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4981por Song, Yang, Hu, Hongqiao, Xiao, Kang, Huang, Xinghu, Guo, Hong, Shi, Yuqing, Zhao, Jiannan, Zhu, Shuangli, Ji, Tianjiao, Xia, Baicheng, Jiang, Jie, Cao, Lei, Zhang, Yong, Zhang, Yan, Xu, Wenbo“…In this study, we evaluated the effectiveness of a synthetic peptide cocktail containing three murine CD4(+) T-cell epitopes from the SARS-CoV-2 nonspike proteome and one B-cell epitope from the Omicron BA.1 receptor-binding domain (RBD), along with aluminum phosphate (Al) adjuvant and 5′ cytosine-phosphate-guanine 3′ oligodeoxynucleotide (CpG-ODN) adjuvant in mice. …”
Publicado 2023
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4982por Villarraza, Javier, Fuselli, Antonela, Gugliotta, Agustina, Garay, Ernesto, Rodríguez, María Celeste, Fontana, Diego, Antuña, Sebastián, Gastaldi, Victoria, Battagliotti, Juan Manuel, Tardivo, María Belén, Alvarez, Diego, Castro, Eliana, Cassataro, Juliana, Ceaglio, Natalia, Prieto, Claudio“…Both formulations demonstrated the presence of anti-RBD antibodies in the plasma of immunized mice, being significantly higher for the latter adjuvant. …”
Publicado 2023
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4983“…An automated chemiluminescence immune assay (CLIA) platform from Abbott Diagnostics was used to quantify IgG antibodies against SARS-CoV-2′s spike receptor-binding domain (RBD) and a surrogate virus neutralization test (sVNT) was performed by enzyme-linked immunosorbent assay (ELISA). …”
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4984por Cao, Huanhuan, Huang, Yufei, Zhong, Chunxiu, Liao, Xingmei, Tan, Wenjuan, Zhao, Siru, Guo, Liangxu, Fan, Rong“…Serum samples were collected and tested for SARS-CoV-2 S-receptor-binding domain (S-RBD) immunoglobulin G (IgG) at enrollment. Data on adverse events (AEs) within 7 days after the second dose were obtained using a questionnaire. …”
Publicado 2023
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4985por Kuzmina, Alona, Korovin, Dina, Cohen lass, Ido, Atari, Nofar, Ottolenghi, Aner, Hu, Pan, Mandelboim, Michal, Rosental, Benyamin, Rosenberg, Elli, Diaz-Griffero, Felipe, Taube, Ran“…While extensive research on the role of the Receptor Binding Domain (RBD) in promoting viral infectivity and vaccine sensitivity has been well documented, the functional significance of the (681)PRRAR/SV(687) polybasic motif of the viral spike is less clear. …”
Publicado 2023
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4986por Benkeser, David, Montefiori, David C., McDermott, Adrian B., Fong, Youyi, Janes, Holly E., Deng, Weiping, Zhou, Honghong, Houchens, Christopher R., Martins, Karen, Jayashankar, Lakshmi, Castellino, Flora, Flach, Britta, Lin, Bob C., O’Connell, Sarah, McDanal, Charlene, Eaton, Amanda, Sarzotti-Kelsoe, Marcella, Lu, Yiwen, Yu, Chenchen, Borate, Bhavesh, van der Laan, Lars W. P., Hejazi, Nima S., Kenny, Avi, Carone, Marco, Williamson, Brian D., Garver, Jennifer, Altonen, Erin, Rudge, Thomas, Huynh, Chuong, Miller, Jacqueline, El Sahly, Hana M., Baden, Lindsey R., Frey, Sharon, Malkin, Elissa, Spector, Stephen A., Andrasik, Michele P., Kublin, James G., Corey, Lawrence, Neuzil, Kathleen M., Carpp, Lindsay N., Pajon, Rolando, Follmann, Dean, Donis, Ruben O., Koup, Richard A., Gilbert, Peter B.“…We previously assessed IgG binding antibodies to the spike protein (spike IgG) or receptor binding domain (RBD IgG) and pseudovirus neutralizing antibody 50 or 80% inhibitory dilution titer measured on day 29 or day 57, as correlates of risk (CoRs) and CoPs against symptomatic COVID-19 over 4 months after dose. …”
Publicado 2023
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4987por Marcinkevics, Ricards, Silva, Pamuditha N., Hankele, Anna-Katharina, Dörnte, Charlyn, Kadelka, Sarah, Csik, Katharina, Godbersen, Svenja, Goga, Algera, Hasenöhrl, Lynn, Hirschi, Pascale, Kabakci, Hasan, LaPierre, Mary P., Mayrhofer, Johanna, Title, Alexandra C., Shu, Xuan, Baiioud, Nouell, Bernal, Sandra, Dassisti, Laura, Saenz-de-Juano, Mara D., Schmidhauser, Meret, Silvestrelli, Giulia, Ulbrich, Simon Z., Ulbrich, Thea J., Wyss, Tamara, Stekhoven, Daniel J., Al-Quaddoomi, Faisal S., Yu, Shuqing, Binder, Mascha, Schultheiβ, Christoph, Zindel, Claudia, Kolling, Christoph, Goldhahn, Jörg, Seighalani, Bahram Kasmapour, Zjablovskaja, Polina, Hardung, Frank, Schuster, Marc, Richter, Anne, Huang, Yi-Ju, Lauer, Gereon, Baurmann, Herrad, Low, Jun Siong, Vaqueirinho, Daniela, Jovic, Sandra, Piccoli, Luca, Ciesek, Sandra, Vogt, Julia E., Sallusto, Federica, Stoffel, Markus, Ulbrich, Susanne E.“…By using statistical and machine learning models, we observed that the T cell response highly correlated with a compound titer of antibodies against the Receptor Binding Domain (RBD), S and N. However, while serum antibodies decayed over time, the cellular phenotype of these individuals remained stable over four months. …”
Publicado 2023
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4988por He, Mingyue, Song, Rui, Shaik, Zakir, Gadegbeku, Crystal A., Enderle, Louise, Petyo, Christina, Quinn, Sally B., Pfeffer, Zoe, Murphy, Kathleen, Kelsen, Steven, Mishkin, Aaron D., Lee, Jean, Gillespie, Avrum“…Monthly quantitative antibody testing was performed using the Beckman Coulter Access SARS-CoV-2 IgG Antibody Test©, which detects IgG antibodies targeting the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. Results: This cohort of 30 participants (mean age: 61 ± 3 years) predominantly self-identified as African American (97%) and male (53%). …”
Publicado 2023
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4989por Duijvestijn, Mirjam B. H. M., Schuurman, Nancy N. M. P., Vernooij, Johannes C. M., van Leeuwen, Michelle A. J. M., Bosch, Berend-Jan, van den Brand, Judith M. A., Wagenaar, Jaap A., van Kuppeveld, Frank J. M., Egberink, Herman F., Verhagen, Josanne H.“…SARS-CoV-2 antibodies against the subunit 1 (S1) and receptor binding domain (RBD) protein were detected in 2.7% (95% CI 1.4–4.8) of stray cats, but sera were negative in the pseudovirus neutralization test and therefore were considered SARS-CoV-2 suspected. …”
Publicado 2023
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4990por Zhang, Hangjie, Xu, Nani, Xu, Yu, Qin, Pan, Dai, Rongrong, Xu, Bicheng, Wang, Shenyu, Ding, Linling, Fu, Jian, Zhang, Shupeng, Hua, Qianhui, Liao, Yuting, Yang, Juan, Hu, Xiaowei, Jiang, Jianmin, Lv, Huakun“…Ad5-nCoV elicits significantly higher RBD-specific IgG levels, with a geometric mean concentration of 2924.0 on day 14 post-booster, 7.8-fold that of the inactivated vaccine. …”
Publicado 2023
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4991por Martel, Fabiola, Cuervo-Rojas, Juliana, Ángel, Juana, Ariza, Beatriz, González, John Mario, Ramírez-Santana, Carolina, Acosta-Ampudia, Yeny, Murcia-Soriano, Luisa, Montoya, Norma, Cardozo-Romero, Claudia Cecilia, Valderrama-Beltrán, Sandra Liliana, Cepeda, Magda, Castellanos, Julio César, Gómez-Restrepo, Carlos, Perdomo-Celis, Federico, Gazquez, Andreu, Dickson, Alexandria, Brien, James D., Mateus, José, Grifoni, Alba, Sette, Alessandro, Weiskopf, Daniela, Franco, Manuel A.“…Here, we examined, in two ambispective cohorts of naturally-infected and/or vaccinated individuals, the titers of anti-RBD antibodies and the frequency of SARS-CoV-2-specific CD4(+) T cells up to 6 months after the last antigen exposure. …”
Publicado 2023
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4992“…The non-synonymous iSNVs in the S gene can largely alter the S protein’s antigenic features, and many of these iSNVs are distributed in the amino-terminal domain (NTD) and receptor-binding domain (RBD). These results suggest that SARS-CoV-2 interacts actively with human hosts and attempts to take different evolutionary strategies to escape human innate and adaptive immunity. …”
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4993por Raglow, Zoe, Surie, Diya, Chappell, James D., Zhu, Yuwei, Martin, Emily T., Kwon, Jennie H., Frosch, Anne E., Mohamed, Amira, Gilbert, Julie, Bendall, Emily E., Bahr, Auden, Halasa, Natasha, Talbot, H. Keipp, Grijalva, Carlos G., Baughman, Adrienne, Womack, Kelsey N., Johnson, Cassandra, Swan, Sydney A., Koumans, Emilia, McMorrow, Meredith L., Harcourt, Jennifer L., Atherton, Lydia J., Burroughs, Ashley, Thornburg, Natalie J., Self, Wesley H., Lauring, Adam S.“…Consensus (>50% frequency) spike mutations were identified in 5 individuals who were rRT-PCR-positive >56 days; 61% were in the receptor-binding domain (RBD). Mutations shared by multiple individuals were rare (<5%) in global circulation. …”
Publicado 2023
