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4861por Das, Depro, Raha, Fahmida Khanam, Adnan, Khondekar Mustaq, Siraj, Md Rubayet, Shapla, Mariam Jamila, Shumy, Farzana, Haque, Md Emdadul, Khan, Monwar Hasanat, Sanyal, Susmita, Hosen, Md Ismail, Nabi, AHM Nurun, Sanyal, Mousumi, Chakraborty, Sajib, Amin, Md Zahid“…In this study, we investigated the impact of comorbidities on humoral antibody responses against the specific receptor-binding domain (RBD) of SARS-CoV2. METHODS: A total of 1005 patients were selected for the SARS-CoV-2 specific immunoglobulin G (IgG1, IgG2, IgG3, and IgG4 subclasses) and total antibody (TAb) tests (IgG and IgM), of which 912 serum samples were ultimately selected based on the specimen cutoff analyte value. …”
Publicado 2023
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4862por Völzke, Jule L., Smatty, Sarah, Döring, Sarah, Ewald, Shireen, Oelze, Marcus, Fratzke, Franziska, Flemig, Sabine, Konthur, Zoltán, Weller, Michael G.“…To show that this method is also suitable for mammalian cell culture supernatants, purification of the SARS-CoV-2-S-RBD-His8 expressed in human Expi293F cells was performed. …”
Publicado 2023
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4863por Dejus, Brigita, Cacivkins, Pāvels, Gudra, Dita, Dejus, Sandis, Ustinova, Maija, Roga, Ance, Strods, Martins, Kibilds, Juris, Boikmanis, Guntis, Ortlova, Karina, Krivko, Laura, Birzniece, Liga, Skinderskis, Edmunds, Berzins, Aivars, Fridmanis, Davids, Juhna, Talis“…The RNA signals in the wastewater were compared to the reported COVID-19 cases, and the strain prevalence data of the SARS-CoV-2 virus were identified by targeted sequencing of receptor binding domain (RBD) and furin cleavage site (FCS) regions employing next-generation sequencing technology. …”
Publicado 2023
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4864por Kuroiwa, Miho, Gahara, Yoshinari, Kato, Hirohito, Morikawa, Yuji, Matsui, Yuki, Adachi, Takumi, Kurosawa, Shin, Kuroita, Tomohiro, Ando, Yoshinori, Rokushima, Masatomo“…In addition, by targeting the receptor binding domain (RBD) of the S protein, which has mutations informative for variant classification, we could discriminate most variants of concern (VOC) and even sublineages of Omicron (BA.1, BA.2, BA.4/5, BA.2.75, BQ.1.1 and XBB.1). …”
Publicado 2023
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4865por Ma, Chengbao, Liu, Chen, Xiong, Qing, Gu, Mengxue, Shi, Lulu, Wang, Chunli, Si, Junyu, Tong, Fei, Liu, Peng, Huang, Meiling, Yan, Huan“…Herein, we characterized the species-specific receptor preference of these viruses by testing ACE2 orthologues from 49 bats and 53 non-bat mammals through receptor-binding domain (RBD)-binding and pseudovirus entry assays. Results based on bat ACE2 orthologues revealed that the two viruses were unable to use most, but not all, ACE2 from Yinpterochiropteran bats (Yin-bats), which is distinct from NL63 and SARS-CoV-2. …”
Publicado 2023
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4866“…This study investigated the adsorption capacity of a geopolymer based on metakaolin incorporating two different ratios (20% and 40% by weight) of cement kiln dust (MC1 and MC2) for the reactive black 5 dyeing bath effluent (RBD) only and in a combination of 1200 mg/L of Pb(2+) and Cd(2+), each separately, in aqueous solutions under different adsorption parameters. …”
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4867por Hertz, Tomer, Levy, Shlomia, Ostrovsky, Daniel, Oppenheimer, Hanna, Zismanov, Shosh, Kuzmina, Alona, Friedman, Lilach M., Trifkovic, Sanja, Brice, David, Chun-Yang, Lin, Cohen-Lavi, Liel, Shemer-Avni, Yonat, Cohen-Lahav, Merav, Amichay, Doron, Keren-Naus, Ayelet, Voloshin, Olga, Weber, Gabriel, Najjar-Debbiny, Ronza, Chazan, Bibiana, McGargill, Maureen A., Webby, Richard, Chowers, Michal, Novack, Lena, Novack, Victor, Taube, Ran, Nesher, Lior, Weinstein, Orly“…A combination of reduced IgG levels to RBD mutants and reduced VOC-recognizing IgA antibodies represented the strongest COP in both the 3-dose group (HR = 6.34, p = 0.008) and four-dose group (HR = 8.14, p = 0.018). …”
Publicado 2023
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4868por Tukhvatulin, Amir I., Dolzhikova, Inna V., Dzharullaeva, Alina S., Grousova, Daria M., Kovyrshina, Anna V., Zubkova, Olga V., Zorkov, Ilya D., Iliukhina, Anna A., Shelkov, Artem Y., Erokhova, Alina S., Popova, Olga, Ozharovskaia, Tatiana A., Zrelkin, Denis I., Izhaeva, Fatima M., Shcheblyakov, Dmitry V., Esmagambetov, Ilias B., Tokarskaya, Elisaveta A., Nikitenko, Natalia A., Lubenets, Nadezhda L., Khadorich, Elizaveta A., Gushchin, Vladimir A., Borzakova, Svetlana N., Vlasova, Anna V., Osmanov, Ismail M., Gorev, Valerii V., Naroditsky, Boris S., Logunov, Denis Y., Gintsburg, Alexander L.“…The 1/5 vaccine dose elicited higher antigen-binding (both S and RBD-specific) as well as virus-neutralising antibody titres at the maximum of response (day 42), also resulting in a statistically significant difference at a distanced timepoint (day 180) compared to the 1/10 vaccine dose. …”
Publicado 2023
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4869por Seaman, William T, Keener, Olive, Mei, Wenwen, Mollan, Katie R, Jones, Corbin D, Pettifor, Audrey, Bowman, Natalie M, Wang, Frank, Webster-Cyriaque, Jennifer“…SARS-CoV-2-anti-S protein RBD LFA assessed IgM and IgG responses. Structural analysis identified host salivary molecules analogous to SARS-CoV-2-N-antigen. …”
Publicado 2023
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4870por Lei, Mengyue, Ma, Ying, Chen, Hongli, Huang, Pu, Sun, Jing, Wang, Xu, Sun, Qiangming, Hu, Yunzhang, Shi, Jiandong“…The critical aa sites that determined the susceptibility of the SARS-CoV-2 to the host were screened by aligning the residues interfacing with the N-terminal domain (NTD) or receptor-binding domain (RBD) of Spike protein. RESULTS: The binding modes of chickens AXL and ACE2 to S protein are similar to that of the ferret. …”
Publicado 2023
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4871por Zemke, Anna C., D'Amico, Emily J., Torres, Angela M., Carreno-Florez, Grace P., Keeley, Patrick, DuPont, Matt, Kasturiarachi, Naomi, Bomberger, Jennifer M.“…Combined deletion of the phosphodiesterases dipA, bifA, and rbdA was required to attenuate the dispersal phenotype. …”
Publicado 2023
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4872por Schest, Silvia, Langer, Claus, Stiegler, Yuriko, Karnuth, Bianca, Arends, Jan, Stiegler, Hugo, Masetto, Thomas, Peter, Christoph, Grimmler, Matthias“…ECLIA and PETIA, which detect total antibodies against the receptor- binding domain (RBD) within the S1 subunit, interact similarly with the convalescent plasma-derived WHO IS but differently with vaccine serum, indicating a high sensitivity to the IgG/IgM/IgA ratio. …”
Publicado 2023
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4873por Onyango, Therese Bredholt, Zhou, Fan, Bredholt, Geir, Brokstad, Karl A., Lartey, Sarah, Mohn, Kristin G.-I., Özgümüs, Türküler, Kittang, Bård Reiakvam, Linchausen, Dagrun Waag, Shafiani, Shahin, Elyanow, Rebecca, Blomberg, Bjørn, Langeland, Nina, Cox, Rebecca Jane“…We determined SARS-CoV-2 spike-specific IgG, IgA, IgM levels by ELISA and neutralising antibody titres by neutralisation assay. RBD- and spike-specific memory B cells were investigated by ELISpot, spike- and non-spike-specific IFN-γ, IL-2 and IFN-γ/IL-2 secreting T cells by FluoroSpot and T cell receptor (TCR) sequencing was performed. …”
Publicado 2023
