior disorder (RBD). ATPmax was not associated with clinical severity or individual symptom(s), years since diagnosis, or quality of life. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4637por Macedo-da-Silva, Janaina, Rosa-Fernandes, Livia, Gomes, Vinicius de Morais, Santiago, Veronica Feijoli, Santos, Deivid Martins, Molnar, Catarina Maria Stanischesk, Barboza, Bruno Rafael, de Souza, Edmarcia Elisa, Marques, Rodolfo Ferreira, Boscardin, Silvia Beatriz, Durigon, Edison Luiz, Marinho, Claudio Romero Farias, Wrenger, Carsten, Marie, Suely Kazue Nagahashi, Palmisano, Giuseppe“…ATE1 and protein arginylation was variant-dependent, as shown using P1 and P2 viral variants and HEK 293T cells transfection with the spike protein and receptor-binding domains (RBD). In addition, we report that ATE1 inhibitors, tannic acid and merbromine (MER) reduce viral load. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4638por Go, Yun Young, Carrai, Maura, Choi, Yan Ru, Brackman, Christopher J., Tam, Karina W. S., Law, Pierra Y. T., Woodhouse, Fiona, Gray, Jane, Kim, Ji Hun, Park, Joohyung, Jeon, Chae Won, Jang, Hyomi, Magouras, Ioannis, Decaro, Nicola, Cheng, Samuel M.S., Peiris, Malik, Beatty, Julia A., Barrs, Vanessa R.“…The discordance between the RBD-ELISA and neutralization tests may indicate possible ELISA cross-reactivity with other coronaviruses, especially in canine sera.…”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4639“…Mutations in the N-terminal domain (NTD) of the spike protein, such as A67V, G142D, and N212I, alter the antigenic structure of Omicron, while mutations in the spike receptor binding domain (RBD), such as R346K, Q493R, and N501Y, increase the affinity for angiotensin-converting enzyme 2 (ACE2). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4640por Rodríguez-Avial, Iciar, García-Salguero, Cristina, Bermejo, Laura, Teja, Juan, Pérez-Cecilia, Elisa, Delgado-Iribarren, Alberto, Vigara, Marta, Gil, Pedro, Culebras, Esther“…METHODS: Vaccine response was evaluated 1, 3 and 6 months after second dose of Pfizer-BioNTech COVID-19 Vaccine and 30 days after booster vaccination. Total anti-RBD (receptor binding domain) IgG immunoglobulins were measured to assess response. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto