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5081por Costa, Larissa Braga, Perez, Lucas Giandoni, Palmeira, Vitória Andrade, Macedo e Cordeiro, Thiago, Ribeiro, Victor Teatini, Lanza, Katharina, Simões e Silva, Ana Cristina“…Following the binding of the S1 receptor-binding domain (RBD) to ACE2, transmembrane protease/serine subfamily 2 (TMPRSS2) cleaves the S2 domain to facilitate membrane fusion. …”
Publicado 2020
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5082“…At first, in domain analysis, we discovered that Pex-ADAR only has one double-stranded RNA-binding domain (dsRBD) and a deaminase domain without a Z-DNA-binding domain (ZBD). …”
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5083por Li, Pei, Guo, Ruixuan, Liu, Yan, Zhang, Yingtao, Hu, Jiaxin, Ou, Xiuyuan, Mi, Dan, Chen, Ting, Mu, Zhixia, Han, Yelin, Chen, Zihan, Cui, Zhewei, Zhang, Leiliang, Wang, Xinquan, Wu, Zhiqiang, Wang, Jianwei, Jin, Qi, Qian, Zhaohui“…Here, we found that Rhinolophus affinis bat ACE2 (RaACE2) is an entry receptor for both SARS-CoV-2 and RaTG13, although the binding of RaACE2 to the receptor-binding domain (RBD) of SARS-CoV-2 is markedly weaker than that of hACE2. …”
Publicado 2021
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5084por Yang, He S., Racine-Brzostek, Sabrina E., Karbaschi, Mohsen, Yee, Jim, Dillard, Alicia, Steel, Peter A.D., Lee, William T., McDonough, Kathleen A., Qiu, Yuqing, Ketas, Thomas J., Francomano, Erik, Klasse, P.J., Hatem, Layla, Westblade, Lars, Wu, Heng, Chen, Haode, Zuk, Robert, Tan, Hong, Girardin, Roxanne C., Dupuis, Alan P., Payne, Anne F., Moore, John P., Cushing, Melissa M., Chadburn, Amy, Zhao, Zhen“…The TOP assays employ an RBD-coated quartz probe using a Cy5-Streptavidin-polysacharide conjugate to improve sensitivity and minimize interference. …”
Publicado 2021
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5085por Gao, Lu, Wang, Yanli, Abbas, Mureed, Zhang, Tingting, Ma, Enbo, Xing, Shuping, Zhu, Kun Yan, Zhang, Jianzhen“…Further sequence analysis revealed that LmR2D2 possesses two tandem dsRNA-binding domains (dsRBD) at the N-terminus. Analysis of the developmental expression profile of LmR2D2 indicated that its transcript level was stable in third-instar nymphs of L. migratoria, whereas the tissue-dependent expression profile exhibited high levels of expression of LmR2D2 in the testis and ovary. …”
Publicado 2021
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5086por Oyebanji, Oladayo A., Wilson, Brigid, Keresztesy, Debbie, Carias, Lenore, Wilk, Dennis, Payne, Michael, Aung, Htin, Denis, Kerri St., Lam, Evan C., Rowley, Christopher F., Berry, Sarah D., Cameron, Cheryl M., Cameron, Mark J., Schmader, Kenneth E., Balazs, Alejandro B., King, Christopher L., Canaday, David H., Gravenstein, Stefan“…Based on our reactogenicity and immunogenicity data, we developed a linear regression model predicting log-transformed anti-spike, anti-receptor-binding domain (RBD), and neutralizing titers, with a dichotomous variable indicating the presence or absence of reported reactions which revealed a statistically significant effect, with estimated shifts in log-transformed titers ranging from 0.32 to 0.37 (all p < 0.01) indicating greater immunogenicity in subjects with one or more reported reactions of varying severity. …”
