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5101por Chiu, Chun-Hsiang, Chang, Yu-Hsiu, Tao, Chi-Wei, Chang, Feng-Yee, Chiu, Kuo-Chou, Chang, Tien-Wei, Yen, Li-Chen“…We found a 12.3- to 16.1-fold increase in antibodies targeting the receptor binding domain (RBD) of the Delta variant with 2× MVC/Mod compared to two doses of MVC (2× MVC) or AZD1222 (2× AZ) regimens and a 26- to 32.2-fold improvement in neutralizing potency against the Omicron variant (BA.1). …”
Publicado 2022
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5102por Stich, Maximilian, Di Cristanziano, Veronica, Tönshoff, Burkhard, Weber, Lutz Thorsten, Dötsch, Jörg, Rammer, Marian Theodor, Rieger, Susanne, Heger, Eva, Garbade, Sven F., Burgmaier, Kathrin, Benning, Louise, Speer, Claudius, Habbig, Sandra, Haumann, Sophie“…Two of 18 (11.1%) and 8 of 16 (50.0%) patients with an anti-S1-RBD IgG of 100–1411 and > 1411 BAU/mL, respectively, showed a neutralization activity against the omicron variant. …”
Publicado 2022
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5103por Misra, Puneet, Kant, Shashi, Guleria, Randeep, Ahmad, Mohammad, Mandal, Suprakash, Chaturvedi, P. K., Medigeshi, Guruprasad R., Meena, Suneeta, Rai, Sanjay Kumar, Rahman, Anisur, Sangral, Meenu, Yadav, Kapil, Bairwa, Mohan, Haldar, Partha“…We aimed at assessing agreement with three serological tests: quantitative anti receptor binding domain ELISA (Q-RBD), qualitative ELISA (WANTAI SARS-CoV-2 Ab) and qualitative chemiluminescence assay (CLIA). …”
Publicado 2022
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5104por Hunsawong, Taweewun, Buddhari, Darunee, Rungrojcharoenkit, Kamonthip, Suthangkornkul, Rungarun, Mongkolsirichaikul, Duangrat, Lohachanakul, Jindarat, Tayong, Kedsara, Sirikajornpan, Kanittha, Rodpradit, Prinyada, Poolpanichupatam, Yongyuth, Klungthong, Chonticha, Utennam, Darunee, Kaewhiran, Surachai, Cotrone, Thomas S., Fernandez, Stefan, Jones, Anthony R.“…The EUROIMMUN ELISA using spike 1 as the antigen detected more positives among the primary DENV infections than the in-house ELISA using spike 1-receptor binding domain (RBD) protein. Among ELISA-positive samples, four had detectable neutralizing antibodies against SARS-CoV-2 reporter virus particles yet none had detectable neutralizing antibodies against the live Wuhan strain of SARS-CoV-2. …”
Publicado 2022
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5105por Domovitz, Tom, Ayoub, Samer, Werbner, Michal, Alter, Joel, Izhaki Tavor, Lee, Yahalom-Ronen, Yfat, Tikhonov, Evgeny, Meirson, Tomer, Maman, Yaakov, Paran, Nir, Israely, Tomer, Dessau, Moshe, Gal-Tanamy, Meital“…In addition, we observed increased binding of spike receptor-binding domain (RBD) protein to Huh7.5(HCV) cells, as well as enhanced cell-to-cell fusion of Huh7.5(HCV) cells with spike-expressing Huh7.5 cells. …”
Publicado 2022
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5106por Godkov, Mikhail A., Ogarkova, Darya A., Gushchin, Vladimir A., Kleymenov, Denis A., Mazunina, Elena P., Bykonia, Evgeniia N., Pochtovyi, Andrei A., Shustov, Valeriy V., Shcheblyakov, Dmitry V., Komarov, Andrey G., Tsibin, Alexander N., Zlobin, Vladimir I., Logunov, Denis Y., Gintsburg, Alexander L.“…Six months after the primary vaccination with Sputnik V, 95.5% of patients maintained a positive level of IgG antibodies to the receptor-binding domain (RBD) of SARS-CoV-2. The degree of increase in the specific virus-neutralizing antibodies level after revaccination increased with a decrease in their initial level just before the booster dose application. …”
Publicado 2022
