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481por Khan, Abbas, Mohammad, Anwar, Haq, Inamul, Nasar, Mohammad, Ahmad, Waqar, Yousafi, Qudsia, Suleman, Muhammad, Ahmad, Sajjad, Albutti, Aqel, Khan, Taimoor, Marafie, Sulaiman K., Alshawaf, Eman, Ali, Syed Shujait, Abubaker, Jehad, Wei, Dong-Qing“…Recently reported mutations in the spike glycoprotein unique to the receptor-binding domain (RBD) of different variants might increase the binding and pathogenesis. …”
Publicado 2021
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482por Wu, Jiajing, Nie, Jianhui, Zhang, Li, Song, Hao, An, Yimeng, Liang, Ziteng, Yang, Jing, Ding, Ruxia, Liu, Shuo, Li, Qianqian, Li, Tao, Cui, Zhimin, Zhang, Mengyi, He, Peng, Wang, Youchun, Qu, Xiaowang, Hu, Zhongyu, Wang, Qihui, Huang, Weijin“…The neutralization activities of Alpha, Beta and Gamma variants’ spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations based on the Delta variant, which were constructed using pseudotyped viruses. …”
Publicado 2022
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483por Kolesov, Denis E., Sinegubova, Maria V., Dayanova, Lutsia K., Dolzhikova, Inna V., Vorobiev, Ivan I., Orlova, Nadezhda A.“…The sVNT assay design with the ACE2-HRP is preferable over the assay with the RBD-HRP reagent and is suitable for mass screening of neutralizing antibodies titers.…”
Publicado 2022
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484por Sughayer, M.A., Souan, L., Abu Alhowr, M.M., Al Rimawi, D., Siag, M., Albadr, S., Owdeh, M., Al Atrash, T.“…BACKGROUND AND OBJECTIVES: Little is known about the efficacy and durability of anti-RBD IgG antibodies induced by certain SARS-CoV-2 vaccines. …”
Publicado 2022
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485por Lo Sasso, Bruna, Agnello, Luisa, Giglio, Rosaria Vincenza, Gambino, Caterina Maria, Ciaccio, Anna Maria, Vidali, Matteo, Ciaccio, Marcello“…We found that anti-S-RBD IgG levels are higher in females than males. …”
Publicado 2022
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486“…This study investigated whether P188 can act as an adjuvant to improve the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain (RBD) subunit vaccine. BALB/c mice were vaccinated twice with the RBD antigen alone or in combination with P188 or MF59 (a commercial adjuvant for comparison purposes). …”
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487por Atzl, Michele, Muendlein, Axel, Winder, Thomas, Fraunberger, Peter, Brandtner, Eva-Maria, Geiger, Kathrin, Klausberger, Miriam, Duerkop, Mark, Sprenger, Lukas, Mutschlechner, Beatrix, Volgger, Andreas, Benda, Magdalena, Severgnini, Luciano, Jaeger, Johannes B, Drexel, Heinz, Lang, Alois, Leiherer, Andreas“…Overall, only 55% of seropositive specimen had antibodies against both antigens RBD and NP; 29% had only RBD-specific and 16% only NP-specific antibodies. …”
Publicado 2022
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488“…In addition, specific total IgG, IgG1/IgG2a isotypes, and ratio as well as anti-RBD IgG responses were assessed with an optimized ELISA. …”
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489“…We showed allosteric changes in residue network paths in both the RBD and hACE2 proteins due to Omicron sub-lineage mutations. …”
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490por Han, Pingping, Liu, Chun, Staples, Reuben, Moran, Corey S., Ramachandra, Srinivas Sulugodu, Gómez-Cerezo, Maria Natividad, Ivanovski, Sašo“…The three-dimensional S1-RBD PCL scaffolds, while demonstrating a kinetic trend comparable to 2D TCP, exhibited significantly higher sensitivity and detection levels for all three immunoglobulins assayed (IgG, IgM, and IgA). …”
Publicado 2022
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491RBD-VLP Vaccines Adjuvanted with Alum or SWE Protect K18-hACE2 Mice against SARS-CoV-2 VOC Challengepor Wong, Ting Y., Russ, Brynnan P., Lee, Katherine S., Miller, Olivia A., Kang, Jason, Cooper, Melissa, Winters, Michael T., Rodriguez-Aponte, Sergio A., Dalvie, Neil C., Johnston, Ryan S., Rader, Nathaniel A., Wong, Zeriel Y., Cyphert, Holly A., Martinez, Ivan, Shaligram, Umesh, Batwal, Saurabh, Lothe, Rakesh, Chandrasekaran, Rahul, Nagar, Gaurav, Rajurkar, Meghraj, Rao, Harish, Bevere, Justin R., Barbier, Mariette, Love, J. Christopher, Damron, F. Heath“…Alum-adjuvanted vaccines were composed of either HBsAg conjugated with Beta RBD alone (β RBD HBsAg+Al) or a combination of both Beta RBD HBsAg and Wuhan RBD HBsAg (β/Wu RBD HBsAg+Al). …”
Publicado 2022
