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4781por Pavot, Vincent, Berry, Catherine, Kishko, Michael, Anosova, Natalie G., Huang, Dean, Tibbitts, Tim, Raillard, Alice, Gautheron, Sylviane, Gutzeit, Cindy, Koutsoukos, Marguerite, Chicz, Roman M., Lecouturier, Valerie“…Interestingly, we show that the booster specifically increases the functional antibody responses as compared to the receptor binding domain (RBD)-specific responses. Our findings show that these vaccine candidates, when used as a booster, have the potential to offer cross-protection against a broad spectrum of variants. …”
Publicado 2022
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4782por Hu, Ye-Fan, Hu, Jing-Chu, Gong, Hua-Rui, Danchin, Antoine, Sun, Ren, Chu, Hin, Hung, Ivan Fan-Ngai, Yuen, Kwok Yung, To, Kelvin Kai-Wang, Zhang, Bao-Zhong, Yau, Thomas, Huang, Jian-Dong“…Based on this correlation, we obtained a computational model for the receptor-binding domain (RBD) of the spike protein to predict the fold decrease in virus–antiserum neutralization titers with high accuracy (~0.79). …”
Publicado 2022
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4783por Campbell, Christopher, Padmanabhan, Nikhil, Romero, Daniel, Joe, Jessica, Gebremeskel, Mikias, Manjula, Navaratnam, Wohlstadter, Noah, Wohlstadter, Rachel, Goodwin, Paul, Quintero, Lillian, Debad, Jeff, Sigal, George, Wohlstadter, Jacob“…We selected classification thresholds for antibodies against SARS-CoV-2 N, RBD and Spike in finger-stick blood and saliva that provided 98% specificity in a set of individuals without known COVID-19 exposure. …”
Publicado 2022
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4784por Khatri, Ritika, Parray, Hilal Ahmad, Agrahari, Ashish Kumar, Rizvi, Zaigham Abbas, Kaul, Rachel, Raj, Sneha, Asthana, Shailendra, Mani, Shailendra, Samal, Sweety, Awasthi, Amit, Ahmed, Shubbir“…The immunized sera can bind both, the receptor binding domain (RBD) and the spike protein, which holds the RBM in its natural context. …”
Publicado 2022
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4785por Chi, Xiangyang, Guo, Yingying, Zhang, Guanying, Sun, Hancong, Zhang, Jun, Li, Min, Chen, Zhengshan, Han, Jin, Zhang, Yuanyuan, Zhang, Xinghai, Fan, Pengfei, Zhang, Zhe, Wang, Busen, Zai, Xiaodong, Han, Xuelian, Hao, Meng, Fang, Ting, Xu, Jinghan, Wu, Shipo, Chen, Yi, Fang, Yingying, Dong, Yunzhu, Sun, Bingjie, Zhang, Jinlong, Li, Jianmin, Zhao, Guangyu, Yu, Changming, Zhou, Qiang, Chen, Wei“…This study affords the potential to develop broadly therapeutic mAb drugs and suggests that the RBD epitope bound by ZWD12 is a rational target for the design of a broad spectrum of vaccines.…”
Publicado 2022
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4786por Bao, Jia-hao, Li, Jiang-bo, Lin, Han-sen, Zhang, Wen-jin, Guo, Bing-yan, Li, Jun-jie, Fu, Liang-min, Sun, Yang-peng“…Additionally, a predictive nomogram with good performance was constructed to enhance the implementation of the constructed signature in a clinical setting. We then employed miRBD, miRTarBase, and TargetScan to predict the target genes of six necroptosis-related miRNAs. …”
Publicado 2022
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4787por Hingankar, Nitin, Deshpande, Suprit, Das, Payel, Rizvi, Zaigham Abbas, Wibmer, Constantinos Kurt, Mashilo, Poppy, Ansari, Mohammed Yousuf, Burns, Alison, Barman, Shawn, Zhao, Fangzhu, Mukherjee, Sohini, Torres, Jonathan L., Chattopadhyay, Souvick, Mehdi, Farha, Sutar, Jyoti, Rathore, Deepak Kumar, Pargai, Kamal, Singh, Janmejay, Sonar, Sudipta, Jakhar, Kamini, Dandotiya, Jyotsna, Bhattacharyya, Sankar, Mani, Shailendra, Samal, Sweety, Singh, Savita, Kshetrapal, Pallavi, Thiruvengadam, Ramachandran, Batra, Gaurav, Medigeshi, Guruprasad, Ward, Andrew B., Bhatnagar, Shinjini, Awasthi, Amit, Sok, Devin, Bhattacharya, Jayanta“…These two mAbs target non-overlapping epitopes on the receptor-binding domain (RBD) of the spike protein and prevent virus attachment to its host receptor, human angiotensin converting enzyme-2 (hACE2). …”
Publicado 2022
