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4821por Ji, Yun, Zhang, Qi, Cheng, Lin, Ge, Jiwan, Wang, Ruoke, Fang, Mengqi, Mucker, Eric M., Chen, Peng, Ma, Ji, Zhang, Rui, Li, Chunming, Hammond, Holly, Baracco, Lauren, Holbrook, Michael, Frieman, Matthew, Zhang, Zheng, Wang, Xinquan, Hooper, Jay W., Zhang, Linqi, Zhu, Qing“…Here we describe two fully human mAbs, amubarvimab (BRII-196) and romlusevimab (BRII-198) that bind to non-competing epitopes on the receptor binding domain (RBD) of spike protein and effectively neutralize SARS-CoV-2 variants. …”
Publicado 2022
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4822por de Boer, Jasper, Saade, Ursula, Granjon, Elodie, Trouillet-Assant, Sophie, Saade, Carla, Pottel, Hans, Zrein, Maan“…RESULTS: Median half-life for the 20 naturally infected vs 74 vaccinated subjects (two doses) was 120 vs 50 days for RBD, 127 vs 53 days for S1 and 187 vs 86 days for S2 antibodies respectively. …”
Publicado 2022
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4823“…Eligible articles measured antibodies against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike or Receptor‐Binding Domain Antibody (S/RBD) postimmunization with COVID‐19 mRNA vaccines. …”
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4824por Martins, Gustavo, Gogola, Jeferson L., Budni, Lucas H., Papi, Maurício A., Bom, Maritza A.T., Budel, Maria L.T., de Souza, Emanuel M., Müller-Santos, Marcelo, Beirão, Breno C.B., Banks, Craig E., Marcolino-Junior, Luiz H., Bergamini, Márcio F.“…It was used as functional substract basis for the recognition site receptor-binding domain (RBD) from coronavirus spike protein (SARS-CoV-2), for the detection of Anti-S antibodies (AbS). …”
Publicado 2022
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4825por Peng, Qiaoli, Zhou, Runhong, Liu, Na, Wang, Hui, Xu, Haoran, Zhao, Meiqing, Yang, Dawei, Au, Ka-Kit, Huang, Haode, Liu, Li, Chen, Zhiwei“…In the B.1.351 lineage, L18F and Del 242–244 in the NTD, K417N in the RBD and A701V in S2 also increased viral entry. …”
Publicado 2022
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4826por Sreekumar, Sreya, M. Kuthe, Abhaykumar, Chandra Tripathi, Satyendra, C. Patil, Ganesh, Ravikumar, C.“…Further, the binding stability and compactness of these moieties with SARS-CoV-2 were analyzed through molecular dynamics (MD) simulations, and the results indicated that these moieties form well-stable complexes with the RBD of spike proteins. The identified moieties could be conjugated to the surfaces of non-toxic nanoparticles to provide multiple interactions to efficiently shield SARS-CoV-2, and inhibit viral entry to the host cells.…”
Publicado 2022
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4827por Lo Sasso, Bruna, Agnello, Luisa, Giglio, Rosaria Vincenza, Scazzone, Concetta, Massa, Davide, Ciaccio, Anna Maria, Gambino, Caterina Maria, Vidali, Matteo, Ciaccio, Marcello“…Median (interquartile range, IQR) anti-S-RBD IgG, Access SARS-CoV-2 IgG (1st IS) and Access SARS-CoV-2 IgG II levels of the subjects investigated were, respectively, 687 BAU/mL (131–2325), 419 IU/mL (58–1091) and 104 AU/mL (14–274). …”
Publicado 2022
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4828por Tzou, Philip L., Tao, Kaiming, Sahoo, Malaya K., Kosakovsky Pond, Sergei L., Pinsky, Benjamin A., Shafer, Robert W.“…To assess its performance on mutations lists, we applied it to 13,578 distinct Spike RBD mutation patterns and showed that exactly or partially matching annotations were available for 88% of patterns CONCLUSION: Sierra SARS-CoV-2 leverages previously published data to improve the quality control of submitted viral genomic data and to provide functional annotation on the impact of mutations in the targets of antiviral SARS-CoV-2 therapy. …”
Publicado 2022
