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5061por Pirabe, Anita, Schrottmaier, Waltraud C., Heber, Stefan, Schmuckenschlager, Anna, Treiber, Sonja, Pereyra, David, Santol, Jonas, Pawelka, Erich, Traugott, Marianna, Schörgenhofer, Christian, Seitz, Tamara, Karolyi, Mario, Jilma, Bernd, Resch, Ulrike, Zoufaly, Alexander, Assinger, Alice“…Three different IgGs against SARS-CoV-2 (spike protein S1, nucleocapsid (NC), and the spike protein receptor binding domain (RBD)) were monitored in plasma of 97 patients upon admission and three times within the first week followed by weekly assessment during their entire hospital stay. …”
Publicado 2023
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5062por Kante, Bhaskar, Vuyyuru, Sudheer Kumar, Gupta, Ritu, Dwivedi, Tanima, Kumar, Peeyush, Mundhra, Sandeep, Golla, Rithvik, Virmani, Shubi, Verma, Mahak, Makharia, Govind, Ahuja, Vineet, Kedia, Saurabh“…METHODS: Patients with IBD and HCs (contact of patients) underwent SARS-CoV-2 antibody testing (chemiluminescent immunoassay: Siemens kit IgG against antigen-S1RBD) between July 2020 and April 2021. Information on demography, disease characteristics, drug history and past history of SARS-CoV-2 infection were noted. …”
Publicado 2023
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5063por Fernandes-Matano, Larissa, Salas-Lais, Angel Gustavo, Grajales-Muñiz, Concepción, Hernández-Ávila, Mauricio, Garfias-Becerra, Yonathan Omar, Rodríguez-Sepúlveda, Mario César, Segura-Sánchez, Carlos, Montes-Herrera, Daniel, Mendoza-Sánchez, Denisse, Angeles-Martínez, Javier, Santos Coy-Arechavaleta, Andrea, Alvarado-Yaah, Julio Elías, Santacruz-Tinoco, Clara Esperanza, Ramón-Gallegos, Eva, Muñoz-Medina, José Esteban“…In Mexico, 5 vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were used, allowing a cohort study to analyze the generation of anti-S1/S2 IgG antibodies and anti-RBD antibodies with neutralizing activity at 0, 21, 90, and 180 days after vaccination. …”
Publicado 2023
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5064“…Initially, the impact of mutations at the receptor-binding domain (RBD) of B.1.617.2 was tested, and it is found that all mutations increase the stability of proteins (ΔΔG) and decrease the entropies. …”
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5065por Bansal, Devendra, Atia, Hassan, Al Badr, Mashael, Nour, Mohamed, Abdulmajeed, Jazeel, Hasan, Amal, Al-Hajri, Noora, Ahmed, Lina, Ibrahim, Rumissa, Zamel, Reham, Mohamed, Almuthana, Pattalaparambil, Hamad, Daraan, Faisal, Chaudhry, Adil, Oraby, Sahar, El-Saleh, Sahar, El-Shafie, Sittana S., Al-Farsi, Affra Faiz, Paul, Jiji, Ismail, Ahmed, Al-Romaihi, Hamad Eid, Al-Thani, Mohammed Hamad, Doi, Suhail A. R., Zughaier, Susu M., Cyprian, Farhan, Farag, Elmobashar, Farooqui, Habib Hasan“…All sera samples were tested by chemiluminescent microparticle immunoassay (CMIA) for the quantitative determination of IgG antibodies to SARS-CoV-2, receptor-binding domain (RBD) of the S1 subunit of the spike protein of SARS-CoV-2. …”
Publicado 2023
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5066por Parker, Eleanor, Thomas, Jordan, Roper, Kelly J., Ijaz, Samreen, Edwards, Tansy, Marchesin, Federica, Katsanovskaja, Ksenia, Lett, Lauren, Jones, Christopher, Hardwick, Hayley E., Davis, Chris, Vink, Elen, McDonald, Sarah E., Moore, Shona C., Dicks, Steve, Jegatheesan, Keerthana, Cook, Nicola J., Hope, Joshua, Cherepanov, Peter, McClure, Myra O., Baillie, J. Kenneth, Openshaw, Peter J. M., Turtle, Lance, Ho, Antonia, Semple, Malcolm G., Paxton, William A., Tedder, Richard S., Pollakis, Georgios“…Overall, the responses in a Double Antigen Binding Assay (DABA) for antibody to the receptor binding domain (anti-RBD) correlated well with IgM as well as IgG responses against viral spike, S1 and nucleocapsid protein (NP) antigens. …”
Publicado 2023
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5067por Roe, Tiffany L., Brady, Tyler, Schuko, Nicolette, Nguyen, Amy, Beloor, Jagadish, Guest, Johnathan D., Aksyuk, Anastasia A., Tuffy, Kevin M., Zhang, Tianhui, Streicher, Katie, Kelly, Elizabeth J., Kijak, Gustavo H.“…AZD7442 (tixagevimab-cilgavimab) is a combination of extended-half-life neutralizing MAbs that bind to distinct epitopes on the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. The Omicron variant of concern carries mutations at >35 positions in the spike protein and has undergone further genetic diversification since its emergence in November 2021. …”
Publicado 2023
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5068por García-López, Rodrigo, Rivera-Gutiérrez, Xaira, Rosales-Rivera, Mauricio, Zárate, Selene, Muñoz-Medina, José Esteban, Roche, Benjamin, Herrera-Estrella, Alfredo, Gómez-Gil, Bruno, Sanchez-Flores, Alejandro, Taboada, Blanca, Arias, Carlos F.“…A phylogenetic and ancestral sequence reconstruction analysis with geographical inference, as well as a longitudinal analysis of point mutations, were performed to trace back their origin and contrast them with key RBD mutations in variant BQ.1, one of the fastest-growing lineages to date. …”
Publicado 2023
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5069por Wang, Chang Yi, Peng, Wen-Jiun, Kuo, Be-Sheng, Ho, Yu-Hsin, Wang, Min-Sheng, Yang, Ya-Ting, Chang, Po-Yen, Shen, Yea-Huei, Hwang, Kao-Pin“…METHODS AND FINDINGS: We explored booster immunogenicity of UB-612, a multitope-vaccine that contains S1-RBD-sFc protein and sequence-conserved promiscuous Th and CTL epitope peptides on the Sarbecovirus N, M and S2 proteins. …”
Publicado 2023
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5070por Nantambi, Hellen, Sembera, Jackson, Ankunda, Violet, Ssali, Ivan, Kalyebi, Arthur Watelo, Oluka, Gerald Kevin, Kato, Laban, Ubaldo, Bahemuka, Kibengo, Freddie, Katende, Joseph Ssebwana, Gombe, Ben, Baine, Claire, Odoch, Geoffrey, Mugaba, Susan, Sande, Obondo James, Kaleebu, Pontiano, Serwanga, Jennifer“…METHODS: We used nucleoprotein (N), spike (S), NTD, RBD, envelope, membrane, SD1/2-directed IFN-γ ELISpots, and an S- and N-IgG antibody ELISA to screen for SARS-CoV-2-specific cross-reactivity. …”
Publicado 2023
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5071por Changsan, Narumon, Sawatdee, Somchai, Suedee, Roongnapa, Chunhachaichana, Charisopon, Srichana, Teerapol“…CBD-β-CDPM-NS demonstrated the formulation's ability to reduce the cytokine produced by S-RBD stimulation in ex vivo porcine nasal mucosa in both preventative and therapeutic modes.…”
Publicado 2023
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5072por Kakavandi, Sareh, Zare, Iman, VaezJalali, Maryam, Dadashi, Masoud, Azarian, Maryam, Akbari, Abdullatif, Ramezani Farani, Marzieh, Zalpoor, Hamidreza, Hajikhani, Bahareh“…It has been demonstrated that the SARS-CoV-2 spike protein has a stronger affinity for human ACE2 than the spike protein of SARS-CoV, leading the current study to hypothesize that the newly produced variant Omicron receptor-binding domain (RBD) binds to human ACE2 more strongly than the primary strain. …”
Publicado 2023
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5073por Shimazu, Haruka, Wada, Daiki, Maruyama, Shuhei, Inoue, Akira, Kashihara, Masami, Yoshihara, Tomoyuki, Saito, Fukuki, Yoshiya, Kazuhisa, Nakamori, Yasushi, Kuwagata, Yasuyuki“…Before COVID-19 treatment, genomic analysis showed no intrahost mutations in the NSP5, the NSP12, and the RBD regions. After COVID-19 treatment, mutations in these regions were found in 12 of 17 cases (71%). …”
Publicado 2023