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4788por Benucci, Maurizio, Damiani, Arianna, Gobbi, Francesca Li, Lari, Barbara, Grossi, Valentina, Infantino, Maria, Manfredi, Mariangela“…The value of anti-SARS-CoV 2 Spike RBD IgG antibodies was determined at T1 (3 weeks after first vaccination) and T2 (3 weeks after booster). …”
Publicado 2022
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4789“…For example, designing of the compounds which bind to the allosteric site and modify hydrogen bonds or the salt bridges can disrupt SARS-CoV2 RBD–ACE2 complex. It seems that quaternary ammonium moiety and quinolin-1-ium structure could act as a negative allosteric modulator to reduce the tendency between spike-ACE2. …”
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4790por Pinpathomrat, Nawamin, Intapiboon, Porntip, Seepathomnarong, Purilap, Ongarj, Jomkwan, Sophonmanee, Ratchanon, Hengprakop, Jariya, Surasombatpattana, Smonrapat, Uppanisakorn, Supattra, Mahasirimongkol, Surakameth, Sawaengdee, Waritta, Phumiamorn, Supaporn, Sapsutthipas, Sompong, Kongkamol, Chanon, Ingviya, Thammasin, Sangsupawanich, Pasuree, Chusri, Sarunyou“…Immediate and delayed local reactions were frequently observed in the fractional intradermal boost, but systemic side effects were significantly decreased compared to the conventional intramuscular boost. The anti-RBD-IgG levels, the neutralising function against delta variants, and T cell responses were significantly increased after boosting via both routes. …”
Publicado 2022
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4791por Wilkins, Hannah, Jastaniah, Ebaa, Spray, Beverly, Forrest, James C., Boehme, Karl W., Kirkpatrick, Catherine, Boyanton, Bobby L., Spiro, David M., Crawley, Lee, Quang, Lawrence, Kennedy, Joshua L.“…Serum antibodies to SARS‐CoV‐2 (IgM and/or IgG) were measured using a 2‐step enzyme‐linked immunosorbent assay (ELISA) to detect antibodies against the Spike protein receptor binding domain (RBD), the ectodomain of Spike (S), and the nucleoprotein (N). …”
Publicado 2022
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4792por Cohen, Guy, Jungsomsri, Pawornrath, Sangwongwanich, Jirath, Tawinprai, Kriangkrai, Siripongboonsitti, Taweegrit, Porntharukchareon, Thachanun, Wittayasak, Kasiruck, Thonwirak, Nawarat, Soonklang, Kamonwan, Sornsamdang, Gaidganok, Auewarakul, Chirayu, Mahanonda, Nithi“…The primary endpoint was the geometric mean ratio (GMR) of the anti-receptor binding domain (RBD) antibody concentration 4 weeks after the booster dose was administered. …”
Publicado 2022
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4793por Gregory, David J., Vannier, Augustin, Duey, Akiro H., Roady, Tyler J., Dzeng, Richard K., Pavlovic, Maia N., Chapin, Michael H., Mukherjee, Sonia, Wilmot, Hannah, Chronos, Nic, Charles, Richelle C., Ryan, Edward T., LaRocque, Regina C., Miller, Tyler E., Garcia-Beltran, Wilfredo F., Thierauf, Julia C., Iafrate, A. John, Mullenbrock, Steven, Stump, Mark D., Wetzel, Randall K., Polakiewicz, Roberto D., Naranbhai, Vivek, Poznansky, Mark C.“…However, apparent cross-reaction with SARS-CoV RBD was evident and some predominantly asymptomatic individuals had antibodies to both MERS-CoV and SARS-CoV RBDs. …”
Publicado 2022
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4794por Padariya, Monikaben, Daniels, Alison, Tait-Burkard, Christine, Hupp, Ted, Kalathiya, Umesh“…The presence of mutation has induced an “up” active conformation of the spike (RBD) domain, responsible for interacting the host cell receptor. …”
Publicado 2022
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4795por Lu-Culligan, Alice, Tabachnikova, Alexandra, Pérez-Then, Eddy, Tokuyama, Maria, Lee, Hannah J., Lucas, Carolina, Silva Monteiro, Valter, Miric, Marija, Brache, Vivian, Cochon, Leila, Muenker, M. Catherine, Mohanty, Subhasis, Huang, Jiefang, Kang, Insoo, Dela Cruz, Charles, Farhadian, Shelli, Campbell, Melissa, Yildirim, Inci, Shaw, Albert C., Ma, Shuangge, Vermund, Sten H., Ko, Albert I., Omer, Saad B., Iwasaki, Akiko“…We also found that term fetuses from these murine pregnancies vaccinated prior to the formation of the definitive placenta exhibit high circulating levels of anti-spike and anti-receptor-binding domain (anti-RBD) antibodies to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) consistent with maternal antibody status, indicating transplacental transfer in the later stages of pregnancy after early immunization. …”