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4994por Kenny, Grace, O’Reilly, Sophie, Wrigley Kelly, Neil, Negi, Riya, Gaillard, Colette, Alalwan, Dana, Saini, Gurvin, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, Garcia Leon, Alejandro Abner, Tinago, Willard, Feeney, Eoin R., Cotter, Aoife G., de Barra, Eoghan, Yousif, Obada, Horgan, Mary, Doran, Peter, Stemler, Jannik, Koehler, Philipp, Cox, Rebecca Jane, O’Shea, Donal, Olesen, Ole F., Landay, Alan, Hogan, Andrew E., Lelievre, Jean-Daniel, Gautier, Virginie, Cornely, Oliver A., Mallon, Patrick W. G.“…In unvaccinated convalescent participants, a receptor binding domain (RBD) IgG of 456 BAU/mL predicts an NT50 against WT of 1000 IU with an accuracy of 80% (95%CI 73–86%). …”
Publicado 2023
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4995“…However, CasBrE SU synthesized in the absence of the transmembrane subunit (TM) does not retain ecotropic receptor binding activity, indicating that folding of the receptor binding domain (RBD) requires this domain. Using a neural stem cell (NSC) based viral trans complementation approach to examine whether misfolded CasBrE SU retained neurovirulence, we observed CasBrE SU interaction with the "non-neurovirulent" amphotropic helper virus, 4070A which restored functional activity of CasBrE SU. …”
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4996por Reddy, BP Niranjan, Shrestha, Sony, Hart, Kevin J., Liang, Xiaoying, Kemirembe, Karen, Cui, Liwang, Lindner, Scott E.“…A representative 3D models for each of the RBD domain identified in P. falciparum was created using I-TESSAR and SWISS-MODEL. …”
Publicado 2015
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4997“…In view of the high homology of gene sequences between SARS-CoV-2 S-protein RBD domain and SARS virus, as well as their similarities in pathogenesis and clinical manifestations, we established SARS-CoV-2 S-protein model using Swiss-Model. …”
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4998por Shukla, S. K., Sharma, Lalan, Jaiswal, V. P., Pathak, A. D., Tiwari, Raghvendra, Awasthi, S. K., Gaur, Asha“…Five treatments viz., T(1); N(0)P(0)K(0); T(2): N(75)P(13)K(25); T(3): N(150)P(26)K(50); T(4): N(75)P(13)K(25) + microbial consortium and T(5): N(150)P(26)K(50) + microbial consortium containing new strains of Trichoderma harzianum, Gluconcetobacter diazotrophicus, and Pseudomonas fluorescens (CFU 10(9–10) per ml liquid culture) were evaluated under four replications in a randomized block design (RBD). Experimental results indicated that integrating microbial consortium and NPK fertilizers' application proved effective in improving soil organic carbon, soil microbial population, microbial biomass carbon, microbial biomass nitrogen, and soil respiration. …”
Publicado 2020
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4999por Wang, Qiu-jing, Yao, Yan-zhen, Song, Jun-shuai, Wang, Qiao, Xu, Li-yun, Bao, Zhou-jun, Mao, Dai-wen, Zhou, Ji-hang, Zhang, Zhe-en, Wang, Yan, Li, Yi-wei, Wang, He-ping, Li, Lue, Pan, Hai-yan, Zhang, Guo-qiang, Li, Shi-bo“…All patients had detectable antibodies to the receptor binding domain (RBD), and 95% of these patients had IgG to viral N proteins. …”
Publicado 2020
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5000por Oved, Kfir, Olmer, Liraz, Shemer-Avni, Yonat, Wolf, Tamar, Supino-Rosin, Lia, Prajgrod, George, Shenhar, Yotam, Payorsky, Irina, Cohen, Yuval, Kohn, Yishai, Indenbaum, Victoria, Lazar, Rachel, Geylis, Valeria, Oikawa, Michal Tepperberg, Shinar, Eilat, Stoyanov, Evgeniy, Keinan-Boker, Lital, Bassal, Ravit, Reicher, Shay, Yishai, Ruti, Bar-Chaim, Adina, Doolman, Ram, Reiter, Yoram, Mendelson, Ella, Livneh, Zvi, Freedman, Laurence S., Lustig, Yaniv“…METHODS: Serology assays from Roche, Abbott, Diasorin, BioMerieux, Beckman-Coulter, Siemens, and an in-house RBD ELISA were included. Negative samples from 2391 individuals representative of the Israeli population, and 698 SARS-CoV-2 PCR positive patients, collected between March and May 2020, were analyzed FINDINGS: Immunoassays sensitivities between 81.5%-89.4% and specificities between 97.7%-100% resulted in a profound impact on the expected Positive Predictive Value (PPV) in low (<15%) prevalence scenarios. …”
Publicado 2020
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