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4901por Shukla, Nidhi, Roelle, Sarah M., Suzart, Vinicius G., Bruchez, Anna M., Matreyek, Kenneth A.“…Our infection results revealed a non-linear relationship between soluble SARS-CoV-2 RBD binding to ACE2 and pseudovirus infection, supporting a major role for binding avidity during entry. …”
Publicado 2021
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4902por Li, Lei, Honda-Okubo, Yoshikazu, Huang, Ying, Jang, Hyesun, Carlock, Michael A., Baldwin, Jeremy, Piplani, Sakshi, Bebin-Blackwell, Anne G., Forgacs, David, Sakamoto, Kaori, Stella, Alberto, Turville, Stuart, Chataway, Tim, Colella, Alex, Triccas, Jamie, Ross, Ted M., Petrovsky, Nikolai“…Ferrets immunised with Covax-19 vaccine intramuscularly twice 2 weeks apart made spike receptor binding domain (RBD) IgG and were protected against an intranasal challenge with SARS-CoV-2 virus given two weeks after the last immunisation. …”
Publicado 2021
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4903por Golan, Yarden, Prahl, Mary, Cassidy, Arianna G., Gay, Caryl, Wu, Alan H.B., Jigmeddagva, Unurzul, Lin, Christine Y., Gonzalez, Veronica J., Basilio, Emilia, Warrier, Lakshmi, Buarpung, Sirirak, Li, Lin, Murtha, Amy P., Asiodu, Ifeyinwa V., Ahituv, Nadav, Flaherman, Valerie J., Gaw, Stephanie L.“…After vaccination, levels of anti-SARS-CoV-2 IgG and IgM significantly increased in maternal plasma and there was significant transfer of anti-SARS-CoV-2-Receptor Binding Domain (anti-RBD) IgA and IgG antibodies to milk. Milk IgA levels after the 2nd dose were negatively associated with infant age. …”
Publicado 2021
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4904por Brejová, Broňa, Boršová, Kristína, Hodorová, Viktória, Čabanová, Viktória, Reizigová, Lenka, Paul, Evan D., Čekan, Pavol, Klempa, Boris, Nosek, Jozef, Vinař, Tomáš“…Phylogenetic analysis shows that the early sublineage of B.1.258 acquired the N439K substitution in the receptor-binding domain (RBD) of the Spike protein and, later on, also the deletion ∆H69/∆V70 in the Spike N-terminal domain (NTD). …”
Publicado 2021
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4905por Dhakal, Santosh, Ruiz-Bedoya, Camilo A., Zhou, Ruifeng, Creisher, Patrick S., Villano, Jason S., Littlefield, Kirsten, Ruelas Castillo, Jennie, Marinho, Paula, Jedlicka, Anne E., Ordonez, Alvaro A., Bahr, Melissa, Majewska, Natalia, Betenbaugh, Michael J., Flavahan, Kelly, Mueller, Alice R. L., Looney, Monika M., Quijada, Darla, Mota, Filipa, Beck, Sarah E., Brockhurst, Jacqueline, Braxton, Alicia M., Castell, Natalie, Stover, Mitchel, D’Alessio, Franco R., Metcalf Pate, Kelly A., Karakousis, Petros C., Mankowski, Joseph L., Pekosz, Andrew, Jain, Sanjay K., Klein, Sabra L.“…However, during the recovery phase of infection, females mounted 2-fold greater IgM, IgG, and IgA responses against the receptor-binding domain of the spike protein (S-RBD) in both plasma and respiratory tissues. Female hamsters also had significantly greater IgG antibodies against whole-inactivated SARS-CoV-2 and mutant S-RBDs as well as virus-neutralizing antibodies in plasma. …”
Publicado 2021
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4906por Pelleau, Stéphane, Woudenberg, Tom, Rosado, Jason, Donnadieu, Françoise, Garcia, Laura, Obadia, Thomas, Gardais, Soazic, Elgharbawy, Yasmine, Velay, Aurelie, Gonzalez, Maria, Nizou, Jacques Yves, Khelil, Nizar, Zannis, Konstantinos, Cockram, Charlotte, Merkling, Sarah Hélène, Meola, Annalisa, Kerneis, Solen, Terrier, Benjamin, de Seze, Jerome, Planas, Delphine, Schwartz, Olivier, Dejardin, François, Petres, Stéphane, von Platen, Cassandre, Pellerin, Sandrine Fernandes, Arowas, Laurence, de Facci, Louise Perrin, Duffy, Darragh, Cheallaigh, Clíona Ní, Dunne, Jean, Conlon, Niall, Townsend, Liam, Duong, Veasna, Auerswald, Heidi, Pinaud, Laurie, Tondeur, Laura, Backovic, Marija, Hoen, Bruno, Fontanet, Arnaud, Mueller, Ivo, Fafi-Kremer, Samira, Bruel, Timothée, White, Michael“…RESULTS: One year after symptoms, we estimate that 36% (95% range, 11%–94%) of anti-Spike immunoglobulin G (IgG) remains, 31% (95% range, 9%–89%) anti-RBD IgG remains, and 7% (1%–31%) of anti-nucleocapsid IgG remains. …”
Publicado 2021
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4907“…The SuperPose findings have revealed a conformational change impact of D614G in allowing the polybasic Furin cleavage site ((682)RRAR↓S(686)) to be closer to the receptor-binding domain (RBD) and hence more exposed to cleavage. The presence of D614G in any clade or subclade, such as 20A, B.1.1.7 (20I/501Y.V1) or Alpha, B.1.351 (20H/501Y.V2) or Beta, P.1 (20J/501Y.V3) or Gamma, B.1.617.2 (21A/478K.V1) or Delta, has increased its stability and flexibility and unified the superimposition among all clades which might impact the virus ability to escape the antibodies neutralization by changing the antigenicity drift of the protein three-dimensional (3D) structure from the wild type clade 19A; this is in agreement with previous study. …”
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4908por Elli, Luca, Facciotti, Federica, Lombardo, Vincenza, Scricciolo, Alice, Sanders, David S., Vaira, Valentina, Barisani, Donatella, Vecchi, Maurizio, Costantino, Andrea, Scaramella, Lucia, dell'Osso, Bernardo, Doneda, Luisa, Roncoroni, Leda“…The presence of anti-SARS-CoV-2 IgG and IgA (anti-RBD and N proteins) was compared to that in non-CD subjects. …”
Publicado 2022
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4909“…We show that infectivity-strengthening and antibody-disruptive co-mutations on the S protein receptor-binding domain (RBD) can quantitatively explain the infectivity and virulence of all prevailing variants. …”
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4910por Chen, Guan-Yu, Pan, Yi-Cheng, Wu, Tung-Ying, Yao, Tsung-You, Wang, Wei-Jan, Shen, Wan-Jou, Ahmed, Azaj, Chan, Shu-Ting, Tang, Chih-Hsin, Huang, Wei-Chien, Hung, Mien-Chie, Yang, Juan-Cheng, Wu, Yang-Chang“…RESULTS AND CONCLUSION: We identified 39 natural products targeting the viral receptor-binding domain (RBD) of the SARS-CoV-2 spike protein in silico. …”
Publicado 2021
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4911por Huo, Jiandong, Mikolajek, Halina, Le Bas, Audrey, Clark, Jordan J., Sharma, Parul, Kipar, Anja, Dormon, Joshua, Norman, Chelsea, Weckener, Miriam, Clare, Daniel K., Harrison, Peter J., Tree, Julia A., Buttigieg, Karen R., Salguero, Francisco J., Watson, Robert, Knott, Daniel, Carnell, Oliver, Ngabo, Didier, Elmore, Michael J., Fotheringham, Susan, Harding, Adam, Moynié, Lucile, Ward, Philip N., Dumoux, Maud, Prince, Tessa, Hall, Yper, Hiscox, Julian A., Owen, Andrew, James, William, Carroll, Miles W., Stewart, James P., Naismith, James H., Owens, Raymond J.“…We report four nanobodies (C5, H3, C1, F2) engineered as homotrimers with pmolar affinity for the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. Crystal structures show C5 and H3 overlap the ACE2 epitope, whilst C1 and F2 bind to a different epitope. …”
Publicado 2021
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4912por Vályi-Nagy, István, Matula, Zsolt, Gönczi, Márton, Tasnády, Szabolcs, Bekő, Gabriella, Réti, Marienn, Ajzner, Éva, Uher, Ferenc“…The BBIBP-CorV vaccine elicited antireceptor-binding domain (RBD) IgG, as well as anti-spike protein (S) IgG and IgA antibodies in healthy individuals, the levels of which were much lower than after BNT162b2 vaccination but still higher than in the convalescent patients. …”
Publicado 2021
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4913por kumar, B. Harish, Manandhar, Suman, Mehta, Chetan H., Nayak, Usha Y., Pai, K. Sreedhara Ranganath“…Computational-based study has highlighted the potential of the many constituents of traditional medicine to interact with the SARS-CoV-2 RBD and ACE2, which might stop the viral entry into the cell. …”
Publicado 2021