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4829por Grubovic Rastvorceva, Rada M., Useini, Sedula, Stevanovic, Milena, Demiri, Ilir, Petkovic, Elena, Franchini, Massimo, Focosi, Daniele“…Treatment was with a single unit of CCP having an anti-RBD IgG concentration higher than 5 AU/mL. Results: There were 189 patients that completed the study, of which 65 (34.4%) had WHO 8-point clinical progression scale score of 3 (requiring hospital care but not oxygen support), 65 (34.4%) had a score of 4 (hospitalized and requiring supplemental oxygen by mask or nasal prongs), and 59 (31.2%) had a score of 5 (hospitalized and requiring supplemental oxygen by non-invasive ventilation or high-flow oxygen). …”
Publicado 2022
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4830por Moghnieh, Rima, El Hajj, Claude, Abdallah, Dania, Jbeily, Nayla, Bizri, Abdul Rahman, Sayegh, Mohamed H.“…The humoral immune response, measured by a SARS-CoV-2 anti-spike receptor-binding domain (RBD) IgG titer, was prospectively assessed after the aforementioned vaccination schemes at different time points. …”
Publicado 2022
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4831por Byazrova, Maria G., Astakhova, Ekaterina A., Minnegalieva, Aygul R., Sukhova, Maria M., Mikhailov, Artem A., Prilipov, Alexey G., Gorchakov, Andrey A., Filatov, Alexander V.“…The titers of anti-SARS-CoV-2 RBD IgGs and antibodies, which neutralized both the wild type and the circulating variants of concern of SARS-CoV-2 such as Delta and Omicron, were independent of the pre-boost levels of Ad26-neutralizing antibodies. …”
Publicado 2022
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4832por Seneviratne, Chaminda Jayampath, Balan, Preethi, de Alwis, Ruklanthi, Udawatte, Nadeeka S., Herath, Thanuja, Toh, Justin Z.N., Tin, Goh Bee, Ooi, Eng Eong, Hong, Jenny Low Guek, Ying, Jean Sim Xiang“…RESULTS: The antibodies to SARS-CoV-2 spike and subdomain proteins (RBD, S1, S2, and NTD) were significantly higher in serum than oral fluids but showed a greater detection rate and higher median titres in GCF than saliva. …”
Publicado 2022
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4833por Liu, Hong, Varvel, Stephen, Chen, Ge, McConnell, Joseph, Caffrey, Rebecca, Galdzicka, Marzena, Shabahang, Shahrokh“…In all comparisons, the RBD antigens demonstrated greater differences between WT and BA.1/BA.2 than the spike antigens. …”
Publicado 2022
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4834por Huo, Jiandong, Dijokaite-Guraliuc, Aiste, Liu, Chang, Zhou, Daming, Ginn, Helen M., Das, Raksha, Supasa, Piyada, Selvaraj, Muneeswaran, Nutalai, Rungtiwa, Tuekprakhon, Aekkachai, Duyvesteyn, Helen M.E., Mentzer, Alexander J., Skelly, Donal, Ritter, Thomas G., Amini, Ali, Bibi, Sagida, Adele, Sandra, Johnson, Sile Ann, Paterson, Neil G., Williams, Mark A., Hall, David R., Plowright, Megan, Newman, Thomas A.H., Hornsby, Hailey, de Silva, Thushan I., Temperton, Nigel, Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Pollard, Andrew J., Lambe, Teresa, Goulder, Philip, Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.“…BA.2.75 is derived from BA.2 and contains four additional mutations in the receptor-binding domain (RBD). Here, we perform an antigenic and biophysical characterization of BA.2.75, revealing an interesting balance between humoral evasion and ACE2 receptor affinity. …”
Publicado 2023
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4835por Taffertshofer, Karin, Walter, Mirko, Mackeben, Peter, Kraemer, Julia, Potapov, Sergej, Jochum, Simon“…Comparison of results was performed to a comparator semi-quantitative anti-S1 assay of indirect detection format as well as a commercially available and an in-house version of a surrogate neutralization assay (ACE2-RBD). RESULTS: The originally assigned units for the ACOV2S assay were shown to be congruent to the units of the First International WHO Standard for anti-SARS-CoV-2 immunoglobulins. …”
Publicado 2022
