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4941por Lubna, Syeda, Chinta, Suma, Burra, Prakruthi, Vedantham, Kiranmayi, Ray, Sibnath, Bandyopadhyay, Debashree“…RESULTS: Eight substitutions were identified in the NS1 Indian sequence from the A(H1N1) pdm09 strain, two in RBD, five in ED, and one in the linker region. Three new substitutions were reported in this study at NS1 sequence positions 2, 80, and 155, which evolved within 2015–2019 and became “consistent.” …”
Publicado 2022
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4942por Zhao, Miao-Miao, Zhu, Yun, Zhang, Li, Zhong, Gongxun, Tai, Linhua, Liu, Shuo, Yin, Guoliang, Lu, Jing, He, Qiong, Li, Ming-Jia, Zhao, Ru-Xuan, Wang, Hao, Huang, Weijin, Fan, Changfa, Shuai, Lei, Wen, Zhiyuan, Wang, Chong, He, Xijun, Chen, Qiuluan, Liu, Banghui, Xiong, Xiaoli, Bu, Zhigao, Wang, Youchun, Sun, Fei, Yang, Jin-Kui“…Our structural studies revealed that CTSL cleavage promoted S to adopt receptor-binding domain (RBD) “up” activated conformations, facilitating receptor-binding and membrane fusion. …”
Publicado 2022
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4943por Singh, Lavanya, San, James E., Tegally, Houriiyah, Brzoska, Pius M., Anyaneji, Ugochukwu J., Wilkinson, Eduan, Clark, Lindsay, Giandhari, Jennifer, Pillay, Sureshnee, Lessells, Richard J., Martin, Darren Patrick, Furtado, Manohar, Kiran, Anmol M., de Oliveira, Tulio“…We designed a custom set of primers to amplify a 401 bp segment of the receptor-binding domain (RBD) (between positions 22698 and 23098 relative to the Wuhan-Hu-1 reference). …”
Publicado 2022
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4944por Andreano, Emanuele, Paciello, Ida, Marchese, Silvia, Donnici, Lorena, Pierleoni, Giulio, Piccini, Giulia, Manganaro, Noemi, Pantano, Elisa, Abbiento, Valentina, Pileri, Piero, Benincasa, Linda, Giglioli, Ginevra, Leonardi, Margherita, Maes, Piet, De Santi, Concetta, Sala, Claudia, Montomoli, Emanuele, De Francesco, Raffaele, Rappuoli, Rino“…These nAbs recognize mainly the SARS-CoV-2 receptor binding domain (RBD) and target Class 3 and Class 4 epitope regions on the SARS-CoV-2 spike protein. …”
Publicado 2022
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4945por Shahhosseini, Nariman“…The main goal of this study was to use In Silico (computer simulation) techniques to examine mutations in the SP, specifically L452R and E484Q (part of the receptor binding domain (RBD) for human angiotensin-converting enzyme 2 (hACE2)) and P681R (upstream of the Furin cleavage motif), for effects in modulating the transmissibility of the B.1.617+ variant. …”
Publicado 2022
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4946por Prange, Stéphane, Klinger, Hélène, Laurencin, Chloé, Danaila, Teodor, Thobois, Stéphane“…Recent advances using in vivo functional and structural imaging demonstrate that PD depression is underpinned by dysfunction of limbic networks and monoaminergic systems, depending on the stage of PD and its associated symptoms, including apathy, anxiety, rapid eye movement sleep behavior disorder (RBD), cognitive impairment and dementia. In particular, the evolution of serotonergic, noradrenergic, and dopaminergic dysfunction and abnormalities of limbic circuits across time, involving the anterior cingulate and orbitofrontal cortices, amygdala, thalamus and ventral striatum, help to delineate the variable expression of depression in patients with prodromal, early and advanced PD. …”
Publicado 2022
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4947“…The SARS-CoV-2 genome encodes spike (S) glycoprotein that plays a very crucial role in viral entry into the host cell via binding of its receptor binding domain (RBD) to the host angiotensin converting enzyme 2 (ACE2) receptor. …”
