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4701por Massacci, Alice, Sperandio, Eleonora, D’Ambrosio, Lorenzo, Maffei, Mariano, Palombo, Fabio, Aurisicchio, Luigi, Ciliberto, Gennaro, Pallocca, Matteo“…Furthermore, we provide immunogenomic analyses to understand the impact of the most frequent RBD variations. RESULTS: Results on the whole GISAID sequence dataset at the time of the writing (October 2020) reveals an emerging mutation, S477N, located on the central part of the Spike protein Receptor Binding Domain, the Receptor Binding Motif. …”
Publicado 2020
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4702por Rosser, Joelle I., Röltgen, Katharina, Dymock, Melissa, Shepard, John, Martin, Andrew, Hogan, Catherine A., Blomkalns, Andra, Mathew, Roshni, Parsonnet, Julie, Pinsky, Benjamin A., Maldonado, Yvonne A., Boyd, Scott D., Chang, Sang-ick, Holubar, Marisa“…METHODS: We reviewed anti–severe acute respiratory coronavirus virus 2 (SARS-CoV-2) receptor-binding domain (RBD) IgG serologic test results and self-reported risk factors for seropositivity among 10,449 asymptomatic HCP who underwent voluntary serology testing between April 20 and May 20, 2020. …”
Publicado 2020
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4703por Diego-Martin, Borja, González, Beatriz, Vazquez-Vilar, Marta, Selma, Sara, Mateos-Fernández, Rubén, Gianoglio, Silvia, Fernández-del-Carmen, Asun, Orzáez, Diego“…In parallel, we also produced the recombinant SARS-CoV-2 N protein and the receptor binding domain (RBD) of the Spike protein in planta and used them to test the binding specificity of the recombinant mAbs. …”
Publicado 2020
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4704por Ojeda, Diego S., Gonzalez Lopez Ledesma, María Mora, Pallarés, Horacio M., Costa Navarro, Guadalupe S., Sanchez, Lautaro, Perazzi, Beatriz, Villordo, Sergio M., Alvarez, Diego E., Echavarria, Marcela, Oguntuyo, Kasopefoluwa Y., Stevens, Christian S., Lee, Benhur, Carradori, Jorge, Caramelo, Julio J., Yanovsky, Marcelo J., Gamarnik, Andrea V.“…The assays, COVIDAR IgG and IgM, which were produced and provided for free to health authorities, private and public health institutions and nursing homes, use a combination of a trimer stabilized spike protein and the receptor binding domain (RBD) in a single enzyme-linked immunosorbent assay (ELISA) plate. …”
Publicado 2021
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4705“…Initial phase of COVID-19 infection is associated with the binding of viral spike protein S1 receptor binding domain (RBD) with the host cell surface receptor, ACE2. …”
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4706por Ghodake, Gajanan Sampatrao, Shinde, Surendra Krushna, Kadam, Avinash Ashok, Saratale, Rijuta Ganesh, Saratale, Ganesh Dattatraya, Syed, Asad, Elgorban, Abdallah M., Marraiki, Najat, Kim, Dae-Young“…Here, we describe recent understandings on the spike glycoprotein (S protein), receptor-binding domain (RBD), and angiotensin-converting enzyme 2 (ACE2) and their receptor complex. …”
Publicado 2021
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4707por Kubo, Sousuke, Ohtake, Norihisa, Miyakawa, Kei, Jeremiah, Sundararaj Stanleyraj, Yamaoka, Yutaro, Murohashi, Kota, Hagiwara, Eri, Mihara, Takahiro, Goto, Atsushi, Yamazaki, Etsuko, Ogura, Takashi, Kaneko, Takeshi, Yamanaka, Takeharu, Ryo, Akihide“…METHODS: We designed and prepared reagents for measuring NP-IgG, NP-Total Ig, SP-IgG, and SP-Total Ig (using N-terminally truncated NP (ΔN-NP) or receptor-binding domain (RBD) antigen) dedicated automated chemiluminescent enzyme immunoassay analyzer AIA-CL1200. …”
Publicado 2021
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4708por Siriwattananon, Konlavat, Manopwisedjaroen, Suwimon, Kanjanasirirat, Phongthon, Budi Purwono, Priyo, Rattanapisit, Kaewta, Shanmugaraj, Balamurugan, Smith, Duncan R., Borwornpinyo, Suparerk, Thitithanyanont, Arunee, Phoolcharoen, Waranyoo“…The recombinant fusion protein showed potent binding to receptor binding domain (RBD) of SARS-CoV-2. Importantly, the plant-produced fusion protein exhibited potent anti-SARS-CoV-2 activity in vitro. …”
Publicado 2021
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4709“…The most frequent mechanism of the antiviral activity is due to disrupting viral uptake into the host cells and disrupting the interaction between receptor- binding domain (RBD) of SARS-COV2 and ACE2 in recent articles. Fifty studies indicate that glycyrrhizin and licorice extract have significant antioxidant, anti-inflammatory and immunomodulatory effects. …”
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4710por Zhou, Dongyan, Chan, Jasper Fuk-Woo, Zhou, Biao, Zhou, Runhong, Li, Shuang, Shan, Sisi, Liu, Li, Zhang, Anna Jinxia, Chen, Serena J., Chan, Chris Chung-Sing, Xu, Haoran, Poon, Vincent Kwok-Man, Yuan, Shuofeng, Li, Cun, Chik, Kenn Ka-Heng, Chan, Chris Chun-Yiu, Cao, Jianli, Chan, Chun-Yin, Kwan, Ka-Yi, Du, Zhenglong, Lau, Thomas Tsz-Kan, Zhang, Qi, Zhou, Jie, To, Kelvin Kai-Wang, Zhang, Linqi, Ho, David D., Yuen, Kwok-Yung, Chen, Zhiwei“…These HuNAbs inhibit SARS-CoV-2 infection by competing with human angiotensin converting enzyme-2 for binding to the viral receptor binding domain (RBD). Prophylactic intraperitoneal or intranasal injection of individual HuNAb or DNA vaccination significantly reduces infection in the lungs but not in the nasal turbinates of hamsters intranasally challenged with SARS-CoV-2. …”
Publicado 2021
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4711por Souza, Pedro F.N., Mesquita, Felipe P., Amaral, Jackson L., Landim, Patrícia G.C., Lima, Karollyny R.P., Costa, Marília B., Farias, Izabelle R., Lima, Luina B., Montenegro, Raquel C.“…Additionally, we investigated the receptor-binding domain (RBD) from all S proteins explaining the mutation and biological importance of all of them. …”
Publicado 2021
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4712por Yan, Renhong, Wang, Ruoke, Ju, Bin, Yu, Jinfang, Zhang, Yuanyuan, Liu, Nan, Wang, Jia, Zhang, Qi, Chen, Peng, Zhou, Bing, Li, Yaning, Shen, Yaping, Zhang, Shuyuan, Tian, Long, Guo, Yingying, Xia, Lu, Zhong, Xinyue, Cheng, Lin, Ge, Xiangyang, Zhao, Juanjuan, Wang, Hong-Wei, Wang, Xinquan, Zhang, Zheng, Zhang, Linqi, Zhou, Qiang“…We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain (RBD) of the viral spike (S) protein and the receptor angiotensin converting enzyme 2 (ACE2). …”
Publicado 2021
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4713por Soleimani, Reza, Khourssaji, Mehdi, Aupaix, Antoine, Rodriguez-Villalobos, Hector, Scohy, Anaïs, Kabamba-Mukadi, Benoît“…Of these 38 samples, 97.4 % of samples showed specific IgG reaction against S1 + S2 antigens, 89.5 % showed against RBD antigen, 86.8 % against S2 antigen reaction on the COVIDOT-TEST kit. …”
Publicado 2021
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4714por Luo, Huanle, Jia, Tingting, Chen, Jiamin, Zeng, Shike, Qiu, Zengzhao, Wu, Shu, Li, Xu, Lei, Yuxuan, Wang, Xin, Wu, Weihua, Zhang, Renli, Zou, Xuan, Feng, Tiejian, Ding, Ruxia, Zhang, Yue, Chen, Yao-Qing, Sun, Caijun, Wang, Tian, Fang, Shisong, Shu, Yuelong“…Nucleocapsid protein (NP)-, spike (S)-, receptor binding domain (RBD)- specific immunoglobulin (Ig) isotypes, IgG subclasses and neutralizing antibody (NAb) were analyzed in 123 serum from 63 hospitalized patients with severe, moderate, mild or asymptomatic COVID-19. …”
Publicado 2021
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4715por Wu, Jun, Liang, Boyun, Chen, Cunrong, Wang, Hua, Fang, Yaohui, Shen, Shu, Yang, Xiaoli, Wang, Baoju, Chen, Liangkai, Chen, Qi, Wu, Yang, Liu, Jia, Yang, Xuecheng, Li, Wei, Zhu, Bin, Zhou, Wenqing, Wang, Huan, Li, Sumeng, Lu, Sihong, Liu, Di, Li, Huadong, Krawczyk, Adalbert, Lu, Mengji, Yang, Dongliang, Deng, Fei, Dittmer, Ulf, Trilling, Mirko, Zheng, Xin“…Here we quantify immunoglobulin M (IgM) and G (IgG) antibodies recognizing the SARS-CoV-2 receptor-binding domain (RBD) of the spike (S) or the nucleocapsid (N) protein, and neutralizing antibodies during a period of 6 months from COVID-19 disease onset in 349 symptomatic COVID-19 patients who were among the first be infected world-wide. …”
Publicado 2021
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4716por Heidbreder, Anna, Sonnweber, Thomas, Stefani, Ambra, Ibrahim, Abubaker, Cesari, Matteo, Bergmann, Melanie, Brandauer, Elisabeth, Tancevski, Ivan, Löffler-Ragg, Judith, Högl, Birgit“…A major finding of this study was the presence of isolated RWA, a recognized prodromal stage of RBD, in more than one third of the patients. Future videopolysomnographic investigations including quantification of RWA in patients after COVID-19 will give more insights into a possible acute or post-infectious CNS pathology related to the SARS-CoV-2 infection.…”
Publicado 2021
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4717por Sagara, Issaka, Woodford, John, Dicko, Alassane, Zeguime, Amatigue, Doucoure, M'Bouye, Kwan, Jennifer, Zaidi, Irfan, Doritchamou, Justin, Snow-Smith, Maryonne, Alani, Nada, Renn, Jonathan, Kosik, Ivan, Holly, Jaroslav, Yewdell, Jonathan, Esposito, Dominic, Sadtler, Kaitlyn, Duffy, Patrick“…Background reactivity to SARS-CoV-2 antigens was common in pre-pandemic samples compared to US controls (43.4% (135/311) for spike protein, 22.8% (71/312) for RBD, and 33.9% (79/233) for nucleocapsid protein). …”
Publicado 2021
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4718por Bestwick, Jonathan P., Auger, Stephen D., Simonet, Cristina, Rees, Richard N., Rack, Daniel, Jitlal, Mark, Giovannoni, Gavin, Lees, Andrew J., Cuzick, Jack, Schrag, Anette E., Noyce, Alastair J.“…Using this algorithm, the PREDICT-PD study identified individuals at increased risk of PD and used tapping speed, hyposmia and REM sleep behaviour disorder (RBD) as “intermediate” markers of prodromal PD in the absence of sufficient incident cases. …”
Publicado 2021
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4719por Lei, Jian, He, Zhen‐Yu, Wang, Jun, Hu, Min, Zhou, Ping, Lian, Chen‐Lu, Hua, Li, Wu, San‐Gang, Zhou, Juan“…Finally, the lncRNAs‐miRNAs‐mRNAs subnetwork was predicted by starBase, TargetScan, miRBD, and LncBase, individually. Correlation of expression and prognosis for mRNAs, miRNAs, and lncRNAs were confirmed by TCGA, Gene Expression Profiling Interactive Analysis 2 (GEPIA 2), starBase, and KM. …”
Publicado 2021
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4720por Goike, Jule, Hsieh, Ching-Lin, Horton, Andrew, Gardner, Elizabeth C., Bartzoka, Foteini, Wang, Nianshuang, Javanmardi, Kamyab, Herbert, Andrew, Abbassi, Shawn, Renberg, Rebecca, Johanson, Michael J., Cardona, Jose A., Segall-Shapiro, Thomas, Zhou, Ling, Nissly, Ruth H., Gontu, Abhinay, Byrom, Michelle, Maranhao, Andre C., Battenhouse, Anna M., Gejji, Varun, Soto-Sierra, Laura, Foster, Emma R., Woodard, Susan L., Nikolov, Zivko L., Lavinder, Jason, Voss, Will N., Annapareddy, Ankur, Ippolito, Gregory C., Ellington, Andrew D., Marcotte, Edward M., Finkelstein, Ilya J., Hughes, Randall A., Musser, James M., Kuchipudi, Suresh V., Kapur, Vivek, Georgiou, George, Dye, John M., Boutz, Daniel R., McLellan, Jason S., Gollihar, Jimmy D.“…Cryo-EM and functional characterization of the antibodies identified N3–1, an antibody that binds avidly (K(d,app) = 68 pM) to the receptor binding domain (RBD) of the spike protein and robustly neutralizes the virus in vitro. …”
Publicado 2021
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