Publicado 2021
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5087por Fulford, Thomas S., Van, Huy, Gherardin, Nicholas A., Zheng, Shuning, Ciula, Marcin, Drummer, Heidi E., Redmond, Samuel, Tan, Hyon-Xhi, Boo, Irene, Center, Rob J., Li, Fan, Grimley, Samantha L., Wines, Bruce D., Nguyen, Thi H.O., Mordant, Francesca L., Ellenberg, Paula, Rowntree, Louise C., Kedzierski, Lukasz, Cheng, Allen C., Doolan, Denise L., Matthews, Gail, Bond, Katherine, Hogarth, P. Mark, McQuilten, Zoe, Subbarao, Kanta, Kedzierska, Katherine, Juno, Jennifer A., Wheatley, Adam K., Kent, Stephen J., Williamson, Deborah A., Purcell, Damian F.J., Anderson, David A., Godfrey, Dale I.“…METHODS: We have developed a lateral flow POC test that can measure levels of RBD-ACE2 neutralising antibody (NAb) from whole blood, with a result that can be determined by eye or quantitatively on a small instrument. …”
Publicado 2021
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5088por Oliveira-Silva, Joana, Reis, Teresa, Lopes, Cristiana, Batista-Silva, Ricardo, Ribeiro, Ricardo, Marques, Gilberto, Pacheco, Vânia, Rodrigues, Tiago, Afonso, Alexandre, Pinheiro, Vítor, Araújo, Lucília, Rodrigues, Fernando, Antunes, Isabel“…Peripheral blood was collected for immunological analysis using the Quant SARS-CoV-2 IgG II Chemiluminescent Microparticle Immunoassay (CMIA) to determine anti-spike IgG, receptor binding domain (RBD), S1 subunit of SARS-CoV-2. FINDINGS: At T0, 96·8% (n = 4129) of participants had IgG antibodies non-reactive to anti-SARS-CoV-2. …”
Publicado 2022
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5089por Colavita, Francesca, Meschi, Silvia, Gruber, Cesare Ernesto Maria, Rueca, Martina, Vairo, Francesco, Matusali, Giulia, Lapa, Daniele, Giombini, Emanuela, De Carli, Gabriella, Spaziante, Martina, Messina, Francesco, Bonfiglio, Giulia, Carletti, Fabrizio, Lalle, Eleonora, Fabeni, Lavinia, Berno, Giulia, Puro, Vincenzo, Bartolini, Barbara, Di Caro, Antonino, Ippolito, Giuseppe, Capobianchi, Maria Rosaria, Castilletti, Concetta“…METHODS: We evaluated clinical features, virological (viral load; viral infectiousness; genomic characterisation), and serological (anti-nucleoprotein Ig; anti-Spike RBD IgG; neutralising antibodies, nAb) characteristics of 94 post-vaccine infections at the time of diagnosis. …”
Publicado 2022
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5090por Dobaño, Carlota, Alonso, Selena, Vidal, Marta, Jiménez, Alfons, Rubio, Rocío, Santano, Rebeca, Barrios, Diana, Pons Tomas, Gemma, Melé Casas, María, Hernández García, María, Girona-Alarcón, Mònica, Puyol, Laura, Baro, Barbara, Millat-Martínez, Pere, Ajanovic, Sara, Balanza, Núria, Arias, Sara, Rodrigo Melero, Natalia, Carolis, Carlo, García-Miquel, Aleix, Bonet-Carné, Elisenda, Claverol, Joana, Cubells, Marta, Fortuny, Claudia, Fumadó, Victoria, Codina, Anna, Bassat, Quique, Muñoz-Almagro, Carmen, Fernández de Sevilla, Mariona, Gratacós, Eduard, Izquierdo, Luis, García-García, Juan José, Aguilar, Ruth, Jordan, Iolanda, Moncunill, Gemma“…Among infected children, males had higher levels of saliva IgG to N and RBD than females. Despite overall correlation, individual clustering analysis suggested that responses that may not be detected in blood could be patent in saliva, and vice versa. …”
