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5041por Goto, Takeyuki, Tani, Naoki, Ikematsu, Hideyuki, Gondo, Kei, Oishi, Ryo, Minami, Junya, Onozawa, Kyoko, Kuwano, Hiroyuki, Akashi, Koichi, Shimono, Nobuyuki, Chong, Yong“…The peri-infection anti-spike RBD protein IgG (anti-S IgG) titers (lowest values between 11 days before and 7 days after onset or diagnosis) of serum samples from the breakthrough-infected persons were quantified. …”
Publicado 2022
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5042por Jia, Jilei, Yin, Zhaojuan, Zhang, Xiao, Li, Huimin, Meng, Dan, Liu, Qianqian, Wang, Hongfang, Han, Meng, Suo, Shixiang, Liu, Yan, Hu, Ping, Sun, Chunyun, Li, Jing, Xie, Liangzhi“…METHODS: HB27, a potent RBD-specific humanized monoclonal antibody (Zhu et al. in National Sci Rev. 8:nwaa297, 2020), showed excellent protection against SARS-CoV-2 in animal model and good safety profile in clinical studies. …”
Publicado 2022
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5043por Szczygioł, Paulina, Łukianowski, Błażej, Kościelska-Kasprzak, Katarzyna, Jakuszko, Katarzyna, Bartoszek, Dorota, Krajewska, Magdalena, Królak-Olejnik, Barbara“…The serum and breastmilk samples of women with COVID-19 was characterized by a higher concentration of anti-RBD IgA and IgG than the serum from the control group without COVID-19. …”
Publicado 2022
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5044por Srivastava, Ashish Kumar, Gupta, Avinash, Chauhan, Deepika, Meena, Ramesh Chand, Sugadev, Ragumani, Eslavath, Malleswara Rao, Gupta, Harshita, Karuna, Singh, Sayar, Singh, Yamini, Tiwari, R. P., Kohli, Veena, Varshney, Rajeev, Ganju, Lilly“…The receptor-binding domain (RBD) of spike and nucleocapsid protein are specific targets for detecting SARS-CoV-2 antibodies. …”
Publicado 2022
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5045por Goh, Yun Shan, Fong, Siew‐Wai, Rouers, Angeline, Chang, Zi Wei, Tay, Matthew Zirui, Chavatte, Jean‐Marc, Zhuo, Nicole Ziyi, Hor, Pei Xiang, Loh, Chiew Yee, Huang, Yuling, Wong, Joel Xu En, Tan, Yong Jie, Lim, Daniel Rui Xiang, Wang, Bei, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Lee, Raphael Tze Chuen, Pada, Surinder, Sun, Louisa Jin, Ong, Desmond Luan Seng, Somani, Jyoti, Lee, Eng Sing, Maurer‐Stroh, Sebastian, Wang, Cheng‐I, Leo, Yee‐Sin, Lin, Raymond TP, Ren, Ee Chee, Lye, David C, Young, Barnaby Edward, Lim, Poh Lian, Ng, Lisa FP, Renia, Laurent“…Although the spike‐specific antibody response was lower, their memory B cell response against the receptor‐binding domain (RBD) of the spike protein was similar, compared with individuals who received two BNT162b2 injections. …”
Publicado 2022
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5046por Zhan, Wuqiang, Tian, Xiaolong, Zhang, Xiang, Xing, Shenghui, Song, Wenping, Liu, Qianying, Hao, Aihua, Hu, Yuxia, Zhang, Meng, Ying, Tianlei, Chen, Zhenguo, Lan, Fei, Sun, Lei“…Comparison of different receptor binding domain (RBD) epitopes revealed that the 553-49 epitope is hidden in the S trimer and keeps a high degree of conservation during SARS-CoV-2 evolution, making 553-49 a promising therapeutic reagent against the emerging Omicron and future variants of SARS-CoV-2.…”
Publicado 2022
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5047por Cervantes-Torres, Jacquelynne, Rosales-Mendoza, Sergio, Cabello, Carlos, Montero, Laura, Hernandez-Aceves, Juan, Granados, Guillermo, Calderón-Gallegos, Arturo, Zúñiga-Flores, Francisco, Ruiz-Rivera, Mirna, Abarca-Magaña, Julio César, Ortega-Francisco, Sandra, Olguin-Alor, Roxana, Díaz, Georgina, Paczka-Garcia, Filipo, Zavala-Gaytan, Rubí, Vázquez-Ramírez, Ricardo, Ayón-Nuñez, Dolores Adriana, Carrero, Julio César, Rios, Diana, Jasso-Ramírez, Mariana, Vázquez-Hernández, Rebeca, Venegas, David, Garzón, Daniel, Cobos, Laura, Segura-Velázquez, René, Villalobos, Nelly, Meneses, Gabriela, Zúñiga, Joaquín, Gamba, Gerardo, Cárdenas, Graciela, Hernández, Marisela, Parkhouse, Michael E., Romano, Marta C., Alonso Herrera, Luis, Bobes, Raúl J., Pérez-Tapia, Mayra, Huerta, Leonor, Fierro, Nora, Gracia, Isabel, Soldevilla, Gloria, Fragoso, Gladis, Suárez-Güemes, Francisco, Laclette, Juan P., Sciutto, Edda“…Here, we describe the immunogenic properties of a group of theoretically predicted RBD peptides to be used as the first step towards the development of an effective, safe and low-cost epitope-focused vaccine. …”