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5107por Taus, Ellie, Hofmann, Christian, Ibarrondo, F. Javier, Gong, Laura S., Hausner, Mary Ann, Fulcher, Jennifer A., Krogstad, Paul, Kitchen, Scott G., Ferbas, Kathie G., Tobin, Nicole H., Rimoin, Anne W., Aldrovandi, Grace M., Yang, Otto O.“…ELISA was performed to quantitate serum antibodies against the spike receptor binding domain (RBD). RESULTS: In two persons receiving primary vaccination, tightly serially evaluated frequencies of anti-spike CD8+ T cells using ELISpot assays revealed strikingly short-lived responses, peaking after about 10 days and becoming undetectable by about 20 days after each dose. …”
Publicado 2023
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5108por Poglajen, G., Žorž, N., Ihan, A., Frljak, S., Cerar, A., Zemljic, G., Okrajsek, R., Sebestjen, M., Vrtovec, B.“…METHODS: In a prospective single-center cohort study we included 54 consecutive adult heart transplant recipients who received 2 doses of mRNA SARS-CoV2 vaccine between January 1 and June 30, 2021. 3 months after the 2(nd) dose, an assessment of humoral (total antibody levels to the receptor-binding domain of SARS-CoV2 spike (S) protein using anti-RBD immunoassay) and cellular (IFN-γ response to S-peptide stimulation of recipient T lymphocyte populations) response to vaccination was assesed. …”
Publicado 2023
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5109por Payen, Shannon Harger, Gorzalski, Andrew, Siao, Danielle Denise, Pandori, Mark, Verma, Subhash C., Rossetto, Cyprian C.“…Our analysis focused on nucleotide mutations that generated amino acid variations in the viral Spike (S) protein, Receptor binding domain (RBD), and the RNA-dependent RNA-polymerase (RdRp) complex. …”
Publicado 2023
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5110por van der Klaauw, Agatha A., Horner, Emily C., Pereyra-Gerber, Pehuén, Agrawal, Utkarsh, Foster, William S., Spencer, Sarah, Vergese, Bensi, Smith, Miriam, Henning, Elana, Ramsay, Isobel D., Smith, Jack A., Guillaume, Stephane M., Sharpe, Hayley J., Hay, Iain M., Thompson, Sam, Innocentin, Silvia, Booth, Lucy H., Robertson, Chris, McCowan, Colin, Kerr, Steven, Mulroney, Thomas E., O’Reilly, Martin J., Gurugama, Thevinya P., Gurugama, Lihinya P., Rust, Maria A., Ferreira, Alex, Ebrahimi, Soraya, Ceron-Gutierrez, Lourdes, Scotucci, Jacopo, Kronsteiner, Barbara, Dunachie, Susanna J., Klenerman, Paul, Park, Adrian J., Rubino, Francesco, Lamikanra, Abigail A., Stark, Hannah, Kingston, Nathalie, Estcourt, Lise, Harvala, Heli, Roberts, David J., Doffinger, Rainer, Linterman, Michelle A., Matheson, Nicholas J., Sheikh, Aziz, Farooqi, I. Sadaf, Thaventhiran, James E. D.“…Furthermore, we observed that, for individuals with severe obesity, at any given anti-spike and anti-receptor-binding domain (RBD) antibody level, neutralizing capacity was lower than that of individuals with a normal BMI. …”
Publicado 2023
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5111por Puspitasari, Metalia, Sattwika, Prenali D., Hidayat, Auliana R. P., Wijaya, Wynne, Wardhani, Yulia, Intansari, Umi S., Kertia, Nyoman, Purwanto, Bambang, Thobari, Jarir At“…RESULTS: The geometric mean titre (GMT) of anti-SARS-CoV-2 S-RBD IgG antibody at 8 months after the primary vaccination increased significantly to 5,296.63 (95%CI: 2,930.89–9,571.94) U/mL (p = < 0.0001) compared to before the primary vaccination. …”
Publicado 2023
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5112por Alfonso-Dunn, Roberto, Lin, Jerry, Lei, Joyce, Liu, Jiayuan, Roche, Morgan, De Oliveira, Antonia, Raisingani, Amol, Kumar, Anjali, Kirschner, Vanessa, Feuer, Grant, Malin, Michaela, Sadiq, Saud A.“…Low rates of seroconversion and RBD-hACE2 blocking activity were observed in aCD20-MS patients, even after multiple exposures (responders after 1st exposure = 17.5%; 2nd exposure = 29.3%). …”
Publicado 2023
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5113por Gonzales, Ma. Liza Antoinette M., Dans, Leonila F., Tan-Lim, Carol Stephanie C., Uy, Elenore, Cutiongco-dela Paz, Eva, Sulit, Maria Vanessa V., Alejandria, Marissa M., Lansang, Mary Ann D., Dans, Antonio L., Dator, Melissa A., Cordero, Cynthia P., Pardilla, Gina F.“…Receptor-binding domain (RBD)-specific antibodies were measured at Days 21, 90, 180, 270 and 360. …”