Publicado 2022
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4796por Faraji, Seyed Nooreddin, Raee, Mohamad Javad, Hashemi, Seyed Mohamad Ali, Daryabor, Gholamreza, Tabrizi, Reza, Dashti, Fateme Sadat, Behboudi, Emad, Heidarnejad, Kamran, Nowrouzi-Sohrabi, Peyman, Hatam, Gholamreza“…Based on the results, ACE2 polymorphisms as well as spike RBD mutations affected the SARS-CoV-2 binding affinity. …”
Publicado 2022
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4797por Bergamaschi, Cristina, Pagoni, Maria, Rosati, Margherita, Angel, Matthew, Tzannou, Ifigeneia, Vlachou, Margarita, Darmani, Ismini, Ullah, Amirah, Bear, Jenifer, Devasundaram, Santhi, Burns, Robert, Baltadakis, Ioannis, Gigantes, Stavros, Dimopoulos, Meletios-Athanasios, Pavlakis, George N., Terpos, Evangelos, Felber, Barbara K.“…The patients had significantly lower SARS-CoV-2 Spike antibodies to the Wuhan strain, with proportional lower cross-recognition of Beta, Delta, and Omicron Spike-RBD proteins. Both cohorts neutralized the wildtype WA1 and Delta but not Omicron. …”
Publicado 2022
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4798por Kangro, Kadri, Kurašin, Mihhail, Gildemann, Kiira, Sankovski, Eve, Žusinaite, Eva, Lello, Laura Sandra, Pert, Raini, Kavak, Ants, Poikalainen, Väino, Lepasalu, Lembit, Kuusk, Marilin, Pau, Robin, Piiskop, Sander, Rom, Siimu, Oltjer, Ruth, Tiirik, Kairi, Kogermann, Karin, Plaas, Mario, Tiirats, Toomas, Aasmäe, Birgit, Plaas, Mihkel, Mumm, Karl, Krinka, Dagni, Talpsep, Ene, Kadaja, Meelis, Gerhold, Joachim M., Planken, Anu, Tover, Andres, Merits, Andres, Männik, Andres, Ustav, Mart, Ustav, Mart“…Here, we immunized cows with SARS-CoV-2 S1 receptor binding domain (RBD) protein in proper adjuvant solutions, followed by one boost with SARS-CoV-2 trimeric S protein and purified immunoglobulins from colostrum. …”
Publicado 2022
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4799por Nayrac, Manon, Dubé, Mathieu, Sannier, Gérémy, Nicolas, Alexandre, Marchitto, Lorie, Tastet, Olivier, Tauzin, Alexandra, Brassard, Nathalie, Lima-Barbosa, Raphaël, Beaudoin-Bussières, Guillaume, Vézina, Dani, Gong, Shang Yu, Benlarbi, Mehdi, Gasser, Romain, Laumaea, Annemarie, Prévost, Jérémie, Bourassa, Catherine, Gendron-Lepage, Gabrielle, Medjahed, Halima, Goyette, Guillaume, Ortega-Delgado, Gloria-Gabrielle, Laporte, Mélanie, Niessl, Julia, Gokool, Laurie, Morrisseau, Chantal, Arlotto, Pascale, Richard, Jonathan, Bélair, Justin, Prat, Alexandre, Tremblay, Cécile, Martel-Laferrière, Valérie, Finzi, Andrés, Kaufmann, Daniel E.“…This regimen elicits robust RBD-specific B cell responses whose kinetics differs between cohorts, the second dose leading to increased magnitude in naive participants only. …”
Publicado 2022
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4800por Lo Tartaro, Domenico, Neroni, Anita, Paolini, Annamaria, Borella, Rebecca, Mattioli, Marco, Fidanza, Lucia, Quong, Andrew, Petes, Carlene, Awong, Geneve, Douglas, Samuel, Lin, Dongxia, Nieto, Jordan, Gozzi, Licia, Franceschini, Erica, Busani, Stefano, Nasi, Milena, Mattioli, Anna Vittoria, Trenti, Tommaso, Meschiari, Marianna, Guaraldi, Giovanni, Girardis, Massimo, Mussini, Cristina, Gibellini, Lara, Cossarizza, Andrea, De Biasi, Sara“…Elderly subjects have higher levels of pro-inflammatory cytokines, more circulating plasmablasts, reduced plasmatic level of anti-S and anti-RBD IgG3 antibodies, lower proportions of central memory CD4(+) T cells, more immature monocytes and CD56(+) pro-inflammatory monocytes, lower percentages of circulating follicular helper T cells (cTfh), antigen-specific cTfh cells with a less activated transcriptomic profile, lung resident activated macrophages that promote collagen deposition and fibrosis. …”
Publicado 2022
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