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  1. 4821
    “…Here we describe two fully human mAbs, amubarvimab (BRII-196) and romlusevimab (BRII-198) that bind to non-competing epitopes on the receptor binding domain (RBD) of spike protein and effectively neutralize SARS-CoV-2 variants. …”
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    Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2
  2. 4822
    “…RESULTS: Median half-life for the 20 naturally infected vs 74 vaccinated subjects (two doses) was 120 vs 50 days for RBD, 127 vs 53 days for S1 and 187 vs 86 days for S2 antibodies respectively. …”
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    A novel assessment method for COVID-19 humoral immunity duration using serial measurements in naturally infected and vaccinated subjects
  3. 4823
    “…Eligible articles measured antibodies against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike or Receptor‐Binding Domain Antibody (S/RBD) postimmunization with COVID‐19 mRNA vaccines. …”
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    Immunogenicity of COVID‐19 mRNA vaccines in hemodialysis patients: Systematic review and meta‐analysis
  4. 4824
    “…It was used as functional substract basis for the recognition site receptor-binding domain (RBD) from coronavirus spike protein (SARS-CoV-2), for the detection of Anti-S antibodies (AbS). …”
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    Novel approach based on GQD-PHB as anchoring platform for the development of SARS-CoV-2 electrochemical immunosensor
  5. 4825
    “…In the B.1.351 lineage, L18F and Del 242–244 in the NTD, K417N in the RBD and A701V in S2 also increased viral entry. …”
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    Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2
  6. 4826
    “…Further, the binding stability and compactness of these moieties with SARS-CoV-2 were analyzed through molecular dynamics (MD) simulations, and the results indicated that these moieties form well-stable complexes with the RBD of spike proteins. The identified moieties could be conjugated to the surfaces of non-toxic nanoparticles to provide multiple interactions to efficiently shield SARS-CoV-2, and inhibit viral entry to the host cells.…”
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    Integrated computational approach towards identification of HSPG and ACE2 mimicking moieties for SARS-CoV-2 inhibition
  7. 4827
    “…Median (interquartile range, IQR) anti-S-RBD IgG, Access SARS-CoV-2 IgG (1st IS) and Access SARS-CoV-2 IgG II levels of the subjects investigated were, respectively, 687 BAU/mL (131–2325), 419 IU/mL (58–1091) and 104 AU/mL (14–274). …”
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    Evaluation of the analytical performance of three chemiluminescence serological assays for detecting anti-SARS-CoV-2 antibodies
  8. 4828
    “…To assess its performance on mutations lists, we applied it to 13,578 distinct Spike RBD mutation patterns and showed that exactly or partially matching annotations were available for 88% of patterns CONCLUSION: Sierra SARS-CoV-2 leverages previously published data to improve the quality control of submitted viral genomic data and to provide functional annotation on the impact of mutations in the targets of antiviral SARS-CoV-2 therapy. …”
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    Sierra SARS-CoV-2 sequence and antiviral resistance analysis program
  9. 4829
    “…Treatment was with a single unit of CCP having an anti-RBD IgG concentration higher than 5 AU/mL. Results: There were 189 patients that completed the study, of which 65 (34.4%) had WHO 8-point clinical progression scale score of 3 (requiring hospital care but not oxygen support), 65 (34.4%) had a score of 4 (hospitalized and requiring supplemental oxygen by mask or nasal prongs), and 59 (31.2%) had a score of 5 (hospitalized and requiring supplemental oxygen by non-invasive ventilation or high-flow oxygen). …”
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    Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients—An Open-Label Phase II Clinical Trial
  10. 4830
    “…The humoral immune response, measured by a SARS-CoV-2 anti-spike receptor-binding domain (RBD) IgG titer, was prospectively assessed after the aforementioned vaccination schemes at different time points. …”
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    Immunogenicity and Effectiveness of Primary and Booster Vaccine Combination Strategies during Periods of SARS-CoV-2 Delta and Omicron Variants
  11. 4831
    “…The titers of anti-SARS-CoV-2 RBD IgGs and antibodies, which neutralized both the wild type and the circulating variants of concern of SARS-CoV-2 such as Delta and Omicron, were independent of the pre-boost levels of Ad26-neutralizing antibodies. …”
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    Anti-Ad26 humoral immunity does not compromise SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac booster vaccination
  12. 4832
    “…RESULTS: The antibodies to SARS-CoV-2 spike and subdomain proteins (RBD, S1, S2, and NTD) were significantly higher in serum than oral fluids but showed a greater detection rate and higher median titres in GCF than saliva. …”
