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4681por Zheng, Lijia, Zhang, Chao, Shi, Chaonan, Yang, Zhirui, Wang, Yu, Zhou, Tong, Sun, Feng, Wang, Hong, Zhao, Shanshan, Qin, Qingqing, Qiao, Rui, Ding, Zuomei, Wei, Chunhong, Xie, Lianhui, Wu, Jianguo, Li, Yi“…Genetic evidence in Arabidopsis showed that NS3 can partially substitute for the function of double-stranded RNA binding domain (dsRBD) of AtDRB1/AtHYL1 during miRNA biogenesis. As a result, NS3 induces the accumulation of several miRNAs, most of which target pivotal genes associated with development or pathogen resistance. …”
Publicado 2017
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4682por Li, Xu-Ying, Yang, Weiwei, Li, Xin, Li, Xu-Ran, Li, Wei, Song, Qihan, Sun, Linjuan, Lin, Feng, Chen, Zhigang, Wang, Chaodong, Yu, Shun“…The levels of pS-α-syn-RBC were negatively correlated with RBD-HK scores and differed between MSA-P and MSA-C subtypes (13.27 ± 1.91 versus 12.19 ± 3.04; p=0.025). …”
Publicado 2020
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4683por Wan, Yushun, Shang, Jian, Sun, Shihui, Tai, Wanbo, Chen, Jing, Geng, Qibin, He, Lei, Chen, Yuehong, Wu, Jianming, Shi, Zhengli, Zhou, Yusen, Du, Lanying, Li, Fang“…In this study, we investigated how a neutralizing monoclonal antibody (MAb), which targets the receptor-binding domain (RBD) of Middle East respiratory syndrome (MERS) coronavirus spike, mediates viral entry using pseudovirus entry and biochemical assays. …”
Publicado 2020
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4684por Kumar, Raman, Palmer, Elizabeth, Gardner, Alison E., Carroll, Renee, Banka, Siddharth, Abdelhadi, Ola, Donnai, Dian, Elgersma, Ype, Curry, Cynthia J., Gardham, Alice, Suri, Mohnish, Malla, Rishikesh, Brady, Lauren Ilana, Tarnopolsky, Mark, Azmanov, Dimitar N., Atkinson, Vanessa, Black, Michael, Baynam, Gareth, Dreyer, Lauren, Hayeems, Robin Z., Marshall, Christian R., Costain, Gregory, Wessels, Marja W., Baptista, Julia, Drummond, James, Leffler, Melanie, Field, Michael, Gecz, Jozef“…The splicing-defective and deletion variants result in a loss of small regions of the C-terminal THOC2 RNA binding domain (RBD). Interestingly, reduced stability of THOC2 variant proteins has a flow-on effect on the stability of the multi-protein TREX complex; specifically on the other NDD-associated THOC subunits. …”
Publicado 2020
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4685“…The dominant CD4(+) T cell epitope (N60) and CD8(+) T cell epitope (N50) located in the receptor-binding domain (RBD) of SARS CoV S protein, which mediated virus combining and fusing to susceptible cells. …”
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4686por Shi, Wan-Zhen, Jiang, Ling-Zhi, Song, Gao-Peng, Wang, Sheng, Xiong, Ping, Ke, Chang-Wen“…However, the potential binding sites of the derivatives with HA did not locate at HA1 sialic acids receptor binding domain (RBD). Taken together, these study data manifested that chlorogenin 3-O-β-chacotrioside derivatives generated antiviral effect against HPAI H5N1 viruses by targeting the hemagglutinin fusion machinery.…”
Publicado 2020
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4687por Lokman, Syed Mohammad, Rasheduzzaman, Md., Salauddin, Asma, Barua, Rocktim, Tanzina, Afsana Yeasmin, Rumi, Meheadi Hasan, Hossain, Md. Imran, Siddiki, A.M.A.M. Zonaed, Mannan, Adnan, Hasan, Md. Mahbub“…Among the 26 variations detected in S, 12 variations were located at the N-terminal domain (NTD) and 6 variations at the receptor-binding domain (RBD) which might alter the interaction of S protein with the host receptor angiotensin-converting enzyme 2 (ACE2). …”
Publicado 2020
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4688por Zemke, Anna C., D’Amico, Emily J., Snell, Emily C., Torres, Angela M., Kasturiarachi, Naomi, Bomberger, Jennifer M.“…From the existing literature, NO-mediated biofilm dispersal is regulated by DipA, NbdA, RbdA, and MucR. Interestingly, altered signaling pathways appear to be used in this model, as deletion of these genes failed to block NO-induced biofilm dispersal. …”
Publicado 2020
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4689por Du, Shuo, Cao, Yunlong, Zhu, Qinyu, Yu, Pin, Qi, Feifei, Wang, Guopeng, Du, Xiaoxia, Bao, Linlin, Deng, Wei, Zhu, Hua, Liu, Jiangning, Nie, Jianhui, Zheng, Yinghui, Liang, Haoyu, Liu, Ruixue, Gong, Shuran, Xu, Hua, Yisimayi, Ayijiang, Lv, Qi, Wang, Bo, He, Runsheng, Han, Yunlin, Zhao, Wenjie, Bai, Yali, Qu, Yajin, Gao, Xiang, Ji, Chenggong, Wang, Qisheng, Gao, Ning, Huang, Weijin, Wang, Youchun, Xie, X. Sunney, Su, Xiao-dong, Xiao, Junyu, Qin, Chuan“…Together, our results rationalized a new RBD epitope that leads to high neutralization potency and demonstrated BD-368-2’s therapeutic potential in treating COVID-19.…”
Publicado 2020
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4690por Pickering, Suzanne, Betancor, Gilberto, Galão, Rui Pedro, Merrick, Blair, Signell, Adrian W., Wilson, Harry D., Kia Ik, Mark Tan, Seow, Jeffrey, Graham, Carl, Acors, Sam, Kouphou, Neophytos, Steel, Kathryn J. A., Hemmings, Oliver, Patel, Amita, Nebbia, Gaia, Douthwaite, Sam, O’Connell, Lorcan, Luptak, Jakub, McCoy, Laura E., Brouwer, Philip, van Gils, Marit J., Sanders, Rogier W., Martinez Nunez, Rocio, Bisnauthsing, Karen, O’Hara, Geraldine, MacMahon, Eithne, Batra, Rahul, Malim, Michael H., Neil, Stuart J. D., Doores, Katie J., Edgeworth, Jonathan D.“…Highly specific in-house ELISAs were developed for the detection of anti-spike (S), -receptor binding domain (RBD) and -nucleocapsid (N) antibodies and used for the cross-comparison of ten commercial serological assays—a chemiluminescence-based platform, two ELISAs and seven colloidal gold lateral flow immunoassays (LFIAs)—on an identical panel of 110 SARS-CoV-2-positive samples and 50 pre-pandemic negatives. …”
Publicado 2020
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4691por Rashed, Mohamed Z., Kopechek, Jonathan A., Priddy, Mariah C., Hamorsky, Krystal T., Palmer, Kenneth E., Mittal, Nikhil, Valdez, Joseph, Flynn, Joseph, Williams, Stuart J.“…A 16-well plate containing sensing electrodes was pre-coated with receptor binding domain (RBD) of SARS-CoV-2 spike protein, and subsequently tested with samples of anti-SARS-CoV-2 monoclonal antibody CR3022 (0.1 [Formula: see text] g/ml, 1.0 [Formula: see text] g/ml, 10 [Formula: see text] g/ml). …”
Publicado 2021
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4692“…We found one putative CTL epitope, S(360-368) related to receptor-binding domain (RBD) region for S protein. The predicted epitopes were non-allergen and showed a high quality of proteasomal cleavage and Tap transport efficiency and 100% conservancy within four different clades of SARS-CoV-2. …”
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4693por Thakur, Mukesh, Singh, Abhishek, Joshi, Bheem Dutt, Ghosh, Avijit, Singh, Sujeet Kumar, Singh, Neha, Sharma, Lalit Kumar, Chandra, Kailash“…Additionally, we identified 18 mutations in the SARS-CoV-2 spike glycoprotein and a few selected mutations showed to increase stability, binding affinity, and molecular flexibility in the overall tertiary structure of the protein that may facilitate interaction between the receptor binding domain (RBD) of spike protein and the human angiotensin-converting enzyme 2 (ACE2) receptor. …”
Publicado 2020
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4694por Ul-Rahman, Aziz, Shabbir, Muhammad Abu Bakr, Aziz, Muhammad Waqar, Yaqub, Saima, Mehmood, Asif, Raza, Muhammad Asif, Shabbir, Muhammad Zubair“…Several residue substitutions were observed in the receptor-binding domain (RBD) of the spike protein, concluding a promiscuous nature of the virus for host species where genomic alternations may be required for the adaptation to novel host/s. …”
Publicado 2020
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4695por Shen, Min, Liu, Chao, Xu, Run, Ruan, Zijing, Zhao, Shiying, Zhang, Huidong, Wang, Wen, Huang, Xinhe, Yang, Li, Tang, Yong, Yang, Tai, Jia, Xu“…Furthermore, based on ACE2(cats)-SARS-CoV-2-RBD model, through high-throughput screening methods using a pool of 30,000 small molecules, eight compounds were selected for binding free energy calculations. …”
Publicado 2020
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4696por Schlesinger, Tobias, Weißbrich, Benedikt, Wedekink, Florian, Notz, Quirin, Herrmann, Johannes, Krone, Manuel, Sitter, Magdalena, Schmid, Benedikt, Kredel, Markus, Stumpner, Jan, Dölken, Lars, Wischhusen, Jörg, Kranke, Peter, Meybohm, Patrick, Lotz, Christopher“…Anti-SARS-CoV-2-Spike-receptor binding domain (RBD) antibody detection of blood samples was performed with an enzyme-linked immunosorbent assay. …”
Publicado 2020
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4697por Gillot, Constant, Douxfils, Jonathan, Cadrobbi, Julie, Laffineur, Kim, Dogné, Jean-Michel, Elsen, Marc, Eucher, Christine, Melchionda, Sabrina, Modaffarri, Élise, Tré-Hardy, Marie, Favresse, Julien“…This study aims at evaluating the clinical performance of an innovative multiplex immunoassay (i.e., CoViDiag assay) detecting simultaneously the presence of antibodies directed against N, S1, S2, RBD and NTD antigens. Sensitivity was evaluated in 135 samples obtained from 94 rRT-PCR confirmed coronavirus disease 2019 (COVID-19) patients. …”
Publicado 2020
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4698por Villalaín, Cecilia, Herraiz, Ignacio, Luczkowiak, Joanna, Pérez-Rivilla, Alfredo, Folgueira, María Dolores, Mejía, Inmaculada, Batllori, Emma, Felipe, Eva, Risco, Beatriz, Galindo, Alberto, Delgado, Rafael“…We tested 769 serum samples obtained from routine serological testing during the first and third trimesters of pregnancy for specific IgG anti SARS-CoV-2 RBD and S proteins. RT-PCR tests were performed in suspected cases according to clinical practice. …”
Publicado 2020
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4699por Xie, Yixin, Karki, Chitra B., Du, Dan, Li, Haotian, Wang, Jun, Sobitan, Adebiyi, Teng, Shaolei, Tang, Qiyi, Li, Lin“…Therefore, understanding the fundamental mechanisms of how SARS-CoV-2 S protein receptor binding domain (RBD) binds to ACE2 is highly demanded for developing treatments for COVID-19. …”
Publicado 2020
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4700por Pisanic, Nora, Randad, Pranay R., Kruczynski, Kate, Manabe, Yukari C., Thomas, David L., Pekosz, Andrew, Klein, Sabra L., Betenbaugh, Michael J., Clarke, William A., Laeyendecker, Oliver, Caturegli, Patrizio P., Larman, H. Benjamin, Detrick, Barbara, Fairley, Jessica K., Sherman, Amy C., Rouphael, Nadine, Edupuganti, Srilatha, Granger, Douglas A., Granger, Steve W., Collins, Matthew H., Heaney, Christopher D.“…The salivary anti-N IgG response resulted in the highest sensitivity (100%), exhibiting a positive response in 24/24 reverse transcription-PCR (RT-PCR)-confirmed COVID-19 cases sampled at >14 days post-symptom onset (DPSO), whereas the salivary anti-receptor binding domain (RBD) IgG response yielded 100% specificity. Temporal kinetics of IgG in saliva were consistent with those observed in blood and indicated that most individuals seroconvert at around 10 DPSO. …”
Publicado 2020
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