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4948por Garib, Victoria, Katsamaki, Stefani, Turdikulova, Shahlo, Levitskaya, Yuliya, Zahidova, Nodira, Bus, Galina, Karamova, Kristina, Rakhmedova, Manona, Magbulova, Nigora, Bruhov, Alexander, Garib, Firuz Y., Abdurakhmonov, Ibrokhim Y.“…We observed a positive correlation of receptor-binding domain (RBD)-specific IgG antibodies between the serum of actively immunized cow and milk-feeding calf during the entire course of vaccination (r = 0.95, p = 0.05). …”
Publicado 2022
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4949por Fathi, Anahita, Dahlke, Christine, Krähling, Verena, Kupke, Alexandra, Okba, Nisreen M. A., Raadsen, Matthijs P., Heidepriem, Jasmin, Müller, Marcel A., Paris, Grigori, Lassen, Susan, Klüver, Michael, Volz, Asisa, Koch, Till, Ly, My L., Friedrich, Monika, Fux, Robert, Tscherne, Alina, Kalodimou, Georgia, Schmiedel, Stefan, Corman, Victor M., Hesterkamp, Thomas, Drosten, Christian, Loeffler, Felix F., Haagmans, Bart L., Sutter, Gerd, Becker, Stephan, Addo, Marylyn M.“…We identify four immunogenic IgG epitopes, located in the receptor-binding domain (RBD, n = 1) and the S2 subunit (n = 3) of MERS-CoV-S. …”
Publicado 2022
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4950por Chakraborty, Chiranjib, Bhattacharya, Manojit, Sharma, Ashish Ranjan, Mallik, Bidyut“…This study has chosen eight significant mutations in Omicron (D614G, E484A, N501Y, Q493K, K417N, S477N, Y505H G496S), and seven of them are located in the RBD region. We also performed a comparative analysis of the ΔΔG score of these mutations to understand the stabilizing or destabilizing properties of the investigated mutations. …”
Publicado 2022
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4951por Guo, Hua, Li, Ang, Lin, Hao-Feng, Liu, Mei-Qin, Chen, Jing, Jiang, Ting-Ting, Li, Bei, Wang, Yi, Letko, Michael C., Peng, Wenjie, Shi, Zheng-Li“…IMPORTANCE Spike N-terminal domains (S-NTD) of sarbecoviruses are highly diverse; however, their function remains largely understudied compared with the receptor-binding domains (RBD). Here, we show that sarbecovirus S-NTD can be phylogenetically clustered into five clades and exhibit various levels of glycan binding in vitro. …”
Publicado 2022
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4952por Dhawan, Manish, Saied, AbdulRahman A., Mitra, Saikat, Alhumaydhi, Fahad A., Emran, Talha Bin, Wilairatana, Polrat“…The increased affinity of the spike protein (S-protein), and host receptor, angiotensin converting enzyme-2 (ACE-2), due to a higher number of mutations in the receptor-binding domain (RBD) of the S-protein has been proposed as the primary reason for the decreased efficacy of majorly available vaccines against the Omicron variant and the increased transmissible nature of the Omicron variant. …”
Publicado 2022
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4953por Mercado-Gómez, Maria, Prieto-Fernández, Endika, Goikoetxea-Usandizaga, Naroa, Vila-Vecilla, Laura, Azkargorta, Mikel, Bravo, Miren, Serrano-Maciá, Marina, Egia-Mendikute, Leire, Rodríguez-Agudo, Rubén, Lachiondo-Ortega, Sofia, Lee, So Young, Eguileor Giné, Alvaro, Gil-Pitarch, Clàudia, González-Recio, Irene, Simón, Jorge, Petrov, Petar, Jover, Ramiro, Martínez-Cruz, Luis Alfonso, Ereño-Orbea, June, Delgado, Teresa Cardoso, Elortza, Felix, Jiménez-Barbero, Jesús, Nogueiras, Ruben, Prevot, Vincent, Palazon, Asis, Martínez-Chantar, María L.“…Pseudotyped viral particles expressing the full-length spike of SARS-CoV-2 and recombinant receptor binding domain (RBD) bind to ACE2 expressed by hepatocytes, promoting metabolic reprogramming towards glycolysis but also impaired mitochondrial activity. …”
Publicado 2022