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5074por Al Hammoud, Roukaya, Del Bianco, Gabriela P, Somasunderam, Anoma, Hernandez, Stacy Gomez, Riggs, Kaleigh, Hashmi, Syed, Murphy, James, Heresi, Gloria“…RESULTS: 100% had Ab to all components of a SARS-CoV-2 screening panel that comprised receptor-binding protein (RBD), spike 1 (S1), and spike 2 (S2). 13 out of 42 (31%) had Ab to nucleocapsid antigen (N) suggesting previous coronavirus infection of whom 7 (53%) reported a previous PCR-confirmed SARS-CoV-2 infection and had significantly higher Ab response to each of the four screening antigens. …”
Publicado 2023
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5075por Ko, Hae Li, Lee, Deuk-ki, Kim, Younghyeon, Jang, Hui Jeong, Lee, Youn Woo, Lee, Ho-Young, Seok, Sang-Hyuk, Park, Jun Won, Limb, Jin-Kyung, On, Da In, Yun, Jun-Won, Lyoo, Kwang-Soo, Song, Daesub, Yeom, Minjoo, Lee, Hanbyeul, Seong, Je Kyung, Lee, Sungjin“…Here, we aimed to develop a potent SARS-CoV-2 antibody with broad neutralizing effect by screening a scFv library with the spike protein receptor-binding domain (RBD) via phage display. METHODS: SKAI-DS84 was identified through phage display, and we performed pseudovirus neutralization assays, authentic virus neutralization assays, and in vivo neutralization efficacy evaluations. …”
Publicado 2023
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5076por Benz, Peter M., Laban, Hebatullah, Zink, Joana, Günther, Lea, Walter, Ulrich, Gambaryan, Stepan, Dib, Karim“…METHODS: Washed platelets from wild type and VASP-deficient mice were stimulated with thrombin, the purinergic receptors agonist ADP, or the thromboxane A2 receptor agonist U46619 and Rap1b activation was measured using the GST-RalGDS-RBD binding assay. Interaction of VASP and Crkl was investigated by co-immunoprecipitation, confocal microscopy, and pull-down assays using Crkl domains expressed as GST-fusion proteins. …”
Publicado 2016
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5077por Qi, Shanshan, Su, Linjia, Li, Jing, Zhao, Pu, Zhang, Qing, Niu, Xiuran, Liu, Jingyuan, Jia, Guhe, Wei, Xiaoxuan, Tavernier, Jan, Jiang, Jianli, Chen, Zhinan, Zhang, Sihe“…Rab GTPase activation was checked by GST-RBD pull-down and MMP activity was measured by gelatin zymography. …”
Publicado 2019
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5078por Jawahar, Abhinaya, Krishnasamy, Sathya S, Ramirez, Allan, O’Hagan, Adrian, Winters, Stephen J“…These findings indicate that CF-related bone disease (CF-RBD) affecting the LS is common in adult men, and that body weight is a major determinant of LS BMD in men with CF. …”
Publicado 2020
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5079por Randad, Pranay R., Pisanic, Nora, Kruczynski, Kate, Manabe, Yukari C., Thomas, David, Pekosz, Andrew, Klein, Sabra L., Betenbaugh, Michael J., Clarke, William A., Laeyendecker, Oliver, Caturegli, Patrizio P., Larman, H. Benjamin, Detrick, Barbara, Fairley, Jessica K., Sherman, Amy C., Rouphael, Nadine, Edupuganti, Srilatha, Granger, Douglas A., Granger, Steve W., Collins, Matthew, Heaney, Christopher D.“…The salivary anti-receptor binding domain (RBD) IgG response resulted in 100% specificity. …”
Publicado 2020
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5080por Islam, M. Rafiul, Hoque, M. Nazmul, Rahman, M. Shaminur, Alam, A. S. M. Rubayet Ul, Akther, Masuda, Puspo, J. Akter, Akter, Salma, Sultana, Munawar, Crandall, Keith A., Hossain, M. Anwar“…Notably, residues of receptor-binding domain (RBD) showing crucial interactions with angiotensin-converting enzyme 2 (ACE2) and cross-reacting neutralizing antibody were found to be conserved among the analyzed virus strains, except for replacement of lysine with arginine at 378th position of the cryptic epitope of a Shanghai isolate, hCoV-19/Shanghai/SH0007/2020 (EPI_ISL_416320). …”
Publicado 2020
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