Publicado 2022
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5091por Kirman, Dogan Can, Renganathan, Bhuvanasundar, Chui, Wai Kit, Chen, Ming Wei, Kaya, Neslihan Arife, Ge, Ruowen“…We show that the central RNA-binding domain (RBD) of NCL is essential and sufficient for its binding to TS5-p45. …”
Publicado 2022
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5092por Bandeira, Carla Carolina Silva, Madureira, Karen Cristina Rolim, Rossi, Meire Bocoli, Gallo, Juliana Failde, da Silva, Ana Paula Marques Aguirra, Torres, Vilanilse Lopes, de Lima, Vinicius Alves, Júnior, Norival Kesper, Almeida, Janete Dias, Zerbinati, Rodrigo Melim, Braz-Silva, Paulo Henrique, Lindoso, José Angelo Lauletta, da Silva Martinho, Herculano“…In contrast it has been also reported that NP-, S-, RBD- specific IgA, IgG, and IgM are not associated with SARS-CoV-2 viral load, indicating that there is no obvious correlation between antibody response and viral antigen detection. …”
Publicado 2022
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5093por Benning, Louise, Morath, Christian, Bartenschlager, Marie, Kim, Heeyoung, Reineke, Marvin, Beimler, Jörg, Buylaert, Mirabel, Nusshag, Christian, Kälble, Florian, Reichel, Paula, Töllner, Maximilian, Schaier, Matthias, Klein, Katrin, Benes, Vladimir, Rausch, Tobias, Rieger, Susanne, Stich, Maximilian, Tönshoff, Burkhard, Weidner, Niklas, Schnitzler, Paul, Zeier, Martin, Süsal, Caner, Hien Tran, Thuong, Bartenschlager, Ralf, Speer, Claudius“…Vaccine-induced cross-neutralization of the B.1.1.529 (omicron) variants was detectable in 15/35 (43%) kidney transplant recipients with seropositivity for anti-S1 IgG, surrogate neutralizing, and/or anti-RBD antibodies. Neutralization of the B.1.1.529 (omicron) variants was significantly reduced compared to neutralization of SARS-CoV-2 wild-type or the B.1.617.2 (delta) variant for both, kidney transplant recipients and healthy controls (p< .001 for all).…”
Publicado 2022
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5094“…Quantitative IgG levels against virus spike protein receptor binding domain (RBD) were measured using chemiluminescent enzyme immunoassay (CLIA). …”
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5095por Banihashemi, Seyed Reza, Es-haghi, Ali, Fallah Mehrabadi, Mohammad Hossein, Nofeli, Mojtaba, Mokarram, Ali Rezaei, Ranjbar, Alireza, Salman, Mo, Hajimoradi, Monireh, Razaz, Seyad Hossein, Taghdiri, Maryam, Bagheri, Mohsen, Dadar, Maryam, Hassan, Zuhair Mohammad, Eslampanah, Mohammad, Salehi Najafabadi, Zahra, Lotfi, Mohsen, Khorasani, Akbar, Rahmani, Fereidoon“…Three different doses of candidate vaccine stimulated remarkable titers of neutralizing antibodies, S1, Receptor-Binding Domain (RBD), and N-terminal domain (NTD) specific IgG antibodies as well as IgA antibodies compared to placebo and control groups (P<0.01). …”
Publicado 2022
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5096por Otten, Antonius T., Bourgonje, Arno R., Horinga, Petra P., van der Meulen, Hedwig H., Festen, Eleonora A. M., van Dullemen, Hendrik M., Weersma, Rinse K., van Leer-Buter, Coretta C., Dijkstra, Gerard, Visschedijk, Marijn C.“…Subsequently, a chemiluminescent microparticle immunoassay was used for the quantitative determination of IgG antibodies against the receptor-binding domain (RBD) of the S1 subunit of the spike protein of SARS-CoV-2. …”
