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  1. 5001
    “…We have also tested them in a pseudovirus assay and used microscale thermophoresis to test the binding of these molecules to the spike protein. They bind to spike RBD protein with K(d) values of 339 nM and 647 nM, respectively. …”
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    Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine and Pyronaridine: In vitro Activity Against SARS-CoV-2 and Potential Mechanisms
  2. 5002
    “…Antibody testing is essential to identify persons exposed to the virus and potentially in predicting disease immunity. 183 COVID-19 patients (68 of whom required mechanical ventilation) and 41 controls were tested for plasma IgG, IgA and IgM against the SARS-CoV-2 S1, S2, receptor binding domain (RBD) and N proteins using the MILLIPLEX(®) SARS-CoV-2 Antigen Panel. …”
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    IgG Antibodies against SARS-CoV-2 Correlate with Days from Symptom Onset, Viral Load and IL-10
  3. 5003
    por Kalish, Heather, Klumpp-Thomas, Carleen, Hunsberger, Sally, Baus, Holly Ann, Fay, Michael P, Siripong, Nalyn, Wang, Jing, Hicks, Jennifer, Mehalko, Jennifer, Travers, Jameson, Drew, Matthew, Pauly, Kyle, Spathies, Jacquelyn, Ngo, Tran, Adusei, Kenneth M., Karkanitsa, Maria, Croker, Jennifer A, Li, Yan, Graubard, Barry I., Czajkowski, Lindsay, Belliveau, Olivia, Chairez, Cheryl, Snead, Kelly, Frank, Peter, Shunmugavel, Anandakumar, Han, Alison, Giurgea, Luca T., Rosas, Luz Angela, Bean, Rachel, Athota, Rani, Cervantes-Medina, Adriana, Gouzoulis, Monica, Heffelfinger, Brittany, Valenti, Shannon, Caldararo, Rocco, Kolberg, Michelle M., Kelly, Andrew, Simon, Reid, Shafiq, Saifullah, Wall, Vanessa, Reed, Susan, Ford, Eric W, Lokwani, Ravi, Denson, John-Paul, Messing, Simon, Michael, Sam G., Gillette, William, Kimberly, Robert P., Reis, Steven E., Hall, Matthew D., Esposito, Dominic, Memoli, Matthew J., Sadtler, Kaitlyn
    Publicado 2021
    “…Samples were analyzed via ELISA for anti-Spike and anti-RBD antibodies. Estimation of seroprevalence was performed by using a weighted analysis to reflect the US population. …”
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    Mapping a Pandemic: SARS-CoV-2 Seropositivity in the United States
  4. 5004
    “…Aliquots from the same units were subjected to enzyme-linked immunosorbent assay (ELISA) that detects IgG antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 S1 protein. The relationship between ELISA titers and CLIA S/Co values was analyzed using linear regression and receiver operating characteristics (ROC) curve. …”
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    Correlation of Automated Chemiluminescent Method with Enzyme-Linked Immunosorbent Assay (ELISA) Antibody Titers in Convalescent COVID-19 Plasma Samples: Development of Rapid, Cost-Effective Semi-Quantitative Diagnostic Methods
  5. 5005
    “…Structural analysis by cryo-EM revealed that CA521(FALA) recognizes an epitope overlapping with angiotensin converting enzyme 2 (ACE2)-binding sites in SARS-CoV-2 RBD in the Spike protein. CA521(FALA) blocks the interaction by binding all three RBDs of one SARS-CoV-2 spike trimer simultaneously. …”
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    Structure and function analysis of a potent human neutralizing antibody CA521(FALA) against SARS-CoV-2
  6. 5006
    “…Experiment was designed as RBD in three replications to evaluate 15 wheat genotypes with moderate saline irrigation (EC(iw) – 6 dS m(−1)) and extreme saline irrigation (EC(iw) – 10 dS m(−1)) along with one set of control (Best available water). …”
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    Effect of saline irrigation on plant water traits, photosynthesis and ionic balance in durum wheat genotypes
  7. 5007
    “…Blood samples for SARS-CoV-2 antibody testing were obtained using a self-sampling kit and analysed using the Abbott SARS-CoV-2 N antibody and/or an in-house receptor binding domain (RBD) assay. FINDINGS: SARS-CoV-2 seroprevalence in 2,905 university students was 17.8% (95%CI, 16.5–19.3), ranging between 7.6%-29.7% across the five universities. …”
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    Seroprevalence of SARS-CoV-2 antibodies in university students: Cross-sectional study, December 2020, England
  8. 5008
    “…Serological tests for immunoglobulin G (IgG), IgA, and IgM antibodies against the receptor binding domain (RBD) of SARS-CoV-2 were evaluated using samples from real-time reverse transcription-quantitative PCR (qRT-PCR)-confirmed inpatient coronavirus disease 2019 (COVID-19) cases. …”
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    Comparison of Antibody Class-Specific SARS-CoV-2 Serologies for the Diagnosis of Acute COVID-19
  9. 5009
    “…Memory B cells specific for full-length spike protein and the spike receptor binding domain (RBD) were also efficiently primed by mRNA vaccination and detectable in all SARS-CoV-2 naive subjects after the second vaccine dose, though the memory B cell response declined slightly with age. …”
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    Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccination
  10. 5010