Publicado 2023
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5114por Jancy, Shine Varghese, Lupitha, Santhik Subhasingh, Chandrasekharan, Aneesh, Varadarajan, Shankara Narayanan, Nelson-Sathi, Shijulal, Prasad, Roshny, Jones, Sara, Easwaran, Sreekumar, Darvin, Pramod, Sivasailam, Aswathy, Santhoshkumar, Thankayyan Retnabai“…BACKGROUND: The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is mediated through the binding of the SARS-CoV-2 Spike protein via the receptor binding domain (RBD) to human angiotensin-converting enzyme 2 (hACE2). …”
Publicado 2023
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5115por Fang, Rui, Yue, Pei-Lin, Li, Hai-Long, Ding, Xue-Fei, Jia, Yu-Xuan, Liu, Zhao-Chuan, Zhou, Hong-Gang, Song, Xu-Dong“…Target miRNAs of hub genes were predicted by miRBD and TargetScan. Furthermore, differentially expressed miRNA(DEmiRNAs) were selected as hub genes’ targets, validated by quantitative real-time polymerase chain reaction(qRT-PCR), and a DEmiRNA-DEmRNA regulatory network was constructed via Cytoscape. …”
Publicado 2023
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5116por Priyadarshi, Megha, Soneja, Manish, Paul, Saurav Sekhar, Agarwal, Ayush, Tirlangi, Praveen Kumar, Sachan, Shilpa, Gupta, Nimesh, Wig, Naveet“…IgG antibodies against the receptor binding domain (RBD) of the SARS-CoV-2 virus were measured in all patients. …”
Publicado 2023
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5117por Richards, David M., Marschall, Viola, Billian-Frey, Katharina, Heinonen, Karl, Merz, Christian, Redondo Müller, Mauricio, Sefrin, Julian P., Schröder, Matthias, Sykora, Jaromir, Fricke, Harald, Hill, Oliver, Gieffers, Christian, Thiemann, Meinolf“…HERA-GITRL is composed of a trivalent but single-chain GITRL-receptor-binding-domain (scGITRL-RBD) unit fused to an IgG1 derived silenced Fc-domain serving as dimerization scaffold. …”
Publicado 2019
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5118por Cashman, Daniel P.“…Resolving this paradox requires looking beyond the binary model of a viral receptor-binding domain (RBD) attaching to the ACE-2 receptor. A NCBI pBlast analysis revealed that the SARS-CoV-2 surface spike protein contains key two calcium-dependent fusion domains that are almost identical to those that were recently discovered SARS-CoV-1. …”
Publicado 2020
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5119por Shawar, Ribhi, O’Leary, Brendan, Kemp, Troy, Cherry, James, Owen, S Michele, Gallagher, Pamela, Thornburg, Natalie, Kondratovich, Marina, Satheshkumar Panayampalli, Subbian, Schuh, Amy, Lester, Sandra, Cassetti, Cristina, Cassetti, Cristina, Lowy, Douglas, Gitterman, Steve R“…NCI-FNLCR also performed a SARS-CoV-2 spike Receptor Binding Domain (RBD) IgG ELISA. Positive samples were assessed at multiple dilutions. …”
Publicado 2020
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5120por Franceschi, Vincius Bonetti, Caldana, Gabriel Dickin, de Menezes Mayer, Amanda, Cybis, Gabriela Bettella, Neves, Carla Andretta Moreira, Ferrareze, Patrcia Aline Grhs, Demoliner, Meriane, de Almeida, Paula Rodrigues, Gularte, Juliana Schons, Hansen, Alana Witt, Weber, Matheus Nunes, Fleck, Juliane Deise, Zimerman, Ricardo Ariel, Kmetzsch, Lvia, Spilki, Fernando Rosado, Thompson, Claudia Elizabeth“…RESULTS: We provided a comprehensive view of mutations from a representative sampling from May to October 2020, highlighting two frequent mutations in spike glycoprotein (D614G and V1176F), an emergent mutation (E484K) in spike Receptor Binding Domain (RBD) characteristic of the B.1.351 and P.1 lineages, and the adjacent replacement of 2 amino acids in Nucleocapsid phosphoprotein (R203K and G204R). …”
Publicado 2021
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