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4914por Gorchakov, Andrey A., Kulemzin, Sergey V., Guselnikov, Sergey V., Baranov, Konstantin O., Belovezhets, Tatyana N., Mechetina, Ludmila V., Volkova, Olga Yu., Najakshin, Alexander M., Chikaev, Nikolai A., Chikaev, Anton N., Solodkov, Pavel P., Larichev, Victor F., Gulyaeva, Marina A., Markhaev, Alexander G., Kononova, Yulia V., Alekseyev, Alexander Yu., Shestopalov, Alexander M., Yusubalieva, Gaukhar M., Klypa, Tatiana V., Ivanov, Alexander V., Valuev-Elliston, Vladimir T., Baklaushev, Vladimir P., Taranin, Alexander V.“…Here, we isolated a panel of 23 RBD-specific human monoclonal antibodies from the B cells of convalescent patients. …”
Publicado 2021
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4915por Carreño, Juan Manuel, Alshammary, Hala, Singh, Gagandeep, Raskin, Ariel, Amanat, Fatima, Amoako, Angela, Gonzalez-Reiche, Ana Silvia, van de Guchte, Adriana, study group, PARIS, Srivastava, Komal, Sordillo, Emilia Mia, Sather, D. Noah, van Bakel, Harm, Krammer, Florian, Simon, Viviana“…METHODS: We used a panel of 30 post-mRNA vaccination sera to determine neutralization and RBD and spike binding activity against a number of emerging viral variants. …”
Publicado 2021
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4916por Brisotto, Giulia, Muraro, Elena, Montico, Marcella, Corso, Chiara, Evangelista, Chiara, Casarotto, Mariateresa, Caffau, Cristina, Vettori, Roberto, Cozzi, Maria Rita, Zanussi, Stefania, Turetta, Matteo, Ronchese, Federico, Steffan, Agostino“…MATERIALS AND METHODS: Anti-Spike RBD IgG antibodies were monitored in a cohort of healthcare workers at CRO Aviano, National Cancer Institute, through MAGLUMI® chemiluminescence assay, at 1 and 4 months after full-schedule of BNT162b2 or mRNA-1273 vaccination. …”
Publicado 2021
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4917por Saluzzo, Francesca, Mantegani, Paola, Poletti De Chaurand, Valeria, Quaresima, Virginia, Cugnata, Federica, Di Serio, Clelia, Macé, Aurélien, De Vos, Margaretha, Sacks, Jilian A., Cirillo, Daniela Maria“…The analysis of postvaccination samples was used to describe the most suitable tests to detect IgG response against S protein receptor binding domain (RBD). Tuberculosis (TB) therapy was identified as a potential factor affecting the specificity of LFAs. …”
Publicado 2021
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4918por Babamahmoodi, Farhang, Saeedi, Majid, Alizadeh-Navaei, Reza, Hedayatizadeh-Omran, Akbar, Mousavi, Seyed Abbas, Ovaise, Gasem, Kordi, Shirafkan, Akbari, Zahra, Azordeh, Mazaher, Ahangarkani, Fatemeh, Alikhani, Ahmad“…Among a total of 238 participants, more than 90% after the first and second dose of vaccine had a detectable level of SARS-CoV-2 RBD antibody and SARS-CoV-2 neutralizing antibody. …”
Publicado 2021
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4919por Lake, Douglas F., Roeder, Alexa J., Kaleta, Erin, Jasbi, Paniz, Pfeffer, Kirsten, Koelbela, Calvin, Periasamy, Sivakumar, Kuzmina, Natalia, Bukreyev, Alexander, Grys, Thomas E., Wu, Liang, Mills, John R, McAulay, Kathrine, Gonzalez-Moa, Maria, Seit-Nebi, Alim, Svarovsky, Sergei“…The LFA is based on the principle that neutralizing antibodies block binding of the receptor-binding domain (RBD) to angiotensin-converting enzyme 2 (ACE2). …”
Publicado 2021
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4920por Golan, Yarden, Prahl, Mary, Cassidy, Arianna G., Gay, Caryl, Wu, Alan H. B., Jigmeddagva, Unurzul, Lin, Christine Y., Gonzalez, Veronica J., Basilio, Emilia, Chidboy, Megan A., Warrier, Lakshmi, Buarpung, Sirirak, Li, Lin, Murtha, Amy P., Asiodu, Ifeyinwa V., Ahituv, Nadav, Flaherman, Valerie J., Gaw, Stephanie L.“…After vaccination, levels of anti-SARS-CoV-2 IgG and IgM significantly increased in maternal plasma and there was significant transfer of anti-SARS-CoV-2-Receptor Binding Domain (anti-RBD) IgA and IgG antibodies to milk. Milk IgA levels after the 2nd dose were negatively associated with infant age. …”
Publicado 2021
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