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4954por Pitsillou, Eleni, Liang, Julia J., Beh, Raymond C., Hung, Andrew, Karagiannis, Tom C.“…Using molecular dynamics simulations, we investigated the binding characteristics of the Delta and Omicron (BA.1) variants in comparison to wild-type (WT) at the interface of the spike protein receptor binding domain (RBD) and human angiotensin converting enzyme-2 (ACE2) ectodomain. …”
Publicado 2022
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4955por Aoki, Akira, Adachi, Hirokazu, Mori, Yoko, Ito, Miyabi, Sato, Katsuhiko, Okuda, Kenji, Sakakibara, Toru, Okamoto, Yoshinori, Jinno, Hideto“…Here, we focused on the mutational spectra at three regions in the spike receptor-binding domain (RBD; R408, G446/L452, and S477/T478) for the variant-selective HRM analysis. …”
Publicado 2022
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4956por Rossotti, Martin A., van Faassen, Henk, Tran, Anh T., Sheff, Joey, Sandhu, Jagdeep K., Duque, Diana, Hewitt, Melissa, Wen, Xiaoxue, Bavananthasivam, Jegarubee, Beitari, Saina, Matte, Kevin, Laroche, Geneviève, Giguère, Patrick M., Gervais, Christian, Stuible, Matthew, Guimond, Julie, Perret, Sylvie, Hussack, Greg, Langlois, Marc-André, Durocher, Yves, Tanha, Jamshid“…In vivo protection was demonstrated with anti-RBD and previously unreported anti-NTD and anti-S2 nanobodies. …”
Publicado 2022
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4957por Søraas, Arne, Grødeland, Gunnveig, Granerud, Beathe Kiland, Ueland, Thor, Lind, Andreas, Fevang, Børre, Murphy, Sarah L., Huse, Camilla, Nygaard, Anders Benteson, Steffensen, Anne Katrine, al-Baldawi, Huda, Holberg-Petersen, Mona, Andresen, Lise Lima, Ågnes, Camilla, Ranheim, Trine, Schanke, Ylva, Istre, Mette, Dahl, John Arne, Chopra, Adity, Dudman, Susanne, Kaarbø, Mari, Andersen, Jan Terje, Vaage, Eline Benno, Tran, Trung The, Vaage, John Torgils, Michelsen, Annika E., Müller, Fredrik, Aukrust, Pål, Halvorsen, Bente, Dahl, Tuva B., Holter, Jan Cato, Lund-Johansen, Fridtjof“…FINDINGS: Infection with Omicron or Delta led to a rapid and similar increase in antibodies to the receptor-binding domain (RBD) of Omicron protein and spike peptide-induced interferon gamma in whole blood. …”
Publicado 2022
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4958por Cao, Yunlong, Song, Weiliang, Wang, Lei, Liu, Pan, Yue, Can, Jian, Fanchong, Yu, Yuanling, Yisimayi, Ayijiang, Wang, Peng, Wang, Yao, Zhu, Qianhui, Deng, Jie, Fu, Wangjun, Yu, Lingling, Zhang, Na, Wang, Jing, Xiao, Tianhe, An, Ran, Wang, Jing, Liu, Lu, Yang, Sijie, Niu, Xiao, Gu, Qingqing, Shao, Fei, Hao, Xiaohua, Meng, Bo, Gupta, Ravindra Kumar, Jin, Ronghua, Wang, Youchun, Xie, Xiaoliang Sunney, Wang, Xiangxi“…Structural analyses of BA.2.75 spike shows its decreased thermostability and increased frequency of the receptor binding domain (RBD) in the “up” conformation under acidic conditions, suggesting enhanced low-pH-endosomal cell entry. …”
Publicado 2022
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4959“…Also, virtual screening using SWISS ADME and Autodock 4.0 program (against 6X2B, SARS-CoV-2 u1S2q 2 RBD Up Spike Protein Trimer) were evaluated for the complex. …”
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4960por Tulimilli, SubbaRao V., Dallavalasa, Siva, Basavaraju, Chaithanya G., Kumar Rao, Vinay, Chikkahonnaiah, Prashanth, Madhunapantula, SubbaRao V., Veeranna, Ravindra P.“…It is reported that the Omicron variant has >60 mutations with at least 30 mutations in the Spike protein (“S” protein) and 15 mutations in the receptor-binding domain (RBD), resulting in rapid attachment to target cells and immune evasion. …”
Publicado 2022
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