Publicado 2022
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5048por Gu, Yue, Low, Jia Ming, Tan, Jolene Su Yi, Ng, Melissa Shu Feng, Ng, Lisa F. P., Shunmuganathan, Bhuvaneshwari, Gupta, Rashi, MacAry, Paul A., Amin, Zubair, Lee, Le Ye, Lian, Derrick, Shek, Lynette Pei-Chi, Zhong, Youjia, Wang, Liang Wei“…All samples were analyzed for IgG and IgA against whole SARS-CoV-2 spike protein, the spike receptor-binding domain (RBD), and previously reported immunodominant epitopes, as well as cytokine levels. …”
Publicado 2022
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5049por Hernández-Solis, Alejandro, Güemes-González, Azmavet M., Ruiz-Gómez, Ximena, Álvarez-Maldonado, Pablo, Castañeda-Casimiro, Jessica, Flores-López, Argelia, Ramírez-Guerra, Martha Alicia, Muñoz-Miranda, Omar, Madera-Sandoval, Ruth L., Arriaga-Pizano, Lourdes A., Nieto-Patlán, Alejandro, Estrada-Parra, Sergio, Pérez-Tapia, Sonia Mayra, Serafín-López, Jeanet, Chacón-Salinas, Rommel, Escobar-Gutiérrez, Alejandro, Soria-Castro, Rodolfo, Ruiz-Sánchez, Bibiana Patricia, Wong-Baeza, Isabel“…We found that non-surviving COVID-19 patients had higher levels of low-affinity anti-RBD IgA antibodies than surviving patients, which may be a response to increased microbial translocation. …”
Publicado 2022
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5050por Ballotta, Laura, Simonetti, Omar, D’Agaro, Pierlanfranco, Segat, Ludovica, Koncan, Raffaella, Martinez-Orellana, Pamela, Dattola, Federica, Orsini, Emanuele, Marcello, Alessandro, Dal Monego, Simeone, Licastro, Danilo, Misin, Andrea, Mohamed, Sara, Sbisà, Eugenio, Lucchini, Elisa, De Sabbata, Giovanni Maria, Zaja, Francesco, Luzzati, Roberto“…In both cases after the infusion of CI, we observed a rapid negativization of the nasal swabs, the resolution of post-COVID-19 condition, and the development of both the IgG against the trimeric spike protein and the receptor-binding domain (RBD) of the spike protein. The analysis of the viral genome in the period elapsed from the time of COVID-19 diagnosis and the administration of mAbs showed the development of new mutations, especially in the S gene. …”
Publicado 2022
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5051por Franzese, Monica, Coppola, Luigi, Silva, Romina, Santini, Stefano Angelo, Cinquanta, Luigi, Ottomano, Cosimo, Salvatore, Marco, Incoronato, Mariarosaria“…This study monitored the anti-spike-receptor-binding domain (RBD) and neutralizing antibodies induced by the Pfizer/BioNTech mRNA BNT162b2 vaccine in a cohort of 163 healthcare workers aged ≤60 years. …”
Publicado 2022
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5052por Abdullahi, Adam, Oladele, David, Owusu, Michael, Kemp, Steven A., Ayorinde, James, Salako, Abideen, Fink, Douglas, Ige, Fehintola, Ferreira, Isabella A. T. M., Meng, Bo, Sylverken, Augustina Angelina, Onwuamah, Chika, Boadu, Kwame Ofori, Osuolale, Kazeem, Frimpong, James Opoku, Abubakar, Rufai, Okuruawe, Azuka, Abdullahi, Haruna Wisso, Liboro, Gideon, Agyemang, Lawrence Duah, Ayisi-Boateng, Nana Kwame, Odubela, Oluwatosin, Ohihoin, Gregory, Ezechi, Oliver, Kamasah, Japhet Senyo, Ameyaw, Emmanuel, Arthur, Joshua, Kyei, Derrick Boakye, Owusu, Dorcas Ohui, Usman, Olagoke, Mogaji, Sunday, Dada, Adedamola, Agyei, George, Ebrahimi, Soraya, Gutierrez, Lourdes Ceron, Aliyu, Sani H., Doffinger, Rainer, Audu, Rosemary, Adegbola, Richard, Mlcochova, Petra, Phillips, Richard Odame, Solako, Babatunde Lawal, Gupta, Ravindra K.“…We found 44 and 28% of pre-vaccination participants showed IgG anti-N positivity, increasing to 59 and 39% respectively with anti-receptor binding domain (RBD) IgG-specific antibodies. Previous IgG anti-N positivity significantly increased post two-dose neutralizing antibody titres in both populations. …”
Publicado 2022
