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4961por Nantel, Sabryna, Bourdin, Benoîte, Adams, Kelsey, Carbonneau, Julie, Rabezanahary, Henintsoa, Hamelin, Marie-Ève, McCormack, Deirdre, Savard, Patrice, Longtin, Yves, Cheng, Matthew P., De Serres, Gaston, Corbeil, Jacques, Gilca, Vladimir, Baz, Mariana, Boivin, Guy, Quach, Caroline, Decaluwe, Hélène“…The main outcome measure was a functional immunity score (zero to three) before and after vaccination, based on anti-RBD IgG levels, serum capacity to neutralize live virus and IFN-γ secretion capacity in response to SARS-CoV-2 peptide pools. …”
Publicado 2022
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4962por Klüpfel, Julia, Paßreiter, Sandra, Rumpf, Melina, Christa, Catharina, Holthoff, Hans-Peter, Ungerer, Martin, Lohse, Martin, Knolle, Percy, Protzer, Ulrike, Elsner, Martin, Seidel, Michael“…The neutralizing antibodies bind to the viral receptor binding domain (RBD) and inhibit the binding to the human angiotensin-converting enzyme 2 (ACE2) receptor. …”
Publicado 2022
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4963por Zhao, Hongxing, Wang, Mengqi, Muthelo, Phathutshedzo, Löf, Liza, Sterky, Fredrik, Gallini, Radiosa, Kumar, Nallani Vijay, Monsen, Tor, Nilsson, Kenneth, Åberg, Mikael, Kamali-Moghaddam, Masood, Mei, Ya-Fang, Landegren, Ulf“…Detection probes were prepared by conjugating the recombinant spike protein subunit 1 (S1), containing the receptor binding domain (RBD) of SARS-CoV-2, to each of a pair of specific oligonucleotides. …”
Publicado 2022
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4964por van Dam, Koos P. J., Hogenboom, Laura, Stalman, Eileen W., Kummer, Laura Y. L., Steenhuis, Maurice, Keijser, Jim B. D., Brinke, Anja ten, van Ham, S. Marieke, Kuijpers, Taco W., Rispens, Theo, Wieske, Luuk, Eftimov, Filip, Strijbis, Eva M., Killestein, Joep, van Kempen, Zoé L. E.“…METHODS: This was a substudy of two prospective cohort studies on SARS-CoV-2 antibodies after SARS-CoV-2 infection and vaccination. RBD-specific IgG titers of patients with MS and healthy controls who had experienced SARS-CoV-2 infection prior to the first vaccination were compared with those patients and healthy controls without prior infection. …”
Publicado 2022
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4965por Özcengiz, Erkan, Keser, Duygu, Özcengiz, Gülay, Çelik, Gözde, Özkul, Aykut, İnçeh, Fatma Nur“…METHODS: From within the spike protein S1 region, a fragmented protein P1 (MW:33 kDa) which includes the receptor‐binding domain (RBD), another fragment protein P2 (MW:17.6) which contains important antigenic epitopes within the spike protein S2 region, and N protein (MW:46 kDa) were obtained after recombinant expression of the corresponding gene regions in Escherichia coli BL21. …”
Publicado 2022
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4966por Egia-Mendikute, Leire, Bosch, Alexandre, Prieto-Fernández, Endika, Vila-Vecilla, Laura, Zanetti, Samanta Romina, Lee, So Young, Jiménez-Lasheras, Borja, García del Río, Ana, Antoñana-Vildosola, Asier, de Blas, Ander, Velasco-Beltrán, Paloma, Serrano-Maciá, Marina, Iruzubieta, Paula, Mehrpouyan, Majid, Goldberg, Edward M., Bornheimer, Scott J., Embade, Nieves, Martínez-Chantar, María L., López-Hoyos, Marcos, Mato, José M., Millet, Óscar, Palazón, Asís“…Here we describe a simple, fast, and cell-free multiplexed flow cytometry assay to interrogate the ability of antibodies to prevent the interaction of Angiotensin-converting enzyme 2 (ACE2) and the receptor binding domain (RBD) of the original Wuhan-1 SARS-CoV-2 strain and emerging variants simultaneously, as a surrogate neutralization assay. …”
Publicado 2022
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4967por Liang, Hong, Nian, Xuanxuan, Wu, Junzheng, Liu, Dong, Feng, Lu, Lu, Jia, Peng, Yan, Zhou, Zhijun, Deng, Tao, Liu, Jing, Ji, Deming, Qiu, Ran, Lin, Lianzhen, Zeng, Yan, Xia, Fei, Hu, Yong, Li, Taojing, Duan, Kai, Li, Xinguo, Wang, Zejun, Zhang, Yong, Zhang, Hang, Zhu, Chen, Wang, Shang, Wu, Xiao, Wang, Xiang, Li, Yuwei, Huang, Shihe, Mao, Min, Guo, Huanhuan, Yang, Yunkai, Jia, Rui, Xufang, Jingwei, Wang, Xuewei, Liang, Shuyan, Qiu, Zhixin, Zhang, Juan, Ding, Yaling, Li, Chunyan, Zhang, Jin, Fu, Daoxing, He, Yanlin, Zhou, Dongbo, Li, Cesheng, Zhang, Jiayou, Yu, Ding, Yang, Xiao-Ming“…Here, we report that the inactivated COVID-19 vaccine can stimulate immunity in recovered patients to maintain high levels of anti-receptor-binding domain (RBD) and anti-nucleocapsid protein (NP) antibody titers within 9 months, and high neutralizing activity against the prototype, Delta, and Omicron strains was observed. …”