Publicado 2022
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5097por Teeyapun, Nattaya, Luangdilok, Sutima, Pakvisal, Nussara, Sainamthip, Panot, Mingmalairak, Siyamol, Poovorawan, Nattaya, Sitthideatphaiboon, Piyada, Parinyanitikul, Napa, Sriuranpong, Virote, Namkanisorn, Teerayuth, Inthasuwan, Pratchaya, Angspatt, Pattama, Wongchanapat, Ploytuangporn, Bamrungnam, Akradach, Leeleakpai, Nutchanok, Uttha, Sutheera, Jaichum, Supaporn, Kongkaew, Peerawich, Suksanong, Chayanin, Veranitinun, Rattiya, Prasomphol, Ampai, Sartsuk, Chada, Patcharajutanon, Cheeraporn, Preaprang, Supreeya, Choengsamor, Hathairat, Phongwan, Rungthong, Preeyasaksa, Charoenpit, Phaibulvatanapong, Ekkamol, Suntronwong, Nungruthai, Yorsaeng, Ritthideach, Vichaiwattana, Preeyaporn, Wanlapakorn, Nasamon, Kerr, Stephen J., Poovorawan, Yong, Wanchaijiraboon, Passakorn, Tanasanvimon, Suebpong“…Blood samples were evaluated for total immunoglobulins against the receptor-binding of SARS-CoV-2 spike protein (anti-RBD total-Ig) before, and 4-week after the first- and second-doses. …”
Publicado 2022
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5098por Parai, Debaprasad, Choudhary, Hari Ram, Dash, Girish Chandra, Behera, Susmita, Mishra, Narayan, Pattnaik, Dipti, Raghav, Sunil Kumar, Mishra, Sanjeeb Kumar, Sahoo, Subrat Kumar, Swain, Aparajita, Mohapatra, Ira, Pattnaik, Matrujyoti, Moharana, Aparnamayee, Jena, Sandhya Rani, Praharaj, Ira, Subhadra, Subhra, Kanungo, Srikanta, Bhattacharya, Debdutta, Pati, Sanghamitra“…IgG antibodies against spike receptor-binding domain (RBD) of SARS-CoV-2 were quantified in an automated chemiluminescence immune assay-based (CLIA) platform and a surrogate virus neutralization test (sVNT) was performed by enzyme-linked immunosorbent assay (ELISA). …”
Publicado 2022
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5099por Ao, Zhujun, Ouyang, Maggie J., Olukitibi, Titus A., Warner, Bryce, Vendramelli, Robert, Truong, Thang, Meilleur, Courtney, Zhang, Manli, Kung, Sam, Fowke, Keith R., Kobasa, Darwyn, Yao, Xiaojian“…These rVSV-based vaccines coexpress SARS-CoV-2 Delta spike protein (SP) bearing the C-terminal 17 amino acid (aa) deletion (SPΔC) and I742A point mutation, or the SPΔC with a deletion of S2 domain, or the RBD domain, and a tandem repeat harboring four copies of the highly conserved influenza M2 ectodomain (M2e) that fused with the Ebola glycoprotein DC-targeting/activation domain. …”
Publicado 2022
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5100por Pulvirenti, Federica, Mortari, Eva Piano, Putotto, Carolina, Terreri, Sara, Fernandez Salinas, Ane, Cinicola, Bianca Laura, Cimini, Eleonora, Di Napoli, Giulia, Sculco, Eleonora, Milito, Cinzia, Versacci, Paolo, Agrati, Chiara, Marino, Bruno, Carsetti, Rita, Quinti, Isabella“…Anti-Spike, and anti–receptor binding domain (RBD) antibody responses, generation of Spike-specific memory B cells (MBCs) and Spike-specific T cells at different time points before and after the mRNA BNT162b2 vaccination were evaluated in 16 22q11.2DS patients. …”
Publicado 2023
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