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5053por Widysanto, Allen, Prasetya, Ignatius Bima, Meriyanti, Tandry, Sungono, Veli, Setiawan, Diane Lukito, Gunawan, Edy, Adiputra, Bayu, Lorens, Jane Olivia, Santi, Theresia, Pradhana, Cindy Meidy Leony, Yusuf, Irawan, Gunawan, Catherine“…This study aimed to evaluate the risk factors of anti-S-RBD IgG levels differences in healthcare workers. …”
Publicado 2022
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5054“…While several computational and experimental investigations comparing the binding of the Omicron and wild type RBD to the human ACE2 receptor have been conducted, many of these report contradictory findings. …”
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5055por Martin, Melanie A., Keith, Monica, Pace, Ryan M., Williams, Janet E., Ley, Sylvia H., Barbosa-Leiker, Celestina, Caffé, Beatrice, Smith, Caroline B., Kunkle, Amanda, Lackey, Kimberly A., Navarrete, Alexandra D., Pace, Christina D. W., Gogel, Alexandra C., Eisenberg, Dan T.A., Fehrenkamp, Bethaney D., McGuire, Mark A., McGuire, Michelle K., Meehan, Courtney L., Brindle, Eleanor“…Dried blood spots were assayed for anti-SARS-CoV-2 S-RBD IgG and IgA positivity and anti-SARS-CoV-2 S1 + S2 IgG concentrations. …”
Publicado 2022
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5056por Eliçabe, Ricardo Javier, Distel, Matías Nicolás, Jofré, Brenda Lucila, Leporati, Marianela, Silva, Juan Eduardo, Arias, José Luis, Gorlino, Carolina Virginia, Funes, Samanta Celeste, Velazquez, Marisol, Vitale, Patricia, Davicino, Roberto Carlos, Di Genaro, María Silvia“…METHODS: Anti-SARS-CoV-2-Spike-RBD IgG and neutralising antibodies were assayed by ELISA in a total of 871 serum samples obtained from 376 volunteers from an educational staff. …”
Publicado 2023
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5057por Olmstead, Andrea D., Nikiforuk, Aidan M., Schwartz, Sydney, Márquez, Ana Citlali, Valadbeigy, Tahereh, Flores, Eri, Saran, Monika, Goldfarb, David M., Hayden, Althea, Masud, Shazia, Russell, Shannon L., Prystajecky, Natalie, Jassem, Agatha N., Morshed, Muhammad, Sekirov, Inna“…Results: Bivariate analysis (complete data for 42 participants, 270 samples over 472 days) found SARS-CoV-2 spike and RBD antibodies increased 14–56 days post-vaccination (p < 0.001) and vaccination prevented waning (regression coefficient, B = 1.66 [95%CI: 1.45–3.46]); while decline of nucleocapsid antibodies over time was observed (regression coefficient, B = −0.24 [95%CI: −1.2-(−0.12)]). …”
Publicado 2022
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5058por Bahoussi, Amina Nawal, Wang, Pei-Hua, Shah, Pir Tariq, Bu, Hongli, Wu, Changxin, Xing, Li“…Prediction of linear B cell epitopes of the spike glycoprotein and the 3D structural mapping of amino acid variations of two representative strains of GI and GII showed that the receptor-binding domain (RBD) of spike glycoprotein underwent a significant antigenic drift, suggesting its contribution in the genetic diversity and the wider spread of PDCoV. …”
Publicado 2022
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5059por Soto, Marta, Iranzo, Alex, Lahoz, Sara, Fernández, Manel, Serradell, Mónica, Gaig, Carles, Melón, Paula, Martí, Maria‐Jose, Santamaría, Joan, Camps, Jordi, Fernández‐Santiago, Rubén, Ezquerra, Mario“…RESULTS: We found sustained cross‐sectional and longitudinal deregulation of 12 miRNAs across the RBD continuum, including DaT‐negative IRBD, DaT‐positive IRBD, and LBD phenoconverted IRBD (let‐7c‐5p, miR‐19b‐3p, miR‐140, miR‐22‐3p, miR‐221‐3p, miR‐24‐3p, miR‐25‐3p, miR‐29c‐3p, miR‐361‐5p, miR‐425‐5p, miR‐4505, and miR‐451a) (false discovery rate P < 0.05). …”
Publicado 2022
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5060por Leitanthem, Vandana Kumari, Chaudhary, Parul, Maiti, Sanjit, Mohini, Madhu, Mondal, Goutam“…Twenty-four goat kids (3 months of age) were distributed into four groups of six animals each, using a randomized block design (RBD). Kids of Group I (control) were fed a basal diet with 70R:30C without any tree leaf supplementation. …”
Publicado 2022
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