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492por Farrell, Ariana Ghez, Dadonaite, Bernadeta, Greaney, Allison J., Eguia, Rachel, Loes, Andrea N., Franko, Nicholas M., Logue, Jennifer, Carreño, Juan Manuel, Abbad, Anass, Chu, Helen Y., Matreyek, Kenneth A., Bloom, Jesse D.“…For high ACE2-expressing target cells, receptor binding domain (RBD) antibodies account for nearly all neutralizing activity in polyclonal human sera. …”
Publicado 2022
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493por Shi, Juan, Zheng, Jian, Tai, Wanbo, Verma, Abhishek K., Zhang, Xiujuan, Geng, Qibin, Wang, Gang, Guan, Xiaoqing, Malisheni, Moffat M., Odle, Abby E., Zhang, Wei, Li, Fang, Perlman, Stanley, Du, Lanying“…This study describes the identification of an immunodominant non-neutralizing epitope on SARS-CoV-2 receptor-binding domain (RBD). A subunit vaccine against this mutant RBD, constructed by masking this epitope with a glycan probe, did not significantly affect RBD’s receptor-binding affinity or antibody-binding affinity, or its ability to induce antibody production. …”
Publicado 2022
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494por Roberts, David S., Mann, Morgan, Li, Brad H., Kim, Donguk, Braiser, Allan R., Jin, Song, Ge, Ying“…The SARS-CoV-2 Omicron (B.1.1.529) variant possesses numerous spike (S) mutations particularly in the S receptor-binding domain (S-RBD) that significantly improve transmissibility and evasion of neutralizing antibodies. …”
Publicado 2022
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495por Farrell, Ariana Ghez, Dadonaite, Bernadeta, Greaney, Allison J., Eguia, Rachel, Loes, Andrea N., Franko, Nicholas M., Logue, Jennifer, Carreño, Juan Manuel, Abbad, Anass, Chu, Helen Y., Matreyek, Kenneth A., Bloom, Jesse D.“…For high ACE2-expressing target cells, receptor-binding domain (RBD) antibodies account for nearly all neutralizing activity in polyclonal human sera. …”
Publicado 2022
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496“…However, few dual RBD/Mpro-targeting agents have been reported. Here, four novel RBD/Mpro dual-targeting peptides, termed as MRs 1-4, were discovered by an integrated virtual screening scheme combining molecular docking-based screening and molecular dynamics simulation. …”
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497por Guo, Lisha, Zafar, Faryar, Moeen, Nawal, Alshabrmi, Fahad M., Lin, Junqi, Ali, Syed Shujait, Munir, Muhammad, Khan, Abbas, Wei, Dongqing“…Hence, the current study used structure-based methods to target the RBD of the recombinant variant (Deltacron) of SARS-CoV-2, which was used as a model variant. …”
Publicado 2022
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498por Pérez-Bernal, Maylin, Hernández, Carlos, Ibargollín, Rafael, Martínez, Midalis, Soria, Migdiala, Delgado, Magali, Valdivia, Onel, Dorta, Dayamí, Domínguez, Andy, Pérez, Enrique, Cabrera, Yeosvany“…RESULTS: High levels of anti-RBD IgA antibodies were detected in breast milk samples 9 weeks after vaccination and anti-RBD IgG antibodies rise from the fifth to the ninth week. …”
Publicado 2022
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499por Sang, Peng, Chen, Yong-Qin, Liu, Meng-Ting, Wang, Yu-Ting, Yue, Ting, Li, Yi, Yin, Yi-Rui, Yang, Li-Quan“…To explore the mechanistic origin that determines the binding affinity of SARS-CoV-2 spike receptor binding domain (RBD) to human angiotensin converting enzyme 2 (ACE2), we constructed the homology models of RBD-ACE2 complexes of four Omicron subvariants (BA.1, BA.2, BA.3 and BA.4/5), and compared them with wild type complex (RBD(WT)-ACE2) in terms of various structural dynamic properties by molecular dynamics (MD) simulations and binding free energy (BFE) calculations. …”
Publicado 2022
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500por Phetsouphanh, Chansavath, Khoo, Weng Hua, Jackson, Katherine, Klemm, Vera, Howe, Annett, Aggarwal, Anupriya, Akerman, Anouschka, Milogiannakis, Vanessa, Stella, Alberto Ospina, Rouet, Romain, Schofield, Peter, Faulks, Megan L., Law, Hannah, Danwilai, Thidarat, Starr, Mitchell, Munier, C. Mee Ling, Christ, Daniel, Singh, Mandeep, Croucher, Peter I., Brilot-Turville, Fabienne, Turville, Stuart, Phan, Tri Giang, Dore, Gregory J., Darley, David, Cunningham, Philip, Matthews, Gail V., Kelleher, Anthony D., Zaunders, John J.“…Conversely, up to half of convalescent individuals had low neutralizing antibody titres together with a lack of receptor binding domain (RBD)-specific memory CD4 T cells. These low antibody subjects had other, non-RBD, spike-specific CD4 T cells, but with more of an inhibitory Foxp3+ and CTLA-4+ cell phenotype, in contrast to the effector T-bet+, cytotoxic granzymes+ and perforin+ cells seen in RBD-specific memory CD4 T cells from high antibody subjects. …”
Publicado 2022
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