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4874por Leung, Daniel, Chan, Eugene Yu-hin, Mu, Xiaofeng, Rosa Duque, Jaime S., Cheng, Samuel M.S., Ho, Fanny Tsz-wai, Tong, Pak-chiu, Lai, Wai-ming, Lee, Matthew H.L., Chim, Stella, Tam, Issan Y.S., Tsang, Leo C.H., Kwan, Kelvin K.H., Chung, Yuet, Wong, Howard H.W., Lee, Amos M.T., Li, Wing Yan, Sze, Summer T.K., Lam, Jennifer H.Y., Lee, Derek H.L., Chan, Sau Man, Tu, Wenwei, Peiris, Malik, Ma, Alison Lap-tak, Lau, Yu Lung“…RESULTS: Three doses of either vaccine type elicited significant antibody responses that included spike receptor-binding domain (S-RBD) IgG (90.5%–93.8% seropositive) and surrogate virus neutralization (geometric mean sVNT% level, 78.6%–79.3%). …”
Publicado 2023
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4875por Gould, Gillian Sandra, Watt, Kerrianne, McEwen, Andy, Cadet-James, Yvonne, Clough, Alan R“…Perceived efficacy for quitting, and perceived threat from smoking, were uniquely assessed with a validated Risk Behaviour Diagnosis (RBD) Scale. MAIN OUTCOME MEASURES: Logistic regression explored the impact of perceived efficacy, perceived threat and consulting previously with a doctor or health professional (HP) on self-reported intentions to quit smoking, controlling for potential confounders, that is, protection responses and fear control responses, home smoking rules, gender and age. …”
Publicado 2015
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4876“…CONCLUSION: It seems that all of these substitutions are not produced at the key residues of the RNA-binding domain (RBD) and the effector domain (ED). Consequently, we can suppose that they will not affect the potency of inhibition of cellular defences, and the virulence of the Moroccan equine strains will be maintained.…”
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4877por Hu, Ben, Zeng, Lei-Ping, Yang, Xing-Lou, Ge, Xing-Yi, Zhang, Wei, Li, Bei, Xie, Jia-Zheng, Shen, Xu-Rui, Zhang, Yun-Zhi, Wang, Ning, Luo, Dong-Sheng, Zheng, Xiao-Shuang, Wang, Mei-Niang, Daszak, Peter, Wang, Lin-Fa, Cui, Jie, Shi, Zheng-Li“…Importantly, strains with high genetic similarity to SARS-CoV in the hypervariable N-terminal domain (NTD) and receptor-binding domain (RBD) of the S1 gene, the ORF3 and ORF8 region, respectively, were all discovered in this cave. …”
Publicado 2017
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4878por Nyon, Mun Peak, Du, Lanying, Tseng, Chien-Te Kent, Seid, Christopher A., Pollet, Jeroen, Naceanceno, Kevin S., Agrawal, Anurodh, Algaissi, Abdullah, Peng, Bi-Hung, Tai, Wanbo, Jiang, Shibo, Bottazzi, Maria Elena, Strych, Ulrich, Hotez, Peter J.“…To address this need, we are developing a subunit recombinant protein vaccine comprising residues 377–588 of the MERS-CoV spike protein receptor-binding domain (RBD), which, when formulated with the AddaVax adjuvant, it induces a significant neutralizing antibody response and protection against MERS-CoV challenge in vaccinated animals. …”
Publicado 2018
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4879“…Entry of the SARS-CoV-2 into the host cell involves interaction of the virus (via the receptor-binding domain (RBD) of its spike glycoprotein) with the membrane-bound form of angiotensin-converting enzyme 2 (ACE2) followed by the virus-ACE2 complex internalization by the cell. …”
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4880por Lv, Liangjie, Zhang, Wenying, Sun, Lijing, Zhao, Aiju, Zhang, Yingjun, Wang, Limei, Liu, Yuping, Li, Ziqian, Li, Hui, Chen, Xiyong“…Twelve central, greatly correlated genes in stage-specific modules were subsequently confirmed and validated at the transcription levels, including TraesCS7D01G417600.1 (PP2C), TraesCS5B01G565300.1 (ERF), TraesCS4A01G068200.1 (HSP), TraesCS2D01G033200.1 (HSP90), TraesCS6B01G425300.1 (RBD), TraesCS7A01G499200.1 (P450), TraesCS4A01G118400.1 (MYB), TraesCS2B01G415500.1 (STK), TraesCS1A01G129300.1 (MYB), TraesCS2D01G326900.1 (ALDH), TraesCS3D01G227400.1 (WRKY), and TraesCS3B01G144800.1 (GT). …”
Publicado 2020
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