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    BNT162b2 mRNA Vaccine–Induced Immune Response in Oral Fluids and Serum
  13. 4833
    “…In all comparisons, the RBD antigens demonstrated greater differences between WT and BA.1/BA.2 than the spike antigens. …”
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    Simultaneous measurement of multiple variant-specific SARS-CoV-2 neutralizing antibodies with a multiplexed flow cytometric assay
  14. 4834
    “…BA.2.75 is derived from BA.2 and contains four additional mutations in the receptor-binding domain (RBD). Here, we perform an antigenic and biophysical characterization of BA.2.75, revealing an interesting balance between humoral evasion and ACE2 receptor affinity. …”
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    A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75
  15. 4835
    “…Comparison of results was performed to a comparator semi-quantitative anti-S1 assay of indirect detection format as well as a commercially available and an in-house version of a surrogate neutralization assay (ACE2-RBD). RESULTS: The originally assigned units for the ACOV2S assay were shown to be congruent to the units of the First International WHO Standard for anti-SARS-CoV-2 immunoglobulins. …”
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    Design and performance characteristics of the Elecsys anti-SARS-CoV-2 S assay
  16. 4836
    “…RESULTS: cCOG cognitive tasks and clinical survey had moderate to strong correlations to standard neuropsychological testing (.61≤ r (s) ≤ .77) and to validated assessments of clinical features (.41≤ r (s) ≤ .65), except for fluctuations and REM‐sleep behavior disorder (RBD) (r (s) = .32 and r (s) = .10). Full cCOG, including both cognitive tasks and brief survey had a diagnostic accuracy (acc) of 0.82 [95% CI 0.73–0.89], with good discrimination of DLB versus AD (acc 0.87 [0.76–0.95]) and DLB versus controls (acc 0.94 [0.86–0.98]). …”
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    Optimizing cCOG, a Web‐based tool, to detect dementia with Lewy Bodies
  17. 4837
    “…Recently, we engineered an ACE2 mimetic that interacts with the Receptor Binding Domain (RBD) of the SARS-2 S protein. Here we present the use of this engineered mini-protein (p-deface2 mut) to develop a detection assay to measure NAbs in patient sera using a competitive ELISA assay. …”
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    In Vitro Diagnostic Assay to Detect SARS-CoV-2-Neutralizing Antibody in Patient Sera Using Engineered ACE-2 Mini-Protein
  18. 4838
    “…RESULTS: Parkinsonism and RBD were most frequently present early in the disease course, while hallucinations were more likely to develop in a later stage. …”
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    Disease progression in dementia with Lewy bodies: A longitudinal study on clinical symptoms, quality of life and functional impairment
  19. 4839
    por Callaway, Heather M., Hastie, Kathryn M., Schendel, Sharon L., Li, Haoyang, Yu, Xiaoying, Shek, Jeremy, Buck, Tierra, Hui, Sean, Bedinger, Dan, Troup, Camille, Dennison, S. Moses, Li, Kan, Alpert, Michael D., Bailey, Charles C., Benzeno, Sharon, Bonnevier, Jody L., Chen, Jin-Qiu, Chen, Charm, Cho, Hyeseon, Crompton, Peter D., Dussupt, Vincent, Entzminger, Kevin C., Ezzyat, Yassine, Fleming, Jonathan K., Geukens, Nick, Gilbert, Amy E., Guan, Yongjun, Han, Xiaojian, Harvey, Christopher J., Hatler, Julia M., Howie, Bryan, Hu, Chao, Huang, Ailong, Imbrechts, Maya, Jin, Aishun, Kamachi, Nik, Keitany, Gladys, Klinger, Mark, Kolls, Jay K., Krebs, Shelly J., Li, Tingting, Luo, Feiyan, Maruyama, Toshiaki, Meehl, Michael A., Mendez-Rivera, Letzibeth, Musa, Andrea, Okumura, C.J., Rubin, Benjamin E.R., Sato, Aaron K., Shen, Meiying, Singh, Anirudh, Song, Shuyi, Tan, Joshua, Trimarchi, Jeffrey M., Upadhyay, Dhruvkumar P., Wang, Yingming, Yu, Lei, Yuan, Tom Z., Yusko, Erik, Peters, Bjoern, Tomaras, Georgia, Saphire, Erica Ollmann
    Publicado 2023
    “…Among natural immunoglobulin Gs (IgGs), especially those in the receptor-binding domain (RBD)-2 epitope community, nearly all Omicron neutralizers recognize spike bivalently, with both antigen-binding fragments (Fabs) simultaneously engaging adjacent RBDs on the same spike. …”
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    Bivalent intra-spike binding provides durability against emergent Omicron lineages: Results from a global consortium
  20. 4840
    “…A low dose of 5 μg monovalent recombinant protein or 2.5 μg bivalent vaccine triggered high-titer antibodies that showed cross-activity to Beta, Delta, and Gamma RBD in mice. The third immunization dose could boost (1.1 to 40.6 times) high levels of cross-binding antibodies and elicit high titers of neutralizing antibodies (64 to 1024) prototype, Beta, Delta, and Omicron variants. …”
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    S Trimer Derived from SARS-CoV-2 B.1.351 and B.1.618 Induced Effective Immune Response against Multiple SARS-CoV-2 Variants
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