    “…Sera from all participants and a cohort of historical (negative) controls (n = 595) were screened for IgG responses against stabilized trimers of the SARS‐CoV‐2 spike (S) glycoprotein and the smaller receptor‐binding domain (RBD). As a complement to standard analytical approaches, a probabilistic (cut‐off independent) Bayesian framework that assigns likelihood of past infection was used to analyse data over time. …”
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    Seropositivity in blood donors and pregnant women during the first year of SARS‐CoV‐2 transmission in Stockholm, Sweden
  11. 5011
    “…The OrientGene, which measures anti-RBD antibodies, can be valuable after vaccination as well.…”
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    Performance of five rapid serological tests in mild-diseased subjects using finger prick blood for exposure assessment to SARS-CoV-2
  12. 5012
    “…Notably, SARS-CoV-2 specific T cell responses positively correlated with B cell IgG and neutralizing antibody responses to the receptor-binding domain (RBD) of the S protein. Our results demonstrate that defined levels of SARS-CoV-2 specific T cell responses are generated in some, but not all, COVID-19-recovered subjects, fostering hope for the protection of a proportion of COVID-19-exposed individuals against reinfection. …”
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    SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjects
  13. 5013
    “…Two pentacyclic terpenoids (24-methylene cycloartenol and isoiguesteri) interacted with the hACE2 binding hotspots for the SARS-CoV-2 spike protein, while the abietane diterpenes were found accommodated within the S1-specificity pocket, interacting strongly with the active site residues TMPRSS2. 3-benzoylhosloppone and cucurbitacin interacted with the RBD and S2 subunit of SARS-CoV-2 spike protein respectively. …”
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    SARS-CoV-2 host cell entry: an in silico investigation of potential inhibitory roles of terpenoids
  14. 5014
    “…The nucleoprotein-based Roche and the glycoprotein-based Abbott receptor binding domain (RBD) and Siemens tests were more sensitive than the N-based Abbott and the Euroimmun antibody tests (p = 0.0001 to p = 0.039). …”
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    Sensitivity of SARS-CoV-2 antibody tests with late convalescent sera
  15. 5015
    “…Mechanistic studies revealed that EGCG blocked infection at the entry step through interfering with the engagement of the receptor binding domain (RBD) of the viral spikes to angiotensin-converting enzyme 2 (ACE2) receptor of the host cells. …”
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    Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor
  16. 5016
    “…Then in vitro studies on the two compounds were conducted including VeroE6 toxicity, anti-COVID-19 activity, determination of inhibitory activity towards papain-like proteinase (PL pro) and spike protein- and receptor- binding domain (RBD) as well as assessment of drug toxicity on RBCs. …”
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    Nanoparticles of ZnO/Berberine complex contract COVID-19 and respiratory co-bacterial infection in addition to elimination of hydroxychloroquine toxicity
  17. 5017
    “…METHODS: In this prospective cohort study, anti-SARS-CoV-2 spike-protein titers were determined using the DiaSorin LIAISON (anti-S trimer) and Roche Elecsys (anti-S RBD) immunoassays in 194 patients (141 LT, 53 cirrhosis Child-Pugh A-C) and 56 healthy controls before and 10 to 84 days after second vaccination. …”
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    SARS-CoV2-specific Humoral and T-cell Immune Response After Second Vaccination in Liver Cirrhosis and Transplant Patients
  18. 5018
    “…The current study encompasses the fabrication of a SERS sensor to study the SARS-CoV-2 S1 (RBD) spike protein of the SARS-CoV-2 virus family. …”
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    Ultra-sensitive and fast optical detection of the spike protein of the SARS-CoV-2 using AgNPs/SiNWs nanohybrid based sensors
  19. 5019
    “…Sera from 55 symptomatic COVID-19 patients and 146 healthy subjects (early-pandemic, reverse transcription-quantitative PCR [qRT-PCR]-negative), collected in Israel between March and April 2020, were screened for SARS-CoV-2-specific IgG, IgM, and IgA antibodies, using a 6-plex antigen microarray presenting the whole inactivated virus and five viral antigens: a stabilized version of the spike ectodomain (S2P), spike subunit 1 (S1), receptor-binding-domain (RBD), N-terminal-domain (NTD), and nucleocapsid (NC). …”
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    A Serological Snapshot of COVID-19 Initial Stages in Israel by a 6-Plex Antigen Array
  20. 5020
    “…The activities of furin, TMPRSS2, and cathepsin L are increased against most of the variants. RBD amino acid mutations comprising K417T/N, L452R, Y453F, S477N, E484K, and N501Y cause significant immune escape from 11 of 13 monoclonal antibodies. …”
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    Ten emerging SARS-CoV-2 spike variants exhibit variable infectivity, animal tropism, and antibody neutralization
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