Publicado 2022
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4968por Rosati, Margherita, Terpos, Evangelos, Bear, Jenifer, Burns, Robert, Devasundaram, Santhi, Ntanasis-Stathopoulos, Ioannis, Gavriatopoulou, Maria, Kastritis, Efstathios, Dimopoulos, Meletios-Athanasios, Pavlakis, George N., Felber, Barbara K.“…ELISA Spike-Receptor Binding Domain (RBD) Ab titers in healthy vaccine recipients and patient cohorts were good predictors of the ability to neutralize not only the original WA1 but also the most divergent Omicron variants BA.4/5. …”
Publicado 2022
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4969por König, Marton, Lorentzen, Åslaug Rudjord, Torgauten, Hilde Marie, Tran, The Trung, Schikora-Rustad, Stine, Vaage, Eline Benno, Mygland, Åse, Wergeland, Stig, Aarseth, Jan, Aaberge, Ingeborg Aase S, Torkildsen, Øivind, Holmøy, Trygve, Berge, Tone, Myhr, Kjell-Morten, Harbo, Hanne Flinstad, Andersen, Jan Terje, Munthe, Ludvig Andre, Søraas, Arne, Celius, Elisabeth Gulowsen, Vaage, John Torgils, Lund-Johansen, Fridtjof, Nygaard, Gro Owren“…Humoral immunity was assessed by measuring anti-SARS-CoV-2 SPIKE RBD IgG response 3–12 weeks after full vaccination, and compared with healthy subjects. …”
Publicado 2023
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4970por Chen, Yuliu, Wu, Yan, Chen, Shaoying, Zhan, Qingping, Wu, Dingzhou, Yang, Chan, He, Xiaoxue, Qiu, Mengjie, Zhang, Nannan, Li, Zhaofeng, Guo, Yunhua, Wen, Minjun, Lu, Lu, Ma, Cuiqing, Guo, Jiayin, Xu, Wei, Li, Xiaojuan, Li, Lin, Jiang, Shibo, Pan, Xiaoyan, Liu, Shuwen, Tan, Suiyi“…It can bind to the S1 subunit of the S protein, especially the receptor binding domain (RBD), thus blocking S-hACE2 interaction and interfering with the proteolysis process of S protein. …”
Publicado 2022
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4971por Łysek-Gładysińska, Małgorzata, Starz, Magdalena, Borowiec-Sęk, Agnieszka, Sufin, Iwona, Wieczorek, Anna, Chrapek, Magdalena, Zarębska-Michaluk, Dorota, Sufin, Patrycja, Głuszek, Stanisław, Adamus-Białek, Wioletta“…The levels of IgG anti-SARS-CoV-2 in serum were identified using the chemiluminescent immunoassay specific for the receptor-binding domain (RBD) of the S1 protein. The analysis of the results was performed using appropriate statistical methods, considering p <0.05 as a statistically significant value. …”
Publicado 2023
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4972por Geng, Jiejie, Yang, Xu, Wang, Kun, Wang, Ke, Chen, Ruo, Chen, Zhi-Nan, Qin, Chuan, Wu, Guizhen, Wang, Youchun, Xu, Ke, Du, Peng, Liu, Jiangning, Chen, Shirui, Zhang, Tao, Sun, Xiuxuan, Guo, Ting, Shi, Ying, Zhang, Zheng, Wei, Ding, Lin, Peng, Wang, Qingyi, Yuan, Jing, Qu, Jiuxin, Zou, Jin, Liu, Yingxia, Lu, Hongzhou, Zhu, Ping, Bian, Huijie, Chen, Liang“…We found Omicron resisted to neutralizing antibody targeting receptor binding domain (RBD) of wildtype SARS-CoV-2. Omicron could hardly be neutralized by sera of Corona Virus Disease 2019 (COVID-19) convalescents infected with the Delta variant. …”
Publicado 2023
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4973por Polvere, Jacopo, Fabbiani, Massimiliano, Pastore, Gabiria, Rancan, Ilaria, Rossetti, Barbara, Durante, Miriam, Zirpoli, Sara, Morelli, Enrico, Pettini, Elena, Lucchesi, Simone, Fiorino, Fabio, Tumbarello, Mario, Ciabattini, Annalisa, Montagnani, Francesca, Medaglini, Donata“…The frequency of subjects with antibodies capable of inhibiting ACE2/RBD binding was comparable between PLWHIV and HCs a month after the second vaccine dose, then a higher drop was observed in PLWHIV. …”
Publicado 2023
