-
4641“…Two months later, the patient experienced acute exacerbation after being infected with COVID-19 (anti-SARS-CoV-2 IgG S-RBD >40,000 AU/mL). The oral lesions healed after a month of treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4642por Muñoz-Basagoiti, Jordana, Monteiro, Fábio Luís Lima, Krumpe, Lauren R. H., Armario-Najera, Victoria, Shenoy, Shilpa R., Perez-Zsolt, Daniel, Westgarth, Harrison James, Villorbina, Gemma, Bomfim, Larissa Maciel, Raïch-Regué, Dàlia, Nogueras, Lara, Henrich, Curtis J., Gallemí, Marçal, Moreira, Filipe Romero Rebello, Torres, Pascual, Wilson, Jennifer, D’arc, Mirela, Marfil, Silvia, Herlinger, Alice Laschuk, Pradenas, Edwards, Higa, Luiza Mendonça, Portero-Otin, Manuel, Trinité, Benjamin, Twyman, Richard M., Capell, Teresa, Tanuri, Amilcar, Blanco, Julià, Izquierdo-Useros, Nuria, Rech, Elibio L., Christou, Paul, O’Keefe, Barry R.“…CV-N binds selectively to Spike with a Kd as low as 15 nM and a stoichiometry of 2 CV-N: 1 Spike but does not bind to the receptor binding domain (RBD). Further mapping of CV-N binding sites on Spike shows that select high-mannose oligosaccharides in the S1 domain of Spike are targeted by CV-N. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4643por Ahmed, Mohamed I. M., Plank, Michael, Castelletti, Noemi, Diepers, Paulina, Eser, Tabea M., Rubio-Acero, Raquel, Noreña, Ivan, Reinkemeyer, Christina, Zapf, Dorinja, Hoelscher, Michael, Janke, Christian, Wieser, Andreas, Geldmacher, Christof“…In contrast, the serological assay detected a factor 100-fold lower median Spike-specific RBD antibody concentration in non-vaccinated Omicron infected patients (n = 12) compared to patients from the pre Omicron era (n = 12) at matched time points, and eight individuals remained below the detection threshold for positivity. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4644por Syroeshkin, Anton V., Petrov, Gleb V., Taranov, Viktor V., Pleteneva, Tatiana V., Koldina, Alena M., Gaydashev, Ivan A., Kolyabina, Ekaterina S., Galkina, Daria A., Sorokina, Ekaterina V., Uspenskaya, Elena V., Kazimova, Ilaha V., Morozova, Mariya A., Lebedeva, Varvara V., Cherepushkin, Stanislav A., Tarabrina, Irina V., Syroeshkin, Sergey A., Tertyshnikov, Alexander V., Grebennikova, Tatiana V.“…To verify this assumption, the intrinsic thermal radio emission in the gigahertz range of the following nanoparticles was studied: virus-like particles (VLP) of SARS-CoV-2 and rotavirus A, monoclonal antibodies to various RBD epitopes of SARS-CoV-2, interferon-α, antibodies to interferon-γ, humic–fulvic acids, and silver proteinate. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4645por Ray, Debashish, Laverty, Kaitlin U., Jolma, Arttu, Nie, Kate, Samson, Reuben, Pour, Sara E., Tam, Cyrus L., von Krosigk, Niklas, Nabeel-Shah, Syed, Albu, Mihai, Zheng, Hong, Perron, Gabrielle, Lee, Hyunmin, Najafabadi, Hamed, Blencowe, Benjamin, Greenblatt, Jack, Morris, Quaid, Hughes, Timothy R.“…CCHC-zf domains from seven human proteins recognized specific RNA motifs, indicating that this is a major class of RBD. For Nudix, HABP4, TPR, RanBP2-zf, and L7Ae domains, however, only isolated members or closely related homologs yielded motifs, consistent with RNA-binding as a derived function. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4646por Facciuolo, Antonio, Van Kessel, Jill, Kroeker, Andrea, Liao, Mingmin, Lew, Jocelyne M., Falzarano, Darryl, Kelvin, Alyson A., Gerdts, Volker, Napper, Scott“…Using the Syrian hamster model, we specifically investigated duration of infection acquired immunity to SARS-CoV-2 ancestral Wuhan strain over 12 months. Plasma spike- and RBD-specific IgG titers against ancestral SARS-CoV-2 peaked at 4 months post-infection and showed a modest decline by 12 months. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4647The Immunological Profile of SARS-CoV-2 Infection in Children Is Linked to Clinical Severity and Agepor Vanetti, Claudia, Lampasona, Vito, Stracuzzi, Marta, Fenizia, Claudio, Biasin, Mara, Saulle, Irma, Limanaqi, Fiona, Abdelsalam, Ahmed, Loretelli, Cristian, Paradiso, Laura, Longoni, Emma, Barcellini, Lucia, Piemonti, Lorenzo, Marzinotto, Ilaria, Dispinseri, Stefania, Amendola, Antonella, Fappani, Clara, Tanzi, Elisabetta, Clerici, Mario Salvatore, Scarlatti, Gabriella, Zuccotti, Gian Vincenzo, Giacomet, Vania, Trabattoni, Daria“…We assessed SARS-CoV-2-specific RBD antibodies (Ab), neutralizing antibodies (nAb), and circulating cytokines/chemokines in the plasma, and the SARS-CoV-2-specific immune response was measured in PBMCs by gene expression and secretome analyses. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4648por Salgado, Bárbara Batista, Jordão, Maele Ferreira, de Morais, Thiago Barros do Nascimento, da Silva, Danielle Severino Sena, Pereira Filho, Ivanildo Vieira, Salgado Sobrinho, Wlademir Braga, Carvalho, Nani Oliveira, dos Santos, Rafaella Oliveira, Forato, Julia, Barbosa, Priscilla Paschoal, Toledo-Teixeira, Daniel A., Pinto, Kerollen Runa, Correia, Ingrid Silva, Cordeiro, Isabelle Bezerra, de Souza Neto, Júlio Nino, de Assunção, Enedina Nogueira, Val, Fernando Fonseca Almeida, Melo, Gisely Cardoso, Sampaio, Vanderson de Souza, Monteiro, Wuelton Marcelo, Granja, Fabiana, de Souza, William M., Astolfi Filho, Spartaco, Proenca-Modena, Jose Luiz, Lalwani, Jaila Dias Borges, de Lacerda, Marcus Vinícius Guimarães, Nogueira, Paulo Afonso, Lalwani, Pritesh“…IgA and total IgG antibody reactivity gradually increased after the first week of symptoms. Magnitude of RBD-ACE2 blocking antibodies identified in a competitive assay and neutralizing antibodies detected by PRNT assay correlated with disease severity. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4649“…In sharp contrast to the massive accumulation of mutations within the SARS-CoV-2 receptor-binding domain (RBD), the S2 fusion subunit has remained highly conserved among variants. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4650por Kaku, Chengzi I., Starr, Tyler N., Zhou, Panpan, Dugan, Haley L., Khalifé, Paul, Song, Ge, Champney, Elizabeth R., Mielcarz, Daniel W., Geoghegan, James C., Burton, Dennis R., Andrabi, Raiees, Bloom, Jesse D., Walker, Laura M.“…Here, we track SARS-CoV-2 receptor binding domain (RBD)-specific antibody responses up to six months following Omicron BA.1 breakthrough infection in six mRNA-vaccinated individuals. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4651por Perez-Saez, Javier, Zaballa, María-Eugenia, Lamour, Julien, Yerly, Sabine, Dubos, Richard, Courvoisier, Delphine S., Villers, Jennifer, Balavoine, Jean-François, Pittet, Didier, Kherad, Omar, Vuilleumier, Nicolas, Kaiser, Laurent, Guessous, Idris, Stringhini, Silvia, Azman, Andrew S.“…Here we show that anti-Spike RBD antibody levels, as quantified by the immunoassay used in this study, are an indirect correlate of protection against Omicron BA.1/BA.2 for individuals previously infected by SARS-CoV-2. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4652por Poumbourios, Pantelis, Langer, Christine, Boo, Irene, Zakir, Tasnim, Center, Rob J., Akerman, Anouschka, Milogiannakis, Vanessa, Aggarwal, Anupriya, Johnstone, Bronte A., Ha, Jungmin, Coulibaly, Fasséli, Turville, Stuart G., Drummer, Heidi E.“…The antigens elicited antibody specificities directed to the receptor-binding domain (RBD), N-terminal domain (NTD), fusion peptide and stem region of S2. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4653por Chao, Fa-An, Chan, Albert H., Dharmaiah, Srisathiyanarayanan, Schwieters, Charles D., Tran, Timothy H., Taylor, Troy, Ramakrishnan, Nitya, Esposito, Dominic, Nissley, Dwight V., McCormick, Frank, Simanshu, Dhirendra K., Cornilescu, Gabriel“…High-resolution crystal structures of active KRAS(G13D) and KRAS(G13D)-RAF1 RBD complex provide snapshots of the State 1 and 2 conformations, respectively. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4654por Liu, Nan, Zheng, Liming, Xu, Jie, Wang, Jia, Hu, Cuixia, Lan, Jun, Zhang, Xing, Zhang, Jincan, Xu, Kui, Cheng, Hang, Yang, Zi, Gao, Xin, Wang, Xinquan, Peng, Hailin, Chen, Yanan, Wang, Hong-Wei“…More importantly, we found that the RGO supporting film is particularly useful in cryo-EM reconstruction of sub-100-kDa biomolecules at near-atomic resolution, as exemplified by the study of RBD-ACE2 complex and other small protein molecules. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4655por Patil, Rajashree, Palkar, Sonali, Mishra, Akhileshchandra, Patil, Rahul, Arankalle, Vidya“…These variants possess immune-evasion-associated mutations in the RBD/S region. In conclusion, our data show that the Nab response of patients to multiple variants depends on the infecting variant. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4656“…We observe preferential adsorption of surfactants on cationic arginine and lysine residues in the receptor-binding domain (RBD) that play an important role in ACE2 binding and are present in higher amounts in Delta and Omicron variants, which may lead to blocking direct Spike-ACE2 interactions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4657por Jangra, Sonia, Landers, Jeffrey J., Laghlali, Gabriel, Rathnasinghe, Raveen, Warang, Prajakta, Park, Seok-Chan, O’Konek, Jessica. J., Singh, Gagandeep, Janczak, Katarzyna W., García-Sastre, Adolfo, Arya, Nandini, Karadag, Dilara, Baker, James R., Schotsaert, Michael, Wong, Pamela T.“…We now demonstrate that NE/IVT with the SARS-CoV-2 receptor binding domain (RBD), induces robust and durable humoral, mucosal, and cellular immune responses of equivalent magnitude and quality in young and aged mice. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4658por Belenkaya, Svetlana V., Merkuleva, Iuliia A., Yarovaya, Olga I., Chirkova, Varvara Yu., Sharlaeva, Elena A., Shanshin, Daniil V., Volosnikova, Ekaterina A., Vatsadze, Sergey Z., Khvostov, Mikhail V., Salakhutdinov, Nariman F., Shcherbakov, Dmitriy N.“…The solubility and immunochemical properties of RBD were preserved. It is very important that in work we have shown that 3CL protease works effectively directly in E. coli cells when co-expressed with the target fusion protein, as well as when expressed as part of a chimeric protein containing the target protein, fusion partner, and 3CL itself. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4659por Govindaraj, Sakthivel, Cheedarla, Narayanaiah, Cheedarla, Suneethamma, Irby, LesShon S., Neish, Andrew S., Roback, John D., Smith, Alicia K., Velu, Vijayakumar“…RESULTS: Our results reveal that the current COVID-19 vaccination induced significantly higher RBD-specific binding IgG titers in cord blood compared to maternal blood for both the Wuhan and Omicron BA1 strain. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
4660por Nelson-Mora, Janikua, Rubio, Diana, Ventura-Martínez, Amairani, González, Luis A., Del-Rio, Diana, Aranda-López, Yuli, Jiménez-Díaz, Edgar, Zamarrón-Hernández, Diego, Ríos-López, Diana G., Aguirre, Stephanie, Ruiz-Hernandez, Yasab, Cruz-Ramírez, Aarón, Barjau, Jonás S., Jáurez, Miguel A., Lopez-Aparicio, Jehú, Campa-Higareda, Andrea, Fiordelisio, Tatiana“…For this purpose, a system with magnetic beads that immobilize the antigen (S protein and RBD) on its surface was used to determine the presence and quantity of antibodies in a sample in a single reaction. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto