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4741por Mohsen, Mona O., Rothen, Dominik, Balke, Ina, Martina, Byron, Zeltina, Vilija, Inchakalody, Varghese, Gharailoo, Zahra, Nasrallah, Gheyath, Dermime, Said, Tars, Kaspars, Vogel, Monique, Zeltins, Andris, Bachmann, Martin F.“…The developed vaccine candidate induced high anti-RBD and anti-spike antibodies in a murine model, showing high binding avidity and an ability to completely neutralize MERS-CoV/EMC/2012 isolate, demonstrating the protective potential of the vaccine candidate for dromedaries and humans.…”
Publicado 2021
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4742por Markmann, Alena J., Giallourou, Natasa, Bhowmik, D. Ryan, Hou, Yixuan J., Lerner, Aaron, Martinez, David R., Premkumar, Lakshmanane, Root, Heather, van Duin, David, Napravnik, Sonia, Graham, Stephen D., Guerra, Quique, Raut, Rajendra, Petropoulos, Christos J., Wrin, Terri, Cornaby, Caleb, Schmitz, John, Kuruc, JoAnn, Weiss, Susan, Park, Yara, Baric, Ralph, de Silva, Aravinda M., Margolis, David M., Bartelt, Luther A.“…IMPORTANCE In this study, we found that neutralizing antibody responses in COVID-19-convalescent individuals vary in magnitude but are durable and correlate well with receptor binding domain (RBD) Ig binding antibody levels compared to other SARS-CoV-2 antigen responses. …”
Publicado 2021
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4743por Jacob, Jobin John, John Fletcher, G., Monisha Priya, T., Veeraraghavan, Balaji, Mutreja, Ankur“…Critical mutations in the spike/RBD region of these variants have raised serious concerns about the virus's increased transmissibility and decreased vaccine effectiveness. …”
Publicado 2021
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4744por Klaus, Julia, Zini, Eric, Hartmann, Katrin, Egberink, Herman, Kipar, Anja, Bergmann, Michèle, Palizzotto, Carlo, Zhao, Shan, Rossi, Francesco, Franco, Vittoria, Porporato, Federico, Hofmann-Lehmann, Regina, Meli, Marina L.“…Analyses of convenience sera from 118 animals identified one dog (1/94; 1.1%; 95% CI: 0.02–5.7%) from Lombardy, but no cats (0/24), as positive for anti-SARS-CoV-2 receptor binding domain (RBD) antibodies and neutralizing activity. These findings support the hypothesis that the prevalence of SARS-CoV-2 infection in pet cat and dog populations, and hence, the risk of zoonotic transmission to veterinary staff, was low during the first wave of the pandemic, even in hotspot areas.…”
Publicado 2021
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4745por Agarwal, Dilip Kumar, Nandwana, Vikas, Henrich, Stephen E., Josyula, Vara Prasad V.N., Thaxton, C. Shad, Qi, Chao, Simons, Lacy M., Hultquist, Judd F., Ozer, Egon A., Shekhawat, Gajendra S., Dravid, Vinayak P.“…Rapid detection of SARS-CoV-2 nucleocapsid (N) and spike (S1) receptor binding domain (RBD) proteins was first demonstrated at a clinically relevant concentration down to 1 ng/mL (33 pM) by real-time monitoring of nanomechanical signal induced by antibody-antigen interaction. …”
Publicado 2022
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4746por Deshpande, Gururaj Rao, Kaduskar, Ojas, Deshpande, Ketki, Bhatt, Vaishali, Yadav, Pragya, Gurav, Yogesh, Potdar, Varsha, Khutwad, Kirti, Vidhate, Shankar, Salunke, Asha, Patil, Chetan, Shingade, Snehal, Jarande, Kajal, Tilekar, Bipin, Salvi, Pavan, Patsuthe, Sudhir, Dange, Varsha, Kumar, Sudeep, Gurav, Shilpa, Chate, Sadhana, Abraham, Priya, Sapkal, Gajanan“…The persistence of antibody response was observed in 76% against N, 80% against SRBD and 80% for NAbs of cases up to 8 months POD. CONCLUSION: RBD and N protein specific IgG persisted till 240 days POD which correlated with NAb response, irrespective of individual`s symptomatic status indicating overall robust protection against re-infection.…”
Publicado 2021
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4747por Sokal, Aurélien, Barba-Spaeth, Giovanna, Fernández, Ignacio, Broketa, Matteo, Azzaoui, Imane, de La Selle, Andréa, Vandenberghe, Alexis, Fourati, Slim, Roeser, Anais, Meola, Annalisa, Bouvier-Alias, Magali, Crickx, Etienne, Languille, Laetitia, Michel, Marc, Godeau, Bertrand, Gallien, Sébastien, Melica, Giovanna, Nguyen, Yann, Zarrouk, Virginie, Canoui-Poitrine, Florence, Pirenne, France, Mégret, Jérôme, Pawlotsky, Jean-Michel, Fillatreau, Simon, Bruhns, Pierre, Rey, Felix A., Weill, Jean-Claude, Reynaud, Claude-Agnès, Chappert, Pascal, Mahévas, Matthieu“…Although naive individuals had weaker neutralizing serum responses, half of their RBD-specific MBCs displayed high affinity toward multiple VOCs, including delta (B.1.617.2), and one-third retained neutralizing potency against beta (B.1.351). …”
Publicado 2021
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4748por Krüttgen, Alexander, Lauen, Maike, Klingel, Hanna, Imöhl, Matthias, Kleines, Michael“…CONCLUSIONS: Surrogate neutralization assays based on the RBD as bait feature a high specificity and sensitivity for identifying humoral neutralizing activity in individuals vaccinated with the spike-based vaccine mRNA-1273. …”
Publicado 2022
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4749por López-Cortés, Georgina I., Palacios-Pérez, Miryam, Zamudio, Gabriel S., Veledíaz, Hannya F., Ortega, Enrique, José, Marco V.“…Specifically, Tyr and Asn have higher occurrence rates on the Receptor Binding Domain (RBD) and in the overall sequence of spike proteins of Betacoronavirus, whereas His and Arg have lower occurrence rates. …”
Publicado 2021
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4750“…The purpose of this work is to provide an in silico molecular rationale of the role eventually played by currently circulating mutations in the receptor binding domain of the SARS-CoV-2 spike protein (S-RBD(CoV‑2)) in evading the immune surveillance effects elicited by the two Eli Lilly LY-CoV555/bamlanivimab and LY-CoV016/etesevimab monoclonal antibodies. …”
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4751por Bittar, Cíntia, Possebon, Fábio Sossai, Ullmann, Leila Sabrina, Geraldini, Dayla Bott, da Costa, Vivaldo G., de Almeida, Luiz G. P., da S. Sanches, Paulo Ricardo, Nascimento-Júnior, Nailton M., Cilli, Eduardo M., Artico Banho, Cecília, Campos, Guilherme R. F., Ferreira, Helena Lage, Sacchetto, Lívia, da Silva, Gislaine C. D., Parra, Maisa C. P., Moraes, Marília M., da Costa, Paulo Inácio, Vasconcelos, Ana Tereza R., Spilki, Fernando Rosado, Nogueira, Maurício L., Rahal, Paula, Araujo Jr, João Pessoa“…While performing epidemiological and genomic surveillance of SARS-CoV-2 in samples from Porto Ferreira—São Paulo—Brazil, we identified sequences classified by pangolin as B.1.1.28 harboring Spike L452R mutation, in the RBD region. Phylogenetic analysis revealed that these sequences grouped into a monophyletic branch, with others from Brazil, mainly from the state of São Paulo. …”
Publicado 2021
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4752por Brill, Livnat, Rechtman, Ariel, Zveik, Omri, Haham, Nitzan, Levin, Netta, Shifrin, Alla, Rozenberg, Ayal, Vaknin-Dembinsky, Adi“…RESULTS: HCs (n = 30) and MS patients treated with cladribine (n = 32) had 100% positive serology response against the SARS-CoV-2 spike protein following the second vaccine dose (mean S1/S2-IgG and RBD-IgG:284.5 ± 104.9, 13,041±9411 AU/mL and 226.3 ± 121.4, 10,554±11,405 AU/mL respectively). …”
Publicado 2022
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4753por Lau, Eric HY, Hui, David SC, Tsang, Owen TY, Chan, Wai-Hung, Kwan, Mike YW, Chiu, Susan S, Cheng, Samuel MS, Ko, Ronald LW, Li, John KC, Chaothai, Sara, Tsang, Chi H, Poon, Leo LM, Peiris, Malik“…METHODS: We collected sera from a cohort of 124 individuals with RT-PCR confirmed SARS-CoV-2 infections from Prince of Wales Hospital, Princess Margaret Hospital, Queen Elizabeth Hospital and Queen Mary Hospitals of the Hospital Authority of Hong Kong, for periods up to 386 days after symptom onset and tested these for antibody to SARS-CoV-2 using 50% virus plaque reduction neutralization tests (PRNT(50)), surrogate neutralization tests and spike receptor binding domain (RBD) binding antibody. Patients were recruited from 21 January 2020 to 16 February 2021 and follow-up samples were collected until 9th March 2021. …”
Publicado 2021
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4754por Gu, Maggie, Torres, Jonathan L., Li, Yijia, Van Ry, Alex, Greenhouse, Jack, Wallace, Shannon, Chiang, Chi-I, Pessaint, Laurent, Jackson, Abigail M., Porto, Maciel, Kar, Swagata, Li, Yuxing, Ward, Andrew B., Wang, Yimeng“…The comparison of serum binding to spike subunits between animals immunized by a spike with and without nanoparticle presentation indicates that nanoparticle prefers the display of spike RBD (Receptor-Binding Domain) over S2 subunit, likely resulting in a more neutralizing but less cross-reactive antibody response. …”
Publicado 2021
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4755por Nugraha, Alexander Patera, Rahmadhani, Desintya, Puspitaningrum, Martining Shoffa, Rizqianti, Yuniar, Kharisma, Viol Dhea, Ernawati, Diah Savitri“…This investigation found that, in the molecular docking simulation, the anthocyanin and ternatin showed producing the negative binding affinity to the ACE2 domain which interacted with RBD glycoprotein SARS-CoV-2. Anthocyanin and ternatin were then predicted to be able to influence any inhibitory activity of TNF-αR, MMP-9, and IL-6; increase IL-10; and increase HBD2 binding affinity values negatively. …”
Publicado 2021
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4756por Eckstrand, Chrissy D., Baldwin, Thomas J., Rood, Kerry A., Clayton, Michael J., Lott, Jason K., Wolking, Rebecca M., Bradway, Daniel S., Baszler, Timothy“…While sharing the N501T mutation which is common in mink, the Utah strains did not share other spike RBD mutations Y453F and F486L found in nearly all mink from the United States. …”
Publicado 2021
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4757por Feng, Shuo, Phillips, Daniel J., White, Thomas, Sayal, Homesh, Aley, Parvinder K., Bibi, Sagida, Dold, Christina, Fuskova, Michelle, Gilbert, Sarah C., Hirsch, Ian, Humphries, Holly E., Jepson, Brett, Kelly, Elizabeth J., Plested, Emma, Shoemaker, Kathryn, Thomas, Kelly M., Vekemans, Johan, Villafana, Tonya L., Lambe, Teresa, Pollard, Andrew J., Voysey, Merryn“…A vaccine efficacy of 80% against symptomatic infection with majority Alpha (B.1.1.7) variant of SARS-CoV-2 was achieved with 264 (95% CI: 108, 806) binding antibody units (BAU)/ml: and 506 (95% CI: 135, not computed (beyond data range) (NC)) BAU/ml for anti-spike and anti-RBD antibodies, and 26 (95% CI: NC, NC) international unit (IU)/ml and 247 (95% CI: 101, NC) normalized neutralization titers (NF(50)) for pseudovirus and live-virus neutralization, respectively. …”
Publicado 2021
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4758por Sartore, Giovanni, Bassani, Davide, Ragazzi, Eugenio, Traldi, Pietro, Lapolla, Annunziata, Moro, Stefano“…A computational analysis was performed, based on the X-ray crystallographic structure of the Spike Receptor-Binding Domain (RBD)-ACE2 system. The possible scenarios of lysine aminoacid residues on surface transformed by glycation were considered: (1) on ACE2 receptor; (2) on Spike protein; (3) on both ACE2 receptor and Spike protein. …”
Publicado 2021
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4759por Galipeau, Yannick, Siragam, Vinayakumar, Laroche, Geneviève, Marion, Erika, Greig, Matthew, McGuinty, Michaeline, Booth, Ronald A, Durocher, Yves, Cuperlovic-Culf, Miroslava, Bennett, Steffany A.L., Crawley, Angela M., Giguère, Patrick M., Cooper, Curtis, Langlois, Marc-André“…METHODS: We performed a cross-sectional analysis of cross-reactivity and cross-neutralization to SARS-CoV-2 antigens (S-RBD, S-trimer, N) using pre-pandemic sera from four different groups: pediatrics and adolescents, individuals 21 to 70 years of age, older than 70 years of age, and individuals living with HCV or HIV. …”
Publicado 2021
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4760por Khan, Riaz Muhammad, Yu, Ping, Sun, Lianping, Abbas, Adil, Shah, Liaqat, Xiang, Xiaojiao, Wang, Dongfei, Sohail, Amir, Zhang, Yingxin, Liu, Qunen, Cheng, Shihua, Cao, Liyong“…DCET1 belongs to the RNA recognition motif (RRM)-containing family also called as the ribonucleoprotein (RNP) domain or RNA-binding domain (RBD) protein, having single-nucleotide polymorphism (SNP) substitution from G (threonine-192) to A (isoleucine-192) located at the fifth exon of LOC_Os08g02330, was responsible for the male sterile phenotype in mutant dcet1. …”
Publicado 2021
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