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4974por Wang, Hao, Yuan, Yu, Wu, Bihao, Xiao, Mingzhong, Wang, Zhen, Diao, Tingyue, Zeng, Rui, Chen, Li, Lei, Yanshou, Long, Pinpin, Guo, Yi, Lai, Xuefeng, Wen, Yuying, Li, Wenhui, Cai, Hao, Song, Lulu, Ni, Wei, Zhao, Youyun, Ouyang, Kani, Wang, Jingzhi, Wang, Qi, Liu, Li, Wang, Chaolong, Pan, An, Li, Xiaodong, Gong, Rui, Wu, Tangchun“…Similarly, the responses of SARS-CoV-2 RBD-specific B cells and memory B cells were boosted by the second vaccine dose. …”
Publicado 2023
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4975por Yao, Ruhui, Hou, Jian, Zhang, Xin, Li, Yi, Lai, Junhui, Wu, Qinqin, Liu, Qinglian, Zhou, Lei“…Hereby we developed a targeted photodynamic approach to neutralize SARS-CoV-2 by engineering a genetically encoded photosensitizer (SOPP3) to a diverse list of antibodies targeting the wild-type (WT) spike protein, including human antibodies isolated from a 2003 Severe acute respiratory syndrome (SARS) patient, potent monomeric and multimeric nanobodies targeting receptor-binding domain (RBD), and non-neutralizing antibodies (non-NAbs) targeting the more conserved N-terminal domain (NTD). …”
Publicado 2023
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4976por Braz, Beatriz A., Hospinal-Santiani, Manuel, Martins, Gustavo, Gogola, Jeferson L., Valenga, Marcia G.P., Beirão, Breno C.B., Bergamini, Márcio F., Marcolino-Junior, Luiz H., Thomaz-Soccol, Vanete, Soccol, Carlos R.“…The peptide used as recognition site has two important portions: one based on the viral receptor binding domain (RBD), capable of recognizing antibodies of the spike protein (Anti-S), and another suitable for interacting with gold nanoparticles. …”
Publicado 2023
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4977por Leong, Darryl P., Zhang, Ali, Breznik, Jessica A., Clare, Rumi, Huynh, Angela, Mushtaha, Maha, Rangarajan, Sumathy, Stacey, Hannah, Kim, Paul Y., Loeb, Mark, Denburg, Judah A., Mertz, Dominik, Chagla, Zain, Nazy, Ishac, Miller, Matthew S., Bowdish, Dawn M. E., Duong, MyLinh“…The magnitude, consistency and durability of response was greater for anti-Spike than anti-RBD antibodies; and for IgG than IgA or IgM. Compared to the shorter schedules, a longer interval of >42 days offered the highest binding and neutralizing antibody titers against SARS-CoV-2 ancestral and Beta (B1.351) variants beyond 3 months post-vaccination. …”
Publicado 2023
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4978por Jazbec, Katerina, Jež, Mojca, Žiberna, Klemen, Mali, Polonca, Ramšak, Živa, Potokar, Urška Rahne, Kvrzić, Zdravko, Černilec, Maja, Gracar, Melita, Šprohar, Marjana, Jovanovič, Petra, Vuletić, Sonja, Rožman, Primož“…RESULTS: The analysis of the four models showed that the chemiluminescent microparticle assay (CMIA) for the quantitative determination of IgG Abs to the RBD of the S1 subunit of the SARS-CoV-2 spike protein was enough to predict the CCP units with a high NAb titer. …”
Publicado 2023
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4979por Thiriard, Anaïs, Meyer, Benjamin, Eberhardt, Christiane S., Loevy, Natasha, Grazioli, Serge, Adouan, Wafae, Fontannaz, Paola, Marechal, Fabienne, L’Huillier, Arnaud G., Siegrist, Claire-Anne, Georges, Daphnée, Putignano, Antonella, Marchant, Arnaud, Didierlaurent, Arnaud M., Blanchard-Rohner, Geraldine“…The functionality of these antibodies was also assessed using a plaque reduction neutralization test, a RBD-specific avidity assay, a complement deposition assay and an antibody-dependent neutrophil phagocytosis (ADNP) assay. …”
Publicado 2023
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4980por Peled, Y., Patel, J., Raanani, E., Segev, A., Matezki, S., Ram, E., Fardman, A., Beigel, R., Atari, N., Kliker, L., Elkader, B. Abd, Afek, A., Mandelboim, M.“…Serum samples, collected longitudinally immediately before and 3 weeks after each dose or SARS-CoV-2 infection, were tested for SARS-CoV-2 anti-RBD IgG antibodies and for neutralizing antibodies (using live virus micro-neutralization assays) against wild-type sublineage B.1.1.50, the B.1.617.2 (delta) variant and four omicron variants (BA.1, BA.2, BA.4 and BA.5). …”
Publicado 2023
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