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4836por van Gils, Aniek M., van de Beek, Marleen, van Unnik, Annemartijn A. J. M., Tolonen, Antti, Handgraaf, Dédé, van Leeuwenstijn, Mardou, Lötjönen, Jyrki, van der Flier, Wiesje M., Lemstra, Afina, Rhodius‐Meester, Hanneke F. M.“…RESULTS: cCOG cognitive tasks and clinical survey had moderate to strong correlations to standard neuropsychological testing (.61≤ r (s) ≤ .77) and to validated assessments of clinical features (.41≤ r (s) ≤ .65), except for fluctuations and REM‐sleep behavior disorder (RBD) (r (s) = .32 and r (s) = .10). Full cCOG, including both cognitive tasks and brief survey had a diagnostic accuracy (acc) of 0.82 [95% CI 0.73–0.89], with good discrimination of DLB versus AD (acc 0.87 [0.76–0.95]) and DLB versus controls (acc 0.94 [0.86–0.98]). …”
Publicado 2022
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4837por Pereira de Jesus, Bruna Andersen, Gomes, Anderson Albino, Clark, Alex E., Rodrigues, Tayse Andrade, Ledgerwood-Lee, Melissa, Van Zant, Westley, Brickner, Howard, Wang, Meiqiao, Blum, David L., Cassera, Maria B., Carlin, Aaron F., Aronoff-Spencer, Eliah S., da Silva, Gustavo Felippe, Magalhães, Maria de Lourdes Borba, Ray, Partha“…Recently, we engineered an ACE2 mimetic that interacts with the Receptor Binding Domain (RBD) of the SARS-2 S protein. Here we present the use of this engineered mini-protein (p-deface2 mut) to develop a detection assay to measure NAbs in patient sera using a competitive ELISA assay. …”
Publicado 2022
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4838por van de Beek, Marleen, van Unnik, Annemartijn, van Steenoven, Inger, van der Zande, Jessica, Barkhof, Frederik, Teunissen, Charlotte E., van der Flier, Wiesje, Lemstra, Afina W.“…RESULTS: Parkinsonism and RBD were most frequently present early in the disease course, while hallucinations were more likely to develop in a later stage. …”
Publicado 2022
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4839por Callaway, Heather M., Hastie, Kathryn M., Schendel, Sharon L., Li, Haoyang, Yu, Xiaoying, Shek, Jeremy, Buck, Tierra, Hui, Sean, Bedinger, Dan, Troup, Camille, Dennison, S. Moses, Li, Kan, Alpert, Michael D., Bailey, Charles C., Benzeno, Sharon, Bonnevier, Jody L., Chen, Jin-Qiu, Chen, Charm, Cho, Hyeseon, Crompton, Peter D., Dussupt, Vincent, Entzminger, Kevin C., Ezzyat, Yassine, Fleming, Jonathan K., Geukens, Nick, Gilbert, Amy E., Guan, Yongjun, Han, Xiaojian, Harvey, Christopher J., Hatler, Julia M., Howie, Bryan, Hu, Chao, Huang, Ailong, Imbrechts, Maya, Jin, Aishun, Kamachi, Nik, Keitany, Gladys, Klinger, Mark, Kolls, Jay K., Krebs, Shelly J., Li, Tingting, Luo, Feiyan, Maruyama, Toshiaki, Meehl, Michael A., Mendez-Rivera, Letzibeth, Musa, Andrea, Okumura, C.J., Rubin, Benjamin E.R., Sato, Aaron K., Shen, Meiying, Singh, Anirudh, Song, Shuyi, Tan, Joshua, Trimarchi, Jeffrey M., Upadhyay, Dhruvkumar P., Wang, Yingming, Yu, Lei, Yuan, Tom Z., Yusko, Erik, Peters, Bjoern, Tomaras, Georgia, Saphire, Erica Ollmann“…Among natural immunoglobulin Gs (IgGs), especially those in the receptor-binding domain (RBD)-2 epitope community, nearly all Omicron neutralizers recognize spike bivalently, with both antigen-binding fragments (Fabs) simultaneously engaging adjacent RBDs on the same spike. …”
Publicado 2023
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4840por Wang, Hongye, Wang, Zengshuai, Ma, Liang, Zhu, Xiaoyong, Li, Bingxiang, Huang, Yuhang, Li, Jingwen, Sun, Ming, Shi, Li, Yao, Yufeng“…A low dose of 5 μg monovalent recombinant protein or 2.5 μg bivalent vaccine triggered high-titer antibodies that showed cross-activity to Beta, Delta, and Gamma RBD in mice. The third immunization dose could boost (1.1 to 40.6 times) high levels of cross-binding antibodies and elicit high titers of neutralizing antibodies (64 to 1024) prototype, Beta, Delta, and Omicron variants. …”
Publicado 2023
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